Bibliography

Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,400 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 5 February 2020) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at enquiries@cprd.com so that we can update the bibliography.

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2019
Y. Li, Sperrin, M., Belmonte, M., Pate, A., Ashcroft, D. M., and van Staa, T. P., “Do population-level risk prediction models that use routinely collected health data reliably predict individual risks?”, Sci Rep, vol. 9, p. 11222, 2019.
R. M. Joseph, van Staa, T. P., Lunt, M., Abrahamowicz, M., and Dixon, W. G., “Exposure measurement error when assessing current glucocorticoid use using UK primary care electronic prescription data”, Pharmacoepidemiol Drug Saf, vol. 28, pp. 179-186, 2019.
Y. Li, Molter, A., White, A., Welfare, W., Palin, V., Belmonte, M., Ashcroft, D. M., Sperrin, M., and van Staa, T. P., “Relationship between prescribing of antibiotics and other medicines in primary care: a cross-sectional study”, Br J Gen Pract, vol. 69, pp. e42-e51, 2019.
2018
S. R. Pye, Sheppard, T., Joseph, R. M., Lunt, M., Girard, N., Haas, J. S., Bates, D. W., Buckeridge, D. L., van Staa, T. P., Tamblyn, R., and Dixon, W. G., “Assumptions made when preparing drug exposure data for analysis have an impact on results: An unreported step in pharmacoepidemiology studies”, Pharmacoepidemiol Drug Saf, vol. 27, pp. 781-788, 2018.
R. Williams, van Staa, T. P., Gallagher, A. M., Hammad, T., Leufkens, H. G. M., and de Vries, F., “Cancer recording in patients with and without type 2 diabetes in the Clinical Practice Research Datalink primary care data and linked hospital admission data: a cohort study”, BMJ Open, vol. 8, p. e020827, 2018.
R. M. Joseph, van Staa, T. P., Lunt, M., Abrahamowicz, M., and Dixon, W. G., “Exposure measurement error when assessing current glucocorticoid use using UK primary care electronic prescription data”, Pharmacoepidemiol Drug Saf, 2018.
D. E. Robinson, van Staa, T. P., Dennison, E. M., Cooper, C., and Dixon, W. G., “The limitations of using simple definitions of glucocorticoid exposure to predict fracture risk: A cohort study”, Bone, vol. 117, pp. 83-90, 2018.
R. M. Joseph, Ray, D. W., Keevil, B., van Staa, T. P., and Dixon, W. G., “Low salivary cortisol levels in patients with rheumatoid arthritis exposed to oral glucocorticoids: a cross-sectional study set within UK electronic health records”, RMD Open, vol. 4, p. e000700, 2018.
H. J. I. De Jong, Tervaert, J. W. Cohen, Lalmohamed, A., de Vries, F., Vandebriel, R. J., Van Loveren, H., Klungel, O. H., and van Staa, T. P., “Pattern of risks of rheumatoid arthritis among patients using statins: A cohort study with the clinical practice research datalink”, PLoS One, vol. 13, p. e0193297, 2018.
E. Martin-Merino, Petersen, I., Hawley, S., Alvarez-Gutierrez, A., Khalid, S., Llorente-Garcia, A., Delmestri, A., Javaid, M. K., van Staa, T. P., Judge, A., Cooper, C., and Prieto-Alhambra, D., “Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK”, Osteoporos Int, vol. 29, pp. 467-478, 2018.
R. M. Joseph, Soames, J., Wright, M., Sultana, K., van Staa, T. P., and Dixon, W. G., “Supplementing electronic health records through sample collection and patient diaries: A study set within a primary care research database”, Pharmacoepidemiol Drug Saf, vol. 27, pp. 239-242, 2018.
2017
A. Thompson, Ashcroft, D. M., Owens, L., van Staa, T. P., and Pirmohamed, M., “Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study”, PLoS One, vol. 12, p. e0173272, 2017.
A. Thompson, Wright, A. K., Ashcroft, D. M., van Staa, T. P., and Pirmohamed, M., “Epidemiology of alcohol dependence in UK primary care: Results from a large observational study using the Clinical Practice Research Datalink”, PLoS One, vol. 12, p. e0174818, 2017.
