Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 5 August 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 187 pages)


Export 2296 results:
Author Title Type [ Year(Asc)]
O. M. Moussa, Ardissino, M., Kulatilake, P., Faraj, A., Muttoni, E., Darzi, A., Ziprin, P., Scholtz, S., and Purkayastha, S., Effect of body mass index on depression in a UK cohort of 363 037 obese patients: A longitudinal analysis of transition, Clin Obes, p. e12305, 2019.
M. J. Cook, Sorial, A. K., Lunt, M., Board, T. N., and O'Neill, T. W., Effect of timing and duration of statin exposure on risk of hip or knee revision arthroplasty: a population-based cohort study, J Rheumatol, 2019.
M. C. Gulliford, Prevost, A. T., Charlton, J., Juszczyk, D., Soames, J., McDermott, L., Sultana, K., Wright, M., Fox, R., Hay, A. D., Little, P., Moore, M. V., Yardley, L., and Ashworth, M., Effectiveness and safety of electronically delivered prescribing feedback and decision support on antibiotic use for respiratory illness in primary care: REDUCE cluster randomised trial, Bmj, vol. 364, p. l236, 2019.
K. Mattishent, Richardson, K., Dhatariya, K., Savva, G. M., Fox, C., and Loke, Y. K., The effects of hypoglycemia and dementia on cardiovascular events, falls and fractures and all-cause mortality in older people - a retrospective cohort study, Diabetes Obes Metab, 2019.
M. C. Gulliford, Juszczyk, D., Prevost, A. T., Soames, J., McDermott, L., Sultana, K., Wright, M., Fox, R., Hay, A. D., Little, P., Moore, M., Yardley, L., Ashworth, M., and Charlton, J., Electronically delivered interventions to reduce antibiotic prescribing for respiratory infections in primary care: cluster RCT using electronic health records and cohort study, Health Technol Assess, vol. 23, pp. 1-70, 2019.
E. Herrett, Gadd, S., Jackson, R., Bhaskaran, K., Williamson, E., Van Staa, T., Sofat, R., Timmis, A., and Smeeth, L., Eligibility and subsequent burden of cardiovascular disease of four strategies for blood pressure-lowering treatment: a retrospective cohort study, Lancet, 2019.
R. Ferguson, Culliford, D., Prieto-Alhambra, D., Pinedo-Villanueva, R., Delmestri, A., Arden, N., and Bowen, C., Encounters for foot and ankle pain in UK primary care: a population-based cohort study of CPRD data, Br J Gen Pract, vol. 69, pp. e422-e429, 2019.
L. Horne, Ashfaq, A., MacLachlan, S., Sinsakul, M., Qin, L., LoCasale, R., and Wetmore, J. B., Epidemiology and health outcomes associated with hyperkalemia in a primary care setting in England, BMC Nephrol, vol. 20, p. 85, 2019.
K. Hedenmalm, Blake, K., Donegan, K., Macia, M. A., Gil, M., Williams, J., Montero, D., Candore, G., Morales, D., Kurz, X., and Arlett, P., A European multicentre drug utilisation study of the impact of regulatory measures on prescribing of codeine for pain in children, Pharmacoepidemiol Drug Saf, 2019.
C. Marley, Y. Hahi, E., Ferreira, G., Woods, L., and A. Villaescusa, R., Evaluation of a risk score to predict future Clostridium difficile disease using UK primary care and hospital data in Clinical Practice Research Datalink, Hum Vaccin Immunother, pp. 1-7, 2019.
L. A. Scott, Berni, T. R., Berni, E. R., De Vries, J., and Currie, C. J., Evaluation of the healthcare resource use and the related financial costs of managing peanut allergy in the United Kingdom, Expert Rev Clin Immunol, vol. 15, pp. 889-896, 2019.
R. M. Joseph, van Staa, T. P., Lunt, M., Abrahamowicz, M., and Dixon, W. G., Exposure measurement error when assessing current glucocorticoid use using UK primary care electronic prescription data, Pharmacoepidemiol Drug Saf, vol. 28, pp. 179-186, 2019.
