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Approved studies using CPRD Data

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Applications to access CPRD data for observational research are reviewed the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC approved protocols, including a lay and technical summary of the proposed research, are published 3 months after researchers have access to the data to begin their study.

The table below includes all ISAC approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval. .

Search Studies

Approval Date ISAC Protocol Title
23/09/2016 Use of common cardiovascular medications and survival in patients with oesophageal carcinoma: a population-based cohort study
Leo Alexandre1, Allan Clark, Simon Chan, Michael Lewis, Tom Roques
Approval Date: 23/09/2015

01/09/2015 Medical resource use and costs associated with diabetes complications in the population of diabetes patients receiving insulin therapy in the United Kingdom
Peter Davis, Didier Morel, BD Kenneth Strauss, Grace Vanterpool
Approval Date: 01/09/2015

23/09/2015 Evidence for and implications of channeling in the use of single-ingredient paracetamol and ibuprofen medications in an electronic medical records database
Daniel Fife, Jesse Berlin, Patrick Ryan, Kayur Patel
Approval Date: 23/09/2015

02/10/2015 Evaluation of the clinical and economic outcomes associated with Bydureon versus basal insulin in people with type 2 diabetes
Bethan Jones, Sara Jenkins-Jones, Kristina Johnsson, Susan Grandy, Qing Qiao
Approval Date: 02/10/2015

26/11/2015 Comparison of the performance of the English NHS Health Checks & Scottish Keep Well programmes
Assem Kurzhangulova, Kiara Chang, Roger Newson, Colin Fischbacher
Approval Date: 26/11/2015

06/10/2015 Investigation of long-term outcomes and healthcare utilisation of survivors of critical illness
Rupert Payne, Ari Ercole, Rebecca Turner, Kirsty Rhodes, David Harrison
Approval Date: 06/10/2015

06/10/2015 What is the burden of foot and ankle pain in the general population of the United Kingdom as recorded by General Practitioners?
Rachel Ferguson, Nigel Arden, Daniel Prieto-Alhambra, Andrew Judge
Approval Date: 06/10/2015

06/10/2015 The association between Huntington’s disease and cancer before and after the Huntington’s diagnosis – a two-phase study
Liam Smeeth, Ian Douglas, Stephen Evans, Krishnan Bhaskaran, Nancy Wexler, Daniel Dedman
Approval Date: 06/10/2015

12/10/2015 Estimating the healthcare use and costs of children born to pregnant smokers
Tim Coleman, Matthew Jones, Laila Tata, Luis Vaz, Stavros Petrou
Approval Date: 12/10/2015

22/09/2015 The risk of fragility fracture in inflammatory arthritis: evidence for the effective and equitable targeting of prevention.
Jo Erwin, Willie Hamilton, Doyo Enki
Approval Date: 22/09/2015

02/10/2015 Developing insights into treatment of chronic/diabetic kidney disease (CKD/DKD) using real world data
Canter Martin, Hilary Phelps, Chi Truong
Approval Date: 02/10/2015

28/10/2015 Disease burden of diabetes patients with high dose insulin treatment in CPRD.
Kate Van Brunt, Dingfeng Jiang, Elemer Balogh, Iskandar Idris
Approval Date: 28/10/2015

12/10/2015 The effectiveness and safety of concomitant treatment with telmisartan, candesartan or bisoprolol in combination with amlodipine in patients with essential arterial hypertension: outcomes in real world practice.
Sarah Holden, Sara Jenkins-Jones, Christopher Ll. Morgan
Approval Date: 12/10/2015

29/09/2015 Secondary prevention of acute coronary syndrome: comparative effectiveness of recommended vs. less intensive drug combination using Clinical Practice Research Datalink (CPRD). The SCARFACE-CPRD study.
M. Sanni Ali, Anthonius de Boer, Rolf H.H. Groenwold, Patrick C. Souverein, Bernard Bégaud, Antoine Pariente, Julien Bezin
Approval Date: 29/09/2015

27/10/2015 Morbidity among HIV-positive people in England: a cross-sectional, population-based CALIBER study.
Spiros Denaxas, Marina Daskalopoulou, Nashaba Matin
Approval Date: 27/10/2015

08/10/2015 Incidence of corticosteroid related adverse events in inflammatory musculoskeletal conditions
Kelvin Jordan, Sam Hider, Trishna Rathod, Christian Mallen
Approval Date: 08/10/2015

05/10/2015 An evaluation of the epidemiology and burden of illness of congenital adrenal hyperplasia in the United Kingdom
Sara Jenkins-Jones, Sarah Holden, Christopher Morgan, Martin Whitaker, Richard Ross
Approval Date: 05/10/2015

08/10/2015 The risk of depression and suicidality in patients with psoriasis, psoriatic arthritis or ankylosing spondylitis: a retrospective United Kingdom database analysis
Sara Jenkins-Jones, Paola Primatesta, Haijun Tian
Approval Date: 08/10/2015

19/10/2015 Usage Patterns of Selected Systemic NSAIDs (Including Diclofenac): A Retrospective Cohort Study
Catherine W. Saltus, Jordi Castellsague, Maria Reynolds, Jennifer Bartsch, Samik Banerjee, Shaloo Pandhi
Approval Date: 19/10/2015

30/11/2015 The association between statin prescribing and the risk of glioma: a matched case-control study
Claudia Becker, Corinna Seliger, Peter Hau, Ulrich Bogdahn, Michael F. Leitzmann, Susan S. Jick
Approval Date: 30/11/2015

04/11/2015 Stress Urinary Incontinence and Suicidality Seen in the Clinical Practice Research Datalink (CPRD)
Dustin Ruff, Jonathan Swain, Mark Bangs
Approval Date: 04/11/2015

05/11/2015 Evaluation of Potential Cardiovascular, Respiratory and Metabolic Effects of Long-term Use of Proton-Pump Inhibitor Therapy in Older Patients
Jan Zirk-Sadowski, Alessandro Ble, Joao Correa-Delgado, Jane Masoli, William Henley, Ruben Mujica Mota, Peter Hughes, Willie Hamilton, David Strain
Approval Date: 05/11/2015

29/10/2015 Predicting individual risk of future hip and knee replacement for osteoarthritis
George Peat, Kelvin Jordan, John Edwards, Vincent Ukachukwu, Daniel Prieto-Alhambra, Christine Walker, Avril Poyner
Approval Date: 29/10/2015

19/11/2015 Effects of selective serotonin reuptake inhibitors on the risk of mortality in patients with epilepsy: a CALIBER study using linked data
Alireza Moayyeri, Spiros Denaxas, Arturo Gonzalez-Izquierdo
Approval Date: 19/11/2015

08/12/2015 Congenital malformations and maternal use of anti-hypertensive medication in the UK
Karin Henriksson, Michael Goodman, Alison Lee, Cecilia Falkenberg
Approval Date: 08/12/2015

04/11/2015 Descriptive Characteristics of the Clinical Practice Research Datalink (CPRD) EMIS database.
Dan Dedman, Wilhelmine Meeraus
Approval Date: 04/11/2015

17/11/2015 The prescribing of codeine for the treatment of pain in children: A descriptive study
Approval Date: 17/11/2015

02/12/2015 Use of Finasteride 1mg for Alopecia and the Incidence of Erectile Dysfunction (ED)
Susan S. Jick
Approval Date: 02/12/2015

