Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 December 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 193 pages)


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R. A. Charlton, Snowball, J. M., Bloomfield, K., and de Vries, C. S., Colorectal cancer risk reduction following macrogol exposure: a cohort and nested case control study in the UK, PLoS One, vol. 8, p. e83203, 2013.
C. J. Crooks, West, J., and Card, T. R., Comorbidities affect risk of nonvariceal upper gastrointestinal bleeding, Gastroenterology, vol. 144, pp. 1384-93, 1393.e1-2; quiz e18-9, 2013.
S. L. Brilleman and Salisbury, C., Comparing measures of multimorbidity to predict outcomes in primary care: a cross sectional study, Fam Pract, vol. 30, pp. 172-8, 2013.
E. Herrett, Shah, A. D., Boggon, R., Denaxas, S., Smeeth, L., Van Staa, T., Timmis, A., and Hemingway, H., Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records: cohort study, Bmj, vol. 346, p. f2350, 2013.
L. Azoulay, Dell'Aniello, S., Simon, T., Renoux, C., and Suissa, S., The concurrent use of antithrombotic therapies and the risk of bleeding in patients with atrial fibrillation, Thromb Haemost, vol. 109, pp. 431-9, 2013.
F. Lapi, Azoulay, L., Yin, H., Nessim, S. J., and Suissa, S., Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study, Bmj, vol. 346, p. e8525, 2013.
R. J. Pitman, Nagy, L. D., and Sculpher, M. J., Cost-effectiveness of childhood influenza vaccination in England and Wales: Results from a dynamic transmission model, Vaccine, vol. 31, pp. 927-42, 2013.
J. Hong, Reed, C., Novick, D., and Happich, M., Costs associated with treatment of chronic low back pain: an analysis of the UK General Practice Research Database, Spine (Phila Pa 1976), vol. 38, pp. 75-82, 2013.
N. M. Davies, Smith, G. D., Windmeijer, F., and Martin, R. M., COX-2 selective nonsteroidal anti-inflammatory drugs and risk of gastrointestinal tract complications and myocardial infarction: an instrumental variable analysis, Epidemiology, vol. 24, pp. 352-62, 2013.
G. Singh, Bell, G. S., Driever, P. H., and Sander, J. W., Cancer risk in people with epilepsy using valproate-sodium, Acta Neurol Scand, vol. 125, pp. 234-40, 2012.
A. Lalmohamed, Bazelier, M. T., van Staa, T. P., Uitdehaag, B. M., Leufkens, H. G., de Boer, A., and de Vries, F., Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study, Eur J Neurol, vol. 19, pp. 1007-14, 2012.
A. Berger, Sadosky, A., Dukes, E., Edelsberg, J., and Oster, G., Clinical characteristics and patterns of healthcare utilization in patients with painful neuropathic disorders in UK general practice: a retrospective cohort study, BMC Neurol, vol. 12, p. 8, 2012.
E. A. Shephard, Stapley, S., Neal, R. D., Rose, P., Walter, F. M., and Hamilton, W. T., Clinical features of bladder cancer in primary care, Br J Gen Pract, vol. 62, pp. e598-604, 2012.
I. J. Douglas, Evans, S. J., Hingorani, A. D., Grosso, A. M., Timmis, A., Hemingway, H., and Smeeth, L., Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs, Bmj, vol. 345, p. e4388, 2012.
A. Dregan, Van Staa, T., McDermott, L., McCann, G., Ashworth, M., Charlton, J., Wolfe, C., Rudd, A., Yardley, L., and Gulliford, M., Cluster randomized trial in the general practice research database: 2. Secondary prevention after first stroke (eCRT study): study protocol for a randomized controlled trial, Trials, vol. 13, p. 181, 2012.
A. Bakhai, Rigney, U., Hollis, S., and Emmas, C., Co-administration of statins with cytochrome P450 3A4 inhibitors in a UK primary care population, Pharmacoepidemiol Drug Saf, vol. 21, pp. 485-93, 2012.
