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S. A. Julious, Horspool, M. J., Davis, S., Franklin, M., Smithson, W. H., Norman, P., Simpson, R. M., Elphick, H., Bortolami, O., and Cooper, C., Open-label, cluster randomised controlled trial and economic evaluation of a brief letter from a GP on unscheduled medical contacts associated with the start of the school year: the PLEASANT trial, BMJ Open, vol. 8, p. e017367, 2018.
C. Garriga, Pazianas, M., Hawley, S., Delmestri, A., Prieto-Alhambra, D., Cooper, C., and Judge, A., Oral bisphosphonate use and age-related macular degeneration: retrospective cohort and nested case-control study, Ann N Y Acad Sci, vol. 1415, pp. 34-46, 2018.
K. Gruntz, Bloechliger, M., Becker, C., Jick, S. S., Fuhr, P., Meier, C. R., and Ruegg, S., Parkinson disease and the risk of epileptic seizures, Ann Neurol, vol. 83, pp. 363-374, 2018.
H. J. I. De Jong, Tervaert, J. W. Cohen, Lalmohamed, A., de Vries, F., Vandebriel, R. J., Van Loveren, H., Klungel, O. H., and van Staa, T. P., Pattern of risks of rheumatoid arthritis among patients using statins: A cohort study with the clinical practice research datalink, PLoS One, vol. 13, p. e0193297, 2018.
J. Tran, Norton, R., Conrad, N., Rahimian, F., Canoy, D., Nazarzadeh, M., and Rahimi, K., Patterns and temporal trends of comorbidity among adult patients with incident cardiovascular disease in the UK between 2000 and 2014: A population-based cohort study, PLoS Med, vol. 15, p. e1002513, 2018.
A. V. Margulis, Linder, M., Arana, A., Pottegard, A., Berglind, I. A., Bui, C. L., Kristiansen, N. S., Bahmanyar, S., McQuay, L. J., Atsma, W. J., Appenteng, K., D'Silva, M., Perez-Gutthann, S., and Hallas, J., Patterns of use of antimuscarinic drugs to treat overactive bladder in Denmark, Sweden, and the United Kingdom, PLoS One, vol. 13, p. e0204456, 2018.
L. McDonald, Schultze, A., Carroll, R., and Ramagopalan, S. V., Performing studies using the UK Clinical Practice Research Datalink: to link or not to link?, Eur J Epidemiol, vol. 33, pp. 601-605, 2018.
F. A. Achana, Fleming, K. M., Tata, L. J., Sultan, A. A., and Petrou, S., Peripartum hysterectomy: an economic analysis of direct healthcare costs using routinely collected data, Bjog, vol. 125, pp. 874-883, 2018.
M. Sabido, Hohenberger, T., and Grassi, G., Pharmacological intervention in hypertension using beta-blockers: Real-world evidence for long-term effectiveness, Pharmacol Res, vol. 130, pp. 191-197, 2018.
H. Strongman, Christopher, S., Majak, M., Williams, R., Bahmanyar, S., Linder, M., Heintjes, E. M., Bennett, D., Korhonen, P., and Hoti, F., Pioglitazone and cause-specific risk of mortality in patients with type 2 diabetes: extended analysis from a European multidatabase cohort study, BMJ Open Diabetes Res Care, vol. 6, p. e000481, 2018.
E. G. Tyrrell, Kendrick, D., Sayal, K., and Orton, E., Poisoning substances taken by young people: a population-based cohort study, Br J Gen Pract, vol. 68, pp. e703-e710, 2018.
A. Cherskov, Pohl, A., Allison, C., Zhang, H., Payne, R. A., and Baron-Cohen, S., Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory, Transl Psychiatry, vol. 8, p. 136, 2018.
T. R. Berni, Morgan, C. L., Berni, E. R., and Rees, D. A., Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes, J Clin Endocrinol Metab, vol. 103, pp. 2116-2125, 2018.
