Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 June 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 183 pages)


Export 2252 results:
Author Title Type [ Year(Asc)]
Y. Vinogradova, Coupland, C., and Hippisley-Cox, J., Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases, Bmj, vol. 364, p. k4810, 2019.
A. Tran-Duy, Connell, N. J., Vanmolkot, F. H., Souverein, P. C., de Wit, N. J., Stehouwer, C. D. A., Hoes, A. W., de Vries, F., and de Boer, A., Use of proton pump inhibitors and risk of iron deficiency: a population-based case-control study, J Intern Med, vol. 285, pp. 205-214, 2019.
T. Burkard, Moser, M., Rauch, M., Jick, S. S., and Meier, C. R., Utilization pattern of hormone therapy in UK general practice between 1996 and 2015: a descriptive study, Menopause, 2019.
J. E. Amegadzie, Badejo, O., Gamble, J. M., Wright, M., Farrell, J., Jackson, B., Sultana, K., Hashmi, M., and Gao, Z., Validated methods to identify patients with asthma-COPD overlap in healthcare databases: a systematic review protocol, BMJ Open, vol. 9, p. e024306, 2019.
A. M. Mueller, Meier, C. R., Jick, S. S., and Schneider, C., Weight change and blood glucose concentration as markers for pancreatic cancer in subjects with new-onset diabetes mellitus: A matched case-control study, Pancreatology, 2019.
C. Broadhurst, Rhodes, A. M. L., Harper, P., Perry, D. C., Clarke, N. M. P., and Aarvold, A., What is the incidence of late detection of developmental dysplasia of the hip in England?, Bone Joint J, vol. 101-b, pp. 281-287, 2019.
A. P. McGovern, Dennis, J. M., Shields, B. M., Hattersley, A. T., Pearson, E. R., and Jones, A. G., What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study, BMC Med, vol. 17, p. 79, 2019.
T. C. Chen, Chen, L. C., and Knaggs, R. D., A 15-year overview of increasing tramadol utilisation and associated mortality and the impact of tramadol classification in the United Kingdom, Pharmacoepidemiol Drug Saf, vol. 27, pp. 487-494, 2018.
I. Tamimi, Nicolau, B., Eimar, H., S. Madathil, A., Kezouh, A., Karp, I., and Tamimi, F., Acetylcholinesterase inhibitors and the risk of osteoporotic fractures: nested case-control study, Osteoporos Int, vol. 29, pp. 849-857, 2018.
T. Khan, Alvand, A., Prieto-Alhambra, D., Culliford, D. J., Judge, A., Jackson, W. F., Scammell, B. E., Arden, N. K., and Price, A. J., ACL and meniscal injuries increase the risk of primary total knee replacement for osteoarthritis: a matched case-control study using the Clinical Practice Research Datalink (CPRD), Br J Sports Med, 2018.
K. E. Mansfield, Douglas, I. J., Nitsch, D., Thomas, S. L., Smeeth, L., and Tomlinson, L. A., Acute kidney injury and infections in patients taking antihypertensive drugs: a self-controlled case series analysis, Clin Epidemiol, vol. 10, pp. 187-202, 2018.
A. J. Hire, Ashcroft, D. M., Springate, D. A., and Steinke, D. T., ADHD in the United Kingdom: Regional and Socioeconomic Variations in Incidence Rates Amongst Children and Adolescents (2004-2013), J Atten Disord, vol. 22, pp. 134-142, 2018.
B. Hayhoe, Kim, D., Aylin, P. P., Majeed, F. A., Cowie, M. R., and Bottle, A., Adherence to guidelines in management of symptoms suggestive of heart failure in primary care, Heart, 2018.
M. Bloechliger, Reinau, D., Spoendlin, J., Chang, S. C., Kuhlbusch, K., Heaney, L. G., Jick, S. S., and Meier, C. R., Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis, Respir Res, vol. 19, p. 75, 2018.
S. Bou-Antoun, Costelloe, C., Honeyford, K., Mazidi, M., Hayhoe, B. W. J., Holmes, A., Johnson, A. P., and Aylin, P., Age-related decline in antibiotic prescribing for uncomplicated respiratory tract infections in primary care in England following the introduction of a national financial incentive (the Quality Premium) for health commissioners to reduce use of antibiotic, J Antimicrob Chemother, vol. 73, pp. 2883-2892, 2018.
B. M. Hicks, Filion, K. B., Yin, H., Sakr, L., Udell, J. A., and Azoulay, L., Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study, Bmj, vol. 363, p. k4209, 2018.
J. Busby, McMenamin, U., Spence, A., Johnston, B. T., Hughes, C., and Cardwell, C. R., Angiotensin receptor blocker use and gastro-oesophageal cancer survival: a population-based cohort study, Aliment Pharmacol Ther, vol. 47, pp. 279-288, 2018.
K. Richardson, Fox, C., Maidment, I., Steel, N., Loke, Y. K., Arthur, A., Myint, P. K., Grossi, C. M., Mattishent, K., Bennett, K., Campbell, N. L., Boustani, M., Robinson, L., Brayne, C., Matthews, F. E., and Savva, G. M., Anticholinergic drugs and risk of dementia: case-control study, Bmj, vol. 361, p. k1315, 2018.
