Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 June 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 183 pages)


Export 2252 results:
Author Title Type [ Year(Asc)]
S. Ramtoola, Ploug, U. J., Kragh, N., and Nyeland, M. E., Characteristics of newly diagnosed adults with Type 1 diabetes in the UK and their evolution over the first 5 years, Diabetic Medicine, vol. 34, p. 146, 2017.
C. Miani, Martin, A., Exley, J., Doble, B., Wilson, E., Payne, R., Avery, A., Meads, C., Kirtley, A., Jones, M. M., and King, S., Clinical effectiveness and cost-effectiveness of issuing longer versus shorter duration (3-month vs. 28-day) prescriptions in patients with chronic conditions: systematic review and economic modelling, Health Technol Assess, vol. 21, pp. 1-128, 2017.
S. A. Stapley, Rubin, G. P., Alsina, D., Shephard, E. A., Rutter, M. D., and Hamilton, W. T., Clinical features of bowel disease in patients aged <50 years in primary care: a large case-control study, Br J Gen Pract, vol. 67, pp. e336-e344, 2017.
S. E. Bailey, Ukoumunne, O. C., Shephard, E. A., and Hamilton, W., Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data, Br J Gen Pract, vol. 67, pp. e405-e413, 2017.
L. R. Rodgers, Weedon, M. N., Henley, W. E., Hattersley, A. T., and Shields, B. M., Cohort profile for the MASTERMIND study: using the Clinical Practice Research Datalink (CPRD) to investigate stratification of response to treatment in patients with type 2 diabetes, BMJ Open, vol. 7, p. e017989, 2017.
S. Venkatesan, Myles, P. R., Manning, H. J., Mozid, A. M., Andersson, C., Jorgensen, M. E., Hardman, J. G., Moonesinghe, S. R., Foex, P., Mythen, M., Grocott, M. P. W., and Sanders, R. D., Cohort study of preoperative blood pressure and risk of 30-day mortality after elective non-cardiac surgery, Br J Anaesth, vol. 119, pp. 65-77, 2017.
O. B. Sanni, Menamin, U. C. Mc, Cardwell, C. R., Sharp, L., Murray, L. J., and Coleman, H. G., Commonly used medications and endometrial cancer survival: a population-based cohort study, Br J Cancer, vol. 117, pp. 432-438, 2017.
L. T. A. Mounce, Price, S., Valderas, J. M., and Hamilton, W., Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records, Br J Cancer, vol. 116, pp. 1536-1543, 2017.
C. S. Murray, Thomas, M., Richardson, K., Price, D. B., and Turner, S. W., Comparative Effectiveness of Step-up Therapies in Children with Asthma Prescribed Inhaled Corticosteroids: A Historical Cohort Study, J Allergy Clin Immunol Pract, vol. 5, pp. 1082-1090.e7, 2017.
T. Sheppard, Tamblyn, R., Abrahamowicz, M., Lunt, M., Sperrin, M., and Dixon, W. G., A comparison of methods for estimating the temporal change in a continuous variable: Example of HbA1c in patients with diabetes, Pharmacoepidemiol Drug Saf, vol. 26, pp. 1474-1482, 2017.
S. Suissa, Dell'Aniello, S., and Ernst, P., Concurrent use of long-acting bronchodilators in COPD and the risk of adverse cardiovascular events, Eur Respir J, vol. 49, 2017.
S. Skrtic, Cabrera, C., Olsson, M., Schnecke, V., and Lind, M., Contemporary risk estimates of three HbA1c variables in relation to heart failure following diagnosis of type 2 diabetes, Heart, vol. 103, pp. 353-358, 2017.
P. Tammes, Purdy, S., Salisbury, C., MacKichan, F., Lasserson, D., and Morris, R. W., Continuity of Primary Care and Emergency Hospital Admissions Among Older Patients in England, Ann Fam Med, vol. 15, pp. 515-522, 2017.
S. J. Ronaldson, Raghunath, A., Torgerson, D. J., and Van Staa, T., Cost-effectiveness of antibiotics for COPD management: observational analysis using CPRD data, ERJ Open Res, vol. 3, 2017.
J. Leal, Gray, A. M., Hawley, S., Prieto-Alhambra, D., Delmestri, A., Arden, N. K., Cooper, C., Javaid, M. K., and Judge, A., Cost-Effectiveness of Orthogeriatric and Fracture Liaison Service Models of Care for Hip Fracture Patients: A Population-Based Study, J Bone Miner Res, vol. 32, pp. 203-211, 2017.
M. C. Gulliford, Charlton, J., Prevost, T., Booth, H., Fildes, A., Ashworth, M., Littlejohns, P., Reddy, M., Khan, O., and Rudisill, C., Costs and Outcomes of Increasing Access to Bariatric Surgery: Cohort Study and Cost-Effectiveness Analysis Using Electronic Health Records, Value Health, vol. 20, pp. 85-92, 2017.