S. Jenkins-Jones, Parviainen, L., Porter, J., Withe, M., Whitaker, M. J., Holden, S. E., Morgan, C. L., Currie, C. J., and Ross, R. J. M., Poor compliance and increased mortality, depression and healthcare costs in patients with congenital adrenal hyperplasia, Eur J Endocrinol, vol. 178, pp. 309-320, 2018.
J. R. Ingram, Jenkins-Jones, S., Knipe, D. W., Morgan, C. L. I., Cannings-John, R., and Piguet, V., Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa, Br J Dermatol, vol. 178, pp. 917-924, 2018.
J. Busby, Mills, K., Zhang, S. D., Liberante, F. G., and Cardwell, C. R., Postdiagnostic Calcium Channel Blocker Use and Breast Cancer Mortality: A Population-based Cohort Study, Epidemiology, vol. 29, pp. 407-413, 2018.
A. M. Mueller, Meier, C. R., Jick, S. S., and Schneider, C., The Potential of Glycemic Control and Body Weight Change as Early Markers for Pancreatic Cancer in Patients With Long-standing Diabetes Mellitus: A Case-Control Study, PancreasPancreasPancreas, vol. 47, pp. 807-815, 2018.
J. W. O'Sullivan, Stevens, S., Oke, J., Hobbs, F. D. R., Salisbury, C., Little, P., Goldacre, B., Bankhead, C., Aronson, J. K., Heneghan, C., and Perera, R., Practice variation in the use of tests in UK primary care: a retrospective analysis of 16 million tests performed over 3.3 million patient years in 2015/16, BMC Med, vol. 16, p. 229, 2018.
J. M. Dennis, Shields, B. M., Hill, A. V., Knight, B. A., McDonald, T. J., Rodgers, L. R., Weedon, M. N., Henley, W. E., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., and Jones, A. G., Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-term Glycemic Response to DPP-4 Inhibitor Therapy, Diabetes Care, vol. 41, pp. 705-712, 2018.
S. W. D. Merriel, May, M. T., and Martin, R. M., Predicting prostate cancer progression: protocol for a retrospective cohort study to identify prognostic factors for prostate cancer outcomes using routine primary care data, BMJ Open, vol. 8, p. e019409, 2018.
C. L. Burton, Chesterton, L. S., Chen, Y., and van der Windt, D. A., Predicting surgical intervention in patients presenting with carpal tunnel syndrome in primary care, Clin Epidemiol, vol. 10, pp. 739-748, 2018.
F. Rahimian, Salimi-Khorshidi, G., Payberah, A. H., Tran, J., R. Solares, A., Raimondi, F., Nazarzadeh, M., Canoy, D., and Rahimi, K., Predicting the risk of emergency admission with machine learning: Development and validation using linked electronic health records, PLoS Med, vol. 15, p. e1002695, 2018.
G. Nakafero, Grainge, M. J., Myles, P. R., Mallen, C. D., Zhang, W., Doherty, M., Nguyen-Van-Tam, J. S., and Abhishek, A., Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study, Rheumatology (Oxford), vol. 57, pp. 1726-1734, 2018.
T. Newlove-Delgado, Ford, T. J., Hamilton, W., Stein, K., and Ukoumunne, O. C., Prescribing of medication for attention deficit hyperactivity disorder among young people in the Clinical Practice Research Datalink 2005-2013: analysis of time to cessation, Eur Child Adolesc Psychiatry, vol. 27, pp. 29-35, 2018.
D. Spanopoulos, Barrett, B., Busse, M., Roman, T., and Poole, C., Prescription of DPP-4 Inhibitors to Patients With Adult Type 2 Diabetes Mellitus and Creatinine Clearance>50 mL/min: The UK Primary Care Experience, Clin Ther, vol. 40, pp. 1424-1428.e4, 2018.
D. Spanopoulos, Barrett, B., Busse, M., Roman, T., and Poole, C., Prescription of DPP-4 Inhibitors to Type 2 Diabetes Mellitus Patients With Renal Impairment: A UK Primary Care Experience, Clin Ther, vol. 40, pp. 152-154, 2018.
