Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 September 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 189 pages)


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Author [ Title(Desc)] Type Year
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R. A. Karasneh, Murray, L. J., Hughes, C. M., and Cardwell, C. R., Digoxin use after diagnosis of prostate cancer and survival: a population-based cohort study, Pharmacoepidemiol Drug Saf, vol. 25, pp. 1099-103, 2016.
D. Abrahami, Douros, A., Yin, H., Yu, O. H. Y., Renoux, C., Bitton, A., and Azoulay, L., Dipeptidyl peptidase-4 inhibitors and incidence of inflammatory bowel disease among patients with type 2 diabetes: population based cohort study, Bmj, vol. 360, p. k872, 2018.
A. Douros, Rouette, J., Yin, H., Yu, O. H. Y., Filion, K. B., and Azoulay, L., Dipeptidyl Peptidase-4 Inhibitors and the Risk of Bullous Pemphigoid Among Patients With Type 2 Diabetes, Diabetes Care, 2019.
J. L. Faillie, Filion, K. B., Patenaude, V., Ernst, P., and Azoulay, L., Dipeptidyl peptidase-4 inhibitors and the risk of community-acquired pneumonia in patients with type 2 diabetes, Diabetes Obes Metab, vol. 17, pp. 379-85, 2015.
T. Holbrook, Tang, Y., Das, R., Shankar, R. R., Tunceli, K., Williams, J., Radican, L., Holden, S. E., Morgan, C. L., Piercy, J., and Currie, C. J., Direct medical costs of severe hypoglycaemic events in patients with type 2 diabetes in England: A retrospective database study, Int J Clin Pract, vol. 71, 2017.
S. V. Ramagopalan, Graham, S., Carroll, R., Raluy-Callado, M., Nordstrom, B. L., Donaldson, R., Colby, C., Mehmud, F., and Alikhan, R., Discontinuation and primary care visits in nonvalvular atrial fibrillation patients treated with apixaban or warfarin, J Comp Eff Res, 2019.
C. C. Yang, Jick, S. S., and Testa, M. A., Discontinuation and switching of therapy after initiation of lipid-lowering drugs: the effects of comorbidities and patient characteristics, Br J Clin Pharmacol, vol. 56, pp. 84-91, 2003.
T. A. Burke, Sturkenboom, M. C., Lu, S. E., Wentworth, C. E., Lin, Y., and Rhoads, G. G., Discontinuation of antihypertensive drugs among newly diagnosed hypertensive patients in UK general practice, J Hypertens, vol. 24, pp. 1193-200, 2006.
P. R. Kalra, Morley, C., Barnes, S., Menown, I., Kassianos, G., Padmanabhan, S., Gupta, S., and Lang, C. C., Discontinuation of beta-blockers in cardiovascular disease: UK primary care cohort study, Int J Cardiol, vol. 167, pp. 2695-9, 2013.
L. M. Fischer, Schlienger, R. G., Matter, C. M., Jick, H., and Meier, C. R., Discontinuation of nonsteroidal anti-inflammatory drug therapy and risk of acute myocardial infarction, Arch Intern Med, vol. 164, pp. 2472-6, 2004.
S. S. Daskalopoulou, Delaney, J. A., Filion, K. B., Brophy, J. M., Mayo, N. E., and Suissa, S., Discontinuation of statin therapy following an acute myocardial infarction: a population-based study, Eur Heart J, vol. 29, pp. 2083-91, 2008.
G. Nakafero, Grainge, M., Valdes, A., Townsend, N., Mallen, C., Zhang, W., Doherty, M., Mamas, M. A., and Abhishek, A., Do beta-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink, BMJ Open, vol. 9, p. e032050, 2019.
J. Ride, Kasteridis, P., Gutacker, N., Kronenberg, C., Doran, T., Mason, A., Rice, N., Gravelle, H., Goddard, M., Kendrick, T., Siddiqi, N., Gilbody, S., Dare, C. R., Aylott, L., Williams, R., and Jacobs, R., Do care plans and annual reviews of physical health influence unplanned hospital utilisation for people with serious mental illness? Analysis of linked longitudinal primary and secondary healthcare records in England, BMJ Open, vol. 8, p. e023135, 2018.
C. Renzi, Lyratzopoulos, G., Card, T., Chu, T. P., Macleod, U., and Rachet, B., Do colorectal cancer patients diagnosed as an emergency differ from non-emergency patients in their consultation patterns and symptoms? A longitudinal data-linkage study in England, Br J Cancer, vol. 115, pp. 866-75, 2016.
A. Leite, Thomas, S. L., and Andrews, N. J., Do delays in data availability limit the implementation of near real-time vaccine safety surveillance using the Clinical Practice Research Datalink?, Pharmacoepidemiol Drug Saf, vol. 27, pp. 25-29, 2018.
