Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,400 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 5 February 2020) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 197 pages)


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D. Ilo, Raluy-Callado, M., Graham-Clarke, P., Sadasivan, R., Birt, J., Donaldson, R., Zhu, E., Kirby, M. G., and Neasham, D., Patient characteristics and treatment patterns for patients with benign prostatic hyperplasia, erectile dysfunction or co-occurring benign prostatic hyperplasia and erectile dysfunction in general practices in the UK: a retrospective observational study, Int J Clin Pract, vol. 69, pp. 853-62, 2015.
M. J. Ridd, Ferreira, D. L., Montgomery, A. A., Salisbury, C., and Hamilton, W., Patient-doctor continuity and diagnosis of cancer: electronic medical records study in general practice, Br J Gen Pract, vol. 65, pp. e305-11, 2015.
Y. Vinogradova, Coupland, C., Brindle, P., and Hippisley-Cox, J., Patients who discontinued statin treatment: a protocol for cohort study using primary care data, BMJ Open, vol. 5, p. e008701, 2015.
T. P. Chu, Shah, A., Walker, D., and Coleman, M. P., Pattern of symptoms and signs of primary intracranial tumours in children and young adults: a record linkage study, Arch Dis Child, vol. 100, pp. 1115-22, 2015.
F. X. Lamy, Chollet, J., Clay, E., Brignone, M., Rive, B., and Saragoussi, D., Pharmacotherapeutic strategies for patients treated for depression in UK primary care: a database analysis, Curr Med Res Opin, vol. 31, pp. 795-807, 2015.
D. Levin, Bell, S., Sund, R., Hartikainen, S. A., Tuomilehto, J., Pukkala, E., Keskimaki, I., Badrick, E., Renehan, A. G., Buchan, I. E., Bowker, S. L., Minhas-Sandhu, J. K., Zafari, Z., Marra, C., Johnson, J. A., Stricker, B. H., Uitterlinden, A. G., Hofman, A., Ruiter, R., de Keyser, C. E., MacDonald, T. M., Wild, S. H., McKeigue, P. M., and Colhoun, H. M., Pioglitazone and bladder cancer risk: a multipopulation pooled, cumulative exposure analysis, Diabetologia, vol. 58, pp. 493-504, 2015.
S. G. Bruderer, Bodmer, M., Jick, S. S., and Meier, C. R., Poorly controlled type 2 diabetes mellitus is associated with a decreased risk of incident gout: a population-based case-control study, Ann Rheum Dis, vol. 74, pp. 1651-8, 2015.
B. M. Hicks, Murray, L. J., Hughes, C., and Cardwell, C. R., Post-diagnostic oral bisphosphonate use and colorectal cancer mortality: a population-based cohort study within the UK Clinical Practice Research Datalink, Br J Cancer, vol. 113, pp. 123-6, 2015.
E. Edson-Heredia, Zhu, B., Lefevre, C., Wang, M., Barrett, A., Bushe, C. J., Cox, A., Wu, J. J., and Maeda-Chubachi, T., Prevalence and incidence rates of cardiovascular, autoimmune, and other diseases in patients with psoriatic or psoriatic arthritis: a retrospective study using Clinical Practice Research Datalink, J Eur Acad Dermatol Venereol, vol. 29, pp. 955-63, 2015.
S. Jick, Li, L., Gastanaga, V. M., and Liede, A., Prevalence of hypercalcemia of malignancy among cancer patients in the UK: analysis of the Clinical Practice Research Datalink database, Cancer Epidemiol, vol. 39, pp. 901-7, 2015.
M. J. Horspool, Julious, S. A., Mooney, C., May, R., Sully, B., and Smithson, W. H., Preventing and Lessening Exacerbations of Asthma in School-aged children Associated with a New Term (PLEASANT): Recruiting Primary Care Research Sites-the PLEASANT experience, NPJ Prim Care Respir Med, vol. 25, p. 15066, 2015.
J. C. Wilson, Toovey, S., Jick, S. S., and Meier, C. R., Previously diagnosed influenza infections and the risk of developing epilepsy, Epidemiol Infect, vol. 143, pp. 2408-15, 2015.
E. Kontopantelis, Olier, I., Planner, C., Reeves, D., Ashcroft, D. M., Gask, L., Doran, T., and Reilly, S., Primary care consultation rates among people with and without severe mental illness: a UK cohort study using the Clinical Practice Research Datalink, BMJ Open, vol. 5, p. e008650, 2015.
A. Fildes, Charlton, J., Rudisill, C., Littlejohns, P., Prevost, A. T., and Gulliford, M. C., Probability of an Obese Person Attaining Normal Body Weight: Cohort Study Using Electronic Health Records, Am J Public Health, vol. 105, pp. e54-9, 2015.