M. H. Secrest, Platt, R. W., Dormuth, C. R., Chateau, D., Targownik, L., Nie, R., Doyle, C. M., Dell'Aniello, S., and Filion, K. B., Extreme restriction design as a method for reducing confounding by indication in pharmacoepidemiologic research, Pharmacoepidemiol Drug Saf, 2019.
A. Bottle, Kim, D., Hayhoe, B., Majeed, A., Aylin, P., Clegg, A., and Cowie, M. R., Frailty and comorbidity predict first hospitalisation after heart failure diagnosis in primary care: population-based observational study in England, Age Ageing, 2019.
M. D. Danese, Halperin, M., Duryea, J., and Duryea, R., The Generalized Data Model for clinical research, BMC Med Inform Decis Mak, vol. 19, p. 117, 2019.
D. F. Carr, Francis, B., Jorgensen, A. L., Zhang, E., Chinoy, H., Heckbert, S. R., Bis, J. C., Brody, J. A., Floyd, J., Psaty, B. M., Molokhia, M., Lapeyre-Mestre, M., Conforti, A., Alfirevic, A., Van Staa, T., and Pirmohamed, M., Genome-wide association study of statin-induced myopathy in patients recruited using the UK clinical practice research datalink, Clin Pharmacol Ther, 2019.
R. Smith, Han, L., Ali, S., Prady, S. L., Taylor, J., Hughes, T., Ajjan, R. A., Siddiqi, N., and Doran, T., Glucose, cholesterol and blood pressure in type II diabetes: A longitudinal observational study comparing patients with and without severe mental illness, J Psychiatr Ment Health Nurs, 2019.
P. H. Wilding J, Rigney, U., Blak, B. T., Nolan, S. T., Fenici, P., and Medina, J., Glycaemic, weight, and blood pressure changes associated with early versus later treatment intensification with dapagliflozin in United Kingdom primary care patients with type 2 diabetes mellitus, Diabetes Res Clin Pract, p. 107791, 2019.
S. Alageel and Gulliford, M. C., Health checks and cardiovascular risk factor values over six years' follow-up: Matched cohort study using electronic health records in England, PLoS Med, vol. 16, p. e1002863, 2019.
C. D. Steer, Macleod, J., Tilling, K., Lim, A. G., Marsden, J., Millar, T., Strang, J., Telfer, M., Whitaker, H., Vickerman, P., and Hickman, M., Health Services and Delivery Research, in The impact of opiate substitution treatment on mortality risk in drug addicts: a natural experiment study, Southampton (UK): NIHR Journals Library Copyright (c) Queen's Printer and Controller of HMSO 2019. This work was produced by Steer et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely repro, 2019.
L. Harris, Graham, S., MacLachlan, S., Exuzides, A., and Jacob, S., Healthcare resource utilization by patients with treatment-refractory myasthenia gravis in England, J Med Econ, pp. 1-7, 2019.
K. Richardson, Mattishent, K., Loke, Y. K., Steel, N., Fox, C., Grossi, C. M., Bennett, K., Maidment, I., Boustani, M., Matthews, F. E., Myint, P. K., Campbell, N. L., Brayne, C., Robinson, L., and Savva, G. M., History of Benzodiazepine Prescriptions and Risk of Dementia: Possible Bias Due to Prevalent Users and Covariate Measurement Timing in a Nested Case-Control Study, Am J Epidemiol, vol. 188, pp. 1228-1236, 2019.
R. E. Ghosh, Crellin, E., Beatty, S., Donegan, K., Myles, P., and Williams, R., How Clinical Practice Research Datalink data are used to support pharmacovigilance, Therapeutic Advances in Drug Safety, 2019.
H. Carreira, Williams, R., Strongman, H., and Bhaskaran, K., Identification of mental health and quality of life outcomes in primary care databases in the UK: a systematic review, BMJ Open, vol. 9, p. e029227, 2019.
