Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 5 August 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 187 pages)


Export 92 results:
Author Title Type [ Year(Asc)]
Filters: First Letter Of Title is M  [Clear All Filters]
J. A. Rassen, Bartels, D. B., Schneeweiss, S., Patrick, A. R., and Murk, W., Measuring prevalence and incidence of chronic conditions in claims and electronic health record databases, Clin Epidemiol, vol. 11, pp. 1-15, 2019.
R. E. Farmer, Ford, D., Mathur, R., Chaturvedi, N., Kaplan, R., Smeeth, L., and Bhaskaran, K., Metformin use and risk of cancer in patients with type 2 diabetes: a cohort study of primary care records using inverse probability weighting of marginal structural models, Int J Epidemiol, 2019.
C. Minassian, Williams, R., Meeraus, W. H., Smeeth, L., Campbell, O. M. R., and Thomas, S. L., Methods to generate and validate a Pregnancy Register in the UK Clinical Practice Research Datalink primary care database, Pharmacoepidemiol Drug Saf, vol. 28, pp. 923-933, 2019.
R. Brauer, Herrero-Zazo, M., Barlow, D. J., Gaughran, F., Taylor, D., and Howard, L. M., Minocycline and the risk of acute psychiatric events in adolescence: A self-controlled case series, J Psychopharmacol, p. 269881118821852, 2019.
A. Green, Shaddick, G., Charlton, R., Snowball, J., Nightingale, A., Smith, C., Tillett, W., and McHugh, N., Modifiable risk factors and the development of psoriatic arthritis in people with psoriasis, Br J Dermatol, 2019.
J. M. Ryan, Peterson, M. D., Ryan, N., Smith, K. J., N, E. O. 'Connell, Liverani, S., Anokye, N., Victor, C., and Allen, E., Mortality due to cardiovascular disease, respiratory disease, and cancer in adults with cerebral palsy, Dev Med Child Neurol, 2019.
R. Persson, Lee, S., Yood, M. U., Wagner, M., Minton, N., Niemcryk, S., Lindholm, A., Evans, A., and Jick, S., Multi-database study of multiple sclerosis: identification, validation and description of MS patients in two countries, J Neurol, 2019.
K. W. Hagberg, Robijn, A. L., and Jick, S., Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring, Clin Epidemiol, vol. 10, pp. 1599-1612, 2018.
L. Scheepers, Burden, A. M., Arts, I. C. W., Spaetgens, B., Souverein, P., de Vries, F., and Boonen, A., Medication adherence among gout patients initiated allopurinol: a retrospective cohort study in the Clinical Practice Research Datalink (CPRD), Rheumatology (Oxford), vol. 57, pp. 1641-1650, 2018.
M. Cainzos-Achirica, Varas-Lorenzo, C., Pottegard, A., Asmar, J., Plana, E., Rasmussen, L., Bizouard, G., Forns, J., Hellfritzsch, M., Zint, K., Perez-Gutthann, S., and Pladevall-Vila, M., Methodological challenges when evaluating potential off-label prescribing of drugs using electronic health care databases: A case study of dabigatran etexilate in Europe, Pharmacoepidemiol Drug Saf, vol. 27, pp. 713-723, 2018.
S. A. J. Schmidt, Langan, S. M., Pedersen, H. S., Schonheyder, H. C., Thomas, S. L., Smeeth, L., Mansfield, K. E., Sorensen, H. T., Forbes, H. J., and Vestergaard, M., Mood Disorders and Risk of Herpes Zoster in 2 Population-Based Case-Control Studies in Denmark and the United Kingdom, Am J Epidemiol, vol. 187, pp. 1019-1028, 2018.
L. Li, Neogi, T., and Jick, S., Mortality in Patients With Giant Cell Arteritis: A Cohort Study in UK Primary Care, Arthritis Care Res (Hoboken), vol. 70, pp. 1251-1256, 2018.
O. M. Moussa, Erridge, S., Chidambaram, S., Ziprin, P., Darzi, A., and Purkayastha, S., Mortality of the Severely Obese: A Population Study, Ann Surg, 2018.
K. J. Rothnie, Connell, O., Mullerova, H., Smeeth, L., Pearce, N., Douglas, I., and Quint, J. K., Myocardial Infarction and Ischemic Stroke after Exacerbations of Chronic Obstructive Pulmonary Disease, Ann Am Thorac Soc, vol. 15, pp. 935-946, 2018.
N. A. Francis, Entwistle, K., Santer, M., Layton, A. M., Eady, E. A., and Butler, C. C., The management of acne vulgaris in primary care: a cohort study of consulting and prescribing patterns using the Clinical Practice Research Datalink, Br J Dermatol, vol. 176, pp. 107-115, 2017.
