Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
11/11/2024	Clinical management and health outcomes of people diagnosed with a personality disorder and those who have harmed themselves: a multi-phase study.
11/11/2024	A real-world evidence study describing characteristics of patients receiving a cardiovascular disease risk assessment in primary care in the UK between 2013 and 2023
11/11/2024	Premature all-cause and cause-specific mortality trends, comorbidities, and medication use among those with gout
11/11/2024	Alzheimer's disease patient diagnosis and disease management in England
08/11/2024	Real-world utilization of and associated outcomes from direct oral anticoagulants for atrial fibrillation and stroke prevention in the United Kingdom
08/11/2024	Assessing Health and Equity Impacts of COVID-19 Mitigation Strategies on Mothers of Young children, Children, Adolescents and Youths: An Observational Population-based Study in Ontario (Canada) and England
07/11/2024	Generating baseline metrics for the assessment of the UK Rare Diseases Framework.
06/11/2024	Chronic obstructive pulmonary disease(COPD)-, infection-, and inflammation-related factors in the moderation and mediation of the inhaled corticosteroids (ICS) and major adverse cardiovascular events (MACE) relationship, amongst people with COPD
06/11/2024	Improving early detection of lung cancer in never-smokers by developing risk prediction models using retrospective primary care medical records
06/11/2024	The association between ever and never having attended diabetes self-management education programmes, hospital admission rates and mortality in type 2 diabetes: A cohort analysis using data from the UK Clinical Practice Research Datalink.
05/11/2024	Multiple Long-term Conditions And Prematurity Study: A cohort study using CPRD and linked hospital data investigating the relationship between preterm and multiple long-term conditions from 0-10 years of age in children born 2000-2014 in England
04/11/2024	The trends and drivers of antibiotic treatment failure in primary care
04/11/2024	Prevalence of Eating Disorders in Children & Adults in England
04/11/2024	The long-term impact of the COVID-19 pandemic on childhood otitis media incidence: a population-based cohort study
04/11/2024	Rates of co-prescribing of opioids with anti-anxiety medicines (benzodiazepines and Z-drugs): a population-based cohort study
04/11/2024	Trends in the Utilization and Persistence on Adjuvant Hormonal Therapy among Women with Early Invasive Breast Cancer in the United Kingdom, 2004 to 2023
04/11/2024	Recurrent Events and Characteristics following a first-ever Transient Ischemic Attack: a multi-database retrospective cohort study
04/11/2024	Are people who die with multiple long-term conditions-multimorbidity considered for a palliative approach to care in the last year of life? A retrospective observational study
01/11/2024	Epidemiology and Risk Characterisation of Vitiligo using a Large UK Population-Based Dataset
01/11/2024	Drug utilisation, patient characterisation and survival for populations of regulatory interest