Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 5 August 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 187 pages)


Export 2296 results:
Author Title Type [ Year(Desc)]
C. I. Bloom, Ricciardi, F., Smeeth, L., Stone, P., and Quint, J. K., Predicting COPD 1-year mortality using prognostic predictors routinely measured in primary care, BMC Med, vol. 17, p. 73, 2019.
S. F. Weng, Vaz, L., Qureshi, N., and Kai, J., Prediction of premature all-cause mortality: A prospective general population cohort study comparing machine-learning and standard epidemiological approaches, PLoS One, vol. 14, p. e0214365, 2019.
J. Watson, Salisbury, C., Banks, J., Whiting, P., and Hamilton, W., Predictive value of inflammatory markers for cancer diagnosis in primary care: a prospective cohort study using electronic health records, Br J Cancer, 2019.
S. Venkatesan, Jorgensen, M. E., Manning, H. J., Andersson, C., Mozid, A. M., Coburn, M., Moonesinghe, S. R., Foex, P., Mythen, M., Grocott, M. P. W., Hardman, J. G., Myles, P. R., and Sanders, R. D., Preoperative chronic beta-blocker prescription in elderly patients as a risk factor for postoperative mortality stratified by preoperative blood pressure: a cohort study, Br J Anaesth, 2019.
T. Newlove-Delgado, Hamilton, W., Ford, T. J., Stein, K., and Ukoumunne, O. C., Prescribing for young people with attention deficit hyperactivity disorder in UK primary care: analysis of data from the Clinical Practice Research Datalink, Atten Defic Hyperact Disord, 2019.
M. J. Carr, Ashcroft, D. M., White, P. D., Kapur, N., and Webb, R. T., Prevalence of comorbid mental and physical illnesses and risks for self-harm and premature death among primary care patients diagnosed with fatigue syndromes, Psychol Med, pp. 1-8, 2019.
K. M. Abel, Hope, H., Swift, E., Parisi, R., Ashcroft, D. M., Kosidou, K., Osam, C. S., Dalman, C., and Pierce, M., Prevalence of maternal mental illness among children and adolescents in the UK between 2005 and 2017: a national retrospective cohort analysis, Lancet Public Health, vol. 4, pp. e291-e300, 2019.
V. W. Zhong, Juhaeri, J., Cole, S. R., Shay, C. M., Gordon-Larsen, P., Kontopantelis, E., and Mayer-Davis, E. J., Proximal HbA1C Level and First Hypoglycemia Hospitalization in Adults with Incident Type 2 Diabetes, J Clin Endocrinol Metab, 2019.
H. P. Booth, Gallagher, A. M., Mullett, D., Carty, L., Padmanabhan, S., Myles, P. R., Welburn, S. J., Hoghton, M., Rafi, I., and Valentine, J., Quality improvement of prescribing safety: a pilot study in primary care using UK electronic health records, Br J Gen Pract, 2019.
A. Gayle, Tebboth, A., Pang, M., Guelfucci, F., Argoubi, R., Sherman, S., and Mak, V., Real-life prescribing of asthmatic treatments in UK general practice over time using 2014 BTS/SIGN steps, NPJ Prim Care Respir Med, vol. 29, p. 25, 2019.
E. A. Shephard, Parkinson, M. A., and Hamilton, W. T., Recognising laryngeal cancer in primary care: a large case-control study using electronic records, Br J Gen Pract, vol. 69, pp. e127-e133, 2019.
X. Sun and Gulliford, M. C., Reducing antibiotic prescribing in primary care in England from 2014 to 2017: population-based cohort study, BMJ Open, vol. 9, p. e023989, 2019.
Y. Li, Molter, A., White, A., Welfare, W., Palin, V., Belmonte, M., Ashcroft, D. M., Sperrin, M., and van Staa, T. P., Relationship between prescribing of antibiotics and other medicines in primary care: a cross-sectional study, Br J Gen Pract, vol. 69, pp. e42-e51, 2019.
S. V. Ramagopalan, Stamp, E., Sammon, C. J., Besford, M., Carroll, R., Mehmud, F., and Alikhan, R., Renal function and oral anticoagulant treatment of incident non-valvular atrial fibrillation: a retrospective study, Future Cardiol, 2019.
S. Weir, Kuo, T. C., Samnaliev, M., Tierney, T. S., Manca, A., Taylor, R. S., Bruce, J., Eldabe, S., and Cumming, D., Reoperation following lumbar spinal surgery: costs and outcomes in a UK population cohort study using the Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES), Eur Spine J, 2019.