M. D. Danese, Gleeson, M., Kutikova, L., Griffiths, R. I., Khunti, K., Seshasai, S. R. K., and Ray, K. K., Management of lipid-lowering therapy in patients with cardiovascular events in the UK: a retrospective cohort study, BMJ Open, vol. 7, p. e013851, 2017.
J. Gordon, McEwan, P., Evans, M., Puelles, J., and Sinclair, A., Managing glycaemia in older people with type 2 diabetes: A retrospective, primary care-based cohort study, with economic assessment of patient outcomes, Diabetes Obes Metab, vol. 19, pp. 644-653, 2017.
S. Lane, Lynn, E., and Shakir, S., Measuring the impact of product withdrawals and other major pharmacovigilance actions on public health burden in the EU: Methodological considerations, Drug Safety, vol. 40, pp. 953-4, 2017.
C. Seliger, Meier, C. R., Becker, C., Jick, S. S., Proescholdt, M., Bogdahn, U., Hau, P., and Leitzmann, M. F., Metabolic syndrome in relation to risk of meningioma, Oncotarget, vol. 8, pp. 2284-2292, 2017.
B. M. Hicks, Yin, H., Sinyavskaya, L., Suissa, S., Azoulay, L., and Brassard, P., Metformin and the incidence of viral associated cancers in patients with type 2 diabetes, Int J Cancer, vol. 141, pp. 121-128, 2017.
C. Becker, Jick, S. S., Meier, C. R., and Bodmer, M., Metformin and the risk of renal cell carcinoma: a case-control analysis, Eur J Cancer Prev, vol. 26, pp. 257-262, 2017.
M. D. Danese, Gleeson, M., Griffiths, R. I., Catterick, D., and Kutikova, L., Methods for estimating costs in patients with hyperlipidemia experiencing their first cardiovascular event in the United Kingdom, J Med Econ, vol. 20, pp. 931-937, 2017.
G. Glover, Williams, R., Heslop, P., Oyinlola, J., and Grey, J., Mortality in people with intellectual disabilities in England, J Intellect Disabil Res, vol. 61, pp. 62-74, 2017.
K. D. Getz, Anderka, M. T., Werler, M. M., and Jick, S. S., Maternal Pre-pregnancy Body Mass Index and Autism Spectrum Disorder among Offspring: A Population-Based Case-Control Study, Paediatr Perinat Epidemiol, vol. 30, pp. 479-87, 2016.
K. A. McGlynn, Hagberg, K., Chen, J., Braunlin, M., Graubard, B. I., Suneja, N., Jick, S., and Sahasrabuddhe, V. V., Menopausal hormone therapy use and risk of primary liver cancer in the clinical practice research datalink, Int J Cancer, vol. 138, pp. 2146-53, 2016.
J. Drahos, Li, L., Jick, S. S., and Cook, M. B., Metabolic syndrome in relation to Barrett's esophagus and esophageal adenocarcinoma: Results from a large population-based case-control study in the Clinical Practice Research Datalink, Cancer Epidemiol, vol. 42, pp. 9-14, 2016.
U. C. Mc Menamin, Murray, L. J., Hughes, C. M., and Cardwell, C. R., Metformin use and survival after colorectal cancer: A population-based cohort study, Int J Cancer, vol. 138, pp. 369-79, 2016.
U. C. Menamin, Cardwell, C. R., Hughes, C. M., and Murray, L. M., Metformin use and survival from lung cancer: A population-based cohort study, Lung Cancer, vol. 94, pp. 35-9, 2016.
A. Afonso, Schmiedl, S., Becker, C., Tcherny-Lessenot, S., Primatesta, P., Plana, E., Souverein, P., Wang, Y., Korevaar, J. C., Hasford, J., Reynolds, R., de Groot, M. C., Schlienger, R., Klungel, O., and Rottenkolber, M., A methodological comparison of two European primary care databases and replication in a US claims database: inhaled long-acting beta-2-agonists and the risk of acute myocardial infarction, Eur J Clin Pharmacol, vol. 72, pp. 1105-16, 2016.
J. R. Brownrigg, Hughes, C. O., Burleigh, D., Karthikesalingam, A., Patterson, B. O., Holt, P. J., Thompson, M. M., de Lusignan, S., Ray, K. K., and Hinchliffe, R. J., Microvascular disease and risk of cardiovascular events among individuals with type 2 diabetes: a population-level cohort study, Lancet Diabetes Endocrinol, vol. 4, pp. 588-97, 2016.
S. Mohiuddin, Reeves, B., Pufulete, M., Maishman, R., Dayer, M., Macleod, J., McDonagh, T., Purdy, S., Rogers, C., and Hollingworth, W., Model-based cost-effectiveness analysis of B-type natriuretic peptide-guided care in patients with heart failure, BMJ Open, vol. 6, p. e014010, 2016.
