Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 November 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 192 pages)


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H. Carreira, Williams, R., Strongman, H., and Bhaskaran, K., Identification of mental health and quality of life outcomes in primary care databases in the UK: a systematic review, BMJ Open, vol. 9, p. e029227, 2019.
B. Carter, C. Bennett, V., Bethel, J., Jones, H. M., Wang, T., and Kemp, A., Identifying cerebral palsy from routinely-collected data in England and Wales, Clin Epidemiol, vol. 11, pp. 457-468, 2019.
M. Pikoula, Quint, J. K., Nissen, F., Hemingway, H., Smeeth, L., and Denaxas, S., Identifying clinically important COPD sub-types using data-driven approaches in primary care population based electronic health records, BMC Med Inform Decis Mak, vol. 19, p. 86, 2019.
B. M. Shields, Hattersley, A. T., and Farmer, A. J., Identifying routine clinical predictors of non-adherence to second line therapies in Type 2 diabetes: a retrospective cohort analysis in a large primary care database, Diabetes Obes Metab, 2019.
P. Tammes, Payne, R. A., Salisbury, C., Chalder, M., Purdy, S., and Morris, R. W., The impact of a named GP scheme on continuity of care and emergency hospital admission: a cohort study among older patients in England, 2012-2016, BMJ Open, vol. 9, p. e029103, 2019.
V. Allan, Sammon, C. J., McDonald, L., Mehmud, F., Alikhan, R., and Ramagopalan, S. V., Impact of atrial fibrillation awareness campaigns: interrupted time series using the Clinical Practice Research Datalink, Future Cardiol, 2019.
N. Al-Attar, Johnston, S., Jamous, N., Mistry, S., Ghosh, E., Gangoli, G., Danker, W., Etter, K., and Ammann, E., Impact of bleeding complications on length of stay and critical care utilization in cardiac surgery patients in England, J Cardiothorac Surg, vol. 14, p. 64, 2019.
E. Burn, Edwards, C. J., Murray, D. W., Silman, A., Cooper, C., Arden, N. K., Prieto-Alhambra, D., and Pinedo-Villanueva, R., The impact of bmi and smoking on risk of revision following knee and hip replacement surgery: evidence from routinely collected data, Osteoarthritis Cartilage, 2019.
J. Ride, Kasteridis, P., Gutacker, N., Doran, T., Rice, N., Gravelle, H., Kendrick, T., Mason, A., Goddard, M., Siddiqi, N., Gilbody, S., Williams, R., Aylott, L., Dare, C., and Jacobs, R., Impact of family practice continuity of care on unplanned hospital use for people with serious mental illness, Health Serv Res, 2019.
L. Han, Clegg, A., Doran, T., and Fraser, L., The impact of frailty on healthcare resource use: a longitudinal analysis using the Clinical Practice Research Datalink in England, Age Ageing, 2019.
C. D. Steer, Macleod, J., Tilling, K., Lim, A. G., Marsden, J., Millar, T., Strang, J., Telfer, M., Whitaker, H., Vickerman, P., and Hickman, M., The impact of opiate substitution treatment on mortality risk in drug addicts: a natural experiment study, Health Services and Delivery Research, vol. 7, no. 3, 2019.
J. T. H. Nielen, Dagnelie, P. C., Boonen, A., Klungel, O., van den Bemt, B., and de Vries, F., Impact of the definition of osteoarthritis and of the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink, Diabetes Res Clin Pract, vol. 148, pp. 240-248, 2019.
R. Gafoor, Charlton, J., Ravindrarajah, R., and Gulliford, M. C., Importance of Frailty for Association of Antipsychotic Drug Use with Risk of Fracture: Cohort Study Using Electronic Health Records, J Am Med Dir Assoc, 2019.
C. I. Bloom, Walker, S., and Quint, J. K., Inadequate specialist care referrals for high-risk asthma patients in the UK: an adult population-based cohort 2006-2017, J Asthma, pp. 1-7, 2019.
L. Ibanez, Sabate, M., Vidal, X., Ballarin, E., Rottenkolber, M., Schmiedl, S., Heeke, A., Huerta, C., E. Merino, M., Montero, D., Leon-Munoz, L. M., Gasse, C., Moore, N., Droz, C., Lassalle, R., Aakjaer, M., Andersen, M., De Bruin, M. L., Groenwold, R., van den Ham, R., Souverein, P., Klungel, O., and Gardarsdottir, H., Incidence of Direct Oral Anticoagulant use in patients with non-valvular atrial fibrillation and characteristics of users in six European countries (2008-2015): A cross-national drug utilization study, Br J Clin Pharmacol, 2019.