C. Francois, Tanasescu, A., Lamy, F. X., Despiegel, N., Falissard, B., Chalem, Y., Lancon, C., Llorca, P. M., Saragoussi, D., Verpillat, P., Wade, A. G., and Zighed, D. A., Creating an index to measure health state of depressed patients in automated healthcare databases: the methodology, J Mark Access Health Policy, vol. 5, p. 1372025, 2017.
J. Wilding, Bailey, C., Rigney, U., Blak, B., Kok, M., and Emmas, C., Dapagliflozin therapy for type 2 diabetes in primary care: Changes in HbA1c, weight and blood pressure over 2 years follow-up, Prim Care Diabetes, vol. 11, pp. 437-444, 2017.
R. Ravindrarajah, Dregan, A., Hazra, N. C., Hamada, S., Jackson, S. H. D., and Gulliford, M. C., Declining blood pressure and intensification of blood pressure management among people over 80 years: cohort study using electronic health records, J Hypertens, vol. 35, pp. 1276-1282, 2017.
J. D. Chalmers, Tebboth, A., Gayle, A., Ternouth, A., and Ramscar, N., Determinants of initial inhaled corticosteroid use in patients with GOLD A/B COPD: a retrospective study of UK general practice, NPJ Prim Care Respir Med, vol. 27, p. 43, 2017.
K. K. Poppe, Doughty, R. N., Wells, S., Gentles, D., Hemingway, H., Jackson, R., and Kerr, A. J., Developing and validating a cardiovascular risk score for patients in the community with prior cardiovascular disease, Heart, vol. 103, pp. 891-892, 2017.
C. Seliger, Meier, C. R., Becker, C., Jick, S. S., Proescholdt, M., Bogdahn, U., Hau, P., and Leitzmann, M. F., Diabetes, use of metformin, and the risk of meningioma, PLoS One, vol. 12, p. e0181089, 2017.
E. G. Tyrrell, Orton, E., Sayal, K., Baker, R., and Kendrick, D., Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population-based cohort study, J Public Health (Oxf), vol. 39, pp. e1-e9, 2017.
T. Holbrook, Tang, Y., Das, R., Shankar, R. R., Tunceli, K., Williams, J., Radican, L., Holden, S. E., Morgan, C. L., Piercy, J., and Currie, C. J., Direct medical costs of severe hypoglycaemic events in patients with type 2 diabetes in England: A retrospective database study, Int J Clin Pract, vol. 71, 2017.
I. M. Carey, Hosking, F. J., Harris, T., DeWilde, S., Beighton, C., Shah, S. M., and Cook, D. G., Do health checks for adults with intellectual disability reduce emergency hospital admissions? Evaluation of a natural experiment, J Epidemiol Community Health, vol. 71, pp. 52-58, 2017.
S. I. Vuik, Fontana, G., Mayer, E., and Darzi, A., Do hospitalisations for ambulatory care sensitive conditions reflect low access to primary care? An observational cohort study of primary care usage prior to hospitalisation, BMJ Open, vol. 7, p. e015704, 2017.
M. Morris, Woods, L. M., Bhaskaran, K., and Rachet, B., Do pre-diagnosis primary care consultation patterns explain deprivation-specific differences in net survival among women with breast cancer? An examination of individually-linked data from the UK West Midlands cancer registry, national screening programme, BMC Cancer, vol. 17, p. 155, 2017.
C. Alexakis, Saxena, S., Chhaya, V., Cecil, E., Curcin, V., and Pollok, R., Do Thiopurines Reduce the Risk of Surgery in Elderly Onset Inflammatory Bowel Disease? A 20-Year National Population-Based Cohort Study, Inflamm Bowel Dis, vol. 23, pp. 672-680, 2017.
S. Weir, Samnaliev, M., Kuo, T. - C., Choitir, C. N., Tierney, T. S., Taylor, R. S., Manca, A., Bruce, J., Cumming, D., and Eldabe, S., Does instrumented spinal surgery have an increased rate of persistent post-operative pain (PPP)?, The Spine Journal, vol. 17, p. S11, 2017.
N. Larivee, Suissa, S., Eberg, M., Joseph, L., Eisenberg, M. J., Abenhaim, H. A., and Filion, K. B., Drospirenone-containing combined oral contraceptives and the risk of arterial thrombosis: a population-based nested case-control study, Bjog, vol. 124, pp. 1672-1679, 2017.
N. Larivee, Suissa, S., Coulombe, J., Tagalakis, V., and Filion, K. B., Drospirenone-Containing Oral Contraceptive Pills and the Risk of Venous Thromboembolism: An Assessment of Risk in First-Time Users and Restarters, Drug Saf, vol. 40, pp. 583-596, 2017.
A. Thompson, Ashcroft, D. M., Owens, L., van Staa, T. P., and Pirmohamed, M., Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study, PLoS One, vol. 12, p. e0173272, 2017.
F. Rees, Doherty, M., Lanyon, P., Davenport, G., Riley, R. D., Zhang, W., and Grainge, M. J., Early Clinical Features in Systemic Lupus Erythematosus: Can They Be Used to Achieve Earlier Diagnosis? A Risk Prediction Model, Arthritis Care Res (Hoboken), vol. 69, pp. 833-841, 2017.
