Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
02/11/2023 Drug utilization study in patients with major depressive disorder - a DARWIN EU study
01/11/2023 Temporal validation of prognostic models for chronic obstructive pulmonary disease (COPD) and evaluation of methods to correct for calibration drift.
01/11/2023 Characterising the clinical features and healthcare resource use associated with thalassaemia in England: a retrospective cohort study
01/11/2023 Using real-world data to replicate a trial on the efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2)
01/11/2023 Epidemiology, outcomes, healthcare resource utilisation, and inequities among amyloidosis patients in the UK, an observational study
30/10/2023 Characterising rectal prolapse and rectopexy in the United Kingdom: population characteristics, incidence and surgical procedures
30/10/2023 Impact of SSRI and (or) SNRI antidepressant use on cardiovascular health in adult patients with a diagnosis of anxiety disorder: a retrospective cohort study
24/10/2023 Prescription of cardiovascular disease prevention in primary care: a cohort study
20/10/2023 Long term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in patients with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink.
19/10/2023 Effectiveness and safety of direct oral anticoagulants versus warfarin in patients with atrial fibrillation and mitral stenosis
18/10/2023 Autism, epilepsy and central sensitivity syndromes: investigating the co-occurrence of conditions associated with increased brain excitation : inhibition balance
18/10/2023 The associations between antihypertensive medications and microvasucalar, macrovascular diseases and major adverse cardiovascular event (MACE) in people with type 2 diabetes: a population-based cohort study
17/10/2023 The efficacy and safety of concomitant treatment with telmisartan and indapamide in patients with essential arterial hypertension: Outcomes in real world practice
16/10/2023 Trends in General Practice and Emergency Department Use in Children
13/10/2023 Incidence of stroke in patients with epilepsy using anti-seizure medication in England: A retrospective cohort study conducted within the Clinical Practice Research Datalink (CPRD)
10/10/2023 Sociodemographic factors, multimorbidity and frailty determinants in the delay of heart failure diagnosis, treatment and subsequent prognosis; UK trends over 20 years and impact of the Covid-19 pandemic
10/10/2023 Cardiovascular mortality and morbidity in patients with chronic obstructive pulmonary disease, obstructive sleep apnoea and the overlap syndrome: a matched cohort study
09/10/2023 Inequalities among marginalised groups, diagnosed with breast cancer, in relation to routes to diagnosis, diagnostic intervals, and pre-treatment intervals, before and after the COVID-19 pandemic: a cross-sectional analysis of national data
09/10/2023 DARWIN EU - EHDS Use Case: Natural history of coagulopathy in COVID-19 patients and persons vaccinated against SARS-CoV-2 in the context of the OMICRON variant, a population-based cohort study
09/10/2023 Effects of the COVID-19 pandemic on primary care recorded anxiety and depression, psychotropic prescribing and referrals to mental health services