Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 December 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 193 pages)


Export 2384 results:
Author Title Type [ Year(Desc)]
R. G. Schlienger, Jick, S. S., and Meier, C. R., Inhaled corticosteroids and the risk of fractures in children and adolescents, Pediatrics, vol. 114, pp. 469-73, 2004.
Y. X. Yang, Hennessy, S., and Lewis, J. D., Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients, Gastroenterology, vol. 127, pp. 1044-50, 2004.
L. A. Garcia Rodriguez and Gonzalez-Perez, A., Inverse association between nonsteroidal anti-inflammatory drugs and prostate cancer, Cancer Epidemiol Biomarkers Prev, vol. 13, pp. 649-53, 2004.
A. L. Nightingale and Farmer, R. D., Ischemic stroke in young women: a nested case-control study using the UK General Practice Research Database, Stroke, vol. 35, pp. 1574-8, 2004.
P. Cleary, Shorvon, S., and Tallis, R., Late-onset seizures as a predictor of subsequent stroke, Lancet, vol. 363, pp. 1184-6, 2004.
J. West, Logan, R. F., Smith, C. J., Hubbard, R. B., and Card, T. R., Malignancy and mortality in people with coeliac disease: population based cohort study, Bmj, vol. 329, pp. 716-9, 2004.
D. J. Margolis, Knauss, J., and Bilker, W., Medical conditions associated with venous leg ulcers, Br J Dermatol, vol. 150, pp. 267-73, 2004.
A. L. Hansell, Lam, K. A., Richardson, S., Visick, G., and Soriano, J. B., Medical event profiling of COPD patients, Pharmacoepidemiol Drug Saf, vol. 13, pp. 547-55, 2004.
L. Smeeth, Cook, C., Fombonne, E., Heavey, L., Rodrigues, L. C., Smith, P. G., and Hall, A. J., MMR vaccination and pervasive developmental disorders: a case-control study, Lancet, vol. 364, pp. 963-9, 2004.
A. Ruigomez, Rodriguez, L. A. Garcia, Wallander, M. A., Johansson, S., Graffner, H., and Dent, J., Natural history of gastro-oesophageal reflux disease diagnosed in general practice, Aliment Pharmacol Ther, vol. 20, pp. 751-60, 2004.
Z. Zhou, Althin, R., Sforzolini, B. S., and Dhawan, R., Persistency and treatment failure in newly diagnosed open angle glaucoma patients in the United Kingdom, Br J Ophthalmol, vol. 88, pp. 1391-4, 2004.
D. J. Torgerson, Sykes, D., Puffer, S., Brown, P., and Cooper, C., Pharmaceutical treatment of symptomatic vertebral fractures in primary care, Ann Rheum Dis, vol. 63, pp. 853-6, 2004.
M. M. Peng and Jick, H., A population-based study of the incidence, cause, and severity of anaphylaxis in the United Kingdom, Arch Intern Med, vol. 164, pp. 317-9, 2004.
M. Frisher, Collins, J., Millson, D., Crome, I., and Croft, P., Prevalence of comorbid psychiatric illness and substance misuse in primary care in England and Wales, J Epidemiol Community Health, vol. 58, pp. 1036-41, 2004.
M. A. Hernan, Logroscino, G., and Rodriguez, L. A., A prospective study of alcoholism and the risk of Parkinson's disease, J Neurol, vol. 251 Suppl 7, pp. vII14-7, 2004.
L. M. Howard, Goss, C., Leese, M., Appleby, L., and Thornicroft, G., The psychosocial outcome of pregnancy in women with psychotic disorders, Schizophr Res, vol. 71, pp. 49-60, 2004.
L. Smeeth, Cook, C., Fombonne, P. E., Heavey, L., Rodrigues, L. C., Smith, P. G., and Hall, A. J., Rate of first recorded diagnosis of autism and other pervasive developmental disorders in United Kingdom general practice, 1988 to 2001, BMC Med, vol. 2, p. 39, 2004.
