Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 September 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 189 pages)


Export 2324 results:
Author Title Type [ Year(Asc)]
C. A. Lawson, Zaccardi, F., Squire, I., Ling, S., Davies, M. J., Lam, C. S. P., Mamas, M. A., Khunti, K., and Kadam, U. T., 20-year trends in cause-specific heart failure outcomes by sex, socioeconomic status, and place of diagnosis: a population-based study, Lancet Public Health, vol. 4, pp. e406-e420, 2019.
A. M. Gallagher, Dedman, D., Padmanabhan, S., Leufkens, H. G. M., and de Vries, F., The accuracy of date of death recording in the Clinical Practice Research Datalink GOLD database in England compared with the Office for National Statistics death registrations, Pharmacoepidemiol Drug Saf, 2019.
C. Becker, Jick, S. S., and Meier, C. R., ACE inhibitor use and risk of cataract: a case-control analysis, Br J Ophthalmol, 2019.
J. Watson, Salisbury, C., Whiting, P., Banks, J., Pyne, Y., and Hamilton, W., Added value and cascade effects of inflammatory marker tests in UK primary care: a cohort study from the Clinical Practice Research Datalink, Br J Gen Pract, vol. 69, pp. e470-e478, 2019.
K. D. Johnson, Lu, X., and Zhang, D., Adherence to hepatitis A and hepatitis B multi-dose vaccination schedules among adults in the United Kingdom: a retrospective cohort study, BMC Public Health, vol. 19, p. 404, 2019.
R. L. Tannen, Barnhart, K. T., and Rubin, J. C., Advantages of large medical record database for outcomes research: Insights into post-menopausal hormone therapy, Learn Health Syst, vol. 3, p. e10193, 2019.
A. J. Klil-Drori, Santella, C., Tascilar, K., Yin, H., Aprikian, A., and Azoulay, L., Androgen Deprivation Therapy for Prostate Cancer and the Risk of Rheumatoid Arthritis: A Population-Based Cohort Study, Drug Saf, 2019.
M. Nowakowska, Van Staa, T., Molter, A., Ashcroft, D. M., Tsang, J. Y., White, A., Welfare, W., and Palin, V., Antibiotic choice in UK general practice: rates and drivers of potentially inappropriate antibiotic prescribing, J Antimicrob Chemother, 2019.
O. van Hecke, Fuller, A., Bankhead, C., Jenkins-Jones, S., Francis, N., Moore, M., Butler, C., and Wang, K., Antibiotic exposure and 'response failure' for subsequent respiratory tract infections: an observational cohort study of UK preschool children in primary care, Br J Gen Pract, vol. 69, pp. e638-e646, 2019.
M. Gharbi, Drysdale, J. H., Lishman, H., Goudie, R., Molokhia, M., Johnson, A. P., Holmes, A. H., and Aylin, P., Antibiotic management of urinary tract infection in elderly patients in primary care and its association with bloodstream infections and all cause mortality: population based cohort study, Bmj, vol. 364, p. l525, 2019.
V. Palin, Molter, A., Belmonte, M., Ashcroft, D. M., White, A., Welfare, W., and Van Staa, T., Antibiotic prescribing for common infections in UK general practice: variability and drivers, J Antimicrob Chemother, 2019.
N. S. Nagra, Robinson, D. E., Douglas, I., Delmestri, A., Dakin, S. G., Snelling, S. J. B., Carr, A. J., and Prieto-Alhambra, D., Antibiotic treatment and flares of rheumatoid arthritis: a self-controlled case series study analysis using CPRD GOLD, Sci Rep, vol. 9, p. 8941, 2019.
A. A. Sultan, Mallen, C., Muller, S., Hider, S., Scott, I., Helliwell, T., and Hall, L. J., Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study, BMC Med, vol. 17, p. 154, 2019.
