Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 September 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 189 pages)


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Author [ Title(Asc)] Type Year
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R. M. Joseph, Movahedi, M., Dixon, W. G., and Symmons, D. P., Risks of smoking and benefits of smoking cessation on hospitalisations for cardiovascular events and respiratory infection in patients with rheumatoid arthritis: a retrospective cohort study using the Clinical Practice Research Datalink, RMD Open, vol. 3, p. e000506, 2017.
Y. Vinogradova, Coupland, C., Hill, T., and Hippisley-Cox, J., Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care, Bmj, vol. 362, p. k2505, 2018.
F. J. de Abajo and Rodriguez, L. A., Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs, Br J Clin Pharmacol, vol. 47, pp. 307-13, 1999.
C. Vasilakis-Scaramozza and Jick, H., Risk of venous thromboembolism with cyproterone or levonorgestrel contraceptives, Lancet, vol. 358, pp. 1427-9, 2001.
H. E. Seaman, de Vries, C. S., and Farmer, R. D., The risk of venous thromboembolism in women prescribed cyproterone acetate in combination with ethinyl estradiol: a nested cohort analysis and case-control study, Hum Reprod, vol. 18, pp. 522-6, 2003.
C. Vasilakis, Jick, S. S., and Jick, H., The risk of venous thromboembolism in users of postcoital contraceptive pills, Contraception, vol. 59, pp. 79-83, 1999.
L. Parkin, Sharples, K., Hernandez, R. K., and Jick, S. S., Risk of venous thromboembolism in users of oral contraceptives containing drospirenone or levonorgestrel: nested case-control study based on UK General Practice Research Database, Bmj, vol. 342, p. d2139, 2011.
A. J. Walker, Baldwin, D. R., Card, T. R., Powell, H. A., Hubbard, R. B., and Grainge, M. J., Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data, Br J Cancer, vol. 115, pp. 115-21, 2016.
P. J. Peeters, Bazelier, M. T., Uitdehaag, B. M., Leufkens, H. G., De Bruin, M. L., and de Vries, F., The risk of venous thromboembolism in patients with multiple sclerosis: the Clinical Practice Research Datalink, J Thromb Haemost, vol. 12, pp. 444-51, 2014.
D. J. Humes, Nordenskjold, A., Walker, A. J., West, J., and Ludvigsson, J. F., Risk of venous thromboembolism in children after general surgery, J Pediatr Surg, vol. 50, pp. 1870-3, 2015.
T. P. C. Chu, Grainge, M. J., and Card, T. R., The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity, Aliment Pharmacol Ther, vol. 48, pp. 1099-1108, 2018.
A. Sundstrom, Seaman, H., Kieler, H., and Alfredsson, L., The risk of venous thromboembolism associated with the use of tranexamic acid and other drugs used to treat menorrhagia: a case-control study using the General Practice Research Database, Bjog, vol. 116, pp. 91-7, 2009.
H. Jick, Kaye, J. A., Vasilakis-Scaramozza, C., and Jick, S. S., Risk of venous thromboembolism among users of third generation oral contraceptives compared with users of oral contraceptives with levonorgestrel before and after 1995: cohort and case-control analysis, Bmj, vol. 321, pp. 1190-5, 2000.
E. Martin-Merino, Petersen, I., Hawley, S., Alvarez-Gutierrez, A., Khalid, S., Llorente-Garcia, A., Delmestri, A., Javaid, M. K., van Staa, T. P., Judge, A., Cooper, C., and Prieto-Alhambra, D., Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK, Osteoporos Int, vol. 29, pp. 467-478, 2018.
A. T. Hancock, Mallen, C. D., Muller, S., Belcher, J., Roddy, E., Helliwell, T., and Hider, S. L., Risk of vascular events in patients with polymyalgia rheumatica, Cmaj, vol. 186, pp. E495-501, 2014.
J. West, Logan, R. F., Card, T. R., Smith, C., and Hubbard, R., Risk of vascular disease in adults with diagnosed coeliac disease: a population-based study, Aliment Pharmacol Ther, vol. 20, pp. 73-9, 2004.
R. Charlton, Green, A., Shaddick, G., Snowball, J., Nightingale, A., Tillett, W., Smith, C. H., and McHugh, N., Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population-based cohort study, Ann Rheum Dis, vol. 77, pp. 277-280, 2018.