M. A. Hernan, Jick, S. S., Olek, M. J., and Jick, H., Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective study, Neurology, vol. 63, pp. 838-42, 2004.
S. J. Varney and Guest, J. F., Relative cost effectiveness of Depo-Provera, Implanon, and Mirena in reversible long-term hormonal contraception in the UK, Pharmacoeconomics, vol. 22, pp. 1141-51, 2004.
A. J. Apter, Kinman, J. L., Bilker, W. B., Herlim, M., Margolis, D. J., Lautenbach, E., Hennessy, S., and Strom, B. L., Represcription of penicillin after allergic-like events, J Allergy Clin Immunol, vol. 113, pp. 764-70, 2004.
J. M. Geoghegan, Clark, D. I., Bainbridge, L. C., Smith, C., and Hubbard, R., Risk factors in carpal tunnel syndrome, J Hand Surg Br, vol. 29, pp. 315-20, 2004.
L. A. Garcia Rodriguez and Gonzalez-Perez, A., Risk of breast cancer among users of aspirin and other anti-inflammatory drugs, Br J Cancer, vol. 91, pp. 525-9, 2004.
M. Solaymani-Dodaran, Logan, R. F., West, J., Card, T., and Coupland, C., Risk of extra-oesophageal malignancies and colorectal cancer in Barrett's oesophagus and gastro-oesophageal reflux, Scand J Gastroenterol, vol. 39, pp. 680-5, 2004.
L. Smeeth, Thomas, S. L., Hall, A. J., Hubbard, R., Farrington, P., and Vallance, P., Risk of myocardial infarction and stroke after acute infection or vaccination, N Engl J Med, vol. 351, pp. 2611-8, 2004.
C. R. Meier, Wilcock, K., and Jick, S. S., The risk of severe depression, psychosis or panic attacks with prophylactic antimalarials, Drug Saf, vol. 27, pp. 203-13, 2004.
J. West, Logan, R. F., Card, T. R., Smith, C., and Hubbard, R., Risk of vascular disease in adults with diagnosed coeliac disease: a population-based study, Aliment Pharmacol Ther, vol. 20, pp. 73-9, 2004.
J. D. Lewis, Aberra, F. N., Lichtenstein, G. R., Bilker, W. B., Brensinger, C., and Strom, B. L., Seasonal variation in flares of inflammatory bowel disease, Gastroenterology, vol. 126, pp. 665-73, 2004.
J. A. Kaye and Jick, H., Statin use and cancer risk in the General Practice Research Database, Br J Cancer, vol. 90, pp. 635-7, 2004.
S. S. Jick and Bradbury, B. D., Statins and newly diagnosed diabetes, Br J Clin Pharmacol, vol. 58, pp. 303-9, 2004.
J. R. Hardy, Holford, T. R., Hall, G. C., and Bracken, M. B., Strategies for identifying pregnancies in the automated medical records of the General Practice Research Database, Pharmacoepidemiol Drug Saf, vol. 13, pp. 749-59, 2004.
B. D. Bradbury, Lash, T. L., Kaye, J. A., and Jick, S. S., Tamoxifen and cataracts: a null association, Breast Cancer Res Treat, vol. 87, pp. 189-96, 2004.
N. Andrews, Miller, E., Grant, A., Stowe, J., Osborne, V., and Taylor, B., Thimerosal exposure in infants and developmental disorders: a retrospective cohort study in the United kingdom does not support a causal association, Pediatrics, vol. 114, pp. 584-91, 2004.
G. C. Hall, Brown, M. M., Mo, J., and MacRae, K. D., Triptans in migraine: the risks of stroke, cardiovascular disease, and death in practice, Neurology, vol. 62, pp. 563-8, 2004.
R. G. Schlienger, Kraenzlin, M. E., Jick, S. S., and Meier, C. R., Use of beta-blockers and risk of fractures, Jama, vol. 292, pp. 1326-32, 2004.
P. C. Souverein, Berard, A., van Staa, T. P., Cooper, C., Egberts, A. C., Leufkens, H. G., and Walker, B. R., Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case-control study, Heart, vol. 90, pp. 859-65, 2004.