T. Newlove-Delgado, Ford, T. J., Hamilton, W., Janssens, A., Stein, K., and Ukoumunne, O. C., Resumption of attention-deficit hyperactivity disorder medication in early adulthood: findings from a UK primary care prescribing study, Eur Child Adolesc Psychiatry, 2019.
A. Uijl, Koudstaal, S., Direk, K., Denaxas, S., Groenwold, R. H. H., Banerjee, A., Hoes, A. W., Hemingway, H., and Asselbergs, F. W., Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records, Eur J Heart Fail, 2019.
J. Bedson, Chen, Y., Ashworth, J., Hayward, R. A., Dunn, K. M., and Jordan, K. P., Risk of adverse events in patients prescribed long-term opioids: A cohort study in the UK Clinical Practice Research Datalink, Eur J Pain, 2019.
E. Williamson, Denaxas, S., Morris, S., Clarke, C. S., Thomas, M., Evans, H., Direk, K., Gonzalez-Izquierdo, A., Little, P., Lund, V., Blackshaw, H., Schilder, A., Philpott, C., Hopkins, C., and Carpenter, J., Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records, Rhinology, 2019.
F. Zaccardi, Husemoen, L. L. Nystrup, Thorsted, B. L., Webb, D. R., Paul, S. K., Davies, M. J., and Khunti, K., Selectivity of beta-blockers, cardiovascular and all-cause mortality in people with hypoglycaemia: An observational study, Nutr Metab Cardiovasc Dis, vol. 29, pp. 481-488, 2019.
C. Linde, Qin, L., Bakhai, A., Furuland, H., Evans, M., Ayoubkhani, D., Palaka, E., Bennett, H., and McEwan, P., Serum potassium and clinical outcomes in heart failure patients: results of risk calculations in 21 334 patients in the UK, ESC Heart Fail, 2019.
M. Weldegiorgis, Smith, M., Herrington, W. G., Bankhead, C., and Woodward, M., Socioeconomic disadvantage and the risk of advanced chronic kidney disease: results from a cohort study with 1.4 million participants, Nephrology Dialysis Transplantation, 2019.
M. S. Chan, van den Hout, A., Pujades-Rodriguez, M., Jones, M. M., Matthews, F. E., Jagger, C., Raine, R., and Bajekal, M., Socio-economic inequalities in life expectancy of older adults with and without multimorbidity: a record linkage study of 1.1 million people in England, Int J Epidemiol, 2019.
J. Fortuny, Gilsenan, A., Cainzos-Achirica, M., Cantero, O. F., Flynn, R. W. V., Garcia-Rodriguez, L., Kollhorst, B., Karlsson, P., Linner, L., MacDonald, T. M., Plana, E., Ruigomez, A., Schink, T., Ziemiecki, R., and Andrews, E. B., Study Design and Cohort Comparability in a Study of Major Cardiovascular Events in New Users of Prucalopride Versus Polyethylene Glycol 3350, Drug Saf, 2019.
R. K. Akyea, Kai, J., Qureshi, N., Iyen, B., and Weng, S. F., Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease, Heart, 2019.
K. B. Filion, Douros, A., Azoulay, L., Yin, H., Yu, O. H., and Suissa, S., Sulfonylureas as initial treatment for type 2 diabetes and the risk of adverse cardiovascular events: A population-based cohort study, Br J Clin Pharmacol, 2019.
D. Spanopoulos, Okhai, H., Zaccardi, F., Tebboth, A., Barrett, B., Busse, M., Webb, J., and Khunti, K., Temporal variation of renal function in people with type 2 diabetes mellitus: a retrospective UK Clinical Practice Research Datalink cohort study, Diabetes Obes Metab, 2019.
C. Santella, Renoux, C., Yin, H., Yu, O. H. Y., and Azoulay, L., Testosterone Replacement Therapy and the Risk of Prostate Cancer in Men with Late-Onset Hypogonadism, Am J Epidemiol, 2019.
J. M. Dennis, Henley, W. E., McGovern, A. P., Farmer, A. J., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., Shields, B. M., and Jones, A. G., Time trends in prescribing of type 2 diabetes drugs, glycemic response and risk factors: a retrospective analysis of primary care data, 2010-2017, Diabetes Obes Metab, 2019.
C. J. Czoski Murray, Kingsbury, S. R., Arden, N. K., Hewison, J., Judge, A., Matu, J., O'Shea, J., Pinedo-Villanueva, R., Smith, L. K., Smith, C., Thomas, C. M., West, R. M., Wright, J. M., Conaghan, P. G., and Stone, M. H., Towards UK poSt Arthroplasty Follow-up rEcommendations (UK SAFE): protocol for an evaluation of the requirements for arthroplasty follow-up, and the production of consensus-based recommendations, BMJ Open, vol. 9, p. e031351, 2019.
