Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,500 peer-reviewed publications. The CPRD bibliography is updated on a monthly basis (last updated 5 June 2020) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


 (PDF, 3MB, 205 pages) 

This work uses data provided by patients and collected by the NHS as part of their care and support. CPRD encourages researchers to use this citation in all publications using CPRD data. Find out more about acknowledging the use of patient data at the Understanding Patient Data website



Export 2528 results:
Author Title Type [ Year(Asc)]
J. Rouette, Yin, H., Yu, O. H. Y., Bouganim, N., Platt, R. W., and Azoulay, L., Incretin-based drugs and risk of lung cancer among individuals with type 2 diabetes, Diabet Med, 2020.
R. Persson, Lee, S., M. Yood, U., Mc, C. M. Wagner, Minton, N., Niemcryk, S., Lindholm, A., Evans, A. M., and Jick, S. S., Infections in patients diagnosed with multiple sclerosis: A multi-database study, Mult Scler Relat Disord, vol. 41, p. 101982, 2020.
C. S. Osam, Pierce, M., Hope, H., Ashcroft, D. M., and Abel, K. M., The influence of maternal mental illness on vaccination uptake in children: a UK population-based cohort study, Eur J Epidemiol, 2020.
L. E. Clarson, Bajpai, R., Whittle, R., Belcher, J., A. Sultan, A., Kwok, C. S., Welsh, V., Mamas, M., and Mallen, C. D., Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction, Heart, 2020.
C. Martinez, Wallenhorst, C., Rietbrock, S., and Freedman, B., Ischemic Stroke and Transient Ischemic Attack Risk Following Vitamin K Antagonist Cessation in Newly Diagnosed Atrial Fibrillation: A Cohort Study, J Am Heart Assoc, vol. 9, p. e014376, 2020.
H. J. L. Heerspink, Karasik, A., Thuresson, M., Melzer-Cohen, C., Chodick, G., Khunti, K., Wilding, J. P. H., Rodriguez, L. A. Garcia, Cea-Soriano, L., Kohsaka, S., Nicolucci, A., Lucisano, G., Lin, F. J., Wang, C. Y., Wittbrodt, E., Fenici, P., and Kosiborod, M., Kidney outcomes associated with use of SGLT2 inhibitors in real-world clinical practice (CVD-REAL 3): a multinational observational cohort study, Lancet Diabetes Endocrinol, vol. 8, pp. 27-35, 2020.
Y. Tang, Weiss, T., Liu, J., Rajpathak, S., and Khunti, K., Metformin adherence and discontinuation among patients with type 2 diabetes: A retrospective cohort study, J Clin Transl Endocrinol, vol. 20, p. 100225, 2020.
C. J. Sammon, Leahy, T. P., and Ramagopalan, S., Nonindependence of patient data in the clinical practice research datalink: a case study in atrial fibrillation patients, J Comp Eff Res, 2020.
C. W. le Roux, Hartvig, N. V., Haase, C. L., Nordsborg, R. B., Olsen, A. H., and Satylganova, A., Obesity, cardiovascular risk and healthcare resource utilization in the UK, Eur J Prev Cardiol, p. 2047487320925639, 2020.
G. Glover, Williams, R., and Oyinlola, J., An observational cohort study of numbers and causes of preventable general hospital admissions in people with and without intellectual disabilities in England, J Intellect Disabil Res, 2020.
C. van Durme, Spaetgens, B., Driessen, J., Nielen, J., Sastry, M., Boonen, A., and de Vries, F., Obstructive sleep apnea and the risk of gout: a population-based case-control study, Arthritis Res Ther, vol. 22, p. 92, 2020.
D. Alarkawi, Ali, M. S., Bliuc, D., Pallares, N., Tebe, C., Elhussein, L., Caskey, F. J., Arden, N. K., Ben-Shlomo, Y., Abrahamsen, B., Diez-Perez, A., Pascual, J., Perez-Saez, M. J., Center, J. R., Judge, A., Cooper, C., Javaid, M. K., and Prieto-Alhambra, D., Oral bisphosphonate use and all-cause mortality in patients with moderate-severe (grade 3B-5D) chronic kidney disease: a population-based cohort study, J Bone Miner Res, 2020.
