Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
11/09/2023 Validation of the Birmingham Lung Improvement Studies (BLISS) prognostic score for predicting acute respiratory admissions among Chronic Obstructive Pulmonary Disease (COPD) patients
11/09/2023 A case-control study of dementia in people taking three commonly prescribed medications: rizatriptan, beclometasone and allopurinol
08/09/2023 Treatment patterns and drug utilisation for medicines of regulatory interest in autoimmune disease
08/09/2023 Care interventions in the development of heart failure and frailty and their impact on outcomes: a cohort study
08/09/2023 The presence of obstructive sleep apnoea and the risk of cardiovascular disease in individuals with atrial fibrillation
06/09/2023 Association of sodium glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists with the risk of developing dementia in people with type 2 diabetes
05/09/2023 To examine the recording of surgical treatments for rectal prolapse in secondary care and explore definitions for establishing establishing the use of surgical mesh: a linked CPRD and HES data feasibility study.
05/09/2023 Estimating Respiratory Syncytial Virus (RSV) burden in adults +50 years in the UK using Real-World Data: a database and time-series modelling study
01/09/2023 Inequalities in unplanned hospital admission and the role of continuity of care.
01/09/2023 Temporal trends in and health conditions associated with "Deaths of Despair" (suicides, alcohol- and drug-related deaths): analysis of interlinked primary and secondary healthcare and mortality records
01/09/2023 The association between the COVID-19 vaccine and herpes zoster, bullous pemphigoid and urticaria
01/09/2023 An estimation of the direct healthcare resource use associated with geographic atrophy: a retrospective cohort study in England
30/08/2023 Treatment Patterns in Dermatomyositis Patients in the UK: A Cohort Study using Clinical Practice Research Data Link (CPRD)
30/08/2023 The association between multimorbidity and subsequent dementia: a descriptive cohort study in a representative UK database
30/08/2023 Exploring the feasibility of CPRD to characterise the health of older people living in poverty
29/08/2023 Risk of Osteonecrosis of the Jaw in Female Users of Osteoporosis Treatments
29/08/2023 Association between propensity to prescribe antibiotics for common infections in primary care and adverse outcomes
22/08/2023 Global COVID Vaccine Safety (GCoVS) Project Investigating COVID-19 Vaccination and Adverse Events, including Myocarditis, Pericarditis, Guillain-Barre Syndrome and Vaccine Induced Thrombosis and Thrombocytopenia: A Self-controlled case series study.
22/08/2023 Primary care for care home residents: Changes over time before and through the COVID-19 pandemic
22/08/2023 Changes in survival, and causes of death in people with idiopathic pulmonary fibrosis in England, 2010 to 2022