Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
18/03/2024 The role of inequalities in asthma care and outcomes in England: a cohort study of people with asthma
01/03/2024 COVID-19 booster vaccine effectiveness in secondary prevention of major adverse cardiovascular events: an emulated target trial in observational data
06/02/2024 Effectiveness of COVID-19 vaccines on severe COVID-19 and post-acute cardiovascular events and diabetes following SARS-CoV-2 infection: A cohort study
29/01/2024 Quantifying the impact of the COVID-19 pandemic and the Kidney Failure Risk Equation on Chronic Kidney Disease care and outcomes in Primary Care
12/01/2024 Exploring Healthcare Use Trajectories and the Impact of Duloxetine on Pain-Related Healthcare Use in People with Fibromyalgia: Cohort Study and Emulated Trial in CPRD Aurum.
12/01/2024 Population-level incidence, prevalence and mortality rates in diseases of regulatory interest
12/01/2024 Epidemiology of Hypophosphatasia (HPP) in the UK: A Retrospective Cohort Study using Clinical Practice Research Data Link (CPRD)
09/01/2024 Association between leukotriene receptor antagonist use and the risk of dementia: a population based cohort study
09/01/2024 Incidence of gastro-intestinal, lower respiratory tract, and acute otitis media infections in infants in the United Kingdom between 2012 and 2022.
09/01/2024 The epidemiology of sarcoidosis in the United Kingdon
08/01/2024 Comparing the Risk of Interstitial Lung Disease Between Oral Anticoagulants in Patients with Atrial Fibrillation: A Population-Based Cohort Study
08/01/2024 Development of prediction models for clinically relevant complications in primary care superficial venous thrombosis patients
08/01/2024 Developing Algorithms to Predict Individual Patient Response to Anticoagulant, Antidiabetic and Antidepressant Drug Treatment
08/01/2024 Calculating the impact of optimising preconception health among women with mental illness
29/12/2023 Retrospective cohort analysis using Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) to investigate adherence to androgen deprivation therapy (ADT) in patients with prostate cancer
29/12/2023 Cancer in people presenting with back pain in primary care (CanBack): a prevalence and diagnostic accuracy study
28/12/2023 Characterization of Pregnancy Outcomes in Women with Generalized Pustular Psoriasis
28/12/2023 Comparing Direct Oral Anticoagulants to Vitamin K Antagonists on bleeding and cardiovascular outcomes: cohort study on the effect of using common data models
28/12/2023 Trends in prescription of oral anticoagulants in elderly individuals with atrial fibrillation in UK primary care
28/12/2023 Comparing Direct Oral Anticoagulants to Vitamin K Antagonists on bleeding and cardiovascular outcomes in patients with atrial fibrillation: effect of using a common protocol only versus a syntactically harmonized Common Data Model