A. Gadoud, Kane, E., Oliver, S. E., Johnson, M. J., Macleod, U., and Allgar, V., Palliative care for non-cancer conditions in primary care: a time trend analysis in the UK (2009-2014), BMJ Support Palliat Care, 2020.
M. M. Loiacono, Mahmud, S. M., Chit, A., van Aalst, R., Kwong, J. C., Mitsakakis, N., Skinner, L., Thommes, E., Bricout, H., and Grootendorst, P., Patient and practice level factors associated with seasonal influenza vaccine uptake among at-risk adults in England, 2011 to 2016: An age-stratified retrospective cohort study, Vaccine X, vol. 4, p. 100054, 2020.
C. Siffel, Page, M., Maxwell, T., Thun, B., Kolb, N., Rosenlund, M., von Bredow, D., and Keja, J., Patterns of Lisdexamfetamine Dimesylate Use in Children, Adolescents, and Adults with Attention-Deficit/Hyperactivity Disorder in Europe, J Child Adolesc Psychopharmacol, 2020.
S. Weir, Samnaliev, M., Kuo, T. C., Tierney, T. S., Manca, A., Taylor, R. S., Bruce, J., Eldabe, S., and Cumming, D., Persistent postoperative pain and healthcare costs associated with instrumented and non-instrumented spinal surgery: a case-control study, J Orthop Surg Res, vol. 15, p. 127, 2020.
K. Bowman, Jones, L., Masoli, J., Mujica-Mota, R., Strain, D., Butchart, J., Valderas, J. M., Fortinsky, R. H., Melzer, D., and Delgado, J., Predicting incident delirium diagnoses using data from primary-care electronic health records, Age Ageing, vol. 49, pp. 374-381, 2020.
C. Martinez, Katholing, A., Wallenhorst, C., and Cohen, A. T., Prediction of significant bleeding during vitamin K antagonist treatment for venous thromboembolism in outpatients, Br J Haematol, 2020.
W. Gao, Gulliford, M., Morgan, M., and Higginson, I. J., Primary care service use by end-of-life cancer patients: a nationwide population-based cohort study in the United Kingdom, BMC Fam Pract, vol. 21, p. 76, 2020.
L. R. Rodgers, Dennis, J. M., Shields, B. M., Mounce, L., Fisher, I., Hattersley, A. T., and Henley, W. E., Prior event rate ratio adjustment produced estimates consistent with randomised trial: a diabetes case study, J Clin Epidemiol, 2020.
Y. Chen, Hayward, R., Chew-Graham, C. A., Hubbard, R., Croft, P., Sims, K., and Jordan, K. P., Prognostic value of first-recorded breathlessness for future chronic respiratory and heart disease a cohort study using a UK national primary care database, Br J Gen Pract, 2020.
S. S. Jick, Hagberg, K. W., Persson, R., Vasilakis-Scaramozza, C., Williams, T., Crellin, E., and Myles, P., Quality and completeness of diagnoses recorded in the new CPRD Aurum Database: evaluation of pulmonary embolism, Pharmacoepidemiol Drug Saf, 2020.
A. Bakhai, Petri, H., Vahidnia, F., Wolf, C., Ding, Y., Foskett, N., and Sculpher, M., Real-world data on the incidence, mortality, and cost of ischaemic stroke and major bleeding events among non-valvular atrial fibrillation patients in England, J Eval Clin Pract, 2020.
R. Lahoz, Fagan, A., McSharry, M., Proudfoot, C., Corda, S., and Studer, R., Recurrent heart failure hospitalizations are associated with increased cardiovascular mortality in patients with heart failure in Clinical Practice Research Datalink, ESC Heart Fail, 2020.
