Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 June 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 183 pages)


Export 2252 results:
Author Title Type [ Year(Asc)]
C. L. Morgan, Qiao, Q., Grandy, S., Johnsson, K., Jenkins-Jones, S., Holden, S., and Currie, C. J., Glucose Control and Weight Change Associated with Treatment with Exenatide Compared with Basal Insulin: A Retrospective Study, Diabetes Ther, vol. 9, pp. 269-283, 2018.
C. Rebordosa, Plana, E., Aguado, J., Thomas, S., Garcia-Gil, E., Perez-Gutthann, S., and Castellsague, J., GOLD assessment of COPD severity in the Clinical Practice Research Datalink (CPRD), Pharmacoepidemiol Drug Saf, 2018.
M. Kerkhof, Tran, T. N., Soriano, J. B., Golam, S., Gibson, D., Hillyer, E. V., and Price, D. B., Healthcare resource use and costs of severe, uncontrolled eosinophilic asthma in the UK general population, Thorax, vol. 73, pp. 116-124, 2018.
H. Otete, Fleming, M. K., West, J., and Orton, E., Healthcare Utilisation, Morbidities and Alcohol Use Monitoring Prior to Alcoholic Psychosis Diagnosis, Alcohol Alcohol, 2018.
S. Vanni, Zattoni, M., Moda, F., Giaccone, G., Tagliavini, F., Haik, S., Deslys, J. P., Zanusso, G., Ironside, J. W., Carmona, M., Ferrer, I., Kovacs, G. G., and Legname, G., Hemoglobin mRNA Changes in the Frontal Cortex of Patients with Neurodegenerative Diseases, Front Neurosci, vol. 12, p. 8, 2018.
R. Kumar, Hepatitis B virus infection and diabetes mellitus: An adverse relationship A letter in response to Incidence and prevalence of hepatitis B in patients with diabetes mellitus in the UK: A population-based cohort study using the UK Clinical Practice Researc, J Viral Hepat, vol. 25, p. 1401, 2018.
M. Ardissino, Moussa, O., Tang, A., Muttoni, E., Ziprin, P., and Purkayastha, S., Idiopathic intracranial hypertension in the British population with obesity, Acta Neurochir (Wien), 2018.
M. Hickman, Steer, C., Tilling, K., Lim, A. G., Marsden, J., Millar, T., Strang, J., Telfer, M., Vickerman, P., and Macleod, J., The impact of buprenorphine and methadone on mortality: a primary care cohort study in the United Kingdom, Addiction, vol. 113, pp. 1461-1476, 2018.
E. Martin-Merino, Calderon-Larranaga, A., Hawley, S., Poblador-Plou, B., Llorente-Garcia, A., Petersen, I., and Prieto-Alhambra, D., The impact of different strategies to handle missing data on both precision and bias in a drug safety study: a multidatabase multinational population-based cohort study, Clin Epidemiol, vol. 10, pp. 643-654, 2018.
C. J. Currie, Holden, S. E., Jenkins-Jones, S., Morgan, C. L., Voss, B., Rajpathak, S. N., Alemayehu, B., Peters, J. R., and Engel, S. S., Impact of differing glucose-lowering regimens on the pattern of association between glucose control and survival, Diabetes Obes Metab, vol. 20, pp. 821-830, 2018.
J. Daugherty, Lin, X., Baxter, R., Suruki, R., and Bradford, E., The impact of long-term systemic glucocorticoid use in severe asthma: A UK retrospective cohort analysis, J Asthma, vol. 55, pp. 651-658, 2018.
J. L. Atkins, Delgado, J., Pilling, L. C., Bowman, K., Masoli, J. A. H., Kuchel, G. A., Ferrucci, L., and Melzer, D., Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts, J Gerontol A Biol Sci Med Sci, 2018.
E. Cecil, Bottle, A., Ma, R., Hargreaves, D. S., Wolfe, I., ,, and Saxena, S., Impact of preventive primary care on children's unplanned hospital admissions: a population-based birth cohort study of UK children 2000-2013, BMC Med, vol. 16, p. 151, 2018.
K. C. Chang, Vamos, E. P., Palladino, R., Majeed, A., Lee, J. T., and Millett, C., Impact of the NHS Health Check on inequalities in cardiovascular disease risk: a difference-in-differences matching analysis, J Epidemiol Community Health, 2018.
C. L. Morgan, Inzucchi, S. E., Puelles, J., Jenkins-Jones, S., and Currie, C. J., Impact of treatment with pioglitazone on stroke outcomes: A real-world database analysis, Diabetes Obes Metab, vol. 20, pp. 2140-2147, 2018.
G. L. C. Ferreira, Marano, C., De Moerlooze, L., Guignard, A., Feng, Y., Y. Hahi, E., and Van Staa, T., Incidence and prevalence of hepatitis B in patients with diabetes mellitus in the UK: A population-based cohort study using the UK Clinical Practice Research Datalink, J Viral Hepat, vol. 25, pp. 571-580, 2018.
