TY - JOUR KW - Humans KW - *Aripiprazole/therapeutic use/adverse effects KW - Female KW - Male KW - Middle Aged KW - *Antipsychotic Agents/therapeutic use/adverse effects KW - Adult KW - *Mental Disorders/drug therapy KW - Quetiapine Fumarate/therapeutic use/adverse effects KW - Treatment Outcome KW - Risperidone/therapeutic use/adverse effects KW - Aged KW - Olanzapine/therapeutic use/adverse effects KW - Hospitalization/statistics & numerical data AU - A. Richards-Belle AU - N. Launders AU - S. Hardoon AU - A. Richards AU - K. Man AU - N. Davies AU - E. Bramon AU - J. Hayes AU - D. Osborn AD - Division of Psychiatry, University College London, London, United Kingdom. Expert by Experience, United Kingdom. Research Department of Practice and Policy, School of Pharmacy, University College London, London, United Kingdom. Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, United Kingdom. Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong. Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park, Pak Shek Kok, Hong Kong. Department of Statistical Sciences, University College London, London, United Kingdom. Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway. Camden and Islington NHS Foundation Trust, London, United Kingdom. AN - 39847591 BT - PLoS Med C2 - PMC11778676 following competing interests: JFH has received consultancy fees from Wellcome Trust and funding grants from juli Health unrelated to the results of the current study. All other authors declare no competing interests. DO - 10.1371/journal.pmed.1004520 DP - NLM ET - 2025/01/23 LA - eng M1 - 1 N1 - 1549-1676 Richards-Belle, Alvin Orcid: 0009-0006-3232-7069 Launders, Naomi Orcid: 0000-0003-4241-938x Hardoon, Sarah Richards, Al Man, Kenneth K C Orcid: 0000-0001-8645-1942 Davies, Neil M Orcid: 0000-0002-2460-0508 Bramon, Elvira Hayes, Joseph F Orcid: 0000-0003-2286-3862 Osborn, David P J WT_/Wellcome Trust/United Kingdom Comparative Study Journal Article Observational Study United States PLoS Med. 2025 Jan 23;22(1):e1004520. doi: 10.1371/journal.pmed.1004520. eCollection 2025 Jan. PY - 2025 SN - 1549-1277 (Print) 1549-1277 EP - e1004520 T2 - PLoS Med TI - Comparative cardiometabolic safety and effectiveness of aripiprazole in people with severe mental illness: A target trial emulation VL - 22 ER -