J. L. Rees, Shah, A., Edwards, K., Sanchez-Santos, M. T., Robinson, D. E., Delmestri, A., Carr, A., Arden, N., Lamb, S. E., Rangan, A., Judge, A., Pinedo-Villanueva, R., Holt, T., Hopewell, S., Prieto-Alhambra, D., and Collins, G., Treatment of first-time traumatic anterior shoulder dislocation: the UK TASH-D cohort study, Health Technol Assess, vol. 23, pp. 1-104, 2019.
T. Appleyard, Ashworth, J., Bedson, J., Yu, D., and Peat, G., Trends in gabapentinoid prescribing in patients with osteoarthritis: a United Kingdom national cohort study in primary care, Osteoarthritis Cartilage, 2019.
B. Feakins, Oke, J., McFadden, E., Aronson, J., Lasserson, D., O'Callaghan, C., Taylor, C., Hill, N., Stevens, R., and Perera, R., Trends in kidney function testing in UK primary care since the introduction of the quality and outcomes framework: a retrospective cohort study using CPRD, BMJ Open, vol. 9, p. e028062, 2019.
C. J. Taylor, Ordonez-Mena, J. M., Roalfe, A. K., Lay-Flurrie, S., Jones, N. R., Marshall, T., and Hobbs, F. D. R., Trends in survival after a diagnosis of heart failure in the United Kingdom 2000-2017: population based cohort study, Bmj, vol. 364, p. l223, 2019.
A. Pate, Emsley, R., Ashcroft, D. M., Brown, B., and Van Staa, T., The uncertainty with using risk prediction models for individual decision making: an exemplar cohort study examining the prediction of cardiovascular disease in English primary care, BMC Med, vol. 17, p. 134, 2019.
C. Rebordosa, Aguado, J., Plana, E., Thomas, S., Frances, A., Lei, A., Garcia-Gil, E., Nuevo, J., Perez-Gutthann, S., and Castellsague, J., Use of aclidinium did not increase the risk of death in a noninterventional cohort study in the Clinical Practice Research Datalink (CPRD), United Kingdom, Respir Med, vol. 152, pp. 37-43, 2019.
Y. Vinogradova, Coupland, C., and Hippisley-Cox, J., Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases, Bmj, vol. 364, p. k4810, 2019.
J. Watson, Jones, H. E., Banks, J., Whiting, P., Salisbury, C., and Hamilton, W., Use of multiple inflammatory marker tests in primary care: using Clinical Practice Research Datalink to evaluate accuracy, Br J Gen Pract, vol. 69, pp. e462-e469, 2019.
A. Tran-Duy, Connell, N. J., Vanmolkot, F. H., Souverein, P. C., de Wit, N. J., Stehouwer, C. D. A., Hoes, A. W., de Vries, F., and de Boer, A., Use of proton pump inhibitors and risk of iron deficiency: a population-based case-control study, J Intern Med, vol. 285, pp. 205-214, 2019.
T. Burkard, Moser, M., Rauch, M., Jick, S. S., and Meier, C. R., Utilization pattern of hormone therapy in UK general practice between 1996 and 2015: a descriptive study, Menopause, 2019.
J. E. Amegadzie, Badejo, O., Gamble, J. M., Wright, M., Farrell, J., Jackson, B., Sultana, K., Hashmi, M., and Gao, Z., Validated methods to identify patients with asthma-COPD overlap in healthcare databases: a systematic review protocol, BMJ Open, vol. 9, p. e024306, 2019.
A. A. Sultan, Muller, S., Whittle, R., Roddy, E., Mallen, C., and Clarson, L., Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy, Cmaj, vol. 191, pp. E597-e603, 2019.
A. M. Mueller, Meier, C. R., Jick, S. S., and Schneider, C., Weight change and blood glucose concentration as markers for pancreatic cancer in subjects with new-onset diabetes mellitus: A matched case-control study, Pancreatology, 2019.
C. Broadhurst, Rhodes, A. M. L., Harper, P., Perry, D. C., Clarke, N. M. P., and Aarvold, A., What is the incidence of late detection of developmental dysplasia of the hip in England?, Bone Joint J, vol. 101-b, pp. 281-287, 2019.
A. P. McGovern, Dennis, J. M., Shields, B. M., Hattersley, A. T., Pearson, E. R., and Jones, A. G., What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study, BMC Med, vol. 17, p. 79, 2019.
C. Gilbert, Allgar, V., and Doran, T., Workload impact of the Quality and Outcomes Framework for patients with diabetes: an interrupted time series in general practice, Br J Gen Pract, vol. 69, pp. e570-e577, 2019.
[Page last reviewed 5 August 2019]