S. H. Mahmoudpour, Asselbergs, F. W., Souverein, P. C., de Boer, A., and van der Zee, A. H. Maitlan, Prescription patterns of angiotensin-converting enzyme inhibitors for various indications: A UK population-based study, Br J Clin Pharmacol, vol. 84, pp. 2365-2372, 2018.
M. D. Danese, Sidelnikov, E., and Kutikova, L., The prevalence, low-density lipoprotein cholesterol levels, and treatment of patients at very high risk of cardiovascular events in the United Kingdom: a cross-sectional study, Curr Med Res Opin, vol. 34, pp. 1441-1447, 2018.
G. Disanto, Zecca, C., MacLachlan, S., Sacco, R., Handunnetthi, L., Meier, U. C., Simpson, A., McDonald, L., Rossi, A., Benkert, P., Kuhle, J., Ramagopalan, S. V., and Gobbi, C., Prodromal symptoms of multiple sclerosis in primary care, Ann Neurol, vol. 83, pp. 1162-1173, 2018.
P. Imfeld, Bodmer, M., Jick, S. S., and Meier, C. R., Proton Pump Inhibitor Use and Risk of Developing Alzheimer's Disease or Vascular Dementia: A Case-Control Analysis, Drug Saf, vol. 41, pp. 1387-1396, 2018.
V. S. Hegade, Mells, G. F., Fisher, H., Kendrick, S., DiBello, J., Gilchrist, K., Alexander, G. J., Hirschfield, G. M., Sandford, R. N., and Jones, D. E. J., Pruritus is Common and Under-treated in Patients with Primary Biliary Cholangitis in the United Kingdom, Clin Gastroenterol Hepatol, 2018.
R. Houghton, Liu, C., and Bolognani, F., Psychiatric Comorbidities and Psychotropic Medication Use in Autism: A Matched Cohort Study with ADHD and General Population Comparator Groups in the United Kingdom, Autism Res, 2018.
R. Parisi, Webb, R. T., Kleyn, C. E., Carr, M. J., Kapur, N., Griffiths, C. E. M., and Ashcroft, D. M., Psychiatric morbidity and suicidal behaviour in psoriasis: a primary care cohort study, Br J Dermatol, 2018.
R. I. Griffiths, McFadden, E. C., Stevens, R. J., Valderas, J. M., Lavery, B. A., Khan, N. F., Keating, N. L., and Bankhead, C. R., Quality of diabetes care in breast, colorectal, and prostate cancer, J Cancer Surviv, vol. 12, pp. 803-812, 2018.
J. Voorham, Roche, N., Benhaddi, H., van der Tol, M., Carter, V., van Boven, J. F. M., Bjermer, L., Miravitlles, M., and Price, D. B., Real-world effectiveness evaluation of budesonide/formoterol Spiromax for the management of asthma and chronic obstructive pulmonary disease in the UK, BMJ Open, vol. 8, p. e022051, 2018.
K. Wing, Williamson, E., Carpenter, J. R., Wise, L., Schneeweiss, S., Smeeth, L., Quint, J. K., and Douglas, I., Real-world effects of medications for chronic obstructive pulmonary disease: protocol for a UK population-based non-interventional cohort study with validation against randomised trial results, BMJ Open, vol. 8, p. e019475, 2018.
A. Bottle, Kim, D., Aylin, P. P., Majeed, F. A., Cowie, M. R., and Hayhoe, B., Real-world presentation with heart failure in primary care: do patients selected to follow diagnostic and management guidelines have better outcomes?, Open Heart, vol. 5, p. e000935, 2018.
J. K. Quint, Moore, E., Lewis, A., Hashmi, M., Sultana, K., Wright, M., Smeeth, L., Chatzidiakou, L., Jones, R., Beevers, S., Kolozali, S., Kelly, F., and Barratt, B., Recruitment of patients with Chronic Obstructive Pulmonary Disease (COPD) from the Clinical Practice Research Datalink (CPRD) for research, NPJ Prim Care Respir Med, vol. 28, p. 21, 2018.