M. Franklin, Davis, S., Horspool, M., Kua, W. S., and Julious, S., Economic Evaluations Alongside Efficient Study Designs Using Large Observational Datasets: the PLEASANT Trial Case Study, Pharmacoeconomics, vol. 35, pp. 561-573, 2017.
L. E. Bayliss, Culliford, D., Monk, A. P., Glyn-Jones, S., Prieto-Alhambra, D., Judge, A., Cooper, C., Carr, A. J., Arden, N. K., Beard, D. J., and Price, A. J., The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study, Lancet, vol. 389, pp. 1424-1430, 2017.
P. Brassard, Wu, J. W., Ernst, P., Dell'Aniello, S., Smiechowski, B., and Suissa, S., The effect of statins on influenza-like illness morbidity and mortality, Pharmacoepidemiol Drug Saf, vol. 26, pp. 63-70, 2017.
M. Pufulete, Maishman, R., Dabner, L., Mohiuddin, S., Hollingworth, W., Rogers, C. A., Higgins, J., Dayer, M., Macleod, J., Purdy, S., McDonagh, T., Nightingale, A., Williams, R., and Reeves, B. C., Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model, Health Technol Assess, vol. 21, pp. 1-150, 2017.
G. M. J. Taylor, Taylor, A. E., Thomas, K. H., Jones, T., Martin, R. M., Munafo, M. R., Windmeijer, F., and Davies, N. M., The effectiveness of varenicline versus nicotine replacement therapy on long-term smoking cessation in primary care: a prospective cohort study of electronic medical records, Int J Epidemiol, vol. 46, pp. 1948-1957, 2017.
E. Moore, Newson, R., Joshi, M., Palmer, T., Rothnie, K. J., Singh, S., Majeed, A., Soljak, M., and Quint, J. K., Effects of Pulmonary Rehabilitation on Exacerbation Number and Severity in People With COPD: An Historical Cohort Study Using Electronic Health Records, Chest, vol. 152, pp. 1188-1202, 2017.
K. Rahimi, Mohseni, H., Otto, C. M., Conrad, N., Tran, J., Nazarzadeh, M., Woodward, M., Dwyer, T., and MacMahon, S., Elevated blood pressure and risk of mitral regurgitation: A longitudinal cohort study of 5.5 million United Kingdom adults, PLoS Med, vol. 14, p. e1002404, 2017.
A. Thompson, Wright, A. K., Ashcroft, D. M., van Staa, T. P., and Pirmohamed, M., Epidemiology of alcohol dependence in UK primary care: Results from a large observational study using the Clinical Practice Research Datalink, PLoS One, vol. 12, p. e0174818, 2017.
A. T. Cohen, Katholing, A., Rietbrock, S., Bamber, L., and Martinez, C., Epidemiology of first and recurrent venous thromboembolism in patients with active cancer. A population-based cohort study, Thromb Haemost, vol. 117, pp. 57-65, 2017.
C. Klop, van Staa, T. P., Cooper, C., Harvey, N. C., and de Vries, F., The epidemiology of mortality after fracture in England: variation by age, sex, time, geographic location, and ethnicity, Osteoporos Int, vol. 28, pp. 161-168, 2017.
N. Frey, Jossi, J., Bodmer, M., Bircher, A., Jick, S. S., Meier, C. R., and Spoendlin, J., The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the UK, J Invest Dermatol, vol. 137, pp. 1240-1247, 2017.
P. P. Toth, Danese, M., Villa, G., Qian, Y., Beaubrun, A., Lira, A., and Jansen, J. P., Estimated burden of cardiovascular disease and value-based price range for evolocumab in a high-risk, secondary-prevention population in the US payer context, J Med Econ, vol. 20, pp. 555-564, 2017.
T. Verstraeten, Cattaert, T., Harris, J., Lopman, B., Tam, C. C., and Ferreira, G., Estimating the Burden of Medically Attended Norovirus Gastroenteritis: Modeling Linked Primary Care and Hospitalization Datasets, J Infect Dis, vol. 216, pp. 957-965, 2017.
E. Chiquette, Oral, E. A., Garg, A., Araujo-Vilar, D., and Dhankhar, P., Estimating the prevalence of generalized and partial lipodystrophy: findings and challenges, Diabetes Metab Syndr Obes, vol. 10, pp. 375-383, 2017.
M. Eberg, Platt, R. W., and Filion, K. B., The Estimation of Gestational Age at Birth in Database Studies, Epidemiology, vol. 28, pp. 854-862, 2017.
J. Langham and Langham, S., European real world data sources to characterise flares in patients with systemic lupus erythematosus: A review, Value in Health, vol. 20, p. A571, 2017.
J. Birks, Bankhead, C., Holt, T. A., Fuller, A., and Patnick, J., Evaluation of a prediction model for colorectal cancer: retrospective analysis of 2.5 million patient records, Cancer Med, vol. 6, pp. 2453-2460, 2017.
[Page last reviewed 6 June 2019]