F. S. Troelsen and Jick, S., Antibiotic Use in Childhood and Adolescence and Risk of Inflammatory Bowel Disease: A Case-Control Study in the UK Clinical Practice Research Datalink, Inflamm Bowel Dis, 2019.
P. Kasteridis, Ride, J., Gutacker, N., Aylott, L., Dare, C., Doran, T., Gilbody, S., Goddard, M., Gravelle, H., Kendrick, T., Mason, A., Rice, N., Siddiqi, N., Williams, R., and Jacobs, R., Association Between Antipsychotic Polypharmacy and Outcomes for People With Serious Mental Illness in England, Psychiatr Serv, p. appips201800504, 2019.
J. Vavanikunnel, Charlier, S., Becker, C., Schneider, C., Jick, S. S., Meier, C. R., and Meier, C., Association between glycemic control and risk of fracture in diabetic patients: A nested case-control study, J Clin Endocrinol Metab, 2019.
G. Nakafero, Grainge, M. J., Myles, P. R., Mallen, C. D., Zhang, W., Doherty, M., Nguyen-Van-Tam, J. S., and Abhishek, A., Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink, Ann Rheum Dis, 2019.
Y. M. F. Andersen, Egeberg, A., Ban, L., Gran, S., Williams, H. C., Francis, N. A., Knop, F. K., Gislason, G. H., Skov, L., and Thyssen, J. P., Association Between Topical Corticosteroid Use and Type 2 Diabetes in Two European Population-Based Adult Cohorts, Diabetes Care, vol. 42, pp. 1095-1103, 2019.
R. Williams, Kothny, W., Serban, C., Lopez-Leon, S., de Vries, F., and Schlienger, R., Association between vildagliptin and risk of angioedema, foot ulcers, skin lesions, hepatic toxicity, and serious infections in patients with type 2 diabetes mellitus: A European multidatabase, noninterventional, postauthorization safety study, Endocrinol Diabetes Metab, vol. 2, p. e00084, 2019.
F. Montastruc, Nie, R., Loo, S., Rej, S., Dell'Aniello, S., Micallef, J., Suissa, S., and Renoux, C., Association of Aripiprazole With the Risk for Psychiatric Hospitalization, Self-harm, or Suicide, JAMA Psychiatry, 2019.
Y. Schonmann, Mansfield, K. E., Hayes, J. F., Abuabara, K., Roberts, A., Smeeth, L., and Langan, S. M., Atopic eczema in adulthood and risk of depression and anxiety: a population-based cohort study, J Allergy Clin Immunol Pract, 2019.
R. Alsaggaf, St George, D. M. M., Zhan, M., Pfeiffer, R. M., Wang, Y., Anderson, L. A., Liu, Z., Koshiol, J., Bauer, A. J., Wagner, K. R., Greene, M. H., Amr, S., and Gadalla, S. M., Benign tumors in myotonic dystrophy type I target disease-related cancer sites, Ann Clin Transl Neurol, vol. 6, pp. 1510-1518, 2019.
O. A. Oshagbemi, Franssen, F. M. E., van Kraaij, S., Braeken, D. C. W., Wouters, E. F. M., van der Zee, A. H. Maitlan, Driessen, J. H. M., and de Vries, F., Blood Eosinophil Counts, Withdrawal of Inhaled Corticosteroids and Risk of COPD Exacerbations and Mortality in the Clinical Practice Research Datalink (CPRD), Copd, pp. 1-8, 2019.
H. Strongman, Brown, A., Smeeth, L., and Bhaskaran, K., Body mass index and Hodgkin's lymphoma: UK population-based cohort study of 5.8 million individuals, Br J Cancer, 2019.
S. Y. Loo, Azoulay, L., Nie, R., Dell'Aniello, S., Yu, O. H. Y., and Renoux, C., Cardiovascular and cerebrovascular safety of testosterone replacement therapy among aging men with low testosterone levels: a cohort study., Am J Med, 2019.