B. Carter, C. Bennett, V., Bethel, J., Jones, H. M., Wang, T., and Kemp, A., Identifying cerebral palsy from routinely-collected data in England and Wales, Clin Epidemiol, vol. 11, pp. 457-468, 2019.
M. Pikoula, Quint, J. K., Nissen, F., Hemingway, H., Smeeth, L., and Denaxas, S., Identifying clinically important COPD sub-types using data-driven approaches in primary care population based electronic health records, BMC Med Inform Decis Mak, vol. 19, p. 86, 2019.
V. Allan, Sammon, C. J., McDonald, L., Mehmud, F., Alikhan, R., and Ramagopalan, S. V., Impact of atrial fibrillation awareness campaigns: interrupted time series using the Clinical Practice Research Datalink, Future Cardiol, 2019.
N. Al-Attar, Johnston, S., Jamous, N., Mistry, S., Ghosh, E., Gangoli, G., Danker, W., Etter, K., and Ammann, E., Impact of bleeding complications on length of stay and critical care utilization in cardiac surgery patients in England, J Cardiothorac Surg, vol. 14, p. 64, 2019.
E. Burn, Edwards, C. J., Murray, D. W., Silman, A., Cooper, C., Arden, N. K., Prieto-Alhambra, D., and Pinedo-Villanueva, R., The impact of bmi and smoking on risk of revision following knee and hip replacement surgery: evidence from routinely collected data, Osteoarthritis Cartilage, 2019.
L. Han, Clegg, A., Doran, T., and Fraser, L., The impact of frailty on healthcare resource use: a longitudinal analysis using the Clinical Practice Research Datalink in England, Age Ageing, 2019.
J. T. H. Nielen, Dagnelie, P. C., Boonen, A., Klungel, O., van den Bemt, B., and de Vries, F., Impact of the definition of osteoarthritis and of the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink, Diabetes Res Clin Pract, vol. 148, pp. 240-248, 2019.
R. Gafoor, Charlton, J., Ravindrarajah, R., and Gulliford, M. C., Importance of Frailty for Association of Antipsychotic Drug Use with Risk of Fracture: Cohort Study Using Electronic Health Records, J Am Med Dir Assoc, 2019.
L. Ibanez, Sabate, M., Vidal, X., Ballarin, E., Rottenkolber, M., Schmiedl, S., Heeke, A., Huerta, C., E. Merino, M., Montero, D., Leon-Munoz, L. M., Gasse, C., Moore, N., Droz, C., Lassalle, R., Aakjaer, M., Andersen, M., De Bruin, M. L., Groenwold, R., van den Ham, R., Souverein, P., Klungel, O., and Gardarsdottir, H., Incidence of Direct Oral Anticoagulant use in patients with non-valvular atrial fibrillation and characteristics of users in six European countries (2008-2015): A cross-national drug utilization study, Br J Clin Pharmacol, 2019.
V. Cairns, Wallenhorst, C., Rietbrock, S., and Martinez, C., Incidence of Lyme disease in the UK: a population-based cohort study, BMJ Open, vol. 9, p. e025916, 2019.
K. Davies, Johnson, E. L., Hollen, L., Jones, H. M., Lyttle, M. D., Maguire, S., and Kemp, A. M., Incidence of medically attended paediatric burns across the UK, Inj Prev, 2019.
N. E. O'Connell, Smith, K. J., Peterson, M. D., Ryan, N., Liverani, S., Anokye, N., Victor, C., and Ryan, J. M., Incidence of osteoarthritis, osteoporosis and inflammatory musculoskeletal diseases in adults with cerebral palsy: A population-based cohort study, Bone, vol. 125, pp. 30-35, 2019.
L. Wei, Lai, E. C., Kao-Yang, Y. H., Walker, B. R., MacDonald, T. M., and Andrew, R., Incidence of type 2 diabetes mellitus in men receiving steroid 5alpha-reductase inhibitors: population based cohort study, Bmj, vol. 365, p. l1204, 2019.