R. Gafoor, Booth, H. P., and Gulliford, M. C., Antidepressant utilisation and incidence of weight gain during 10 years' follow-up: population based cohort study, Bmj, vol. 361, p. k1951, 2018.
S. W. Turner, Murray, C., Thomas, M., Burden, A., and Price, D. B., Applying UK real-world primary care data to predict asthma attacks in 3776 well-characterised children: a retrospective cohort study, NPJ Prim Care Respir Med, vol. 28, p. 28, 2018.
S. Padmanabhan, Carty, L., Cameron, E., Ghosh, R. E., Williams, R., and Strongman, H., Approach to record linkage of primary care data from Clinical Practice Research Datalink to other health-related patient data: overview and implications, Eur J Epidemiol, 2018.
I. M. Carey, Anderson, H. R., Atkinson, R. W., Beevers, S. D., Cook, D. G., Strachan, D. P., Dajnak, D., Gulliver, J., and Kelly, F. J., Are noise and air pollution related to the incidence of dementia? A cohort study in London, England, BMJ Open, vol. 8, p. e022404, 2018.
F. Khosrow-Khavar, Yin, H., Barkun, A., Bouganim, N., and Azoulay, L., Aromatase inhibitors and the risk of colorectal cancer in postmenopausal women with breast cancer, Ann Oncol, vol. 29, pp. 744-748, 2018.
J. D. Chalmers, Poole, C., Webster, S., Tebboth, A., Dickinson, S., and Gayle, A., Assessing the healthcare resource use associated with inappropriate prescribing of inhaled corticosteroids for people with chronic obstructive pulmonary disease (COPD) in GOLD groups A or B: an observational study using the Clinical Practice Research Data, Respir Res, vol. 19, p. 63, 2018.
V. Balinskaite, Bou-Antoun, S., Johnson, A. P., Holmes, A., and Aylin, P., An assessment of potential unintended consequences following a national antimicrobial stewardship programme in England: an interrupted time series analysis, Clin Infect Dis, 2018.
M. Kerkhof, Tran, T. N., van den Berge, M., Brusselle, G. G., Gopalan, G., Jones, R. C. M., Kocks, J. W. H., Menzies-Gow, A., Nuevo, J., Pavord, I. D., Rastogi, S., and Price, D. B., Association between blood eosinophil count and risk of readmission for patients with asthma: Historical cohort study, PLoS One, vol. 13, p. e0201143, 2018.
S. Hawley, Cordtz, R., Dreyer, L., Edwards, C. J., Arden, N. K., Delmestri, A., Silman, A., Cooper, C., Judge, A., and Prieto-Alhambra, D., Association between NICE guidance on biologic therapies with rates of hip and knee replacement among rheumatoid arthritis patients in England and Wales: An interrupted time-series analysis, Semin Arthritis Rheum, vol. 47, pp. 605-610, 2018.
A. M. van Strien, Souverein, P. C., Keijsers, C., Heerdink, E. R., Derijks, H. J., and van Marum, R. J., Association Between Urinary Tract Infections and Antipsychotic Drug Use in Older Adults, J Clin Psychopharmacol, vol. 38, pp. 296-301, 2018.
K. Khunti, Danese, M. D., Kutikova, L., Catterick, D., Sorio-Vilela, F., Gleeson, M., Seshasai, S. R. Kondapa, Brownrigg, J., and Ray, K. K., Association of a Combined Measure of Adherence and Treatment Intensity With Cardiovascular Outcomes in Patients With Atherosclerosis or Other Cardiovascular Risk Factors Treated With Statins and/or Ezetimibe, JAMA Netw Open, vol. 1, p. e185554, 2018.
K. Bhaskaran, dos-Santos-Silva, I., Leon, D. A., Douglas, I. J., and Smeeth, L., Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3.6 million adults in the UK, Lancet Diabetes Endocrinol, vol. 6, pp. 944-953, 2018.
J. P. Sheppard, Stevens, S., Stevens, R. J., Mant, J., Martin, U., Hobbs, F. D. R., and McManus, R. J., Association of guideline and policy changes with incidence of lifestyle advice and treatment for uncomplicated mild hypertension in primary care: a longitudinal cohort study in the Clinical Practice Research Datalink, BMJ Open, vol. 8, p. e021827, 2018.
S. R. Pye, Sheppard, T., Joseph, R. M., Lunt, M., Girard, N., Haas, J. S., Bates, D. W., Buckeridge, D. L., van Staa, T. P., Tamblyn, R., and Dixon, W. G., Assumptions made when preparing drug exposure data for analysis have an impact on results: An unreported step in pharmacoepidemiology studies, Pharmacoepidemiol Drug Saf, vol. 27, pp. 781-788, 2018.
V. Prasad, West, J., Kendrick, D., and Sayal, K., Attention-deficit/hyperactivity disorder: variation by socioeconomic deprivation, Arch Dis Child, 2018.
