Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,400 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 5 February 2020) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 197 pages)


Export 2449 results:
Author Title Type [ Year(Desc)]
K. B. Handoko, Souverein, P. C., van Staa, T. P., Meyboom, R. H., Leufkens, H. G., Egberts, T. C., and van den Bemt, P. M., Risk of aplastic anemia in patients using antiepileptic drugs, Epilepsia, vol. 47, pp. 1232-6, 2006.
J. M. Gelfand, Shin, D. B., Neimann, A. L., Wang, X., Margolis, D. J., and Troxel, A. B., The risk of lymphoma in patients with psoriasis, J Invest Dermatol, vol. 126, pp. 2194-201, 2006.
J. M. Gelfand, Neimann, A. L., Shin, D. B., Wang, X., Margolis, D. J., and Troxel, A. B., Risk of myocardial infarction in patients with psoriasis, Jama, vol. 296, pp. 1735-41, 2006.
J. West, Logan, R. F., Hubbard, R. B., and Card, T. R., Risk of schizophrenia in people with coeliac disease, ulcerative colitis and Crohn's disease: a general population-based study, Aliment Pharmacol Ther, vol. 23, pp. 71-4, 2006.
J. R. Hardy, Leaderer, B. P., Holford, T. R., Hall, G. C., and Bracken, M. B., Safety of medications prescribed before and during early pregnancy in a cohort of 81,975 mothers from the UK General Practice Research Database, Pharmacoepidemiol Drug Saf, vol. 15, pp. 555-64, 2006.
R. L. Tannen, Weiner, M. G., and Marcus, S. M., Simulation of the Syst-Eur randomized control trial using a primary care electronic medical record was feasible, J Clin Epidemiol, vol. 59, pp. 254-64, 2006.
E. M. van de Garde, Hak, E., Souverein, P. C., Hoes, A. W., van den Bosch, J. M., and Leufkens, H. G., Statin treatment and reduced risk of pneumonia in patients with diabetes, Thorax, vol. 61, pp. 957-61, 2006.
A. J. Apter, Kinman, J. L., Bilker, W. B., Herlim, M., Margolis, D. J., Lautenbach, E., Hennessy, S., and Strom, B. L., Is there cross-reactivity between penicillins and cephalosporins?, Am J Med, vol. 119, pp. 354.e11-9, 2006.
J. A. Cassell, Mercer, C. H., Sutcliffe, L., Petersen, I., Islam, A., Brook, M. G., Ross, J. D., Kinghorn, G. R., Simms, I., Hughes, G., Majeed, A., Stephenson, J. M., Johnson, A. M., and Hayward, A. C., Trends in sexually transmitted infections in general practice 1990-2000: population based study using data from the UK general practice research database, Bmj, vol. 332, pp. 332-4, 2006.
A. Gonzalez-Perez and Rodriguez, L. A., Upper gastrointestinal complications among users of paracetamol, Basic Clin Pharmacol Toxicol, vol. 98, pp. 297-303, 2006.
P. C. Souverein, Webb, D. J., Weil, J. G., van Staa, T. P., and Egberts, A. C., Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy, Neurology, vol. 66, pp. 1318-24, 2006.
F. Andersohn, Suissa, S., and Garbe, E., Use of first- and second-generation cyclooxygenase-2-selective nonsteroidal antiinflammatory drugs and risk of acute myocardial infarction, Circulation, vol. 113, pp. 1950-7, 2006.
R. Jones, Latinovic, R., Charlton, J., and Gulliford, M. C., Alarm symptoms in early diagnosis of cancer in primary care: cohort study using General Practice Research Database, Bmj, vol. 334, p. 1040, 2007.
E. M. van de Garde, Souverein, P. C., Hak, E., Deneer, V. H., van den Bosch, J. M., and Leufkens, H. G., Angiotensin-converting enzyme inhibitor use and protection against pneumonia in patients with diabetes, J Hypertens, vol. 25, pp. 235-9, 2007.
I. Petersen and Hayward, A. C., Antibacterial prescribing in primary care, J Antimicrob Chemother, vol. 60 Suppl 1, pp. i43-47, 2007.
R. J. Pitman, Melegaro, A., Gelb, D., Siddiqui, M. R., Gay, N. J., and Edmunds, W. J., Assessing the burden of influenza and other respiratory infections in England and Wales, J Infect, vol. 54, pp. 530-8, 2007.