N. Bhattarai, Charlton, J., Rudisill, C., and Gulliford, M. C., Coding, recording and incidence of different forms of coronary heart disease in primary care, PLoS One, vol. 7, p. e29776, 2012.
R. Charlton, Snowball, J., Bloomfield, K., and de Vries, C., Colorectal cancer incidence on the General Practice Research Database, Pharmacoepidemiol Drug Saf, vol. 21, pp. 775-783, 2012.
N. M. Hawkins, Scholes, S., Bajekal, M., Love, H., O'Flaherty, M., Raine, R., and Capewell, S., Community care in England: reducing socioeconomic inequalities in heart failure, Circulation, vol. 126, pp. 1050-7, 2012.
H. Li, Hodgson, E., Watson, L., Shukla, A., and Nelson, J. J., Comorbidities and Concomitant Medication Use in Men with Prostate Cancer or High Levels of PSA Compared to Matched Controls: A GPRD Analysis, J Cancer Epidemiol, vol. 2012, p. 291704, 2012.
D. C. Perry, Bruce, C. E., Pope, D., Dangerfield, P., Platt, M. J., and Hall, A. J., Comorbidities in Perthes' disease: a case control study using the General Practice Research database, J Bone Joint Surg Br, vol. 94, pp. 1684-9, 2012.
H. Jick, Wilson, A., Wiggins, P., and Chamberlain, D. P., Comparison of prescription drug costs in the United States and the United Kingdom, part 2: proton pump inhibitors, Pharmacotherapy, vol. 32, pp. 489-92, 2012.
R. Boggon, Eaton, S., Timmis, A., Hemingway, H., Gabriel, H., Minhas, I., and van Staa, T. P., Current prescribing of statins and persistence to statins following ACS in the UK: a MINAP/GPRD study, Br J Cardiol, vol. 19, p. 24, 2012.
D. Prieto-Alhambra, Javaid, M. K., Maskell, J., Judge, A., Nevitt, M., Cooper, C., and Arden, N. K., Changes in hip fracture rate before and after total knee replacement due to osteoarthritis: a population-based cohort study, Ann Rheum Dis, vol. 70, pp. 134-8, 2011.
R. Boggon, van Staa, T. P., Timmis, A., Hemingway, H., Ray, K. K., Begg, A., Emmas, C., and Fox, K. A., Clopidogrel discontinuation after acute coronary syndromes: frequency, predictors and associations with death and myocardial infarction–a hospital registry-primary care linked cohort (MINAP-GPRD), Eur Heart J, vol. 32, pp. 2376-86, 2011.
M. C. Gulliford, Van Staa, T., McDermott, L., Dregan, A., McCann, G., Ashworth, M., Charlton, J., Grieve, A. P., Little, P., Moore, M. V., and Yardley, L., Cluster randomised trial in the General Practice Research Database: 1. Electronic decision support to reduce antibiotic prescribing in primary care (eCRT study), Trials, vol. 12, p. 115, 2011.
R. A. Charlton, Weil, J. G., Cunnington, M. C., Ray, S., and de Vries, C. S., Comparing the General Practice Research Database and the UK Epilepsy and Pregnancy Register as tools for postmarketing teratogen surveillance: anticonvulsants and the risk of major congenital malformations, Drug Saf, vol. 34, pp. 157-71, 2011.
T. P. van Staa, Setakis, E., Di Tanna, G. L., Lane, D. A., and Lip, G. Y., A comparison of risk stratification schemes for stroke in 79,884 atrial fibrillation patients in general practice, J Thromb Haemost, vol. 9, pp. 39-48, 2011.
L. Parkin, Hagberg, K. W., and Jick, H., Comprehensive comparison of drug prescribing in the United States and United Kingdom, Pharmacotherapy, vol. 31, pp. 623-9, 2011.
D. J. Humes, Fleming, K. M., Spiller, R. C., and West, J., Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study, Gut, vol. 60, pp. 219-24, 2011.
L. Azoulay, Dell'Aniello, S., Huiart, L., Fort, G. G. du, and Suissa, S., Concurrent use of tamoxifen with CYP2D6 inhibitors and the risk of breast cancer recurrence, Breast Cancer Res Treat, vol. 126, pp. 695-703, 2011.