24/11/2015 Utilization of Standard and Target-Specific Oral Anticoagulants among Adults in the United Kingdom with Incident Non-Valvular Atrial Fibrillation
Todd A. Durham, Kristen Hasmiller Lich, Stacie Dusetzina, Anthony Viera, Jason Fine, Jayanti Mukherjee
Approval Date: 24/11/2015

16/11/2015 Is gout a risk factor for erectile dysfunction?
Sara Muller, Rebecca Whittle, Richard Hayward, Christian Mallen
Approval Date: 16/11/2015

20/11/2015 Risk of MI associated with acute exacerbations of chronic obstructive pulmonary disease (COPD): a self-controlled case series
Kieran Rothnie, Hana Müllerová, Ian Douglas, Liam Smeeth, Neil Pearce
Approval Date: 20/11/2015

30/11/2015 Association between Use of Beta-blockers or Diuretics and Incident Meniere’s Disease
Saskia Bruderer, Daniel Bodmer, Susan S. Jick, Nadja Stohler
Approval Date: 30/11/2015

30/11/2015 A descriptive study of LAIV utilization to identify and characterize medication errors due to expired vaccine use in individuals 2-17 years of age in the CPRD
Herve Caspard, Amy Steffey, Robert Wise
Approval Date: 30/11/2015

26/11/2015 Near real-time vaccine safety surveillance using the Clinical Practice Research Datalink (CPRD) – a feasibility study
Andreia Leite, Stephen Evans, Nick Andrews, Phil Brian
Approval Date: 26/11/2015

27/11/2015 Prescribing Trends of ADHD Medications in UK Primary Care
Christel Renoux, Sophie Dell’Aniello, Ju-Young Shin
Approval Date: 27/11/2015

07/12/2015 Bile duct and gallbladder diseases associated with the use of incretin-based drugs in patients with type 2 diabetes
Laurent Azoulay, Oriana H. Yu, Alan Barkun, Jean-Luc Faillie, Hui Yin, Dominique Hillaire-Buys
Approval Date: 07/12/2015

03/12/2015 Statin Potency and the Risk of Hospitalization for Community-Acquired Pneumonia
Kristian B. Filion, Ju-Young Shin, Pierre Ernst, Maria Eberg
Approval Date: 03/12/2015

12/12/2015 Trends and factors associated with therapy decisions in newly diagnosed COPD patients in GOLD groups A and B. A non-interventional study using the Clinical Practice Research Datalink (CPRD) database.
Andrew Ternouth, Nick Ramscar
Approval Date: 12/12/2015

08/12/2015 Patterns of prescribing in end of life care using CPRD data.
Amelia Harshfield, Stephen Barclay, Kirsty Rhodes
Approval Date: 08/12/2015

08/12/2015 Cost Effectiveness of Different Patterns of Monitoring of Cardiovascular Medications in General Practices
Vladislav Berdunov, Rachel Elliott, Li-Chia Chen
Approval Date: 08/12/2015

22/12/2015 Neuroprotective Effects of Minocycline in Schizophrenia Patients: Retrospective Cohort Studies Using the Clinical Practice Research Datalink
Louise Howard, Ruth Brauer, Maria Herrero Zazo, David Taylor, Fiona Gaughran
Approval Date: 22/12/2015

22/12/2015 Psychological stress and risk of herpes zoster
Sigrún Alba Jóhannesdóttir Schmidt, Harriet Forbes, Liam Smeeth, Sara Thomas, Kathryn Mansfield, Henrik Toft Sørensen, Henrik Carl Schønheyder, Mogens Vestergaard, Henrik Søndergaard Pedersen
Approval Date: 22/12/2015

05/01/2016 Mapping patient cohort data from a clinical coding space into a distance space: novel tools for hypothesis generation, stratification and cohort identification
Thamer Ba-Dhfari, Darren Ashcroft, Tjeerd Van Staa, Mark Davies, James Weatherall
Approval Date: 05/01/2016

23/12/2015 Novel Prediction Models for the One-Year Competing Risks of Death, Stroke, Intracranial Hemorrhage, and Extracranial Hemorrhage in Adults with Incident Non-Valvular Atrial Fibrillation
Todd A. Durham, Kristen Hasmiller, Stacie Dusetzina, Anthony Viera, Jayanti Mukherjee
Approval Date: 23/12/2015

30/12/2015 Quality and completeness of recording of social factors related to vaccine uptake in linked electronic health records
Anu Jain1, Albert Jan van Hoek, Jemma Walker, Liam Smeeth, Rohini Mathur
Approval Date: 30/12/2015

31/12/2015 Association between Diabetes Mellitus and Incident Meniere’s Disease
Saskia Bruderer, Daniel Bodmer, Nadja A. Stohler, Susan S. Jick
Approval Date: 31/12/2015

31/12/2015 Validation of the recording of asthma diagnosis in adult patients in the Clinical Practice Research Datalink
Francis Nissen, Ian Douglas, Liam Smeeth, Neil Pearce, Hana Müllerova, Daniel Morales
Approval Date: 31/12/2015

15/09/2015 Assessing channelling bias and effectiveness in newly marketed glucose-lowering medications – a cohort study
O.H Klungel, M.Z Ankarfeldt, B.L Thorsted, J. A Adalsteinsson, V. Metha, S.M Ali, R.H.H Groenwold
Approval Date: 15/09/2015

04/09/2015 Domperidone and risk of primary liver cancer in the UK Clinical Practice Research Datalink
Barry I. Graubard, Baiyu Yang
Approval Date: 04/09/2015

16/09/2015 Can continuity of primary care decrease unscheduled secondary care use?
R. Morris, S. Purdy, C. Salisbury, P. Tammes, F. MacKichan, D. Lasserson
Approval Date: 16/09/2015

11/09/2015 Healthcare resource utilisation and economic impact among kidney transplant patients during the last year before graft failure in the UK: a retrospective observational study
W. Hart, G. Muduma, C. Poole
Approval Date: 11/09/2015

11/09/2015 Healthcare resource utilisation and economic impact among liver transplant patients during the last year before graft failure in the UK: a retrospective observational study
W. Hart, G. Muduma, C. Poole
Approval Date: 11/09/2015

14/09/2015 The incidence of Guillain-Barre Syndrome in the United Kingdom from April 2005 to March 2015
G. Ferrerira, T. Verstraeten, T. Cattaert, K. Bollaerts
Approval Date: 14/09/2015

05/08/2015 Use of COX-2 inhibitors and risk of glioma
C.R Meier, C. Seliger, P. Hau, U. Bogdahn, C. Becker, S.S Jick, M.F Leitzmann
Approval Date: 05/08/2015

07/08/2015 A drug utilisation cohort study of patients prescribed medicines from different classes of renin-angiotensin system blocking agents in UK primary care
C. Allen, K. Donegan
Approval Date:07/08/2015

12/08/2015 Ethnicity and adherence to oral hypoglycaemic agents in T2DM
M. Soljak, R.A Watson, A. Majeed, A. McKay, J. Valabhji
Approval Date:12/08/2015

23/07/2015 The effect of metformin on patient outcome after acute myocardial infarction
D. Yellon, D.L. Bromage, X. Rossello, E Herrett, M. Pujades, H. Hemingway
Approval Date: 23/07/2015

15/07/2015 The impact of obesity on healthcare resource utilisation
A.R Borglykke, A. H Olsen, B. K Bjerregaard
Approval Date: 15/07/2015

17/08/2015 Resource use associated with Idiopathic Pulmonary Fibrosis
Jamie Garside, Shaneil Sonecha, Michael Storm
Approval Date: 17/08/2015

