Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
06/09/2024	Treatment patterns, clinical outcomes and healthcare resource use in glycaemic therapy-using patients with Type 1 or 2 diabetes: a retrospective cohort analysis
06/09/2024	The Excess Risk of Death Outcomes Study (ERDOS) in Chronic Obstructive Pulmonary Disease (COPD): A real-world study to understand the leading causes and excess risk of mortality in people living with COPD using the CPRD in England
06/09/2024	Comparing data fusion methods for combining clinical trial and real-world data to estimate cardiovascular outcomes: a methodological study
05/09/2024	The Impact of Estradiol + Dydrogesterone on Menopause Oestrogen Deficiency Symptoms Treatment
05/09/2024	Progression of frailty following severe infections: a matched cohort study in individuals aged 65 years and over using the Clinical Practice Research Datalink
05/09/2024	Effects of ursodeoxycholic acid on the risk of Parkinson's: a cohort study
03/09/2024	Population-based cohort study on the utilisation, adherence, discontinuation, switching, and restarting of treatments and medications of regulatory interest
02/09/2024	Methodological Approaches to Minimizing Immeasurable Time Bias in Oral Anticoagulant Use and the Risks of All-cause Mortality, Recurrent Stroke, and Major Bleeding Among Patients with Ischemic Stroke
02/09/2024	Developing a prediction model for upper gastrointestinal and pancreatic cancers from patients who have presented to primary care with upper gastrointestinal symptoms.
29/08/2024	A study to characterise the burden of illness among patients with chronic obstructive respiratory disease with eosinophilic phenotype who frequently exacerbate: An analysis of English linked primary and secondary care data
23/08/2024	Cost-effectiveness of Shingrix vaccination and revaccination in immunocompetent and immunosuppressed adults in England: a repeated cross-sectional study and economic modelling analysis
23/08/2024	Effects of Discontinuation and Tapering of Antipsychotics in Older Adults Living with Dementia Using the Target Trial Emulation Framework
22/08/2024	Investigating which symptoms, tests and medications are associated with lymphoma diagnosis in the primary care population: a case control and cohort study
22/08/2024	Sex-specific effectiveness and safety of sacubitril-valsartan compared to angiotensin-converting enzyme inhibitors in heart failure; target trial emulation of the PARADIGM-HF trial
20/08/2024	Patterns of anti-depressant prescribing in inflammatory bowel disease
16/08/2024	Clinical relevance of neutrophil and associated blood tests in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data
15/08/2024	Cardiovascular Risk of Menopausal Hormone Therapy in Women with Diabetes: A Cohort Study
14/08/2024	A comparison of clinical outcomes in patients with asthma newly initiating Inhaled Corticosteroid (ICS) and Long-acting beta 2 agonist (LABA) Relvar and Symbicort combination inhalers in England.
14/08/2024	Describing the prescribing trends of drug classes which may produce dependency: gabapentinoids, benzodiazepines and Z-drugs.
14/08/2024	Effect of thiazolidinediones on preventing vascular dementia in type 2 diabetes in the UK