J. C. Wilson, Sarsour, K., Gale, S., Petho-Schramm, A., Jick, S. S., and Meier, C. R., Incidence and risk of glucocorticoid-associated adverse effects in patients with rheumatoid arthritis, Arthritis Care Res (Hoboken), 2018.
R. Y. van der Velde, Wyers, C. E., Geusens, P., van den Bergh, J. P. W., de Vries, F., Cooper, C., van de Staa, T. P., and Harvey, N. C., Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older, Osteoporos Int, vol. 29, pp. 2469-2475, 2018.
H. Strongman, Kausar, I., and Maher, T. M., Incidence, Prevalence, and Survival of Patients with Idiopathic Pulmonary Fibrosis in the UK, Adv Ther, vol. 35, pp. 724-736, 2018.
J. G. Royle, Lanyon, P. C., Grainge, M. J., Abhishek, A., and Pearce, F. A., The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink, Clin Rheumatol, vol. 37, pp. 2103-2111, 2018.
R. J. Partington, Muller, S., Helliwell, T., Mallen, C. D., and A. Sultan, A., Incidence, prevalence and treatment burden of polymyalgia rheumatica in the UK over two decades: a population-based study, Ann Rheum Dis, vol. 77, pp. 1750-1756, 2018.
C. Conradt, Guo, D., Miclea, A., Nisslein, T., Ismail, C., Chatamra, K., and Andersohn, F., Increased Prevalence of Polyneuropathy in Parkinson's Disease Patients: An Observational Study, J Parkinsons Dis, vol. 8, pp. 141-144, 2018.
M. Simeonova, de Vries, F., Pouwels, S., Driessen, J. H. M., Leufkens, H. G. M., Cadarette, S. M., and Burden, A. M., Increased risk of all-cause mortality associated with domperidone use in Parkinson's patients: a population-based cohort study in the UK, Br J Clin Pharmacol, vol. 84, pp. 2551-2561, 2018.
E. Richardson, Bedson, J., Chen, Y., Lacey, R., and Dunn, K. M., Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: A matched cohort study in the Clinical Practice Research Datalink, Eur J Pain, vol. 22, pp. 1701-1708, 2018.
D. Abrahami, Douros, A., Yin, H., Yu, O. H., Faillie, J. L., Montastruc, F., Platt, R. W., Bouganim, N., and Azoulay, L., Incretin based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: population based cohort study, Bmj, vol. 363, p. k4880, 2018.
D. Abrahami, Yin, H., Yu, O. H. Y., Pollak, M. N., and Azoulay, L., Incretin-based Drugs and the Incidence of Colorectal Cancer in Patients with Type 2 Diabetes, Epidemiology, vol. 29, pp. 246-253, 2018.
A. Jain, van Hoek, A. J., Walker, J. L., Forbes, H. J., Langan, S. M., Root, A., Smeeth, L., and Thomas, S. L., Inequalities in zoster disease burden: a population-based cohort study to identify social determinants using linked data from the U.K. Clinical Practice Research Datalink, Br J Dermatol, vol. 178, pp. 1324-1330, 2018.
A. Matcho, Ryan, P., Fife, D., Gifkins, D., Knoll, C., and Friedman, A., Inferring pregnancy episodes and outcomes within a network of observational databases, PLoS One, vol. 13, p. e0192033, 2018.
S. R. Markar, Arhi, C., Leusink, A., Vidal-Diez, A., Karthikesalingam, A., Darzi, A., Lagergren, J., and Hanna, G. B., The Influence of Antireflux Surgery on Esophageal Cancer Risk in England: National Population-based Cohort Study, Ann Surg, vol. 268, pp. 861-867, 2018.
V. Prasad, West, J., Sayal, K., and Kendrick, D., Injury among children and young people with and without attention-deficit hyperactivity disorder in the community: The risk of fractures, thermal injuries, and poisonings, Child Care Health Dev, vol. 44, pp. 871-878, 2018.
D. E. Robinson, van Staa, T. P., Dennison, E. M., Cooper, C., and Dixon, W. G., The limitations of using simple definitions of glucocorticoid exposure to predict fracture risk: A cohort study, Bone, vol. 117, pp. 83-90, 2018.
E. Badrick, Renehan, I., and Renehan, A. G., Linkage of the UK Clinical Practice Research Datalink with the national cancer registry, Eur J Epidemiol, 2018.
M. Sabido, Thilo, H., and Guido, G., Long-term effectiveness of bisoprolol in patients with angina: A real-world evidence study, Pharmacol Res, vol. 139, pp. 106-112, 2018.
U. Koppe, Nitsch, D., Mansfield, K. E., Mathur, R., Bhaskaran, K., Batterham, R. L., Smeeth, L., and Douglas, I. J., Long-term effects of bariatric surgery on acute kidney injury: a propensity-matched cohort in the UK Clinical Practice Research Datalink, BMJ Open, vol. 8, p. e020371, 2018.