18/08/2015 Estimating the prevalence of myasthenia gravis and neuromyelitis optica through the Clinical Practice Research Datalink
C. Morgan, S. Jenkins-Jones, B. Jones
Approval Date: 18/08/2015

17/08/2015 Alcohol misuse and injury outcomes in adolescents aged 10-24 using linked UK health data
E. Orton, L. Lester, R. Baker
Approval Date: 17/08/2015

28/08/2015 Characteristics of newly diagnosed adults with Type 1 diabetes in the UK and their evolution over the first 5 years
S. Ramtoola, U.J Ploug, N. Kragh, M. Nyeland
Approval Date: 28/08/2015

28/08/2015 Cluster Headache Patient Prevalence and Prescribed Treatments in the UK Clinical Practice Research Datalink
E.M Flahavan, J.M Martinez, A.H Ahn, J.L Swain, L. Mitchell, M. Jones
Approval Date: 28/08/2015

04/09/2015 Coronary Artery Disease in the Ageing Population of Adults with Congenital Heart Disease
M.A Gatzoulis, M. Boutsikou, K. Dimopoulos, A. Gonzalez-Izquierdo, G. Giannakoulas, H. Hemingway, A. Kempny, M. Pujades-Rodriguez
Approval Date: 04/09/2015

04/09/2015 Time to treatment intensification and associated outcomes among patients with Type 2 diabetes mellitus in the UK
N. Kirson, U. Desai, Khunti K, J. Mukherjee, N. Smith, J. Kim, N. Varol, K. Tsai, P. Hunt, S. King
Approval Date: 04/09/2015

17/07/2015 To establish the causal roles of environmental factors on exacerbations of COPD
J. Quint, L Smeeth, Antonis A. Kousoulis, Miland Joshi
Approval Date: 17/07/2015

16/07/2015 Chief Medical Officer Annual Report
Tarita Murray-Thomas, Jennifer Campbell
Approval Date: 16/07/2015

12/08/2015 Mortality of people with learning disability
Rachael Williams, Jessie Oyinlola, Pauline Heslop
Approval Date: 12/08/2015

06/10/2015 Effects of pulmonary rehabilitation on exacerbation number and severity in people with Chronic Obstructive Pulmonary Disease
Miland Joshi, Roger Newson, Michael Soljak
Approval Date: 06/10/2015

27/10/2015 Determinants of Zoster vaccination acceptance in people eligible for NHS shingles vaccination programme
Laurence Torcel-Pagnon, Stephane Thomas, Xavier Cornen, Nick Sevdalis, Emma Boyle, Ana Wheelock, Coralie Lecomte
Approval Date: 27/10/2015

14/10/2015 A study of multifactorial intervention in type 2 diabetes and chronic kidney disease
Martin Gulliford
Approval Date: 14/10/2015

08/12/2015 An observational evaluation of prescribing of fixed-dose combination inhaled corticosteroid / long-acting beta2-agonist (ICS/LABA): fluticasone propionate / formoterol (FP/FOR) and adverse events in routine primary care at 18-months post launch
Jessica Martin, Vicky Thomas, Derek Skinner, Frank Andersohn, Karin Thelen, Andrew Cooper
Approval Date: 08/12/2015

14/10/2015 The association between lansoprazole and tuberculosis disease; a primary care based cohort study
Laurie Tomlinson, Krishnan Bhaskaran, Sinead Langan, Sara Thomas, Liam Smeeth, Tom Yates
Approval Date: 14/10/2015

27/10/2015 Prediagnostic presentations of multiple sclerosis in primary care: a case-control study
Sreeram Ramagopalan
Approval Date: 27/10/2015

19/11/2015 Using pharmacoepidemiology to test medications associated with altered breast cancer risk identified from connectivity mapping
Liam Murray, Ken Mills, Shu-Dong Zhang, Fabio Liberante, Gayathri Thillaiyampalam
Approval Date: 19/11/2015

03/12/2015 Clinical and economic burden of diabetic foot ulcer care pathways in the UK
Julie Dorey, David Neasham
Approval Date: 03/12/2015

29/12/2015 Prescribing of antidepressants and adverse outcomes in patients with chronic kidney disease
Masao Iwagami, Laurie Tomlinson, Kathryn Mansfield, Ian Douglas, Liam Smeeth, Helen McDonald
Approval Date: 29/12/2015

21/12/2015 Comparison of the risk of acute outcomes between patients with type 2 diabetes exposed to dapagliflozin and those exposed to other antidiabetic treatments
Leah McGrath, Elizabeth Andrews, Alejandro Arana, Jordi Castellsague, Joan Fortuny, Alicia Gilsenan, Lia Gutierrez, Ryan Ziemiecki, Xiaolei Zhou, Lisa McQuay, Brian Calingaert, Jaume Aguado, Shannon Hunter, Estel Plana, Maria Reynolds, Jenn Bartsch, Sophie Shen, Karolina Andersson Sundell
Approval Date: 21/12/2015

09/02/2016 Does better quality of primary care influence admissions and health outcomes for people with serious mental illness (SMI)? A linked patient-level analysis of the full patient care pathway
Tim Doran, Simon Gilbody, Maria Goddard, Hugh Gravelle, Nils Gutacker, Panos Kasteridis, Anne Mason, Nigel Rice, Christoph Kronenberg, Ruth Helstrip, Giuseppe Moscelli, Katja Grasic, Mark Wilson, Tony Kendrick, Lauren Aylott, Ceri Owen<
Approval Date: 09/02/2016

17/11/2015 The role of systemic inflammatory diseases in long-term morbidity and mortality: a retrospective, matched-cohort study in the Clinical Practice Research Datalink
Christian Mallen, John Belcher, Rebecca Whittle
Approval Date: 17/11/2015

21/12/2015 Comparison of the risk of cancer outcomes between patients with type 2 diabetes exposed to dapagliflozin and those exposed to other antidiabetic treatments
Leah McGrath, Elizabeth Andrews, Joan Fortuny, Alicia Gilsenan, Catherine Johannes, James Kaye, Brian Calingaert, Lisa McQuay, Jaume Aguado, Shannon Hunter, Estel Plana, Maria Reynolds, Jenn Bartsch, Xiaolei Zhou, Catherine Saltus, Sophie Shen, Karolina Andersson Sundell
Approval Date: 21/12/2015

23/12/2015 Incidence and Prevalence of the Parkinson's Disease in the United Kingdom during 1987-2014

Approval Date:23/12/2015

12/01/2015 The risk of Clostridium difficile colitis and of pneumonia in persons with pernicious anaemia
Fatmah Othman, Colin Crooks
Approval Date: 12/01/2015

10/02/2016 Depression, prescription of antidepressant drugs and changes in body weight: A cohort study using electronic health records
Martin Gulliford, Salma Ayis, Judith Charlton
Approval Date: 10/02/2016

14/01/2016 Burden of Multiple Myeloma (MM) in England: regional equity based on Real world data from CPRD HES, and Cancer Registry linked data
Cinira Lefevre, HoK Pang, James Harrison, Andrew Jones, Anthony Wesselbaum
Approval Date: 14/01/2016

19/02/2016 Investigating the effects of commonly prescribed drugs on the prevention and treatment of Alzheimer’s and other neurodegenerative diseases: are there drugs already available that can be repurposed?
Richard Martin, Neil Davies, Venexia Walker
Approval Date: 19/02/2016

18/02/2016 Use of routinely collected national data to determine the delays that lead to poor outcome for cancer patients in the UK
Chanpreet Arhi, George Bouras, Ara Darzi
Approval Date: 18/02/2016