S. R. Markar, Arhi, C., Wiggins, T., Vidal-Diez, A., Karthikesalingam, A., Darzi, A., Lagergren, J., and Hanna, G. B., Reintervention After Antireflux Surgery for Gastroesophageal Reflux Disease in England, Ann Surg, 2018.
G. Geulayov, Ferrey, A., Casey, D., Wells, C., Fuller, A., Bankhead, C., Gunnell, D., Clements, C., Kapur, N., Ness, J., Waters, K., and Hawton, K., Relative toxicity of benzodiazepines and hypnotics commonly used for self-poisoning: An epidemiological study of fatal toxicity and case fatality, J Psychopharmacol, vol. 32, pp. 654-662, 2018.
A. E. Ferrey, Geulayov, G., Casey, D., Wells, C., Fuller, A., Bankhead, C., Ness, J., Clements, C., Gunnell, D., Kapur, N., and Hawton, K., Relative toxicity of mood stabilisers and antipsychotics: case fatality and fatal toxicity associated with self-poisoning, BMC Psychiatry, vol. 18, p. 399, 2018.
G. Dell'Agnello, Desai, U., Kirson, N. Y., Wen, J., Meiselbach, M. K., Reed, C. C., Belger, M., Lenox-Smith, A., Martinez, C., and Rasmussen, J., Reliability of coded data to identify earliest indications of cognitive decline, cognitive evaluation and Alzheimer's disease diagnosis: a pilot study in England, BMJ Open, vol. 8, p. e019684, 2018.
R. Costello, Jacklin, C., M. Evans, J., McBeth, J., and Dixon, W. G., Representativeness of a digitally engaged population and a patient organisation population with rheumatoid arthritis and their willingness to participate in research: a cross-sectional study, RMD Open, vol. 4, p. e000664, 2018.
S. Rajaram, Wiecek, W., Lawson, R., Blak, B., Zhao, Y., Hackett, J., Brody, R., Salimi, T., Amzal, B., and Patel, V., A retrospective observational analysis of post-pandemic influenza-related outcomes in the United Kingdom, 2010-2014, Hum Vaccin Immunother, vol. 14, pp. 368-377, 2018.
A. Abhishek, Nakafero, G., Kuo, C. F., Mallen, C., Zhang, W., Grainge, M. J., and Doherty, M., Rheumatoid arthritis and excess mortality: down but not out. A primary care cohort study using data from Clinical Practice Research Datalink, Rheumatology (Oxford), vol. 57, pp. 977-981, 2018.
S. Gale, Wilson, J. C., Chia, J., Trinh, H., Tuckwell, K., Collinson, N., Dimonaco, S., Jick, S., Meier, C., Mohan, S. V., and Sarsour, K., Risk Associated with Cumulative Oral Glucocorticoid Use in Patients with Giant Cell Arteritis in Real-World Databases from the USA and UK, Rheumatol Ther, 2018.
E. L. Axson, Bual, N., Bloom, C. I., and Quint, J. K., Risk factors and secondary care utilisation in a primary care population with non-tuberculous mycobacterial disease in the UK, Eur J Clin Microbiol Infect Dis, 2018.
P. Karimi, Birmann, B. M., Anderson, L. A., McShane, C. M., Gadalla, S. M., Sampson, J. N., and Mbulaiteye, S. M., Risk factors for Burkitt lymphoma: a nested case-control study in the UK Clinical Practice Research Datalink, Br J Haematol, vol. 181, pp. 505-514, 2018.
J. J. Lee, Bankhead, C., Smith, M., Kousoulis, A. A., Butler, C. C., and Wang, K., Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data, Epidemiol Infect, vol. 146, pp. 817-823, 2018.
H. C. Gorton, Webb, R. T., Pickrell, W. O., Carr, M. J., and Ashcroft, D. M., Risk factors for self-harm in people with epilepsy, J Neurol, vol. 265, pp. 3009-3016, 2018.