A. Price, Ford, T., Janssens, A., Williams, A. J., and Newlove-Delgado, T., Regional analysis of UK primary care prescribing and adult service referrals for young people with attention-deficit hyperactivity disorder, BJPsych Open, vol. 6, p. e7, 2020.
T. Burkard, Rauch, M., Spoendlin, J., Prieto-Alhambra, D., Jick, S. S., and Meier, C. R., Risk of hand osteoarthritis in new users of hormone replacement therapy: A nested case-control analysis, Maturitas, vol. 132, pp. 17-23, 2020.
H. Forbes, Douglas, I., Finn, A., Breuer, J., Bhaskaran, K., Smeeth, L., Packer, S., Langan, S. M., Mansfield, K. E., Marlow, R., Whitaker, H., and Warren-Gash, C., Risk of herpes zoster after exposure to varicella to explore the exogenous boosting hypothesis: self controlled case series study using UK electronic healthcare data, Bmj, vol. 368, p. l6987, 2020.
Z. Z. N. Yiu, Parisi, R., Lunt, M., Warren, R. B., Griffiths, C. E. M., Langan, S. M., and Ashcroft, D. M., Risk of Hospitalisation and Death due to Infection in People with Psoriasis: a Population-based Cohort Study using the Clinical Practice Research Datalink, Br J Dermatol, 2020.
Y. Zhang, Souverein, P. C., Gardarsdottir, H., van den Ham, H. A., van der Zee, A. H. Maitlan, and de Boer, A., Risk of major bleeding among users of direct oral anticoagulants combined with interacting drugs: A population-based nested case-control study, Br J Clin Pharmacol, 2020.
I. J. A. de Bruin, Wyers, C. E., Souverein, P. C., van Staa, T. P., Geusens, P., van den Bergh, J. P. W., de Vries, F., and Driessen, J. H. M., The risk of new fragility fractures in patients with chronic kidney disease and hip fracture-a population-based cohort study in the UK, Osteoporos Int, 2020.
D. J. Grint, McDonald, H. I., Walker, J. L., Amirthalingam, G., Andrews, N., and Thomas, S., Safety of inadvertent administration of live zoster vaccine to immunosuppressed individuals in a UK-based observational cohort analysis, BMJ Open, vol. 10, p. e034886, 2020.
M. C. Gulliford, Sun, X., Charlton, J., Winter, J. R., Bunce, C., Boiko, O., Fox, R., Little, P., Moore, M., Hay, A. D., and Ashworth, M., Serious bacterial infections and antibiotic prescribing in primary care: cohort study using electronic health records in the UK, BMJ Open, vol. 10, p. e036975, 2020.
A. Sarmanova, Doherty, M., Kuo, C., Wei, J., Abhishek, A., Mallen, C., Zeng, C., Wang, Y., Lei, G., and Zhang, W., Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study, Rheumatology (Oxford), 2020.
E. L. Axson, Sundaram, V., Bloom, C. I., Bottle, A., Cowie, M. R., and Quint, J. K., Temporal Trends in the Incidence of Heart Failure among Patients with COPD and Its Association with Mortality, Ann Am Thorac Soc, 2020.
D. C. Gibbons, Aggarwal, B., Fairburn-Beech, J., Hinds, D., Fletcher, M., Bosnic-Anticevich, S., and Price, D., Treatment patterns among non-active users of maintenance asthma medication in the United Kingdom: a retrospective cohort study in the Clinical Practice Research Datalink, J Asthma, pp. 1-12, 2020.
J. Ruzangi, Blair, M., Cecil, E., Greenfield, G., Bottle, A., Hargreaves, D. S., and Saxena, S., Trends in healthcare use in children aged less than 15 years: a population-based cohort study in England from 2007 to 2017, BMJ Open, vol. 10, p. e033761, 2020.
S. Swain, Sarmanova, A., Mallen, C., Kuo, C. F., Coupland, C., Doherty, M., and Zhang, W., Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD), Osteoarthritis Cartilage, 2020.