A. Gayle, Dickinson, S., Poole, C., Pang, M., Fauconnot, O., and Quint, J. K., Incidence of type II diabetes in chronic obstructive pulmonary disease: a nested case-control study, NPJ Prim Care Respir Med, vol. 29, p. 28, 2019.
T. S. Field, Weijs, B., Curcio, A., Giustozzi, M., Sudikas, S., Katholing, A., Wallenhorst, C., Weitz, J. I., Cohen, A. T., and Martinez, C., Incident Atrial Fibrillation, Dementia and the Role of Anticoagulation: A Population-Based Cohort Study, Thromb Haemost, 2019.
H. R. Whittaker, Mullerova, H., Jarvis, D., Barnes, N. C., Jones, P. W., Compton, C. H., Kiddle, S. J., and Quint, J. K., Inhaled corticosteroids, blood eosinophils, and FEV1 decline in patients with COPD in a large UK primary health care setting, Int J Chron Obstruct Pulmon Dis, vol. 14, pp. 1063-1073, 2019.
G. Muduma, Aluvihare, V., Clancy, M., de Nigris, E., Whitlock, C., Landeira, M., and Nazir, J., The Last Year Before Graft Failure Negatively Impacts Economic Outcomes and is Associated With Greater Healthcare Resource Utilization Compared With Previous Years in the United Kingdom: Results of a Retrospective Observational Study, Transplant Direct, vol. 5, p. e443, 2019.
H. Strongman, Williams, R., Meeraus, W., Murray-Thomas, T., Campbell, J., Carty, L., Dedman, D., Gallagher, A., Oyinlola, J., Kousoulis, A., and Valentine, J., Limitations for health research with restricted data collection from UK primary care, Pharmacoepidemiol Drug Saf, 2019.
M. Sabido, Thilo, H., and Guido, G., Long-term effectiveness of bisoprolol in patients with angina: A real-world evidence study, Pharmacol Res, vol. 139, pp. 106-112, 2019.
J. A. Rassen, Bartels, D. B., Schneeweiss, S., Patrick, A. R., and Murk, W., Measuring prevalence and incidence of chronic conditions in claims and electronic health record databases, Clin Epidemiol, vol. 11, pp. 1-15, 2019.
R. E. Farmer, Ford, D., Mathur, R., Chaturvedi, N., Kaplan, R., Smeeth, L., and Bhaskaran, K., Metformin use and risk of cancer in patients with type 2 diabetes: a cohort study of primary care records using inverse probability weighting of marginal structural models, Int J Epidemiol, 2019.
C. Minassian, Williams, R., Meeraus, W. H., Smeeth, L., Campbell, O. M. R., and Thomas, S. L., Methods to generate and validate a Pregnancy Register in the UK Clinical Practice Research Datalink primary care database, Pharmacoepidemiol Drug Saf, vol. 28, pp. 923-933, 2019.
R. Brauer, Herrero-Zazo, M., Barlow, D. J., Gaughran, F., Taylor, D., and Howard, L. M., Minocycline and the risk of acute psychiatric events in adolescence: A self-controlled case series, J Psychopharmacol, p. 269881118821852, 2019.
A. Green, Shaddick, G., Charlton, R., Snowball, J., Nightingale, A., Smith, C., Tillett, W., and McHugh, N., Modifiable risk factors and the development of psoriatic arthritis in people with psoriasis, Br J Dermatol, 2019.
J. M. Ryan, Peterson, M. D., Ryan, N., Smith, K. J., N, E. O. 'Connell, Liverani, S., Anokye, N., Victor, C., and Allen, E., Mortality due to cardiovascular disease, respiratory disease, and cancer in adults with cerebral palsy, Dev Med Child Neurol, 2019.
R. Persson, Lee, S., Yood, M. U., Wagner, M., Minton, N., Niemcryk, S., Lindholm, A., Evans, A., and Jick, S., Multi-database study of multiple sclerosis: identification, validation and description of MS patients in two countries, J Neurol, 2019.
[Page last reviewed 5 August 2019]