A. Harshfield, Abel, G. A., Barclay, S., and Payne, R. A., Do GPs accurately record date of death? A UK observational analysis, BMJ Support Palliat Care, 2018.
I. M. Carey, Hosking, F. J., Harris, T., DeWilde, S., Beighton, C., Shah, S. M., and Cook, D. G., Do health checks for adults with intellectual disability reduce emergency hospital admissions? Evaluation of a natural experiment, J Epidemiol Community Health, vol. 71, pp. 52-58, 2017.
A. S. Forster, Burgess, C., Dodhia, H., Fuller, F., Miller, J., McDermott, L., and Gulliford, M. C., Do health checks improve risk factor detection in primary care? Matched cohort study using electronic health records, J Public Health (Oxf), vol. 38, pp. 552-559, 2016.
S. I. Vuik, Fontana, G., Mayer, E., and Darzi, A., Do hospitalisations for ambulatory care sensitive conditions reflect low access to primary care? An observational cohort study of primary care usage prior to hospitalisation, BMJ Open, vol. 7, p. e015704, 2017.
Y. Li, Sperrin, M., Belmonte, M., Pate, A., Ashcroft, D. M., and van Staa, T. P., Do population-level risk prediction models that use routinely collected health data reliably predict individual risks?, Sci Rep, vol. 9, p. 11222, 2019.
M. Morris, Woods, L. M., Bhaskaran, K., and Rachet, B., Do pre-diagnosis primary care consultation patterns explain deprivation-specific differences in net survival among women with breast cancer? An examination of individually-linked data from the UK West Midlands cancer registry, national screening programme, BMC Cancer, vol. 17, p. 155, 2017.
C. Alexakis, Saxena, S., Chhaya, V., Cecil, E., Curcin, V., and Pollok, R., Do Thiopurines Reduce the Risk of Surgery in Elderly Onset Inflammatory Bowel Disease? A 20-Year National Population-Based Cohort Study, Inflamm Bowel Dis, vol. 23, pp. 672-680, 2017.
T. P. van Staa, Leufkens, H. G., and Cooper, C., Does a fracture at one site predict later fractures at other sites? A British cohort study, Osteoporos Int, vol. 13, pp. 624-9, 2002.
K. W. Hagberg, Sahasrabuddhe, V. V., McGlynn, K. A., and Jick, S. S., Does Angiotensin-Converting Enzyme Inhibitor and beta-Blocker Use Reduce the Risk of Primary Liver Cancer? A Case-Control Study Using the U.K. Clinical Practice Research Datalink, Pharmacotherapy, vol. 36, pp. 187-95, 2016.
P. Dhiman, Andersen, S., Vestergaard, P., Masud, T., and Qureshi, N., Does bone mineral density improve the predictive accuracy of fracture risk assessment? A prospective cohort study in Northern Denmark, BMJ Open, vol. 8, p. e018898, 2018.
L. J. Tata, West, J., Harrison, T., Farrington, P., Smith, C., and Hubbard, R., Does influenza vaccination increase consultations, corticosteroid prescriptions, or exacerbations in subjects with asthma or chronic obstructive pulmonary disease?, Thorax, vol. 58, pp. 835-9, 2003.
S. Weir, Samnaliev, M., Kuo, T. - C., Choitir, C. N., Tierney, T. S., Taylor, R. S., Manca, A., Bruce, J., Cumming, D., and Eldabe, S., Does instrumented spinal surgery have an increased rate of persistent post-operative pain (PPP)?, The Spine Journal, vol. 17, p. S11, 2017.
N. Dunn, Holmes, C., and Mullee, M., Does lithium therapy protect against the onset of dementia?, Alzheimer Dis Assoc Disord, vol. 19, pp. 20-2, 2005.
N. Andrews, Miller, E., Waight, P., Farrington, P., Crowcroft, N., Stowe, J., and Taylor, B., Does oral polio vaccine cause intussusception in infants? Evidence from a sequence of three self-controlled cases series studies in the United Kingdom, Eur J Epidemiol, vol. 17, pp. 701-6, 2001.
I. Karp, Sivaswamy, A., and Booth, C., Does the use of incretin-based medications increase the risk of cancer in patients with type-2 diabetes mellitus?, Pharmacoepidemiol Drug Saf, 2019.
T. P. van Staa, Rietbrock, S., Setakis, E., and Leufkens, H. G., Does the varied use of NSAIDs explain the differences in the risk of myocardial infarction?, J Intern Med, vol. 264, pp. 481-92, 2008.
