Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
11/04/2025	Transitions in dementia and biomarkers trajectories in the UK population (TraDBiT)
09/04/2025	Comparison of patient characteristics when screened for their malnutrition risk or treated for malnutrition in primary care in England
09/04/2025	Examining the Association between Ethnicity, Socioeconomic Status and the Initiation of Cardiorenal Protective Medication in Eligible Type 2 Diabetes Mellitus Patients.
09/04/2025	Type and timing of menopausal hormone therapy use in relation to risk of breast cancer, ovarian cancer, and endometrial cancer.
09/04/2025	Refining and validating a clinical prediction model for childhood chronic kidney disease.
07/04/2025	Target Trial Approach to Evaluate Strategies for Improving Cardiovascular Outcomes
07/04/2025	Assessment of the winter burden of asthma and chronic obstructive pulmonary disease after treatment review: An electronic healthcare record study.
07/04/2025	Incidence rates of flares of auto-immune chronic diseases using European electronic healthcare record databases: SAFETY-VAC
04/04/2025	Effect of combined oral contraceptives on stroke among individuals with migraine with aura
04/04/2025	Understanding inequalities in cancer diagnostic outcomes for people with Learning Disabilities
03/04/2025	Real-World Comparative Outcomes in Multiple Myeloma: Evaluating Maintenance Therapy, Bispecific Antibodies, and Treatment Regimens
03/04/2025	Inequalities in treatment receipt and time-to-treatment among patients diagnosed with breast, bowel, lung or prostate cancer: a matched cohort study
03/04/2025	Identifying disparities in prescribing of SGLT2- inhibitors in people with Chronic Kidney Disease
03/04/2025	Do cholesterol-lowering treatments bring on or make atopic eczema worse?
03/04/2025	The Use of Incretin-Based Drugs and Sodium-Glucose Co-Transporter-2 Inhibitors for the Prevention of Parkinson's Disease Among Patients with Type 2 Diabetes
28/03/2025	Cardiovascular Adverse Events of Non-Steroidal Anti-Inflammatory Drugs: A Sequence Symmetry Study
28/03/2025	Association between white blood cell counts and risk and severity of infections in individuals with cardiometabolic disease: An observational cohort study
28/03/2025	Evaluating the Real-World Representativeness of Randomized Controlled Trials of People with Type 2 Diabetes in Primary Care.
26/03/2025	Real world utilisation of oral semaglutide and association with HbA1c in primary care clinical practice in the United Kingdom
26/03/2025	Incidence, Treatment, and Natural History of Lyme Disease in the United Kingdon: A Population-Based Cohort Study