D. J. Margolis, Hoffstad, O., and Isseroff, R. R., Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers, Arch Dermatol, vol. 143, pp. 1275-80, 2007.
I. J. Douglas, Cook, C., Chakravarthy, U., Hubbard, R., Fletcher, A. E., and Smeeth, L., A case-control study of drug risk factors for age-related macular degeneration, Ophthalmology, vol. 114, pp. 1164-9, 2007.
Y. X. Yang, Hennessy, S., Propert, K., Hwang, W. T., Sedarat, A., and Lewis, J. D., Chronic proton pump inhibitor therapy and the risk of colorectal cancer, Gastroenterology, vol. 133, pp. 748-54, 2007.
W. Hamilton and Kernick, D., Clinical features of primary brain tumours: a case-control study using electronic primary care records, Br J Gen Pract, vol. 57, pp. 695-9, 2007.
A. Lafuma and Berdeaux, G., Costs and effectiveness of travoprost versus a dorzolamide + timolol fixed combination in first-line treatment of glaucoma: analysis conducted on the United Kingdom General Practitioner Research Database, Curr Med Res Opin, vol. 23, pp. 3009-16, 2007.
S. S. Jick, Kaye, J. A., and Jick, H., Diclofenac and acute myocardial infarction in patients with no major risk factors, Br J Clin Pharmacol, vol. 64, pp. 662-7, 2007.
R. Schade, Andersohn, F., Suissa, S., Haverkamp, W., and Garbe, E., Dopamine agonists and the risk of cardiac-valve regurgitation, N Engl J Med, vol. 356, pp. 29-38, 2007.
J. A. Delaney, Opatrny, L., Brophy, J. M., and Suissa, S., Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding, Cmaj, vol. 177, pp. 347-51, 2007.
T. M. MacDonald, Morant, S. V., and Mozaffari, E., Drug treatment discontinuation and achievement of target blood pressure and cholesterol in United Kingdom primary care, Curr Med Res Opin, vol. 23, pp. 2765-74, 2007.
T. A. Burke, Sturkenboom, M. C., Ohman-Strickland, P. A., Wentworth, C. E., and Rhoads, G. G., The effect of antihypertensive drugs and drug combinations on the incidence of new-onset type-2 diabetes mellitus, Pharmacoepidemiol Drug Saf, vol. 16, pp. 979-87, 2007.
A. Ruigomez, Rodriguez, L. A., Wallander, M. A., Johansson, S., and Dent, J., Endoscopic findings in a cohort of newly diagnosed gastroesophageal reflux disease patients registered in a UK primary care database, Dis Esophagus, vol. 20, pp. 504-9, 2007.
R. L. Tannen, Weiner, M. G., Xie, D., and Barnhart, K., Estrogen affects post-menopausal women differently than estrogen plus progestin replacement therapy, Hum Reprod, vol. 22, pp. 1769-77, 2007.
K. E. Wurst, Ephross, S. A., Loehr, J., Clark, D. W., and Guess, H. A., Evaluation of the General Practice Research Database congenital heart defects prevalence: comparison to United Kingdom national systems, Birth Defects Res A Clin Mol Teratol, vol. 79, pp. 309-16, 2007.
F. de Vries, Bracke, M., Leufkens, H. G., Lammers, J. W., Cooper, C., and van Staa, T. P., Fracture risk with intermittent high-dose oral glucocorticoid therapy, Arthritis Rheum, vol. 56, pp. 208-14, 2007.
A. Alonso, Rodriguez, L. A., Logroscino, G., and Hernan, M. A., Gout and risk of Parkinson disease: a prospective study, Neurology, vol. 69, pp. 1696-700, 2007.
K. B. Filion, Delaney, J. A., Brophy, J. M., Ernst, P., and Suissa, S., The impact of over-the-counter simvastatin on the number of statin prescriptions in the United Kingdom: a view from the General Practice Research Database, Pharmacoepidemiol Drug Saf, vol. 16, pp. 1-4, 2007.
C. J. Edwards, Cooper, C., Fisher, D., Field, M., van Staa, T. P., and Arden, N. K., The importance of the disease process and disease-modifying antirheumatic drug treatment in the development of septic arthritis in patients with rheumatoid arthritis, Arthritis Rheum, vol. 57, pp. 1151-7, 2007.
C. Huerta, Rivero, E., and Rodriguez, L. A., Incidence and risk factors for psoriasis in the general population, Arch Dermatol, vol. 143, pp. 1559-65, 2007.
