Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
10/03/2025	DARWIN EU: Association of venous thromboembolism with non-steroidal anti-inflammatory drug use in women 15-49 years using hormonal contraceptives
10/03/2025	Place of death in people with pulmonary fibrosis in the England: A cohort study
10/03/2025	A retrospective observational study on the epidemiology of diseases of the circulatory system and the healthcare resource use and treatment of patients with these conditions
07/03/2025	QEMISTRY-Dementia: Quantifying and Explaining MortalIty aSsociaTed with PsYchotropic Drug Prescribing in Dementia.
06/03/2025	The analysis of multiple long term conditions: Patient Profiles, Trends, Health Outcomes, and Economic Burden
06/03/2025	Sex-specific effectiveness and safety of carvedilol compared to metoprolol in heart failure.
05/03/2025	Prevalence, risk factors and healthcare use associated with multi-person morbidity of chronic health conditions in children and parents
05/03/2025	PREscription of statins and antipsychotics associated with diabetes deVelopmENT (PREVENT).
03/03/2025	A Post-Authorisation Safety Study (PASS) of Abrysvo (Respiratory Syncytial Virus Stabilised Prefusion Subunit Vaccine) in Immunocompromised, or Renally or Hepatically Impaired Adults Aged 60 Years and Older in a Real World Setting in Europe and UK
03/03/2025	PREDICTion of GastroIntestinal malignancy in patients with IRON Deficiency (PREDICT-GI-IRON)
26/02/2025	Optimising transient ischaemic attack (TIA) pathways to reduce ethnicity-based inequalities
26/02/2025	Understanding the link between kidney health and pregnancy outcomes
26/02/2025	The effect of bariatric surgery upon long-term survival in high-risk cardiovascular patients
26/02/2025	Assessing and predicting the excess risk of diabetes progression in at-risk subpopulations
25/02/2025	Epidemiology, patients characteristics, management and outcomes of cardiovascular, renal and metabolic disease: a UK retrospective database analysis
25/02/2025	Vaccine uptake in adults with inflammatory conditions treated with immune suppressing drugs: a prospective study using data from the Clinical Practice Research Datalink (CPRD)
25/02/2025	Global Vaccine Data Network (GVDN) Project - A multi-centre international database study evaluating maternal and neonatal safety post COVID-19 vaccination in pregnant women
25/02/2025	Improving assessment of the risk of underlying cancer and non-neoplastic disease in primary care
21/02/2025	The Impact of Estradiol + Dydrogesterone on Menopause Estrogen Deficiency Symptoms Treatment
21/02/2025	The impact of living alone with dementia in health care service usage and costs: a matched cohort study