G. Karystianis, Sheppard, T., Dixon, W. G., and Nenadic, G., Modelling and extraction of variability in free-text medication prescriptions from an anonymised primary care electronic medical record research database, BMC Med Inform Decis Mak, vol. 16, p. 18, 2016.
I. Olier, Springate, D. A., Ashcroft, D. M., Doran, T., Reeves, D., Planner, C., Reilly, S., and Kontopantelis, E., Modelling Conditions and Health Care Processes in Electronic Health Records: An Application to Severe Mental Illness with the Clinical Practice Research Datalink, PLoS One, vol. 11, p. e0146715, 2016.
S. Taylor, Taylor, R. J., Lustig, R. L., Schuck-Paim, C., Haguinet, F., Webb, D. J., Logie, J., Matias, G., and Fleming, D. M., Modelling estimates of the burden of respiratory syncytial virus infection in children in the UK, BMJ Open, vol. 6, p. e009337, 2016.
J. R. Olsen, Piguet, V., Gallacher, J., and Francis, N. A., Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care, Br J Gen Pract, vol. 66, pp. e53-8, 2016.
M. Alexander, Petri, H., Ding, Y., Wandel, C., Khwaja, O., and Foskett, N., Morbidity and medication in a large population of individuals with Down syndrome compared to the general population, Dev Med Child Neurol, vol. 58, pp. 246-54, 2016.
F. J. Hosking, Carey, I. M., Shah, S. M., Harris, T., DeWilde, S., Beighton, C., and Cook, D. G., Mortality Among Adults With Intellectual Disability in England: Comparisons With the General Population, Am J Public Health, vol. 106, pp. 1483-90, 2016.
F. Rees, Doherty, M., Grainge, M. J., Lanyon, P., Davenport, G., and Zhang, W., Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012, Rheumatology (Oxford), vol. 55, pp. 854-60, 2016.
K. B. Filion, Azoulay, L., Platt, R. W., Dahl, M., Dormuth, C. R., Clemens, K. K., Hu, N., Paterson, J. M., Targownik, L., Turin, T. C., Udell, J. A., and Ernst, P., A Multicenter Observational Study of Incretin-based Drugs and Heart Failure, N Engl J Med, vol. 374, pp. 1145-54, 2016.
M. Bloechliger, Schlagenhauf, P., Toovey, S., Schnetzler, G., Tatt, I., Tomianovic, D., Jick, S. S., and Meier, C. R., Malaria chemoprophylaxis regimens: a descriptive drug utilization study, Travel Med Infect Dis, vol. 12, pp. 718-25, 2014.
W. Gao, Gulliford, M., Bennett, M. I., Murtagh, F. E., and Higginson, I. J., Managing cancer pain at the end of life with multiple strong opioids: a population-based retrospective cohort study in primary care, PLoS One, vol. 9, p. e79266, 2014.
L. Huiart, Ferdynus, C., Dell'Aniello, S., Bakiri, N., Giorgi, R., and Suissa, S., Measuring persistence to hormonal therapy in patients with breast cancer: accounting for temporary treatment discontinuation, Pharmacoepidemiol Drug Saf, vol. 23, pp. 882-9, 2014.
J. P. Fournier, Yin, H., Yu, O. H., and Azoulay, L., Metformin and low levels of thyroid-stimulating hormone in patients with type 2 diabetes mellitus, Cmaj, vol. 186, pp. 1138-45, 2014.
C. Becker, Jick, S. S., Meier, C. R., and Bodmer, M., Metformin and the risk of head and neck cancer: a case-control analysis, Diabetes Obes Metab, vol. 16, pp. 1148-54, 2014.
K. K. Tsilidis, Capothanassi, D., Allen, N. E., Rizos, E. C., Lopez, D. S., van Veldhoven, K., Sacerdote, C., Ashby, D., Vineis, P., Tzoulaki, I., and Ioannidis, J. P., Metformin does not affect cancer risk: a cohort study in the U.K. Clinical Practice Research Datalink analyzed like an intention-to-treat trial, Diabetes Care, vol. 37, pp. 2522-32, 2014.
C. Klop, Welsing, P. M., Cooper, C., Harvey, N. C., Elders, P. J., Bijlsma, J. W., Leufkens, H. G., and de Vries, F., Mortality in British hip fracture patients, 2000-2010: a population-based retrospective cohort study, Bone, vol. 66, pp. 171-7, 2014.
S. S. Jick, Li, L., Falcone, G. J., Vassilev, Z. P., and Wallander, M. A., Mortality of patients with multiple sclerosis: a cohort study in UK primary care, J Neurol, vol. 261, pp. 1508-17, 2014.
[Page last reviewed 5 August 2019]