V. Cairns, Wallenhorst, C., Rietbrock, S., and Martinez, C., Incidence of Lyme disease in the UK: a population-based cohort study, BMJ Open, vol. 9, p. e025916, 2019.
K. Davies, Johnson, E. L., Hollen, L., Jones, H. M., Lyttle, M. D., Maguire, S., and Kemp, A. M., Incidence of medically attended paediatric burns across the UK, Inj Prev, 2019.
N. E. O'Connell, Smith, K. J., Peterson, M. D., Ryan, N., Liverani, S., Anokye, N., Victor, C., and Ryan, J. M., Incidence of osteoarthritis, osteoporosis and inflammatory musculoskeletal diseases in adults with cerebral palsy: A population-based cohort study, Bone, vol. 125, pp. 30-35, 2019.
L. Wei, Lai, E. C., Kao-Yang, Y. H., Walker, B. R., MacDonald, T. M., and Andrew, R., Incidence of type 2 diabetes mellitus in men receiving steroid 5alpha-reductase inhibitors: population based cohort study, Bmj, vol. 365, p. l1204, 2019.
A. Gayle, Dickinson, S., Poole, C., Pang, M., Fauconnot, O., and Quint, J. K., Incidence of type II diabetes in chronic obstructive pulmonary disease: a nested case-control study, NPJ Prim Care Respir Med, vol. 29, p. 28, 2019.
T. S. Field, Weijs, B., Curcio, A., Giustozzi, M., Sudikas, S., Katholing, A., Wallenhorst, C., Weitz, J. I., Cohen, A. T., and Martinez, C., Incident Atrial Fibrillation, Dementia and the Role of Anticoagulation: A Population-Based Cohort Study, Thromb Haemost, 2019.
H. R. Whittaker, Mullerova, H., Jarvis, D., Barnes, N. C., Jones, P. W., Compton, C. H., Kiddle, S. J., and Quint, J. K., Inhaled corticosteroids, blood eosinophils, and FEV1 decline in patients with COPD in a large UK primary health care setting, Int J Chron Obstruct Pulmon Dis, vol. 14, pp. 1063-1073, 2019.
M. Pujades-Rodriguez, Guttmann, O. P., Gonzalez-Izquierdo, A., Duyx, B., O'Mahony, C., Elliott, P., and Hemingway, H., Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records, PLoS One, vol. 13, p. e0191214, 2018.
M. Ardissino, Moussa, O., Tang, A., Muttoni, E., Ziprin, P., and Purkayastha, S., Idiopathic intracranial hypertension in the British population with obesity, Acta Neurochir (Wien), 2018.
M. Hickman, Steer, C., Tilling, K., Lim, A. G., Marsden, J., Millar, T., Strang, J., Telfer, M., Vickerman, P., and Macleod, J., The impact of buprenorphine and methadone on mortality: a primary care cohort study in the United Kingdom, Addiction, vol. 113, pp. 1461-1476, 2018.
E. Martin-Merino, Calderon-Larranaga, A., Hawley, S., Poblador-Plou, B., Llorente-Garcia, A., Petersen, I., and Prieto-Alhambra, D., The impact of different strategies to handle missing data on both precision and bias in a drug safety study: a multidatabase multinational population-based cohort study, Clin Epidemiol, vol. 10, pp. 643-654, 2018.
C. J. Currie, Holden, S. E., Jenkins-Jones, S., Morgan, C. L., Voss, B., Rajpathak, S. N., Alemayehu, B., Peters, J. R., and Engel, S. S., Impact of differing glucose-lowering regimens on the pattern of association between glucose control and survival, Diabetes Obes Metab, vol. 20, pp. 821-830, 2018.
J. Daugherty, Lin, X., Baxter, R., Suruki, R., and Bradford, E., The impact of long-term systemic glucocorticoid use in severe asthma: A UK retrospective cohort analysis, J Asthma, vol. 55, pp. 651-658, 2018.
J. L. Atkins, Delgado, J., Pilling, L. C., Bowman, K., Masoli, J. A. H., Kuchel, G. A., Ferrucci, L., and Melzer, D., Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts, J Gerontol A Biol Sci Med Sci, 2018.
E. Cecil, Bottle, A., Ma, R., Hargreaves, D. S., Wolfe, I., ,, and Saxena, S., Impact of preventive primary care on children's unplanned hospital admissions: a population-based birth cohort study of UK children 2000-2013, BMC Med, vol. 16, p. 151, 2018.
K. C. Chang, Vamos, E. P., Palladino, R., Majeed, A., Lee, J. T., and Millett, C., Impact of the NHS Health Check on inequalities in cardiovascular disease risk: a difference-in-differences matching analysis, J Epidemiol Community Health, 2018.
