Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
24/01/2025	Prevalence and socioeconomic and geographic associations in type 2 diabetes with comorbid depression and anxiety in the UK
22/01/2025	Predicting rheumatoid arthritis risk using electronic healthcare records: the RheumDetect study
22/01/2025	Identifying and characterising groups of people with multiple long-term conditions _ multimorbidity: an analysis of observation data
22/01/2025	Examining patterns and health inequalities of clusters of multiple long-term conditions in England
22/01/2025	Characterization of neurodevelopmental disorders in children exposed or unexposed in utero to valproate and(or) other antiepileptic drugs with long-term follow-up: retrospective study
22/01/2025	Feasibility study to assess polypharmacy and associated health outcomes using Clinical Practice Research Datalink data in older adults receiving home care in England
22/01/2025	The incidence of diuretic associated sequential prescribing cascades: a feasibility study
22/01/2025	Investigating changes in general practitioner admission patterns following introduction of emergency admission risk stratification tools, a natural experiment using linked routine data.
22/01/2025	Large weight loss and risk of developing micro- and macrovascular disease in adults living with both obesity and type 2 diabetes: a cohort study
22/01/2025	Diagnosis and management of vitamin B12 deficiency across primary care in England
22/01/2025	Glucocorticoid use and initiation of Selective Serotonin Reuptake Inhibitors among patients with rheumatoid arthritis: a nested case-control study in CPRD Aurum
21/01/2025	Evaluating and addressing the impact of COVID-19 restrictions on electronic health records in estimating causal effects: oral fluoroquinolone antibiotics and tendon rupture
21/01/2025	Diagnosis and Treatment of Vasomotor Symptoms in Women with Breast Cancer Receiving Adjuvant Endocrine Therapy in England: A Descriptive Observational Cohort Study
17/01/2025	Understanding the impact of cancer related risk factors on incidence, prevalence and survival of cancers in individuals under 50 years of age
17/01/2025	Adverse Drug Events in Ageing Populations (ADDRESS-AP): A prediction modelling and causal inference study examining the association between stopping medications and adverse drug events in high-risk patients
17/01/2025	Alcohol use and risk of dementia: a historical cohort study
17/01/2025	Describing prescribing of opioid medications in the UK: a feasibility study
15/01/2025	Clinical management and disease outcomes of patients with pulmonary fibrosis in England
15/01/2025	Developing transdiagnostic symptom phenotypes of mental illness using primary care data (DeTraP)
14/01/2025	Predicting gastrointestinal disease following faecal calprotectin testing in primary care: a feasibility study