R. Denholm, van der Werf, E. T., and Hay, A. D., Use of antibiotics and asthma medication for acute lower respiratory tract infections in people with and without asthma: retrospective cohort study, Respir Res, vol. 21, p. 4, 2020.
N. M. Davies, Taylor, A. E., Taylor, G. M., Itani, T., Jones, T., Martin, R. M., Munafo, M. R., Windmeijer, F., and Thomas, K. H., Varenicline versus nicotine replacement therapy for long-term smoking cessation: an observational study using the Clinical Practice Research Datalink, Health Technol Assess, vol. 24, pp. 1-46, 2020.
M. Giustozzi, Curcio, A., Weijs, B., Field, T. S., Sudikas, S., Katholing, A., Wallenhorst, C., Weitz, J. I., Martinez, C., and Cohen, A. T., Variation in the Association between Antineoplastic Therapies and Venous Thromboembolism in Patients with Active Cancer, Thromb Haemost, vol. 120, pp. 847-856, 2020.
C. Santella, Yin, H., Hicks, B. M., Yu, O. H. Y., Bouganim, N., and Azoulay, L., Weight-lowering effects of glucagon-like peptide-1 receptor agonists and detection of breast cancer among obese women with diabetes, Epidemiology, 2020.
J. S. Minhas, Coles, B., Mistri, A. K., Eveson, D. J., Hussain, S. T., Potter, J. F., Khunti, K., and Robinson, T. G., What is the optimal blood pressure level for patients with atrial fibrillation treated with direct oral anticoagulants?, J Hypertens, 2020.
W. D. Strain, Tsang, C., Hurst, M., McEwan, P., Unadkat, M., Meadowcroft, S., Shardlow, R., and Evans, M., What Next After Metformin in Type 2 Diabetes? Selecting the Right Drug for the Right Patient, Diabetes Ther, vol. 11, pp. 1381-1395, 2020.
C. A. Lawson, Zaccardi, F., Squire, I., Ling, S., Davies, M. J., Lam, C. S. P., Mamas, M. A., Khunti, K., and Kadam, U. T., 20-year trends in cause-specific heart failure outcomes by sex, socioeconomic status, and place of diagnosis: a population-based study, Lancet Public Health, vol. 4, pp. e406-e420, 2019.
A. M. Gallagher, Dedman, D., Padmanabhan, S., Leufkens, H. G. M., and de Vries, F., The accuracy of date of death recording in the Clinical Practice Research Datalink GOLD database in England compared with the Office for National Statistics death registrations, Pharmacoepidemiol Drug Saf, 2019.
C. Becker, Jick, S. S., and Meier, C. R., ACE inhibitor use and risk of cataract: a case-control analysis, Br J Ophthalmol, 2019.
J. Watson, Salisbury, C., Whiting, P., Banks, J., Pyne, Y., and Hamilton, W., Added value and cascade effects of inflammatory marker tests in UK primary care: a cohort study from the Clinical Practice Research Datalink, Br J Gen Pract, vol. 69, pp. e470-e478, 2019.
K. D. Johnson, Lu, X., and Zhang, D., Adherence to hepatitis A and hepatitis B multi-dose vaccination schedules among adults in the United Kingdom: a retrospective cohort study, BMC Public Health, vol. 19, p. 404, 2019.
R. L. Tannen, Barnhart, K. T., and Rubin, J. C., Advantages of large medical record database for outcomes research: Insights into post-menopausal hormone therapy, Learn Health Syst, vol. 3, p. e10193, 2019.
M. Rafiq, Hayward, A., Warren-Gash, C., Denaxas, S., Gonzalez-Izquierdo, A., Lyratzopoulos, G., and Thomas, S., Allergic disease, corticosteroid use and risk of Hodgkin's lymphoma: A UK Nationwide case-control study, J Allergy Clin Immunol, 2019.
[Page last reviewed 5 June 2020]