C. Becker, Brobert, G. P., Johansson, S., Jick, S. S., and Meier, C. R., Cancer risk in association with Parkinson disease: a population-based study, Parkinsonism Relat Disord, vol. 16, pp. 186-90, 2010.
K. Abuabara, Azfar, R. S., Shin, D. B., Neimann, A. L., Troxel, A. B., and Gelfand, J. M., Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the U.K, Br J Dermatol, vol. 163, pp. 586-92, 2010.
C. Schneider, Bothner, U., Jick, S. S., and Meier, C. R., Chronic obstructive pulmonary disease and the risk of cardiovascular diseases, Eur J Epidemiol, vol. 25, pp. 253-60, 2010.
L. Azoulay, Schneider-Lindner, V., Dell'Aniello, S., Schiffrin, A., and Suissa, S., Combination therapy with sulfonylureas and metformin and the prevention of death in type 2 diabetes: a nested case-control study, Pharmacoepidemiol Drug Saf, vol. 19, pp. 335-42, 2010.
F. de Vries, Setakis, E., and van Staa, T. P., Concomitant use of ibuprofen and paracetamol and the risk of major clinical safety outcomes, Br J Clin Pharmacol, vol. 70, pp. 429-38, 2010.
N. F. Khan, Ward, A. M., Watson, E., and Rose, P. W., Consulting and prescribing behaviour for anxiety and depression in long-term survivors of cancer in the UK, Eur J Cancer, vol. 46, pp. 3339-44, 2010.
C. Schneider, Jick, S. S., Bothner, U., and Meier, C. R., COPD and the risk of depression, Chest, vol. 137, pp. 341-7, 2010.
I. C. Wong, Asherson, P., Bilbow, A., Clifford, S., Coghill, D., DeSoysa, R., Hollis, C., McCarthy, S., Murray, M., Planner, C., Potts, L., Sayal, K., and Taylor, E., Cessation of attention deficit hyperactivity disorder drugs in the young (CADDY)–a pharmacoepidemiological and qualitative study, Health Technol Assess, vol. 13, pp. iii-iv, ix-xi, 1-120, 2009.
R. Ackers, Besag, F. M., Wade, A., Murray, M. L., and Wong, I. C., Changing trends in antiepileptic drug prescribing in girls of child-bearing potential, Arch Dis Child, vol. 94, pp. 443-7, 2009.
A. Ruigomez, Masso-Gonzalez, E. L., Johansson, S., Wallander, M. A., and Garcia-Rodriguez, L. A., Chest pain without established ischaemic heart disease in primary care patients: associated comorbidities and mortality, Br J Gen Pract, vol. 59, pp. e78-86, 2009.
L. A. Garcia Rodriguez, Wallander, M. A., Tolosa, L. B., and Johansson, S., Chronic obstructive pulmonary disease in UK primary care: incidence and risk factors, Copd, vol. 6, pp. 369-79, 2009.
M. O. Bernier, Mikaeloff, Y., Hudson, M., and Suissa, S., Combined oral contraceptive use and the risk of systemic lupus erythematosus, Arthritis Rheum, vol. 61, pp. 476-81, 2009.
M. A. Feudjo-Tepie, Le Roux, G., Beach, K. J., Bennett, D., and Robinson, N. J., Comorbidities of idiopathic thrombocytopenic purpura: a population-based study, Adv Hematol, vol. 2009, p. 963506, 2009.
T. P. van Staa, Leufkens, H. G., Zhang, B., and Smeeth, L., A comparison of cost effectiveness using data from randomized trials or actual clinical practice: selective cox-2 inhibitors as an example, PLoS Med, vol. 6, p. e1000194, 2009.
R. De Natale, Lafuma, A., and Berdeaux, G., Cost effectiveness of travoprost versus a fixed combination of latanoprost/timolol in patients with ocular hypertension or glaucoma: analysis based on the UK general practitioner research database, Clin Drug Investig, vol. 29, pp. 111-20, 2009.
[Page last reviewed 6 December 2019]