S. E. Bromley, de Vries, C. S., and Farmer, R. D., Utilisation of hormone replacement therapy in the United Kingdom. A descriptive study using the general practice research database, Bjog, vol. 111, pp. 369-76, 2004.
T. M. McKeever, Lewis, S. A., Smith, C., and Hubbard, R., Vaccination and allergic disease: a birth cohort study, Am J Public Health, vol. 94, pp. 985-9, 2004.
E. Fombonne, Heavey, L., Smeeth, L., Rodrigues, L. C., Cook, C., Smith, P. G., Meng, L., and Hall, A. J., Validation of the diagnosis of autism in general practitioner records, BMC Public Health, vol. 4, p. 5, 2004.
H. E. Seaman, de Vries, C. S., and Farmer, R. D., Venous thromboembolism associated with cyproterone acetate in combination with ethinyloestradiol (Dianette): observational studies using the UK General Practice Research Database, Pharmacoepidemiol Drug Saf, vol. 13, pp. 427-36, 2004.
G. E. Smith, Smith, S., Heatlie, H., Bashford, J. N., Hawker, J., Ashcroft, D., Millson, D., Verlander, N. Q., and Warren, R., What has happened to antimicrobial usage in primary care in the United Kingdom since the SMAC report? - description of trends in antimicrobial usage using the General Practice Research Database, J Public Health (Oxf), vol. 26, pp. 359-64, 2004.
M. Ashworth, Latinovic, R., Charlton, J., Cox, K., Rowlands, G., and Gulliford, M., Why has antibiotic prescribing for respiratory illness declined in primary care? A longitudinal study using the General Practice Research Database, J Public Health (Oxf), vol. 26, pp. 268-74, 2004.
T. P. van Staa, Card, T., Logan, R. F., and Leufkens, H. G., 5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study, Gut, vol. 54, pp. 1573-8, 2005.
D. J. Margolis, Bowe, W. P., Hoffstad, O., and Berlin, J. A., Antibiotic treatment of acne may be associated with upper respiratory tract infections, Arch Dermatol, vol. 141, pp. 1132-6, 2005.
F. N. Aberra, Brensinger, C. M., Bilker, W. B., Lichtenstein, G. R., and Lewis, J. D., Antibiotic use and the risk of flare of inflammatory bowel disease, Clin Gastroenterol Hepatol, vol. 3, pp. 459-65, 2005.
J. A. Kaye and Jick, H., Antibiotics and the risk of breast cancer, Epidemiology, vol. 16, pp. 688-90, 2005.
C. Martinez, Rietbrock, S., Wise, L., Ashby, D., Chick, J., Moseley, J., Evans, S., and Gunnell, D., Antidepressant treatment and the risk of fatal and non-fatal self harm in first episode depression: nested case-control study, Bmj, vol. 330, p. 389, 2005.
S. Maru, Koch, G. G., Stender, M., Clark, D., Gibowski, L., Petri, H., White, A. D., and Simpson, Jr., R. J., Antidiabetic drugs and heart failure risk in patients with type 2 diabetes in the U.K. primary care setting, Diabetes Care, vol. 28, pp. 20-6, 2005.
C. E. Koro, Bowlin, S. J., and Weiss, S. R., Antidiabetic therapy and the risk of heart failure in type 2 diabetic patients: an independent effect or confounding by indication, Pharmacoepidemiol Drug Saf, vol. 14, pp. 697-703, 2005.
N. Dunn, Mullee, M., Perry, V. H., and Holmes, C., Association between dementia and infectious disease: evidence from a case-control study, Alzheimer Dis Assoc Disord, vol. 19, pp. 91-4, 2005.
A. Lawson, West, J., Aithal, G. P., and Logan, R. F., Autoimmune cholestatic liver disease in people with coeliac disease: a population-based study of their association, Aliment Pharmacol Ther, vol. 21, pp. 401-5, 2005.
[Page last reviewed 6 December 2019]