14/01/2016 Risk factors for influenza-related complications in children
Joseph Lee, Clare Bankhead, Christopher Butler, Ruth Allanson, Antonis Kousoulis
Approval Date: 14/01/2016

02/02/2016 Bleeding Events and oral Anticoagulant Treatment in non-valvular atrial fibrillation (Heart-BEAT study): a cohort study based on CPRD-HES data
Laure Lacoin, Essra Ridha, Andrew Maguire, Michelle Johnson, Shuk-Li Collings, Vicky Parsons
Approval Date: 02/02/2016

28/01/2016 The longitudinal incidence rate of severe hypoglycaemia and the relationship between HbA1c or HbA1c variability and risk of severe hypoglycaemia in the UK.
Victor W. Zhong, Christina M. Shay, Stephen R. Cole, Penny Gordon-Larsen, Juhaeri Juhaeri, Evangelos Kontopantelis,
Approval Date: 28/01/2016

22/01/2016 Treatment of first-time traumatic anterior shoulder dislocation (UK.TASH-D Study)
Andrew Judge, Sally Hopewell, Nigel Arden, Gary Collins, Sallie Lamb, Andrew Carr, Tim Holt, Daniel Prieto-Alhambra, Amar Ranga
Approval Date: 22/01/2016

23/02/2016 Comorbidity in the aging HIV population of the UK: a CPRD analysis
Ryan Dillon, Eilish McCann, Ruth Farquhar
Approval Date: 23/02/2016

25/02/2016 Predicting first admission and readmission in heart failure patients
Azeem Majeed, Martin R Cowie, Paul Aylin
Approval Date: 25/02/2016

14/03/2016 Benign and Malignant Tumors in Patients with Myotonic Dystrophy Type I
S. Gadalla, J. Gage, R. Pfeiffer, M.H. Greene, L. Anderson, H. Lochmuller, W. Meeraus
Approval Date: 14/03/2016

14/03/2016 Treatment of uncomplicated mild hypertension in Primary Care
J. Sheppard, S. Stevens, R. Stevens, R. Hobbs, J. Mant
Approval Date: 14/03/2016

10/02/2016 Drospirenone-containing combined oral contraceptives and risk of venous thromboembolism
N. Larivee, K. B. Filion, V. Tagalakis, P. Reynier, J. Coulombe
Approval Date: 10/02/2016

16/02/2016 Cancer Survival Programme and Early Diagnosis of Cancer
M. Coleman, K. Bhaskaran, C. Renzi, T.P.C Chu, T. Card, R. Williams
Approval Date: 16/02/2016

08/03/2016 Natural history, characteristics, and treatment patterns in patients with primary biliary cirrhosis and cholestatic pruritis
K. Gilchrist, Stuart Kendrick
Approval Date: 08/03/2016

28/01/2016 Statin use and incident Achilles or biceps tendon rupture
J. Spoendlin, C. Meier, S.S. Jick, J.B. Layton, , M. Mundkur
Approval Date: 28/01/2016

24/02/2016 The last year of life in COPD: prognostication, preparation, palliation
L.J. Smith, C. Minelli, P. Stone L. Smeeth
Approval Date: 24/02/2016

11/02/2016 Using Linked Primary And Secondary Care Data To Explore Complex Pathways Through Complex Systems For Patients With Long-Term Conditions
A. Hutchings1, J. Robson, K. Boomla, S. Denaxas
Approval Date: 11/02/2016

23/02/2016 Risk of hypoglycaemia in users of sulphonylureas with renal impairment: a population-based cohort study
A. Burden, H. Leufkens, A. Driessen1, J. van Dalem, M. Brouwers, A. Krings
Approval Date: 23/02/2016

09/03/2016 Predictors of complications of venous thromboembolism
A. Katholing, A. Cohen
Approval Date: 09/03/2016

10/02/2016 A Study Of Antibiotic Utilisation In Primary Care
X. Sun, A. Dregan
Approval Date: 10/02/2016

24/03/2016 Disease clusters and multimorbidity patterns: a UK population cohort study
V. Kuan, J.P Casas Romero, D. Prieto-Merino, S. Denaxas, H. Hemingway, A. Moayyeri
Approval Date: 24/03/2016

17/03/2016 The risk of cardiovascular related death following cytomegalovirus (CMV) infection in England: an open cohort study using data from the Clinical Practice Research Datalink (CPRD)
J. Van-Tam, R. Puleston, J. Mair-Jenkins
Approval Date: 17/03/2016

16/02/2016 Serum creatinine elevation following renin-angiotensin-aldosterone system blockade, adherence to monitoring and discontinuation guidelines, and long-term cardiorenal risks
K. Mansfield, K. Bhaskaran, D. Nitsch, L. Smeeth, M. Schmidt, H.T. Sørensen
Approval Date: 16/02/2016

14/03/2016 Low-density lipoprotein cholesterol, high-density cholesterol, and diverse non-cardiovascular diseases: a large population-based cohort study using CALIBER dataset.
N. Na-Ek, A. Banerjee, A. Moayyeri
Approval Date: 14/03/2016

24/02/2016 Epidemiology of venous thromboembolism in patients with active cancer: a population-based cohort study
A. Katholing, A. Cohen
Approval Date: 24/02/2016

11/02/2016 The characteristics of rheumatoid arthritis patient organisation members and online community members with rheumatoid arthritis compared to the general rheumatoid arthritis population
J. McBeth, B. Brown, R. Costello
Approval Date: 11/02/2016

14/03/2016 Child Outcome REVIEW Programme: Chronic Disability
B. Carter, M. Wright, S. Wood, H. Jones, A. John
Approval Date: 14/03/2016

10/03/2016 Investigating the utility of blood pressure variability in cardiovascular risk prediction
S. Stevens, R. McManus
Approval Date: 10/03/2016

24/03/2016 Hyperglycaemia and early detection of pancreatic cancer
A. Mueller, C. Schneider, S. S. Jick
Approval Date: 24/03/2016

02/10/2015 Statins for Prevention of Cardiovascular Disease in Older Primary Care UK Patients
Alessandro Ble, Joao Correa-Delgado, Kirsty Bowman, Jane Masoli, William Henley, Adam Streeter, Ruben Mujica Mota, Peter Hughes, Jose M. Valderas
Approval Date: 02/10/2015

22/01/2016 Assessing the management and clinical outcomes of patients with non-diabetic intermediate hyperglycaemia in UK primary care
Azeem Majeed, Eszter P Vamos, Raffaele Palladino, Utz Pape, Mahsa Mazidi
Approval Date: 22/01/2016

10/02/2016 Demography and pattern of causes of death in recognised alcohol misusers in the English General Practice (GP) population
Abdul-Kareem Abdul-Rahman, Kate Fleming
Approval Date: 10/02/2016

20/04/2016 Developing and validating a risk prediction model based on frailty syndrome using primary care data
L. Dinesen, R. Palladino, M. Mazidi, A. Poots, J. Soong, D. Bell
Approval Date: 20/04/2016

23/02/2016 Association between HbA1c and all-cause mortality in people with type 2 diabetes treated with glucose-lowering therapies with a higher an lower risk of inducing hypoglycaemia: a retrospective cohort study using data from the UK Clinical Practice Research Datalink
S. Holden, S. Jenkins-Jones
Approval Date: 23/02/2016

21/04/2016 Assessing drivers of effectiveness and safety using real life data: anticoagulants as a case study
R. van den Ham, M.S. Ali, R. Groenwold, T. van Staa, B. Leufkens, F. de Vries, M. Vinay, E. Adalsteinsson, M.Z. Ankarfeldt, A Burden, C. Girman
Approval Date: 21/04/2016