C. Klop, van Staa, T. P., Cooper, C., Harvey, N. C., and de Vries, F., “The epidemiology of mortality after fracture in England: variation by age, sex, time, geographic location, and ethnicity”, Osteoporos Int, vol. 28, pp. 161-168, 2017.
H. J. I. De Jong, van Staa, T. P., Lalmohamed, A., de Vries, F., Vandebriel, R. J., Van Loveren, H., Klungel, O. H., and Tervaert, J. W. Cohen, “Pattern of risks of systemic lupus erythematosus among statin users: a population-based cohort study”, Ann Rheum Dis, vol. 76, pp. 1723-1730, 2017.
K. Wing, Bhaskaran, K., Pealing, L., Root, A., Smeeth, L., van Staa, T. P., Klungel, O. H., Reynolds, R. F., and Douglas, I., “Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study”, J Antimicrob Chemother, vol. 72, pp. 2636-2646, 2017.
D. C. Braeken, Rohde, G. G., Franssen, F. M., Driessen, J. H., van Staa, T. P., Souverein, P. C., Wouters, E. F., and de Vries, F., “Risk of community-acquired pneumonia in chronic obstructive pulmonary disease stratified by smoking status: a population-based cohort study in the United Kingdom”, Int J Chron Obstruct Pulmon Dis, vol. 12, pp. 2425-2432, 2017.
R. Y. van der Velde, Wyers, C. E., Teesselink, E., Geusens, P., van den Bergh, J. P. W., de Vries, F., Cooper, C., Harvey, N. C., and van Staa, T. P., “Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity”, Bone, vol. 94, pp. 50-55, 2017.
2016
E. M. Curtis, van der Velde, R., Moon, R. J., van den Bergh, J. P., Geusens, P., de Vries, F., van Staa, T. P., Cooper, C., and Harvey, N. C., “Epidemiology of fractures in the United Kingdom 1988-2012: Variation with age, sex, geography, ethnicity and socioeconomic status”, Bone, vol. 87, pp. 19-26, 2016.
P. J. Peeters, Bazelier, M. T., Leufkens, H. G., Auvinen, A., van Staa, T. P., de Vries, F., and De Bruin, M. L., “Insulin glargine use and breast cancer risk: Associations with cumulative exposure”, Acta Oncol, vol. 55, pp. 851-8, 2016.
K. Wing, Bhaskaran, K., Smeeth, L., van Staa, T. P., Klungel, O. H., Reynolds, R. F., and Douglas, I., “Optimising case detection within UK electronic health records: use of multiple linked databases for detecting liver injury”, BMJ Open, vol. 6, p. e012102, 2016.
S. Bours, de Vries, F., van den Bergh, J. P. W., Lalmohamed, A., van Staa, T. P., Leufkens, H. G. M., Geusens, P. P. P., Drent, M., and Harvey, N. C., “Risk of vertebral and non-vertebral fractures in patients with sarcoidosis: a population-based cohort”, Osteoporos Int, vol. 27, pp. 1603-1610, 2016.
J. T. Nielen, Dagnelie, P. C., Emans, P. J., Veldhorst-Janssen, N., Lalmohamed, A., van Staa, T. P., Boonen, A. E., van den Bemt, B. J., and de Vries, F., “Safety and efficacy of new oral anticoagulants and low-molecular-weight heparins compared with aspirin in patients undergoing total knee and hip replacements”, Pharmacoepidemiol Drug Saf, vol. 25, pp. 1245-1252, 2016.
R. Y. van der Velde, Wyers, C. E., Curtis, E. M., Geusens, P., van den Bergh, J. P. W., de Vries, F., Cooper, C., van Staa, T. P., and Harvey, N. C., “Secular trends in fracture incidence in the UK between 1990 and 2012”, Osteoporos Int, vol. 27, pp. 3197-3206, 2016.
2015
C. Klop, Gibson-Smith, D., Elders, P. J., Welsing, P. M., Leufkens, H. G., Harvey, N. C., Bijlsma, J. W., van Staa, T. P., and de Vries, F., “Anti-osteoporosis drug prescribing after hip fracture in the UK: 2000-2010”, Osteoporos Int, vol. 26, pp. 1919-28, 2015.
