Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
01/03/2024	Investigating adverse mental health outcomes related to glucagon-like peptide-1 receptor agonists: target trial emulation using interlinked primary and secondary healthcare records
01/03/2024	COVID-19 booster vaccine effectiveness in secondary prevention of major adverse cardiovascular events: an emulated target trial in observational data
27/02/2024	Predicting remission of type 2 diabetes following bariatric surgery: external validation of existing models and model update within England primary care electronic health records
26/02/2024	Comparing direct and indirect methods to estimate prevalence of chronic diseases using real-world data
21/02/2024	A cohort study to assess drug utilisation and long-term safety of galcanezumab in UK patients in the course of routine clinical care
21/02/2024	Assessing the utility of clinical criteria and prediction models for classification of diabetes subtypes in primary care
21/02/2024	The epidemiological risks of non-fatal self-harm, suicide or emergency services readmission of youth following discharge from inpatient psychiatric care
20/02/2024	Ethnic variations in risk trajectories for type 2 diabetes: an observational cohort study
20/02/2024	Comparison of cardiovascular outcomes in patients with long term exposure to Evolocumab in trial and open label extension study with an external control arm using real world data
19/02/2024	Association between herpes zoster vaccination and autoimmune rheumatic diseases in UK: A regression discontinuity analysis
14/02/2024	An observational study of the characteristics, epidemiology and healthcare resource utilisation of patients with type 1 diabetes pre, peri, and post diagnosis in England.
14/02/2024	Using machine learning to understand inequalities in early-onset Type 2 Diabetes and co-occurring long-term conditions
13/02/2024	Incidence and prevalence of Endometriosis in England between 2010 and 2020
13/02/2024	Glucagon-like peptide-1 receptor agonists and the risk of suicide, suicidal ideation, and self-harm among patients with type 2 diabetes
12/02/2024	Comparison of participant characteristics in decentralized clinical trials conducted at home, conventional clinical trials conducted at investigative sites, and real-world patients: a descriptive study
12/02/2024	The impact of the National Data Opt-out programme on representativeness of the Clinical Practice Research Datalink (CPRD) database.
08/02/2024	The efficacy and safety of concomitant treatment with dapagliflozin and sitagliptin in patients with type II diabetes: Outcomes in real world practice.
08/02/2024	Use of treatments for bipolar disorder in pregnancy and risk of congenital anomalies and developmental disorders in offspring
08/02/2024	Prescribing of Opioids in Menopausal and Postmenopausal Women in the UK: A Population-based Drug Utilization Study
06/02/2024	Exogenous sex steroid hormones and asthma phenotypes: a population-based prospective cohort study using UK-wide primary care data