S. Mt-Isa, Tomlin, S., Sutcliffe, A., Underwood, M., Williamson, P., Croft, N. M., and Ashby, D., Prokinetics prescribing in paediatrics: evidence on cisapride, domperidone, and metoclopramide, J Pediatr Gastroenterol Nutr, vol. 60, pp. 508-14, 2015.
R. Parisi, Rutter, M. K., Lunt, M., Young, H. S., Symmons, D. P. M., Griffiths, C. E. M., and Ashcroft, D. M., Psoriasis and the Risk of Major Cardiovascular Events: Cohort Study Using the Clinical Practice Research Datalink, J Invest Dermatol, vol. 135, pp. 2189-2197, 2015.
A. Gadoud, Kane, E., Macleod, U., Ansell, P., Oliver, S., and Johnson, M., Palliative care among heart failure patients in primary care: a comparison to cancer patients using English family practice data, PLoS One, vol. 9, p. e113188, 2014.
A. V. Margulis, Kang, E. M., and Hammad, T. A., Patterns of prescription of antidepressants and antipsychotics across and within pregnancies in a population-based UK cohort, Matern Child Health J, vol. 18, pp. 1742-52, 2014.
J. Hippisley-Cox, Coupland, C., and Brindle, P., The performance of seven QPrediction risk scores in an independent external sample of patients from general practice: a validation study, BMJ Open, vol. 4, p. e005809, 2014.
A. Dregan, van Staa, T. P., McDermott, L., McCann, G., Ashworth, M., Charlton, J., Wolfe, C. D., Rudd, A., Yardley, L., Gulliford, M. C., and Steering, C. Trial, Point-of-care cluster randomized trial in stroke secondary prevention using electronic health records, Stroke, vol. 45, pp. 2066-71, 2014.
A. M. Gallagher, van Staa, T. P., Murray-Thomas, T., Schoof, N., Clemens, A., Ackermann, D., and Bartels, D. B., Population-based cohort study of warfarin-treated patients with atrial fibrillation: incidence of cardiovascular and bleeding outcomes, BMJ Open, vol. 4, p. e003839, 2014.
L. J. Murray, Cooper, J. A., Hughes, C. M., Powe, D. G., and Cardwell, C. R., Post-diagnostic prescriptions for low-dose aspirin and breast cancer-specific survival: a nested case-control study in a breast cancer cohort from the UK Clinical Practice Research Datalink, Breast Cancer Res, vol. 16, p. R34, 2014.
M. C. Bradley, Motterlini, N., Padmanabhan, S., Cahir, C., Williams, T., Fahey, T., and Hughes, C. M., Potentially inappropriate prescribing among older people in the United Kingdom, BMC Geriatr, vol. 14, p. 72, 2014.
T. P. van Staa, Gulliford, M., Ng, E. S., Goldacre, B., and Smeeth, L., Prediction of cardiovascular risk using Framingham, ASSIGN and QRISK2: how well do they predict individual rather than population risk?, PLoS One, vol. 9, p. e106455, 2014.
T. P. van Staa, Carr, D. F., O'Meara, H., McCann, G., and Pirmohamed, M., Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment, Br J Clin Pharmacol, vol. 78, pp. 649-59, 2014.
A. A. Sultan, Tata, L. J., Fleming, K. M., Crooks, C. J., Ludvigsson, J. F., Dhalwani, N. N., Ban, L., and West, J., Pregnancy complications and adverse birth outcomes among women with celiac disease: a population-based study from England, Am J Gastroenterol, vol. 109, pp. 1653-61, 2014.
A. McGrogan, Snowball, J., and de Vries, C. S., Pregnancy losses in women with Type 1 or Type 2 diabetes in the UK: an investigation using primary care records, Diabet Med, vol. 31, pp. 357-65, 2014.
H. Mullerova, Lu, C., Li, H., and Tabberer, M., Prevalence and burden of breathlessness in patients with chronic obstructive pulmonary disease managed in primary care, PLoS One, vol. 9, p. e85540, 2014.
K. Jameson, Jick, S., Hagberg, K. W., Ambegaonkar, B., Giles, A., and O'Donoghue, D., Prevalence and management of chronic kidney disease in primary care patients in the UK, Int J Clin Pract, vol. 68, pp. 1110-21, 2014.
J. Sondergaard and Halling, A., The PROTECCT-M study: a cohort study investigating associations between novel specific biomarkers, patient-related, healthcare system markers and the trajectory of COPD patients treated in primary care, BMC Pulm Med, vol. 14, p. 88, 2014.
K. B. Filion, Chateau, D., Targownik, L. E., Gershon, A., Durand, M., Tamim, H., Teare, G. F., Ravani, P., Ernst, P., and Dormuth, C. R., Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis, Gut, vol. 63, pp. 552-8, 2014.