C. L. Morgan, Inzucchi, S. E., Puelles, J., Jenkins-Jones, S., and Currie, C. J., Impact of treatment with pioglitazone on stroke outcomes: A real-world database analysis, Diabetes Obes Metab, vol. 20, pp. 2140-2147, 2018.
G. L. C. Ferreira, Marano, C., De Moerlooze, L., Guignard, A., Feng, Y., Y. Hahi, E., and Van Staa, T., Incidence and prevalence of hepatitis B in patients with diabetes mellitus in the UK: A population-based cohort study using the UK Clinical Practice Research Datalink, J Viral Hepat, vol. 25, pp. 571-580, 2018.
J. C. Wilson, Sarsour, K., Gale, S., Petho-Schramm, A., Jick, S. S., and Meier, C. R., Incidence and risk of glucocorticoid-associated adverse effects in patients with rheumatoid arthritis, Arthritis Care Res (Hoboken), 2018.
R. Y. van der Velde, Wyers, C. E., Geusens, P., van den Bergh, J. P. W., de Vries, F., Cooper, C., van de Staa, T. P., and Harvey, N. C., Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older, Osteoporos Int, vol. 29, pp. 2469-2475, 2018.
H. Strongman, Kausar, I., and Maher, T. M., Incidence, Prevalence, and Survival of Patients with Idiopathic Pulmonary Fibrosis in the UK, Adv Ther, vol. 35, pp. 724-736, 2018.
J. G. Royle, Lanyon, P. C., Grainge, M. J., Abhishek, A., and Pearce, F. A., The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink, Clin Rheumatol, vol. 37, pp. 2103-2111, 2018.
R. J. Partington, Muller, S., Helliwell, T., Mallen, C. D., and A. Sultan, A., Incidence, prevalence and treatment burden of polymyalgia rheumatica in the UK over two decades: a population-based study, Ann Rheum Dis, vol. 77, pp. 1750-1756, 2018.
C. Conradt, Guo, D., Miclea, A., Nisslein, T., Ismail, C., Chatamra, K., and Andersohn, F., Increased Prevalence of Polyneuropathy in Parkinson's Disease Patients: An Observational Study, J Parkinsons Dis, vol. 8, pp. 141-144, 2018.
M. Simeonova, de Vries, F., Pouwels, S., Driessen, J. H. M., Leufkens, H. G. M., Cadarette, S. M., and Burden, A. M., Increased risk of all-cause mortality associated with domperidone use in Parkinson's patients: a population-based cohort study in the UK, Br J Clin Pharmacol, vol. 84, pp. 2551-2561, 2018.
E. Richardson, Bedson, J., Chen, Y., Lacey, R., and Dunn, K. M., Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: A matched cohort study in the Clinical Practice Research Datalink, Eur J Pain, vol. 22, pp. 1701-1708, 2018.
D. Abrahami, Douros, A., Yin, H., Yu, O. H., Faillie, J. L., Montastruc, F., Platt, R. W., Bouganim, N., and Azoulay, L., Incretin based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: population based cohort study, Bmj, vol. 363, p. k4880, 2018.
D. Abrahami, Yin, H., Yu, O. H. Y., Pollak, M. N., and Azoulay, L., Incretin-based Drugs and the Incidence of Colorectal Cancer in Patients with Type 2 Diabetes, Epidemiology, vol. 29, pp. 246-253, 2018.
A. Jain, van Hoek, A. J., Walker, J. L., Forbes, H. J., Langan, S. M., Root, A., Smeeth, L., and Thomas, S. L., Inequalities in zoster disease burden: a population-based cohort study to identify social determinants using linked data from the U.K. Clinical Practice Research Datalink, Br J Dermatol, vol. 178, pp. 1324-1330, 2018.
A. Matcho, Ryan, P., Fife, D., Gifkins, D., Knoll, C., and Friedman, A., Inferring pregnancy episodes and outcomes within a network of observational databases, PLoS One, vol. 13, p. e0192033, 2018.
S. R. Markar, Arhi, C., Leusink, A., Vidal-Diez, A., Karthikesalingam, A., Darzi, A., Lagergren, J., and Hanna, G. B., The Influence of Antireflux Surgery on Esophageal Cancer Risk in England: National Population-based Cohort Study, Ann Surg, vol. 268, pp. 861-867, 2018.
V. Prasad, West, J., Sayal, K., and Kendrick, D., Injury among children and young people with and without attention-deficit hyperactivity disorder in the community: The risk of fractures, thermal injuries, and poisonings, Child Care Health Dev, vol. 44, pp. 871-878, 2018.
[Page last reviewed 4 November 2019]