S. Walker, Hyde, C., and Hamilton, W., Risk of uterine cancer in symptomatic women in primary care: case-control study using electronic records, Br J Gen Pract, vol. 63, pp. e643-8, 2013.
F. J. de Abajo and Garcia-Rodriguez, L. A., Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents, Arch Gen Psychiatry, vol. 65, pp. 795-803, 2008.
L. A. Garcia Rodriguez and Hernandez-Diaz, S., The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents, Arthritis Res, vol. 3, pp. 98-101, 2001.
F. J. de Abajo and Rodriguez, L. A. Garcia, Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations, BMC Clin Pharmacol, vol. 1, p. 1, 2001.
L. A. Garcia Rodriguez and Jick, H., Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs, Lancet, vol. 343, pp. 769-72, 1994.
H. C. Gorton, Webb, R. T., Carr, M. J., DelPozo-Banos, M., John, A., and Ashcroft, D. M., Risk of Unnatural Mortality in People With Epilepsy, JAMA Neurol, vol. 75, pp. 929-938, 2018.
S. S. Jick, Hagberg, K. W., Kaye, J. A., and Jick, H., The risk of unintended pregnancies in users of the contraceptive patch compared to users of oral contraceptives in the UK General Practice Research Database, Contraception, vol. 80, pp. 142-51, 2009.
R. Charlton, Green, A., Shaddick, G., Snowball, J., Nightingale, A., Tillett, W., Smith, C., and McHugh, N., Risk of type 2 diabetes and cardiovascular disease in an incident cohort of people with psoriatic arthritis: a population-based cohort study, Rheumatology (Oxford), 2018.
D. Zenner, Kruijshaar, M. E., Andrews, N., and Abubakar, I., Risk of tuberculosis in pregnancy: a national, primary care-based cohort and self-controlled case series study, Am J Respir Crit Care Med, vol. 185, pp. 779-84, 2012.
D. J. Humes, Walker, A. J., Hunt, B. J., Sultan, A. A., Ludvigsson, J. F., and West, J., Risk of symptomatic venous thromboembolism following emergency appendicectomy in adults, Br J Surg, vol. 103, pp. 443-50, 2016.
H. Jick, Myers, M. W., and Dean, A. D., The risk of sulfasalazine- and mesalazine-associated blood disorders, Pharmacotherapy, vol. 15, pp. 176-81, 1995.
A. Rubino, Roskell, N., Tennis, P., Mines, D., Weich, S., and Andrews, E., Risk of suicide during treatment with venlafaxine, citalopram, fluoxetine, and dothiepin: retrospective cohort study, Bmj, vol. 334, p. 242, 2007.
C. Gasse, Derby, L. E., Vasilakis, C., and Jick, H., Risk of suicide among users of calcium channel blockers: population based, nested case-control study, Bmj, vol. 320, p. 1251, 2000.
J. M. Gelfand, Dommasch, E. D., Shin, D. B., Azfar, R. S., Kurd, S. K., Wang, X., and Troxel, A. B., The risk of stroke in patients with psoriasis, J Invest Dermatol, vol. 129, pp. 2411-8, 2009.
C. Becker, Jick, S. S., and Meier, C. R., Risk of stroke in patients with idiopathic Parkinson disease, Parkinsonism Relat Disord, vol. 16, pp. 31-5, 2010.
S. M. Langan, Minassian, C., Smeeth, L., and Thomas, S. L., Risk of stroke following herpes zoster: a self-controlled case-series study, Clin Infect Dis, vol. 58, pp. 1497-503, 2014.
S. L. Wood, Jick, H., and Sauve, R., The risk of stillbirth in pregnancies before and after the onset of diabetes, Diabet Med, vol. 20, pp. 703-7, 2003.
N. Frey, Bodmer, M., Bircher, A., Ruegg, S., Jick, S. S., Meier, C. R., and Spoendlin, J., The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs, Epilepsia, vol. 58, pp. 2178-2185, 2017.
L. Baril, Rosillon, D., Willame, C., Angelo, M. G., Zima, J., van den Bosch, J. H., Van Staa, T., Boggon, R., Bunge, E. M., Hernandez-Diaz, S., and Chambers, C. D., Risk of spontaneous abortion and other pregnancy outcomes in 15-25 year old women exposed to human papillomavirus-16/18 AS04-adjuvanted vaccine in the United Kingdom, Vaccine, vol. 33, pp. 6884-91, 2015.