K. W. Littink, Stappers, P. T. Y., Riemslag, F. C. C., Talsma, H. E., van Genderen, M. M., Cremers, F. P. M., Collin, R. W. J., and van den Born, L. I., Autosomal Recessive NRL Mutations in Patients with Enhanced S-Cone Syndrome, Genes (Basel), vol. 9, 2018.
J. P. Sheppard, Stevens, S., Stevens, R., Martin, U., Mant, J., Hobbs, F. D. R., and McManus, R. J., Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension, JAMA Intern Med, vol. 178, pp. 1626-1634, 2018.
D. B. Wolfson, Best, A. F., Addona, V., Wolfson, J., and Gadalla, S. M., Benefits of combining prevalent and incident cohorts: An application to myotonic dystrophy, Stat Methods Med Res, p. 962280218804275, 2018.
O. A. Oshagbemi, Franssen, F. M. E., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., van der Zee, A. H. Maitlan, Burden, A. M., and de Vries, F., Blood eosinophilia, use of inhaled corticosteroids, and risk of COPD exacerbations and mortality, Pharmacoepidemiol Drug Saf, vol. 27, pp. 1191-1199, 2018.
J. Delgado, Bowman, K., Ble, A., Masoli, J., Han, Y., Henley, W., Welsh, S., Kuchel, G. A., Ferrucci, L., and Melzer, D., Blood Pressure Trajectories in the 20 Years Before Death, JAMA Intern Med, vol. 178, pp. 93-99, 2018.
S. Kent, Jebb, S. A., Gray, A., Green, J., Reeves, G., Beral, V., Mihaylova, B., and Cairns, B. J., Body mass index and use and costs of primary care services among women aged 55-79 years in England: a cohort and linked data study, Int J Obes (Lond), 2018.
E. A. Yanni, Ferreira, G., Guennec, M., Y. Hahi, E., A. Ghachi, E., Haguinet, F., Espie, E., and Bianco, V., Burden of herpes zoster in 16 selected immunocompromised populations in England: a cohort study in the Clinical Practice Research Datalink 2000-2012, BMJ Open, vol. 8, p. e020528, 2018.
F. A. Pearce, Hubbard, R. B., Grainge, M. J., Watts, R. A., Abhishek, A., and Lanyon, P. C., Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study, Qjm, vol. 111, pp. 39-45, 2018.
E. Ankus, Price, S. J., Ukoumunne, O. C., Hamilton, W., and Bailey, S. E. R., Cancer incidence in patients with a high normal platelet count: a cohort study using primary care data, Fam Pract, vol. 35, pp. 671-675, 2018.
R. Williams, van Staa, T. P., Gallagher, A. M., Hammad, T., Leufkens, H. G. M., and de Vries, F., Cancer recording in patients with and without type 2 diabetes in the Clinical Practice Research Datalink primary care data and linked hospital admission data: a cohort study, BMJ Open, vol. 8, p. e020827, 2018.
R. Alsaggaf, St George, D. M. M., Zhan, M., Pfeiffer, R. M., Wang, Y., Wagner, K. R., Greene, M. H., Amr, S., and Gadalla, S. M., Cancer Risk in Myotonic Dystrophy Type I: Evidence of a Role for Disease Severity, JNCI Cancer Spectr, vol. 2, p. pky052, 2018.
C. Becker, Schneider, C., Aballea, S., Bailey, C., Bourne, R., Jick, S., and Meier, C., Cataract in patients with diabetes mellitus-incidence rates in the UK and risk factors, Eye (Lond), vol. 32, pp. 1028-1035, 2018.
M. Smith, Herrington, W. G., Weldegiorgis, M., Hobbs, F. R., Bankhead, C., and Woodward, M., Change in Albuminuria and Risk of Renal and Cardiovascular Outcomes: Natural Variation Should Be Taken into Account, Kidney Int Rep, vol. 3, pp. 939-949, 2018.
J. Wilding, Godec, T., Khunti, K., Pocock, S., Fox, R., Smeeth, L., Clauson, P., Fenici, P., Hammar, N., and Medina, J., Changes in HbA1c and weight, and treatment persistence, over the 18 months following initiation of second-line therapy in patients with type 2 diabetes: results from the United Kingdom Clinical Practice Research Datalink, BMC Med, vol. 16, p. 116, 2018.
S. Wilkinson, Douglas, I., Stirnadel-Farrant, H., Fogarty, D., Pokrajac, A., Smeeth, L., and Tomlinson, L., Changing use of antidiabetic drugs in the UK: trends in prescribing 2000-2017, BMJ Open, vol. 8, p. e022768, 2018.
M. Iwagami, Caplin, B., Smeeth, L., Tomlinson, L. A., and Nitsch, D., Chronic kidney disease and cause-specific hospitalisation: a matched cohort study using primary and secondary care patient data, Br J Gen Pract, vol. 68, pp. e512-e523, 2018.
A. D. Morgan, Rothnie, K. J., Bhaskaran, K., Smeeth, L., and Quint, J. K., Chronic obstructive pulmonary disease and the risk of 12 cardiovascular diseases: a population-based study using UK primary care data, Thorax, vol. 73, pp. 877-879, 2018.
[Page last reviewed 6 June 2019]