A. K. Wright, Kontopantelis, E., Emsley, R., Buchan, I. E., Mamas, M. A., Sattar, N., Ashcroft, D. M., and Rutter, M. K., Cardiovascular Risk and Risk Factor Management in Type 2 Diabetes: A Population-Based Cohort Study Assessing Sex Disparities, Circulation, 2019.
A. Gilsenan, Fortuny, J., Cainzos-Achirica, M., Cantero, O. F., Flynn, R. W. V., Garcia-Rodriguez, L., Harding, A., Kollhorst, B., Karlsson, P., Linner, L., MacDonald, T. M., Odsbu, I., Plana, E., Ruigomez, A., Schink, T., Ziemiecki, R., and Andrews, E. B., Cardiovascular Safety of Prucalopride in Patients with Chronic Constipation: A Multinational Population-Based Cohort Study, Drug Saf, 2019.
M. A. C. Tanke, Feyman, Y., Bernal-Delgado, E., Deeny, S. R., Imanaka, Y., Jeurissen, P., Lange, L., Pimperl, A., Sasaki, N., Schull, M., Wammes, J. J. G., Wodchis, W. P., and Meyer, G. S., A challenge to all. A primer on inter-country differences of high-need, high-cost patients, PLoS One, vol. 14, p. e0217353, 2019.
A. V. Gayle, Axson, E. L., Bloom, C. I., Navaratnam, V., and Quint, J. K., Changing causes of death for patients with chronic respiratory disease in England, 2005-2015, Thorax, 2019.
S. V. Ramagopalan, Carroll, R., Ulvestad, M., Mehmud, F., and Alikhan, R., The changing face of venous thromboembolism management in England, Future Cardiol, 2019.
den C. Heijer, Hoebe, C., Driessen, J. H., Wolffs, P., van den Broek, I., Hoenderboom, B., Williams, R., de Vries, F., and Dukers-Muijrers, N., Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study Among Primary Care Patients, Clinical Infectious Diseases, 2019.
S. Menon, Nightingale, P., and Trudgill, N., Chronic Obstructive Pulmonary Disease and the Risk of Esophagitis, Barrett Esophagus, and Esophageal Adenocarcinoma: A Primary Care Case-Control Study, J Clin Gastroenterol, 2019.
V. Kuan, Denaxas, S., A Izquierdo, G. -, Direk, K., Bhatti, O., Husain, S., Sutaria, S., Hingorani, M., Nitsch, D., Parisinos, C. A., Lumbers, T., Mathur, R., Sofat, R., Casas, J. P., Wong, I. C. K., Hemingway, H., and Hingorani, A. D., A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service, The Lancet Digital Health, 2019.
R. Persson and Jick, S., Clinical implications of the association between fluoroquinolones and tendon rupture: the magnitude of the effect with and without corticosteroids, Br J Clin Pharmacol, 2019.
L. Fiaschi, Nelson-Piercy, C., Deb, S., King, R., and Tata, L. J., Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population based study, Bjog, 2019.
F. Nissen, Douglas, I. J., Mullerova, H., Pearce, N., Bloom, C. I., Smeeth, L., and Quint, J. K., Clinical profile of predefined asthma phenotypes in a large cohort of UK primary care patients (Clinical Practice Research Datalink), J Asthma Allergy, vol. 12, pp. 7-19, 2019.
D. Metcalfe, Masters, J., Delmestri, A., Judge, A., Perry, D., Zogg, C., Gabbe, B., and Costa, M., Coding algorithms for defining Charlson and Elixhauser co-morbidities in Read-coded databases, BMC Med Res Methodol, vol. 19, p. 115, 2019.
A. Dregan, Matcham, F., Harber-Aschan, L., Rayner, L., Brailean, A., Davis, K., Hatch, S., Pariante, C., Armstrong, D., Stewart, R., and Hotopf, M., Common mental disorders within chronic inflammatory disorders: a primary care database prospective investigation, Ann Rheum Dis, 2019.
