Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
20/05/2024 Isotretinoin exposure during pregnancy
15/05/2024 Health and Labor Market Impacts of Hormone Replacement Therapy: A Descriptive Retrospective Analysis of Hormone Replacement Therapy Prescriptions Using UK Primary Care Data and Supplementary Labour Force Survey and Understanding Society Survey Data
15/05/2024 Incidence and Prevalence of Ectopic Pregnancy
13/05/2024 Safety of Paxlovid for the Treatment of COVID-19 During Pregnancy: Investigating Adverse Pregnancy, Maternal and Offspring Outcomes
09/05/2024 Predicting serious cutaneous adverse reaction due to allopurinol in people with gout
09/05/2024 Adverse cardiovascular impact of erectile dysfunction in people with and without type 2 diabetes
08/05/2024 Factors that can affect antihypertensive response in patients newly diagnosed with hypertension
08/05/2024 Safety of Paxlovid Among Patients with Moderate or Severe Hepatic or Renal Impairment: Investigation of Any Safety Events and Events of Special Interest
07/05/2024 A study of the association between diabetes and fibrotic multimorbidity
07/05/2024 Does gestational diabetes confer a significant risk of diabetic retinopathy in women with diabetes? A retrospective cohort study using real-world evidence
07/05/2024 Exploring temporal trends in the incidence and prevalence of rheumatoid arthritis, and venous thromboembolism risk factors in women with rheumatoid arthritis in England
03/05/2024 To explore factors associated with non-engagement in asthma care and understand the impact of non-engagement on asthma outcomes
30/04/2024 Incidence, prevalence and clinical consequences of bronchiectasis
30/04/2024 Evaluating the relationship between pregnancy complications and health before and after pregnancy using electronic health record data in England
29/04/2024 Real-world use and effectiveness of COVID-19 vaccines in pregnant women
29/04/2024 Associations between lisinopril and amlodipine use and risk of aneurysmal subarachnoid haemorrhage: A UK population-based cohort study
29/04/2024 Exploring clinical pathways in large-scale electronic healthcare record data: applying sequence analysis to pre-arthroplasty pathways in osteoarthritis
29/04/2024 Exploring the role of health inequalities as determined by socioeconomic status in the diagnosis, management and outcomes of patients with asthma in England
29/04/2024 Trends in incidence and mortality of pancreatic cancer and risk prediction from primary care records in England
25/04/2024 Analysing trends in primary care diagnoses of chlamydia and chlamydia-related sequelae in young people