21/04/2016 Urinary tract infections in the elderly – care pathways and characteristics
M. Gharbi, A. Holmes, R. Goudie, H. Lishman, A. Johnson, M. Molokhia
Approval Date: 21/04/2016

24/02/2016 Validity of UK general practice prescribing safety indicators in predicting adverse events
E. Paige, K. Rhodes, A. Wood
Approval Date: 24/02/2016

17/05/2016 Development and critical assessment of methods for estimation of multi-treatment effects from observational data with application to diabetes mellitus
R.J. Smith, D.D. Dore, W.R. Hiatt
Approval Date: 17/05/2016

24/03/2016 Evaluating the impact of NICE guidelines for suspected cancers in respect of diagnostic interval and other outcomes
A. Spencer, S. Stapley, R. Mujica-Mota, O. Okoumunne
Approval Date: 24/03/2016

19/04/2016 Historical cohort study to evaluate undertreatment and disease outcomes for patients with coexisting Heart Failure and Chronic Obstructive Pulmonary Disease
J. Martin, J. Soriano, L. Gardener, D. Skinner, R. Jones, E. Loefroth, R. Fogel, J.B. Gruenberger, K. Kostikas, J. Hurst, P. Agostoni
Approval Date: 19/04/2016

11/05/2016 Health Care Utilisation, Care Pathways and Educational Status in Children and Young People with Adolescent Mental Health Disorders
S. Wood, S. Rees, A. Akbari A. Kemp, M. Wright, ,B. Carter
Approval Date: 11/05/2016

11/04/2016 Hematological malignancies in patients with systemic lupus erythematosus versus matched controls: a population-based study in the United Kingdom.
I.E.M. Bultink, A. Lalmohamed, M. Wondergem
Approval Date: 11/04/2016

11/04/2016 Vaccine effectiveness of the national rotavirus vaccination programme against acute gastroenteritis in England
Fenty, J. Walker, N. Andrews, J. Stowe, S. Ladhani
Approval Date: 11/04/2016

29/04/2016 Premature mortality and non-fatal self-harm in patients diagnosed with Chronic Fatigue Syndrome.
M. Carr, R. Webb, N. Kapur, P.D. White
Approval Date: 29/04/2016

12/04/2016 An epidemiological study of diabetes and diabetes-related morbidities in the UK children and young adults.
A. Abbasi
Approval Date: 12/04/2016

05/05/2016 Androgen Deprivation Therapy for Prostate Cancer and the Risk of Anaemia.
B. Hicks, A.J. Klil-Drori, L. Campeau, L. Azoulay, H. Yin
Approval Date: 05/05/2016

21/04/2016 The association between severe mental illness and chronic kidney disease: a cross sectional study.
M. Iwagami, D. Nitsch, L. Smeeth, K. Mansfield, D. Osborn, K. Walters, J. Hayes
Approval Date: 21/04/2016

20/04/2016 Association Between Blood Eosinophil Level and Exacerbation Risk in Patients with COPD
J. Maskel, E. Hilton
Approval Date: 20/04/2016

20/04/2016 Characterization of patients with COPD by mepolizumab eligibility criteria
J. Maskell, S. Landis
Approval Date: 20/04/2016

23/05/2016 The utilization and toxicity profile of oral corticosteroids among asthma patients in the UK: an epidemiological study using Data from the Clinical Practice Research Datalink (CPRD)
M. Bloechliger, J. Spoendlin, S.S. Jick, S.-C. Chang, K. Kuhlbusch, L. Heaney
Approval Date: 23/05/2016

20/04/2016 The epidemiology and treatment patterns of patients with Gastro-oesophageal reflux disease (GORD) in routine general practice.
D. Williams, E. Berni
Approval Date: 20/04/2016

10/02/2016 Evaluating the utility of the CPRD GOLD-HTI linkage: anticoagulant prescribing at the GP practice compared to hospital dispensed medication at discharge date.
T. Williams, H. Dattani, A. Collier, R. Tham
Approval Date: 10/02/2016

31/03/2016 Risk of eczema in children: a population-based study
L. Ban, K. Thomas, A.A. Sultan, T. Sach, E. McManus, S. Langan, K. Abuabara, M. Santer
Approval Date: 31/03/2016

21/07/2015 Creation of a model of GP workload in terms of patient, practice and geographical variables to inform the GMS Contract Formula
Sam Beatson, Katherine Everard, Hugh Gravelle, Tarita Murray-Thomas
Approval Date: 21/07/2015

16/02/2016 Characterising the safety profile of lurasidone in clinical practice: A drug utilisation and safety study using a United Kingdom primary care database
Shuk-Li Collings, Michelle Johnson, Shreya Davé
Approval Date: 16/02/2016

06/06/2016 Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin aldosterone system blockers using CPRD
T. Jones, M.T. Redaniel, Y. Ben-Shlomo1, P. Whiting, K. Tilling
Approval Date: 06/06/2016

06/06/2016 Cataract in patients with diabetes mellitus
C. Becker, C. Schneider, A. Beiderbeck, S. Aballea, S.S. Jick, J. Hall , Clare Bailey, Rupert Bourne
Approval Date: 06/06/2016

06/06/2016 Using pharmacoepidemiology to test medications associated with altered risk of breast cancer progression identified from connectivity mapping
L. Murray, K. Mills, S. Zhang, F. Liberante, G. Thillaiyampalam
Approval Date: 06/06/2016

29/07/2016 Trimethoprim and sudden death in patients over 65 years with urinary tract infection
E. Crellin1, D. Nitsch, I. Douglas, A. Root, K. Mansfield, E. Williamson, C. Leyrat, L. Smeeth1, T. Smieszek, P. Frey
Approval Date: 29/07/2016

05/07/2016 Statin use and incident hand osteoarthritis: A propensity-score matched sequential cohort study
J. Spoendlin, T. Burkard, , S. S. Jick, T. Hügle, J. B. Layton, N. Frey1, M. Bloechliger
Approval Date: 05/07/2016

14/06/2016 GLP-1 agonists and the risk of breast cancer in patients with type 2 diabetes
B. Hicks, H. Yin, O.Yu, M. Pollak, R.Platt, L.Azoulay
Approval Date: 14/06/2016

14/07/2016 Incidence and risk factors for paediatric acute kidney injury in the UK
K. Mansfield, M Iwagami, L. Tomlinson, A. Henderson
Approval Date: 14/07/2016

29/06/2016 Characterisation and cardiovascular risk profile of type 2 diabetes mellitus patients according to initiation of antidiabetic medications
B.T. Blak, N. Arya, P. Fenici, N. Hammar, L .A. Garcia Rodriguez, L.C. Soriano
Approval Date: 29/06/2016

01/06/2016 Post-authorisation safety study in patients with type 2 diabetes mellitus to assess the risk of acute liver injury, acute kidney injury and chronic kidney disease, severe complications of urinary tract infection, and the risk of genital infections, among patients treated with empagliflozin compared to patients treated with other SGLT2 inhibitors or DPP-4 inhibitors.
M. Pladevall-Vila, L. Rasouliyan, E. Plana, S. Perez-Gutthann, A. Tormos, K. Rothman, S Thomas, S.F. Farsani, K. Brodovicz
Approval Date: 01/06/2016