A. Schultze, Graham, S., Nordstrom, B. L., Mehmud, F., and Ramagopalan, S. V., Commonly used definitions in real-world studies may underestimate the prevalence of renal disease among nonvalvular atrial fibrillation patients, J Comp Eff Res, 2019.
M. Nowakowska, Zghebi, S. S., Ashcroft, D. M., Buchan, I., Chew-Graham, C., Holt, T., Mallen, C., van Marwijk, H., Peek, N., Perera-Salazar, R., Reeves, D., Rutter, M. K., Weng, S. F., Qureshi, N., Mamas, M. A., and Kontopantelis, E., The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort, BMC Med, vol. 17, p. 145, 2019.
I. J. Chou, Kuo, C. F., Tanasescu, R., Tench, C. R., Tiley, C. G., Constantinescu, C. S., and Whitehouse, W. P., Comorbidity in multiple sclerosis: its temporal relationships with disease onset and dose effect on mortality, Eur J Neurol, 2019.
S. Suissa, Dell'Aniello, S., and Ernst, P., Comparative effectiveness and safety of LABA-LAMA versus LABA-ICS treatment of COPD in real world clinical practice, Chest, 2019.
S. J. Sinnott, Smeeth, L., Williamson, E., Perel, P., Nitsch, D., Tomlinson, L. A., and Douglas, I. J., The comparative effectiveness of fourth-line drugs in resistant hypertension: An application in electronic health record data, Pharmacoepidemiol Drug Saf, 2019.
M. Pufulete, Harris, J., Sterne, J. A. C., Johnson, T. W., Lasserson, D., Mumford, A., Doble, B., Wordsworth, S., Benedetto, U., Rogers, C. A., Loke, Y., Pithara, C., Redwood, S., and Reeves, B. C., Comprehensive ascertainment of bleeding in patients prescribed different combinations of dual antiplatelet therapy (DAPT) and triple therapy (TT) in the UK: study protocol for three population-based cohort studies emulating 'target trials' (the ADAPTT Stu, BMJ Open, vol. 9, p. e029388, 2019.
M. E. Saine, Carbonari, D. M., Newcomb, C. W., Gallagher, A. M., Blak, B. T., Roy, J. A., Wood, J., Cardillo, S., Hennessy, S., Strom, B. L., and , Concordance of hospitalizations between Clinical Practice Research Datalink and linked Hospital Episode Statistics among patients treated with oral antidiabetic therapies, Pharmacoepidemiol Drug Saf, 2019.
C. I. Bloom, Douglas, I., Olney, J., D'Ancona, G., Smeeth, L., and Quint, J. K., Cost saving of switching to equivalent inhalers and its effect on health outcomes, Thorax, 2019.
S. V. Ramagopalan, Samnaliev, M., Weir, S., Sammon, C. J., Carroll, R., and Alikhan, R., Costs of gastrointestinal bleeding events in atrial fibrillation: a UK Clinical Practice Research Datalink study, Future Cardiol, 2019.
A. Wolf, Dedman, D., Campbell, J., Booth, H., Lunn, D., Chapman, J., and Myles, P., Data resource profile: Clinical Practice Research Datalink (CPRD) Aurum, Int J Epidemiol, 2019.
A. Douros, Dell'Aniello, S., Dehghan, G., Boivin, J. F., and Renoux, C., Degree of serotonin reuptake inhibition of antidepressants and ischemic risk: A cohort study, Neurology, vol. 93, pp. e1010-e1020, 2019.
C. S. Arhi, Markar, S., Burns, E. M., Bouras, G., Bottle, A., Hanna, G., Aylin, P., Ziprin, P., and Darzi, A., Delays in referral from primary care are associated with a worse survival in patients with esophagogastric cancer, Dis Esophagus, 2019.
[Page last reviewed 6 September 2019]