A. Alonso, Jick, S. S., Olek, M. J., and Hernan, M. A., Incidence of multiple sclerosis in the United Kingdom : findings from a population-based cohort, J Neurol, vol. 254, pp. 1736-41, 2007.
W. Hogler, Wehl, G., Van Staa, T., Meister, B., Klein-Franke, A., and Kropshofer, G., Incidence of skeletal complications during treatment of childhood acute lymphoblastic leukemia: comparison of fracture risk with the General Practice Research Database, Pediatr Blood Cancer, vol. 48, pp. 21-7, 2007.
E. C. Somers, Thomas, S. L., Smeeth, L., Schoonen, W. M., and Hall, A. J., Incidence of systemic lupus erythematosus in the United Kingdom, 1990-1999, Arthritis Rheum, vol. 57, pp. 612-8, 2007.
T. P. van Staa, Geusens, P., Zhang, B., Leufkens, H. G., Boonen, A., and Cooper, C., Individual fracture risk and the cost-effectiveness of bisphosphonates in patients using oral glucocorticoids, Rheumatology (Oxford), vol. 46, pp. 460-6, 2007.
H. Jackson, Solaymani-Dodaran, M., Card, T. R., Aithal, G. P., Logan, R., and West, J., Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study, Hepatology, vol. 46, pp. 1131-7, 2007.
M. N. Cook, Girman, C. J., Stein, P. P., and Alexander, C. M., Initial monotherapy with either metformin or sulphonylureas often fails to achieve or maintain current glycaemic goals in patients with Type 2 diabetes in UK primary care, Diabet Med, vol. 24, pp. 350-8, 2007.
J. A. Delaney, Daskalopoulou, S. S., Brophy, J. M., Steele, R. J., Opatrny, L., and Suissa, S., Lifestyle variables and the risk of myocardial infarction in the general practice research database, BMC Cardiovasc Disord, vol. 7, p. 38, 2007.
I. Wilting, de Vries, F., Thio, B. M., Cooper, C., Heerdink, E. R., Leufkens, H. G., Nolen, W. A., Egberts, A. C., and van Staa, T. P., Lithium use and the risk of fractures, Bone, vol. 40, pp. 1252-8, 2007.
K. Jordan, Clarke, A. M., Symmons, D. P., Fleming, D., Porcheret, M., Kadam, U. T., and Croft, P., Measuring disease prevalence: a comparison of musculoskeletal disease using four general practice consultation databases, Br J Gen Pract, vol. 57, pp. 7-14, 2007.
C. Becker, Brobert, G. P., Almqvist, P. M., Johansson, S., Jick, S. S., and Meier, C. R., Migraine and the risk of stroke, TIA, or death in the UK (CME), Headache, vol. 47, pp. 1374-84, 2007.
M. A. Wallander, Johansson, S., Ruigomez, A., Rodriguez, L. A. Garcia, and Jones, R., Morbidity associated with sleep disorders in primary care: a longitudinal cohort study, Prim Care Companion J Clin Psychiatry, vol. 9, pp. 338-45, 2007.
S. Hennessy, Bilker, W. B., Leonard, C. E., Chittams, J., Palumbo, C. M., Karlawish, J. H., Yang, Y. X., Lautenbach, E., Baine, W. B., and Metlay, J. P., Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures, J Clin Epidemiol, vol. 60, pp. 911-8, 2007.
E. J. Velthui Wierik, Hendricks, P. T., and Martinez, C., Preferential prescribing of tibolone and combined estrogen plus progestogen therapy in postmenopausal women, Menopause, vol. 14, pp. 518-27, 2007.
R. Ackers, Murray, M. L., Besag, F. M., and Wong, I. C., Prioritizing children's medicines for research: a pharmaco-epidemiological study of antiepileptic drugs, Br J Clin Pharmacol, vol. 63, pp. 689-97, 2007.
I. Petersen, Johnson, A. M., Islam, A., Duckworth, G., Livermore, D. M., and Hayward, A. C., Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database, Bmj, vol. 335, p. 982, 2007.
D. P. Osborn, Levy, G., Nazareth, I., Petersen, I., Islam, A., and King, M. B., Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the United Kingdom's General Practice Rsearch Database, Arch Gen Psychiatry, vol. 64, pp. 242-9, 2007.
[Page last reviewed 5 February 2020]