A. D. Mosholder, Lee, J. Y., Zhou, E. H., Kang, E. M., Ghosh, M., Izem, R., Major, J. M., and Graham, D. J., Long-Term Risk of Acute Myocardial Infarction, Stroke, and Death With Outpatient Use of Clarithromycin: A Retrospective Cohort Study, Am J Epidemiol, vol. 187, pp. 786-792, 2018.
A. Dregan, Ravindrarajah, R., Charlton, J., Ashworth, M., and Molokhia, M., Long-term trends in antithrombotic drug prescriptions among adults aged 80 years and over from primary care: a temporal trends analysis using electronic health records, Ann Epidemiol, vol. 28, pp. 440-446, 2018.
R. M. Joseph, Ray, D. W., Keevil, B., van Staa, T. P., and Dixon, W. G., Low salivary cortisol levels in patients with rheumatoid arthritis exposed to oral glucocorticoids: a cross-sectional study set within UK electronic health records, RMD Open, vol. 4, p. e000700, 2018.
K. W. Hagberg, Robijn, A. L., and Jick, S., Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring, Clin Epidemiol, vol. 10, pp. 1599-1612, 2018.
L. Scheepers, Burden, A. M., Arts, I. C. W., Spaetgens, B., Souverein, P., de Vries, F., and Boonen, A., Medication adherence among gout patients initiated allopurinol: a retrospective cohort study in the Clinical Practice Research Datalink (CPRD), Rheumatology (Oxford), vol. 57, pp. 1641-1650, 2018.
M. Cainzos-Achirica, Varas-Lorenzo, C., Pottegard, A., Asmar, J., Plana, E., Rasmussen, L., Bizouard, G., Forns, J., Hellfritzsch, M., Zint, K., Perez-Gutthann, S., and Pladevall-Vila, M., Methodological challenges when evaluating potential off-label prescribing of drugs using electronic health care databases: A case study of dabigatran etexilate in Europe, Pharmacoepidemiol Drug Saf, vol. 27, pp. 713-723, 2018.
S. A. J. Schmidt, Langan, S. M., Pedersen, H. S., Schonheyder, H. C., Thomas, S. L., Smeeth, L., Mansfield, K. E., Sorensen, H. T., Forbes, H. J., and Vestergaard, M., Mood Disorders and Risk of Herpes Zoster in 2 Population-Based Case-Control Studies in Denmark and the United Kingdom, Am J Epidemiol, vol. 187, pp. 1019-1028, 2018.
L. Li, Neogi, T., and Jick, S., Mortality in Patients With Giant Cell Arteritis: A Cohort Study in UK Primary Care, Arthritis Care Res (Hoboken), vol. 70, pp. 1251-1256, 2018.
O. M. Moussa, Erridge, S., Chidambaram, S., Ziprin, P., Darzi, A., and Purkayastha, S., Mortality of the Severely Obese: A Population Study, Ann Surg, 2018.
K. J. Rothnie, Connell, O., Mullerova, H., Smeeth, L., Pearce, N., Douglas, I., and Quint, J. K., Myocardial Infarction and Ischemic Stroke after Exacerbations of Chronic Obstructive Pulmonary Disease, Ann Am Thorac Soc, vol. 15, pp. 935-946, 2018.
K. J. Rothnie, Mullerova, H., Smeeth, L., and Quint, J. K., Natural History of Chronic Obstructive Pulmonary Disease Exacerbations in a General Practice-based Population with Chronic Obstructive Pulmonary Disease, Am J Respir Crit Care Med, vol. 198, pp. 464-471, 2018.
E. L. Axson, Bloom, C. I., and Quint, J. K., Nontuberculous mycobacterial disease managed within UK primary care, 2006-2016, Eur J Clin Microbiol Infect Dis, vol. 37, pp. 1795-1803, 2018.
F. A. Pearce, Lanyon, P. C., Watts, R. A., Grainge, M. J., Abhishek, A., and Hubbard, R. B., Novel insights into the aetiology of granulomatosis with polyangiitis-a case-control study using the Clinical Practice Research Datalink, Rheumatology (Oxford), vol. 57, pp. 1002-1010, 2018.
E. Nortoft, Chubb, B., and Borglykke, A., Obesity and healthcare resource utilization: comparative results from the UK and the USA, Obes Sci Pract, vol. 4, pp. 41-45, 2018.
C. W. le Roux, Chubb, B., Nortoft, E., and Borglykke, A., Obesity and healthcare resource utilization: results from Clinical Practice Research Database (CPRD), Obes Sci Pract, vol. 4, pp. 409-416, 2018.
G. Glover, Williams, R., Tompkins, G., and Oyinlola, J., An observational study of the use of acute hospital care by people with intellectual disabilities in England, J Intellect Disabil Res, 2018.
[Page last reviewed 6 June 2019]