09/06/2016 A retrospective database study of the prescribing of zonisamide in UK general practice: a drug utilisation study as part of post marketing safety surveillance
Luigi Giorgi, Moira Murphy
Approval Date: 09/06/2016

29/06/2016 Long-term severe non-dermatological outcomes in eczema
H. Forbes, L. Smeeth, K. Abuabara, M. Schmidt, S. A. J. Schmidt, E. Williamson
Approval Date: 29/06/2016

09/06/2016 β-blocker effects on the association of hypoglycaemia with cardiovascular and all-cause mortality
F Zaccardi, B L Thorsted, L L N Husemoen,
Approval Date: 09/06/2016

30/06/2016 Assessment of Metformin Use Pattern in UK using CPRD
J.Liu, X. Huang
Approval Date: 30/06/2016

22/06/2016 Immunosuppressive therapy and Parkinson’s disease risk
R. Payne, C. Brayne,K. Scott, K Saunders
Approval Date: 22/06/2016

26/07/2016 Association between cardiovascular disease and zoster risk– case-control study in the Clinical Practice Research Datalink
H. Forbes, L. Smeeth
Approval Date: 26/07/2016

29/06/2016 Pharmacoepidemiology of pancreatin use in non-cystic fibrosis patients and comparison of all-cause mortality with that of their matched controls
C.Bannister, H. Schrem, K. Roberts, N. Ewald, M. Löhr, M. Kirby, B. Kalsch, H.Koch and A. Diaz
Approval Date: 29/06/2016

05/07/2016 Risk of stroke following discontinuation of oral anticoagulant treatment for atrial fibrillation: a cohort study
B. S. Freedman and C. Wallenhorst
Approval Date: 05/07/2016

20/07/2016 Longitudinal Analyses of Body Mass Index and Risk of Parkinson's Disease in CPRD
S. Pocock, K. Wing1, I. Douglas, N. Pearce, M. Johnson and J. Gregson
Approval Date: 20/07/2016

28/07/2016 Androgen Deprivation Therapy for Prostate Cancer and the Risk of Hospitalisation for Community-Acquired Pneumonia
L. Azoulay, B. Hicks, H. Yin, P. Ernst, F.Bladou
Approval Date: 28/07/2016

15/08/2016 Proton pump inhibitors and kidney disease: a self-controlled case series and cohort study
K. Mansfield, D. Nitsch, A. Root, L. Tomlinso, K Tseng, L. Smeeth
Approval Date: 15/08/2016

04/08/2016 Obstructive airway disease phenotype discovery using cluster analysis techniques in CPRD
J. Quint, L. Smeeth, F. Nissen, M Pikoula
Approval Date: 04/08/2016

27/05/2016 Discovering prognostic subtypes of cardiovascular diseases, using linked electronic healthcare records from 2 million people
T. Tillmann, R.Patel, S. Denaxas, A. Banerjee, M. Pikoula, D. Prieto-Merino, A. Moayyeri
Approval Date: 27/05/2016

02/06/2016 Development of small population prevalence model for heart failure
M. Cowie, R. Newson, A. Majeed, M. Mazidi
Approval Date: 02/06/2016

06/07/2016 Towards an understanding of persistence, switching, and adherence with medications for over-active bladder: a retrospective observational study in UK clinical practice
J. Nazir, Z. Hakimi, F. Fatoye, A. Wagg, A. Jaggi, A. Khemiri
Approval Date: 06/07/2016

14/06/2016 Descriptive assessment of the Hospital Treatment Insights database and its link to the Clinical Practice Research Datalink for research on antibiotic dispensing in English hospitals
P Rockenshaub, E Williamson, L Shallcross, M Hankins, E King, R Tham
Approval Date: 14/06/2016

15/06/2016 Oral anticoagulants for atrial fibrillation and the risk of fractures
A J. Klil-Drori, H.Yin, K. Filion, L. Azoulay
Approval Date: 15/06/2016

05/07/2016 Patient Characteristics Associated With Initiation Of Insulin Glargine Among Patients With Type 1 Or Type 2 Diabetes Mellitus In The United Kingdom
J. Liu, G. Fernandes, B. Alemayehu
Approval Date: 05/07/2016

29/06/2016 Comparative effectiveness of lansoprazole and omeprazole for the prevention of gastrointestinal bleeding and malignancy
L. Tomlinson and M. Iwagami
Approval Date: 29/06/2016

29/06/2016 Eligibility for lung volume reduction surgery for COPD in the UK
N Hopkinson, J Campbell
Approval Date: 29/06/2016

20/07/2016 Risk of major bleeds associated with the use of direct oral anticoagulants in venous thromboembolism
C. Renoux, S. Dell’Aniello, P. Ernst, B. Hemmelgarn, M. Jun, L. Lix
Approval Date: 20/07/2016

11/07/2016 Cancer and risk of herpes zoster – case-control study in the Clinical Practice Research Datalink
S Langan, H Forbes, L Smeeth
Approval Date: 11/07/2016

21/06/2016 Diabetes, use of metformin and the risk of meningioma
M. F. Leitzmann, S. S. Jick, C. Becker, U. Bogdahn, P. Hau and C. Seliger
Approval Date: 21/06/2016

02/08/2016 Metabolic syndrome and risk of meningioma – population-based case-control analysis
M. F. Leitzmann, S. S. Jick, C. Becker, U.Bogdahn, P. Hau and C. Seliger
Approval Date: 02/08/2016

25/07/2016 Proton pump inhibitor use and risk of developing Alzheimer’s disease or vascular dementia
P. Imfeld, M. Bodmer, S. S. Jick
Approval Date: 25/07/2016

21/06/2016 What is the occurrence of clinically diagnosed coeliac disease and dermatitis herpetiformis in the UK today? A population based cohort study utilising electronically linked health records
H. Otete and J. West
Approval Date: 21/06/2016

06/07/2016 Stability of blood eosinophils in COPD and controls and the impact of eosinophil count, age, gender and smoking status
F. Franssen, Y. Henskens, E. Wouters, A.Maitland-van deer Zee, A. Burden, O. Oshagbemi and D. Braeken
Approval Date: 06/07/2016

20/07/2016 Estimation of undiagnosed lysosomal acid lipase deficiency in a paediatric population: a UK database study
S. Jenkins-Jones, J. A. Cole and S. Fang
Approval Date: 20/07/2016

02/08/2016 Comparison of information on diagnosis of musculoskeletal outcomes in the Million Women Study cohort and CPRD-GOLD: a record linkage study
V. Beral, D. Furniss, J. Lane, L.Wright
Approval Date: 02/08/2016

01/08/2016 Use and costs of primary care consultations and prescription medications in relation to the body mass index in middle-aged UK women
B. Caims, S. Kent, B. Mihaylova, A. Gray, S. Jebb, V. Beral
Approval Date: 01/08/2016

15/08/2016 Comprehensive ascertainment of bleeding in patients prescribed different combinations of dual antiplatelet therapy (DAPT) and triple therapy (TT, DAPT plus an anticoagulant) after coronary interventions in the UK: a population based cohort study (The ADAPTT Study)
B. Reeves, J. Harris, C. Rogers, A. Mumford, T. Johnson, Y. Loke, D. Lasserson4 S. Wordsworth, J. Sterne, U. Benedetto
Approval Date: 15/08/2016

17/08/2016 Residual Risk of experiencing Cardiovascular events and Burden of Cardiovascular Diseases among patients receiving lipid lowering therapy in the United Kingdom
S. MacLachlan, R. Donaldson
Approval Date: 17/08/2016