H. A. van den Ham, Klungel, O. H., Singer, D. E., Leufkens, H. G., and van Staa, T. P., “Comparative Performance of ATRIA, CHADS2, and CHA2DS2-VASc Risk Scores Predicting Stroke in Patients With Atrial Fibrillation: Results From a National Primary Care Database”, J Am Coll Cardiol, vol. 66, pp. 1851-9, 2015.
S. Venkatesan, Myles, P. R., McCann, G., Kousoulis, A. A., Hashmi, M., Belatri, R., Boyle, E., Barcroft, A., van Staa, T. P., Kirkham, J. J., Van Tam, J. S. Nguyen, Williams, T. J., and Semple, M. G., “Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study”, Health Technol Assess, vol. 19, pp. 1-132, 2015.
J. T. Nielen, van den Bemt, B. J., Boonen, A., Dagnelie, P. C., Emans, P. J., Veldhorst, N., Lalmohamed, A., van Staa, T. P., and de Vries, F., “Identification of antithrombotic drugs related to total joint replacement using anonymised free-text notes: a search strategy in the Clinical Practice Research Datalink”, BMJ Open, vol. 5, p. e009017, 2015.
R. W. Atkinson, Carey, I. M., Kent, A. J., van Staa, T. P., Anderson, H. R., and Cook, D. G., “Long-term exposure to outdoor air pollution and the incidence of chronic obstructive pulmonary disease in a national English cohort”, Occup Environ Med, vol. 72, pp. 42-8, 2015.
J. V. Been, Szatkowski, L., van Staa, T. P., Leufkens, H. G., van Schayck, O. C., Sheikh, A., de Vries, F., and Souverein, P., “Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations”, Sci Rep, vol. 5, p. 15246, 2015.
2014
V. Abbing-Karahagopian, Huerta, C., Souverein, P. C., de Abajo, F., Leufkens, H. G., Slattery, J., Alvarez, Y., Miret, M., Gil, M., Oliva, B., Hesse, U., Requena, G., de Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlienger, R. G., de Groot, M. C., Klungel, O. H., van Staa, T. P., van Dijk, L., Egberts, A. C., Gardarsdottir, H., and De Bruin, M. L., “Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications”, Eur J Clin Pharmacol, vol. 70, pp. 849-57, 2014.
V. Abbing-Karahagopian, Kurz, X., de Vries, F., van Staa, T. P., Alvarez, Y., Hesse, U., Hasford, J., Dijk, L., de Abajo, F. J., Weil, J. G., Grimaldi-Bensouda, L., Egberts, A. C., Reynolds, R. F., and Klungel, O. H., “Bridging differences in outcomes of pharmacoepidemiological studies: design and first results of the PROTECT project”, Curr Clin Pharmacol, vol. 9, pp. 130-8, 2014.
M. C. Gulliford, van Staa, T. P., McDermott, L., McCann, G., Charlton, J., and Dregan, A., “Cluster randomized trials utilizing primary care electronic health records: methodological issues in design, conduct, and analysis (eCRT Study)”, Trials, vol. 15, p. 220, 2014.
K. Wing, Douglas, I., Bhaskaran, K., Klungel, O. H., Reynolds, R. F., Pirmohamed, M., Smeeth, L., and van Staa, T. P., “Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records”, Drug Discov Today, vol. 19, pp. 361-6, 2014.
I. E. Bultink, Harvey, N. C., Lalmohamed, A., Cooper, C., Lems, W. F., van Staa, T. P., and de Vries, F., “Elevated risk of clinical fractures and associated risk factors in patients with systemic lupus erythematosus versus matched controls: a population-based study in the United Kingdom”, Osteoporos Int, vol. 25, pp. 1275-83, 2014.
T. P. van Staa, Dyson, L., McCann, G., Padmanabhan, S., Belatri, R., Goldacre, B., Cassell, J., Pirmohamed, M., Torgerson, D., Ronaldson, S., Adamson, J., Taweel, A., Delaney, B., Mahmood, S., Baracaia, S., Round, T., Fox, R., Hunter, T., Gulliford, M., and Smeeth, L., “The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials”, Health Technol Assess, vol. 18, pp. 1-146, 2014.
