Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
27/11/2024	Dihydropyridine Calcium Channel Blockers for the Prevention of Dementia in Patients with Hypertension
27/11/2024	Evaluating cardiovascular disease risk in people with diabetes remission and relapse in a UK based- population: a real- world retrospective cohort study.
27/11/2024	Assessment of the Burden and Association of Cardiopulmonary Outcomes and Risks with COPD: Focus on Cardiopulmonary Related Risks (ABACOS-Risk)
25/11/2024	Associations between primary care recorded cannabis use and healthcare utilisation in the UK: a population-based retrospective cohort study of patients with osteoarthritis using UK primary care data
21/11/2024	Observational study designs and analytical options for the evaluation of safety of multi-dose vaccines: An application to COVID-19 and rotavirus vaccines.
20/11/2024	Towards Precision Treatment for Type 2 Diabetes using Real-World Data: When And How Should Antihyperglycemic Therapy be Intensified among Individuals with Type 2 Diabetes and Multiple Chronic Conditions?
18/11/2024	Clinical and Economic Burden of Adults at risk for atherosclerotic cardiovascular disease in England
15/11/2024	Sedative medications and their effect on respiratory outcomes in patients with asthma and COPD
15/11/2024	Exploring disease signatures and compounded risk assessment scores from longitudinal common blood markers in the Clinical Practice Research Datalink
13/11/2024	Pediatric Hypertension Feasibility Assessment
11/11/2024	Comparison of United Kingdom Biobank Population to a CPRD Aurum random sample population: a descriptive cohort study
11/11/2024	Premature all-cause and cause-specific mortality trends, comorbidities, and medication use among those with gout
11/11/2024	Drug utilisation and disease epidemiology for conditions of regulatory interest
11/11/2024	A real-world evidence study describing characteristics of patients receiving a cardiovascular disease risk assessment in primary care in the UK between 2013 and 2023
11/11/2024	Alzheimer's disease patient diagnosis and disease management in England
11/11/2024	Clinical management and health outcomes of people diagnosed with a personality disorder and those who have harmed themselves: a multi-phase study.
08/11/2024	Real-world utilization of and associated outcomes from direct oral anticoagulants for atrial fibrillation and stroke prevention in the United Kingdom
08/11/2024	Assessing Health and Equity Impacts of COVID-19 Mitigation Strategies on Mothers of Young children, Children, Adolescents and Youths: An Observational Population-based Study in Ontario (Canada) and England
07/11/2024	Generating baseline metrics for the assessment of the UK Rare Diseases Framework.
06/11/2024	Chronic obstructive pulmonary disease(COPD)-, infection-, and inflammation-related factors in the moderation and mediation of the inhaled corticosteroids (ICS) and major adverse cardiovascular events (MACE) relationship, amongst people with COPD