16/08/2016 External validation of risk scores for dementia in the CPRD population
L. Middleton, R. Newson, M. Mazidi, B. Su, A. Majeed, A. Kulatilake, I. Tzoulaki
Approval Date: 16/08/2016

16/08/2016 Vaildating the CirCom Score in the English CPRD population
J. West, P. Jepsen
Approval Date: 16/08/2016

16/08/2016 Cohort study on the uptake of pharmacological treatments to prevent cardiovascular diseases in UK cancer survivors versus general population from 2005-2013
Anthony Matthew, Kendal Chidwick, Liam Smeeth
Approval Date: 16/08/2016

24/08/2016 The role of social determinants in vaccine uptake and burden of vaccine preventable diseases
A. Jain, A. J. van Hoek, J. Walker, N. Andrews, S. Langan, H. Forbes, R. Mathur, L. Smeeth
Approval Date: 24/08/2016

24/08/2016 Body mass index and cause-specific mortality - population-based cohort study using record linkage
Ian Douglas, Liam Smeeth, Isabel dos Santos Silva, David Leon
Approval Date: 24/08/2016

23/08/2016 Domperidone for insufficient lactation: a drug utilization study with interrupted time-series analysis
Kristian B Filion, Azar Mehrabadi, Robert W Platt, Pauline Reynier
Approval Date: 23/08/2016

24/10/2016 Impact of hospital admission upon patterns of primary care prescribing
R. Denholm, R. Morris, S. Purdy
Approval Date: 24/10/2016

05/07/2016 Androgen Deprivation Therapy and Risk of Dementia
L. Azoulay, F. Khosrow-Khavar, S. Rej, H. Yin and A. Aprikian
Approval Date: 05/07/2016

03/04/2016 Can Novel Integrated Risk Schemes Change Treatment Decisions and Improve Health Outcomes in the Year after a Diagnosis of Atrial Fibrillation? An Individual-Based Simulation
T. A. Durham, K. Hasmiller Lich, S. Dusetzina, J. Fine, A. Viera1 , J. Mukherjee
Approval Date: 03/04/2016

20/07/2016 Characteristics of patients initiating empagliflozin or other non-insulin glucose lowering drugs in the United Kingdom
S. Fazeli Farsani, C. Raabe, W. Spencer, J. George, P. Verpillat, C. Girman
Approval Date: 20/07/2016

20/07/2016 Use of Nalmefene (Selincro®) in the UK: Cohort design using longitudinal electronic medical records (EMR)
Approval Date: 20/07/2016

20/07/2016 Safety and associated costs of glucocorticoid therapy for the treatment of chronic inflammatory diseases.
A. Morgan, P. Baxter,P. Stewart, R. Hubbard
Approval Date: 20/07/2016

20/10/2016 Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints: Mortality Study.
C.Rebordosa, S. Perez-Gutthann, N. Riera, E. Plana, J. Aguado, C. Bui, A. Frances, E. Garcia-Gil
Approval Date: 20/10/2016

25/10/2016 Optimal minimum length of treatment with buprenorphine: A European analysis of medically discontinued opioid dependent patients
J. Ruby
Approval Date: 25/10/2016

14/10/2016 The relationship between prior antibiotic exposure and antibiotic “response failure” in children presenting with acute respiratory tract infections (RTI) in primary care: an observational cohort study.
O. van Hecke, K. Wang, C. Butler, A. Fuller, M. Moore, N. Francis, S. Jenkins-Jones
Approval Date: 14/10/2016

24/10/2016 Clinical effectiveness of combining two drugs versus monotherapy as initial treatment strategy in hypertension – a matched cohort study in CPRD.
P. Macouillard, N. Poulter, G. Mancia, M. de Champvallins
Approval Date: 24/10/2016

14/09/2016 Prescription trends among drug pairs with a known drug-drug interaction in primary care.
A. Root, L. Smeeth, B. Guthrie, R. Payne
Approval Date: 14/09/2016

14/10/2016 Renal Outcomes with DPP-4 Inhibitors Compared with Sulfonylurea as Add-on to Metformin among Patients with Type 2 Diabetes Mellitus in the UK
U. Desai, M.Hellstern, M. Meiselbach, B. Jia, K. Khunti, J. Mukherjee, H. Teh, K. Tsai, C.Edmonds, P.Hunt
Approval Date: 14/010/2016

22/09/2016 Metformin and the incidence of viral-induced cancers in patients with Type-2 diabetes
B. Hicks, H. Yin,L. Sinyavskaya, L. Azoulay, P. Brassard
Approval Date: 22/09/2016

14/10/2016 Oophorectomy and risk of primary liver cancer and fatty liver disease among women in the UK Clinical Practice Research Datalink
B. Graubard, B. Yang, J. Petrick
Approval Date: 14/10/2016

19/10/2016 Hearing problems in adults; mapping the patient pathway and burden recorded within the NHS
A. Schilder, R. Groenwold, A. Hayward, S. Denaxas, G. Rait
Approval Date: 19/10/2016

18/10/2016 Primary care and access to surgical treatment for women with urinary incontinence
A. Schilder, R. Groenwold, A. Hayward, S. Denaxas, G. Rait
Approval Date: 18/10/2016

14/10/2016 What are the long-term health outcomes (measures of respiratory health, measures of growth, and healthcare resource use) in low birth weight and premature babies born with chronic lung disease who are discharged home on oxygen?
D. Sharkey, S. Tan, L. Fiaschi, T. McKeever, W. Moreton
Approval Date: 14/10/2016

24/10/2016 Incidence, prevalence, mortality and health-service use among people with systemic sclerosis (scleroderma) in the UK Clinical Practice Research Datalink
J. Royle, F. Pearce, A. Abhishek, P. Lanyon
Approval Date: 24/10/2016

26/09/2016 Estimating the annual incidence of paediatric burns across the United Kingdom
K. Davies, E. Johnson, S. Maguire, H. Jones
Approval Date: 26/09/16

28/10/2016 Annual Healthcare Resource Use and Costs for Eczema in Children: A Cost of Illness Study for the English NHS
E. McManus, K. Thomas, S. Ratib, L. Ban, K.Abuabara, S. Langhan, N. Levell, M. Santer, M.Ridd
Approval Date: 28/10/2016

09/11/2016 Diagnosis and treatment of dementia in primary care in the UK
Katherine Donegan
Approval Date: 09/11/2016

07/11/2016 20 year trends for prevalence and incidence of Resistant Hypertension in the United Kingdom and outcomes in adults with hypertension
Sarah-Jo Sinnott
Approval Date: 07/11/2016

07/11/2016 Is Hydroxychloroquine associated with decreased mortality among people with Rheumatoid Arthritis?
Mathew Grainge
Approval Date: 07/11/2016

08/11/2016 Gender differences in Chronic Obstructive Pulmonary Disease: baseline characteristics, progression, and exacerbations in the United Kingdom’s Clinical Practice Research Datalink.
Emil Loefroth
Approval Date: 08/11/2016

07/11/2016 Metformin and the incidence of lymphoid malignancies in patients with type 2 diabetes
L. Azoulay, K. Thomas, A. J. Klil-Drori, H. Yin , M. N. Pollak
Approval Date: 07/11/2016

14/11/2016 Benefits of high dose ICS in patients with asthma and high blood eosinophil counts
M. Kerkhof, R. Jones, D. Skinner, T. Tan, J. Nuevo, S. Rastogi, G. Gopalan, I. Pavord, J. W. Kocks, G. G. Brusselle, A. Menzies-Gow
Approval Date: 14/11/2016

