Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
09/10/2023 Inequalities among marginalised groups, diagnosed with breast cancer, in relation to routes to diagnosis, diagnostic intervals, and pre-treatment intervals, before and after the COVID-19 pandemic: a cross-sectional analysis of national data
05/10/2023 Exploring the standard of care among Very High Fracture Risk patients using Real World Data from Clinical Practice Research Datalink (CPRD) with linkage to Hospital Episode Statistics (HES) and Office for National Statistics (ONS) Death Registration
05/10/2023 Characterising and assessing long term outcomes in patients with prostate cancer
02/10/2023 Long-term mortality, neurodevelopmental impairments, and economic outcomes after invasive group B streptococcal disease in the first three months of life in England: A retrospective cohort study based on electronic health care records
02/10/2023 Analysis of chronic multimorbidity in observational data: part of the GEMINI study.
28/09/2023 Characterisation and treatment pathways of heavy menstrual bleeding using the Clinical Practice Research Datalink: a descriptive study
28/09/2023 Does the cumulative dose of aspirin affect cancer risk
28/09/2023 Predictors of discontinuation or reduction of long-term opioid therapy and its associated adverse events in patients with chronic non-cancer pain in the UK primary care: a retrospective cohort study
27/09/2023 Development and validation of risk scoring tools for acute exacerbations and cardiovascular outcomes among patients with chronic obstructive pulmonary disease (COPD).
27/09/2023 Demographic characteristics of a population with obesity, atherosclerotic cardiovascular disease, and no diabetes
27/09/2023 Identifying treatable traits of people with asthma prescribed an Inhaled Corticosteroid and Long Acing Beta-2 Agonist (ICS-LABA) - a descriptive analytic study in England
25/09/2023 A feasibility study to estimate subgroups of atrial fibrillation population
22/09/2023 An observational study program to investigate the management and consequences of hyperkalemia in cardiorenal patients in routine clinical practice
22/09/2023 Use of systemic fluoroquinolones in the UK: a drug utilisation study
21/09/2023 Artificial intelligence to identify medications in primary care associated with increased risk of keratinocyte skin cancer; an exploratory and nested case control study.
20/09/2023 Management of people with asthma in primary care by smoking status: a descriptive cohort study
20/09/2023 Cardiovascular risk with discontinuation of sodium-containing medications after a hypertension diagnosis
20/09/2023 A descriptive study measuring the uptake of NICE (National Institute for Health and Care Excellence) guidance on cardiovascular disease risk assessments and lipid lowering therapies for primary and secondary prevention of cardiovascular disease
20/09/2023 Linaclotide Safety Study for the Assessment of Diarrhoea Complications and Associated Risk Factors in the UK population with Irritable Bowel Syndrome predominantly with constipation (IBS-C)
18/09/2023 Multi-region evaluation of the national roll out of social prescribing link workers in primary care