D. G. Santos, Haguinet, F., Cohet, C., Webb, D., Logie, J., Ferreira, G. L., Rosillon, D., and Shinde, V., Risk of solid organ transplant rejection following vaccination with seasonal trivalent inactivated influenza vaccines in England: A self-controlled case-series, Vaccine, vol. 34, pp. 3598-606, 2016.
Y. Wang, Pfeiffer, R. M., Alsaggaf, R., Meeraus, W., Gage, J. C., Anderson, L. A., Bremer, R. C., Nikolenko, N., Lochmuller, H., Greene, M. H., and Gadalla, S. M., Risk of skin cancer among patients with myotonic dystrophy type 1 based on primary care physician data from the U.K. Clinical Practice Research Datalink, Int J Cancer, vol. 142, pp. 1174-1181, 2018.
C. R. Meier, Wilcock, K., and Jick, S. S., The risk of severe depression, psychosis or panic attacks with prophylactic antimalarials, Drug Saf, vol. 27, pp. 203-13, 2004.
J. Castellsague, Garcia-Rodriguez, L. A., Duque, A., and Perez, S., Risk of serious skin disorders among users of oral antifungals: a population-based study, BMC Dermatol, vol. 2, p. 14, 2002.
T. Lancaster, Swart, A. M., and Jick, H., Risk of serious haematological toxicity with use of chloramphenicol eye drops in a British general practice database, Bmj, vol. 316, p. 667, 1998.
R. T. Webb, Kontopantelis, E., Doran, T., Qin, P., Creed, F., and Kapur, N., Risk of self-harm in physically ill patients in UK primary care, J Psychosom Res, vol. 73, pp. 92-7, 2012.
H. Jick, Derby, L. E., Vasilakis, C., and Fife, D., The risk of seizures associated with tramadol, Pharmacotherapy, vol. 18, pp. 607-11, 1998.
M. Bloechliger, Ceschi, A., Ruegg, S., Kupferschmidt, H., Kraehenbuehl, S., Jick, S. S., Meier, C. R., and Bodmer, M., Risk of Seizures Associated with Antidepressant Use in Patients with Depressive Disorder: Follow-up Study with a Nested Case-Control Analysis Using the Clinical Practice Research Datalink, Drug Saf, vol. 39, pp. 307-21, 2016.
J. West, Logan, R. F., Hubbard, R. B., and Card, T. R., Risk of schizophrenia in people with coeliac disease, ulcerative colitis and Crohn's disease: a general population-based study, Aliment Pharmacol Ther, vol. 23, pp. 71-4, 2006.
C. Martinez, Katholing, A., Folkerts, K., and Cohen, A. T., Risk of recurrent venous thromboembolism after discontinuation of vitamin K antagonist treatment: a nested case-control study, J Thromb Haemost, vol. 14, pp. 1374-83, 2016.
G. Bouras, Burns, E. M., Howell, A. M., Bottle, A., Athanasiou, T., and Darzi, A., Risk of Post-Discharge Venous Thromboembolism and Associated Mortality in General Surgery: A Population-Based Cohort Study Using Linked Hospital and Primary Care Data in England, PLoS One, vol. 10, p. e0145759, 2015.
S. Stapley, Peters, T. J., Neal, R. D., Rose, P. W., Walter, F. M., and Hamilton, W., The risk of pancreatic cancer in symptomatic patients in primary care: a large case-control study using electronic records, Br J Cancer, vol. 106, pp. 1940-4, 2012.
A. Arana, Johannes, C. B., McQuay, L. J., Varas-Lorenzo, C., Fife, D., and Rothman, K. J., Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Proton Pump Inhibitors, or Metoclopramide: A Population-Based Nested Case-Control Study, Drug Saf, vol. 38, pp. 1187-99, 2015.
C. Huerta, Rodriguez, L. A. Garcia, Moller, C. S., and Arellano, F. M., The risk of obstructive airways disease in a glaucoma population, Pharmacoepidemiol Drug Saf, vol. 10, pp. 157-63, 2001.
[Page last reviewed 6 September 2019]