C. Hopkins, Andrews, P., and Holy, C. E., Does time to endoscopic sinus surgery impact outcomes in chronic rhinosinusitis? Retrospective analysis using the UK clinical practice research data, Rhinology, vol. 53, pp. 18-24, 2015.
A. Mehrabadi, Reynier, P., Platt, R. W., and Filion, K. B., Domperidone for insufficient lactation in England 2002-2015: A drug utilization study with interrupted time series analysis, Pharmacoepidemiol Drug Saf, vol. 27, pp. 1316-1324, 2018.
J. E. Thistle, Petrick, J. L., Yang, B., Bradley, M. C., Graubard, B. I., and McGlynn, K. A., Domperidone use and risk of primary liver cancer in the Clinical Practice Research Datalink, Cancer Epidemiol, vol. 55, pp. 170-175, 2018.
C. Renoux, Dell'Aniello, S., Brophy, J. M., and Suissa, S., Dopamine agonist use and the risk of heart failure, Pharmacoepidemiol Drug Saf, vol. 21, pp. 34-41, 2012.
R. Schade, Andersohn, F., Suissa, S., Haverkamp, W., and Garbe, E., Dopamine agonists and the risk of cardiac-valve regurgitation, N Engl J Med, vol. 356, pp. 29-38, 2007.
Y. Tao and Fu, H., Doubly robust estimation of the weighted average treatment effect for a target population, Stat Med, vol. 38, pp. 315-325, 2019.
S. Jick and Pennap, D., Drospirenone- and levonorgestrel-containing oral contraceptives and the risk of gallbladder disease, Contraception, vol. 86, pp. 220-3, 2012.
N. Larivee, Suissa, S., Eberg, M., Joseph, L., Eisenberg, M. J., Abenhaim, H. A., and Filion, K. B., Drospirenone-containing combined oral contraceptives and the risk of arterial thrombosis: a population-based nested case-control study, Bjog, vol. 124, pp. 1672-1679, 2017.
N. Larivee, Suissa, S., Coulombe, J., Tagalakis, V., and Filion, K. B., Drospirenone-Containing Oral Contraceptive Pills and the Risk of Venous Thromboembolism: An Assessment of Risk in First-Time Users and Restarters, Drug Saf, vol. 40, pp. 583-596, 2017.
J. A. Delaney, Opatrny, L., Brophy, J. M., and Suissa, S., Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding, Cmaj, vol. 177, pp. 347-51, 2007.
C. Gasse, Hollowell, J., Meier, C. R., and Haefeli, W. E., Drug interactions and risk of acute bleeding leading to hospitalisation or death in patients with chronic atrial fibrillation treated with warfarin, Thromb Haemost, vol. 94, pp. 537-43, 2005.
G. M. Clifford and Farmer, R. D., Drug or symptom-induced depression in men treated with alpha 1-blockers for benign prostatic hyperplasia? A nested case-control study, Pharmacoepidemiol Drug Saf, vol. 11, pp. 55-61, 2002.
A. Thompson, Ashcroft, D. M., Owens, L., van Staa, T. P., and Pirmohamed, M., Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study, PLoS One, vol. 12, p. e0173272, 2017.
T. M. MacDonald, Morant, S. V., and Mozaffari, E., Drug treatment discontinuation and achievement of target blood pressure and cholesterol in United Kingdom primary care, Curr Med Res Opin, vol. 23, pp. 2765-74, 2007.
C. R. Meier and Jick, H., Drug use and pulmonary death rates in increasingly symptomatic asthma patients in the UK, Thorax, vol. 52, pp. 612-7, 1997.
M. L. Murray, de Vries, C. S., and Wong, I. C., A drug utilisation study of antidepressants in children and adolescents using the General Practice Research Database, Arch Dis Child, vol. 89, pp. 1098-102, 2004.
A. Jaggi, Nazir, J., Fatoye, F., Siddiqui, E., Choudhury, N., Argoubi, R., Ali, M., de Ridder, D., and Drake, M. J., Drug utilization patterns and healthcare resource use and costs in patients with neurogenic bladder in the United Kingdom: A retrospective primary care database study, Neurourol Urodyn, 2019.
R. K. Amar, Jick, S. S., Rosenberg, D., Maher, T. M., and Meier, C. R., Drug-/radiation-induced interstitial lung disease in the United Kingdom general population: incidence, all-cause mortality and characteristics at diagnosis, Respirology, vol. 17, pp. 861-8, 2012.
C. R. Cardwell, Menamin, U. C. Mc, Hicks, B. M., Hughes, C., Cantwell, M. M., and Murray, L. J., Drugs affecting the renin-angiotensin system and survival from cancer: a population based study of breast, colorectal and prostate cancer patient cohorts, BMC Med, vol. 12, p. 28, 2014.
[Page last reviewed 6 September 2019]