Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
27/12/2023 Reinforcement Learning approach to evaluate and rank AI models that use clinical parameters to predict hospitalisation and mortality of adults with Multiple Long-Term Conditions
27/12/2023 Risks factors and causes of postnatal General Practitioner consultations and hospital admissions following perinatal mortality: a cohort study
27/12/2023 Evaluation of foot screening in primary care in people with diabetes in England
27/12/2023 Epidemiological analysis of inflammatory eye and central nervous system conditions and their risk factors, association with infectious and immune-mediated inflammatory diseases, and health impacts. A UK population-based observational study
27/12/2023 Incidence, Prevalence, and Predictors of Fibromyalgia in People with Inflammatory Arthritis: An Observational Cohort Study using the Clinical Practice Research Datalink Aurum.
22/12/2023 Incidence, prevalence, and characterisation of medicines with suggested drug shortages in Europe
20/12/2023 Measuring current practice and inequalities in type 2 diabetes treatment and intensification: a population-based cohort study
20/12/2023 Does flucloxacillin increase the risk of stroke and systemic embolism in patients who are already using direct oral anticoagulants?
20/12/2023 Investigating the impact of SARS-CoV-2 on gastrointestinal illness using advanced linked data systems
20/12/2023 Monitoring the prescription in primary care of antibiotics for public health emergencies that may be at risk of shortages in the European Union
19/12/2023 The effect of antiseizure medications on the effectiveness and safety of anticoagulants in patients with stroke: A population-based study in the United Kingdom.
15/12/2023 Benefits and risks of pausing long-term osteoporosis treatment: nested case-control and cohort studies using data from the Clinical Practice Research Datalink.
14/12/2023 Incidence and prevalence of Parkinson's: secular and demographic patterns
08/12/2023 Associations between sociodemographic and environmental factors and cardiovascular disease risk in the UK.
07/12/2023 Disease epidemiology and drug utilisation for disease-specific treatments of regulatory interest
07/12/2023 Feasibility study of the occurrence of severe clinical events in steatotic liver disease
07/12/2023 Antipsychotics and Type 2 Diabetes in Children and Young People: A Population-based Study
05/12/2023 Longitudinal Treatment Patterns, Health Outcomes and Costs of Cancer Associated Thrombosis (CAT) in the United Kingdom: A Real-World Study Using Clinical Practice Research Datalink (CPRD)
01/12/2023 Incidence of stroke in patients with epilepsy using anti-seizure medication in England: A retrospective cohort study conducted within the Clinical Practice Research Datalink (CPRD)
30/11/2023 Use of topiramate and risk of glaucoma: a case-control study in UK primary care