14/11/2016 Blood eosinophil count and prospective asthma disease burden
M. Kerkhof, R. Jones, D. Skinner, T. Tan, J. Nuevo, S. Rastogi, G. Gopalan, I. Pavord, J. W. Kocks, G. G. Brusselle, A. Menzies-Gow
Approval Date: 14/11/2016

16/11/2016 Impact of affluence, atopy and childhood infections on Hodgkin’s Lymphoma incidence in the UK
S. Thomas, C. Warren-Gash, S. Denaxas, M. Rafiq
Approval Date: 16/11/2016

08/12/2016 Burden of Hyperkalemia among individuals seeking health care services in England
L. Horne, A. Ashfaq, L. Qin, S. MacLachlan, R. Mukherjee
Approval Date: 08/12/2016

08/12/2016 Equitable access to smoking cessation therapies for older smokers
M. Hidajat, K. Walters
Approval Date: 08/12/2016

08/12/2016 Diabetes, glycaemic control and risk of infectious disease: cohort and case-crossover studies in primary care
D. Cook, I. Carey, T. Harris, S. De Wilde, P. Whincup
Approval Date: 08/12/2016

08/12/2016 Ethnicity, Cardiovascular Disease and the Risk of dementia
A.Kulatilake, L. Middleton, R. Newson, M. Mazidi, A. Majeed
Approval Date: 08/12/2016

12/12/2016 The risk of hypomagnesemia and electrolyte disturbances associated with the use of long-term proton pump Inhibitor: a population-based cohort study.
C. Crooks, F. Othman
Approval Date: 12/12/2016

16/12/2016 Association of Polycystic Ovary Syndrome with patient and offspring mental health outcomes: a retrospective, observational study
C. Morgan, S. Jenkins Jones, T. Berni
Approval Date: 16/12/2016

18/12/2016 Using Big data Research to tackle antIbiotic resisTance (BRIT)
D. Ashcroft, A. Molter, M. Belmonte, V. Palin
Approval Date: 18/12/2016

19/12/2016 Post-authorization Safety Study: Evaluation of Neoplasm Events in Users of Mirabegron and Other Treatments for Overactive Bladder in the CPRD
A. Margulis, S. Perez-Gutthann, A. Gilsenan, J. Kaye, C. Bui, J. Bartsch, M. Reynolds, R. Ziemiecki, L. McQuay, K. Rothman, M. D’Silva, K. Appenteng, B. Franks, S. de Vogel, W. J. Atsma
Approval Date: 19/12/2016

21/12/2016 Cohort study assessing the association between hormone therapy use in female breast cancer survivors and subsequent risk of cardiovascular diseases in the UK
A. Matthews, L. Smeeth, S. Stanway, A. Lyons
Approval Date: 21/12/2016

06/04/2017 The role of systemic inflammatory diseases in long-term morbidity and mortality: a retrospective, matched-cohort study in the Clinical Practice Research Datalink
C. Mallen, J. Belcher, A. A. Sultan, R. Whittle
Approval Date: 06/04/2017

08/03/2017 Statin prescribing and depression after incident stroke
Z. Yang, L. Gerza, J. Mant, J. Brimicombe
Approval Date: 08/03/2017

08/03/2017 Pattern of use of Direct Oral AntiCoagulant (DOAC) in Non-Valvular Atrial Fibrillation (NVAF) patients in UK general practices
L. A. G. Rodriguez, A. Ruigomez, K. Suzart-Woischnik, M. S. Gabarro, P. Vora, Y. Lenz, M. Homering, L. Robert
Approval Date: 08/03/2017

13/03/2017 Accounting for multimorbidity, competing risk and direct treatment disutility in risk prediction tools for the primary prevention of cardiovascular disease.
D. Morales, S. Livingstone, P. Donnan
Approval Date: 13/03/2017

14/03/2017 The diagnostic utility of inflammatory markers in primary care: a prospective cohort study.
W. Hamilton, C. Salisbury, P. Whiting, H. Jones, M. T. Redaniel
Approval Date: 14/03/2017

14/03/2017 Hypoglycaemia and serious adverse events in older people living with diabetes and dementia – a population-based cohort study
K. Mattishent, G. Savva, K. Richardson
Approval Date: 14/03/2017

29/03/2017 The relationship between non-valvular atrial fibrillation and dementia
B. Weijs T. Field M. Giustozzi A. Curcio S. Sudikas A. Katholing A. Cohen
Approval Date: 29/03/2017

29/03/2017 Evaluation of the impact of glucose-lowering treatment with pioglitazone on stroke outcomes.
S. Jenkins-Jones, S. Holden
Approval Date: 29/03/2017

29/03/2017 Management of patients with Non-Valvular Atrial Fibrillation following a first clinically relevant bleed whilst being treated with an Oral Anticoagulant English clinical practice: a cohort study based on Clinical Practice Research Datalink-Hospital Episode Statistics data.
C. Sammon, A. Cohen, C. Lefevre, G. Stynes, B. D. Caritey, N. Hill, M. Lumley, D. Fountain, S. Weir, M. Samnaliev
Approval Date: 29/03/2017

29/03/2017 Primary and secondary healthcare contacts in children born preterm and their households
J. van der Muelen, L. Smeeth, R. Gilbert, S. Thomas, C. Minassian1, L. Pettigre, D. Cromwell
Approval Date: 29/03/2017

29/03/2017 Acute exacerbations of chronic obstructive pulmonary disease: Clinical history and effects on rate of recurrent events and risk of death
K. Rothnie, H. Müllerová, L. Smeeth
Approval Date: 29/03/2017

30/03/2017 Short term High Density Lipoprotein cholesterol decrease and cardiovascular risk
B. Layton, T. Sturmer
Approval Date: 30/03/2017

03/04/2017 Prescribing Pathways to Triple Therapy in Chronic Obstructive Pulmonary Disease
M. Myland, J. Quint, K. Rothnie, C. O’Leary, A. Venerus, C. Cabrera, G. Lucrezi, R. Tham, S. Ballal, U. Holmgren, H. Petri
Approval Date: 03/04/2017

06/04/2017 Low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride and diverse non-cardiovascular diseases: a large population-based cohort study using CALIBER dataset.
N. Na-Ek, A. Banerjee, A. Moayyeri
Approval Date: 06/04/2017

06/04/2017 Unintended effects of novel oral anticoagulants (NOAC) vs warfarin in real world settings
Y. Vinogradova, C. Coupland
Approval Date: 06/04/2017

06/04/2017 Evaluation and monitoring of the routine shingles immunisation programme
E. Miller, N. Andrews, K. Donegan, P. Keel, J. Stowe, J. Walker, S. Thomas, H. Forbes, S. Langan
Approval Date: 06/04/2017

18/05/2017 The role of hepatitis B in the progression of Non-Alcoholic Fatty Liver Disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients.
T. Cattaert, A. Stuurman, K. Bollaerts, M. Alexandridou, T. Verstraeten, Y. Horsmans, A. Guignard, V. Bianco
Approval Date: 18/05/2017

27/06/2017 Understanding the role of serum electrolytes in the presentation of specific fatal and non-fatal cardiovascular disease syndromes: a research proposal using linked CPRD-HES-ONS data
L. McCallum, H. Hemingway, A. Moayyeri, S. Anderson, S. Denaxas, M. Katsoulis
Approval Date: 27/06/2017

25/07/2017 Drug utilisation study of new users of fluticasone furoate / vilanterol (FF/VI) in the primary care setting.
S. Landis
Approval Date: 25/07/2017