A. Dregan, van Staa, T. P., McDermott, L., McCann, G., Ashworth, M., Charlton, J., Wolfe, C. D., Rudd, A., Yardley, L., Gulliford, M. C., and Steering, C. Trial, “Point-of-care cluster randomized trial in stroke secondary prevention using electronic health records”, Stroke, vol. 45, pp. 2066-71, 2014.
A. M. Gallagher, van Staa, T. P., Murray-Thomas, T., Schoof, N., Clemens, A., Ackermann, D., and Bartels, D. B., “Population-based cohort study of warfarin-treated patients with atrial fibrillation: incidence of cardiovascular and bleeding outcomes”, BMJ Open, vol. 4, p. e003839, 2014.
T. P. van Staa, Gulliford, M., Ng, E. S., Goldacre, B., and Smeeth, L., “Prediction of cardiovascular risk using Framingham, ASSIGN and QRISK2: how well do they predict individual rather than population risk?”, PLoS One, vol. 9, p. e106455, 2014.
T. P. van Staa, Carr, D. F., O'Meara, H., McCann, G., and Pirmohamed, M., “Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment”, Br J Clin Pharmacol, vol. 78, pp. 649-59, 2014.
S. Pouwels, de Boer, A., Leufkens, H. G., Weber, W. E., Cooper, C., van Staa, T. P., and de Vries, F., “Risk of fracture in patients with Guillain-Barre syndrome”, Osteoporos Int, vol. 25, pp. 1845-51, 2014.
D. Gibson-Smith, Klop, C., Elders, P. J., Welsing, P. M., van Schoor, N., Leufkens, H. G., Harvey, N. C., van Staa, T. P., and de Vries, F., “The risk of major and any (non-hip) fragility fracture after hip fracture in the United Kingdom: 2000-2010”, Osteoporos Int, vol. 25, pp. 2555-63, 2014.
R. Boggon, Timmis, A., Hemingway, H., Raju, S., Malvestiti, F. M., and van Staa, T. P., “Smoking cessation interventions following acute coronary syndrome: a missed opportunity?”, Eur J Prev Cardiol, vol. 21, pp. 767-73, 2014.
2013
R. Boggon, van Staa, T. P., Chapman, M., Gallagher, A. M., Hammad, T. A., and Richards, M. A., “Cancer recording and mortality in the General Practice Research Database and linked cancer registries”, Pharmacoepidemiol Drug Saf, vol. 22, pp. 168-75, 2013.
T. P. van Staa, Smeeth, L., Ng, E. S., Goldacre, B., and Gulliford, M., “The efficiency of cardiovascular risk assessment: do the right patients get statin treatment?”, Heart, vol. 99, pp. 1597-602, 2013.
R. W. Atkinson, Carey, I. M., Kent, A. J., van Staa, T. P., Anderson, H. R., and Cook, D. G., “Long-term exposure to outdoor air pollution and incidence of cardiovascular diseases”, Epidemiology, vol. 24, pp. 44-53, 2013.
H. A. van den Ham, Klungel, O. H., Leufkens, H. G., and van Staa, T. P., “The patterns of anticoagulation control and the risk of stroke, bleeding and mortality in patients with non-valvular atrial fibrillation”, J Thromb Haemost, vol. 11, pp. 107-15, 2013.
A. Lalmohamed, Macgregor, A. J., de Vries, F., Leufkens, H. G., and van Staa, T. P., “Patterns of risk of cancer in patients with metal-on-metal hip replacements versus other bearing surface types: a record linkage study between a prospective joint registry and general practice electronic health records in England”, PLoS One, vol. 8, p. e65891, 2013.
M. T. Bazelier, de Vries, F., Vestergaard, P., Herings, R. M., Gallagher, A. M., Leufkens, H. G., and van Staa, T. P., “Risk of fracture with thiazolidinediones: an individual patient data meta-analysis”, Front Endocrinol (Lausanne), vol. 4, p. 11, 2013.
M. E. Jones, Campbell, G., Patel, D., Brunner, E., Shatapathy, C. C., Murray-Thomas, T., van Staa, T. P., and Motsko, S., “Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics: A Study with the General Practice Research Database”, Cardiovasc Psychiatry Neurol, vol. 2013, p. 647476, 2013.
[Page last reviewed 5 February 2020]