C. J. Sammon, McGrogan, A., Snowball, J., and de Vries, C. S., Pandemic influenza vaccination during pregnancy: an investigation of vaccine uptake during the 2009/10 pandemic vaccination campaign in Great Britain, Hum Vaccin Immunother, vol. 9, pp. 917-23, 2013.
H. A. van den Ham, Klungel, O. H., Leufkens, H. G., and van Staa, T. P., The patterns of anticoagulation control and the risk of stroke, bleeding and mortality in patients with non-valvular atrial fibrillation, J Thromb Haemost, vol. 11, pp. 107-15, 2013.
A. Lalmohamed, Macgregor, A. J., de Vries, F., Leufkens, H. G., and van Staa, T. P., Patterns of risk of cancer in patients with metal-on-metal hip replacements versus other bearing surface types: a record linkage study between a prospective joint registry and general practice electronic health records in England, PLoS One, vol. 8, p. e65891, 2013.
N. M. Davies, Gunnell, D., Thomas, K. H., Metcalfe, C., Windmeijer, F., and Martin, R. M., Physicians' prescribing preferences were a potential instrument for patients' actual prescriptions of antidepressants, J Clin Epidemiol, vol. 66, pp. 1386-96, 2013.
L. Wei, MacDonald, T. M., and Mackenzie, I. S., Pioglitazone and bladder cancer: a propensity score matched cohort study, Br J Clin Pharmacol, vol. 75, pp. 254-9, 2013.
D. J. Humes, Radcliffe, R. S., Camm, C., and West, J., Population-based study of presentation and adverse outcomes after femoral hernia surgery, Br J Surg, vol. 100, pp. 1827-32, 2013.
D. Culliford, Maskell, J., Judge, A., and Arden, N. K., A population-based survival analysis describing the association of body mass index on time to revision for total hip and knee replacements: results from the UK general practice research database, BMJ Open, vol. 3, p. e003614, 2013.
J. Hippisley-Cox and Coupland, C., Predicting risk of emergency admission to hospital using primary care data: derivation and validation of QAdmissions score, BMJ Open, vol. 3, p. e003482, 2013.
B. Taylor, Jick, H., and Maclaughlin, D., Prevalence and incidence rates of autism in the UK: time trend from 2004-2010 in children aged 8 years, BMJ Open, vol. 3, p. e003219, 2013.
S. E. Holden, Jenkins-Jones, S., Poole, C. D., Morgan, C. L., Coghill, D., and Currie, C. J., The prevalence and incidence, resource use and financial costs of treating people with attention deficit/hyperactivity disorder (ADHD) in the United Kingdom (1998 to 2010), Child Adolesc Psychiatry Ment Health, vol. 7, p. 34, 2013.
S. J. Evans, Douglas, I., Rawlins, M. D., Wexler, N. S., Tabrizi, S. J., and Smeeth, L., Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records, J Neurol Neurosurg Psychiatry, vol. 84, pp. 1156-60, 2013.
F. K. Varyani, West, J., and Card, T. R., Primary biliary cirrhosis does not increase the risk of UTIs following diagnosis compared to other chronic liver diseases?, Liver Int, vol. 33, pp. 384-8, 2013.
C. L. Morgan, Owens, D. R., Aubonnet, P., Carr, E. S., Jenkins-Jones, S., Poole, C. D., and Currie, C. J., Primary prevention of diabetic retinopathy with fibrates: a retrospective, matched cohort study, BMJ Open, vol. 3, p. e004025, 2013.
R. K. Hernandez, Do, T. P., Critchlow, C. W., Dent, R. E., and Jick, S. S., Patient-related risk factors for fracture-healing complications in the United Kingdom General Practice Research Database, Acta Orthop, vol. 83, pp. 653-60, 2012.
L. Li, Roddam, A., Gitlin, M., Taylor, A., Shepherd, S., Shearer, A., and Jick, S., Persistence with osteoporosis medications among postmenopausal women in the UK General Practice Research Database, Menopause, vol. 19, pp. 33-40, 2012.
R. W. Platt, Delaney, J. A., and Suissa, S., The positivity assumption and marginal structural models: the example of warfarin use and risk of bleeding, Eur J Epidemiol, vol. 27, pp. 77-83, 2012.
S. Toovey, Prinssen, E. P., Rayner, C. R., Thakrar, B. T., Dutkowski, R., Koerner, A., Chu, T., Sirzen-Zelenskaya, A., Britschgi, M., Bansod, S., and Donner, B., Post-marketing assessment of neuropsychiatric adverse events in influenza patients treated with oseltamivir: an updated review, Adv Ther, vol. 29, pp. 826-48, 2012.
T. P. Staa, Goldacre, B., Gulliford, M., Cassell, J., Pirmohamed, M., Taweel, A., Delaney, B., and Smeeth, L., Pragmatic randomised trials using routine electronic health records: putting them to the test, Bmj, vol. 344, p. e55, 2012.
[Page last reviewed 5 February 2020]