Interventional studies

CPRD can improve the efficiency of clinical studies delivery through innovative data-driven approaches.

Services are based on access to a potential recruitment pool of 16 million patients registered at CPRD’s extensive network of GP practices across the UK. 


CPRD SPRINT (Speedy Patient Recruitment INto Trials) is tailored to support commercial organisations rapidly recruit high quality patients living with chronic conditions in the community, into phase 2 and 3 trials. Services are based on centralised near-real time primary care electronic health record searches, followed by clinical review. Only patients who are suitable for a trial are contacted by their GP practice. This highly targeted approach for quickly finding the right patients located across the UK at the outset, reduces screen failures, saving valuable patient and investigator time and cost. 

Find out more about CPRD SPRINT.

CPRD PROVE (PRoviding Online Verification of EHR)

CPRD PROVE: simple verification of coded records for selected patients for observational studies. GPs verify coded data by responding to a short standard questionnaire.

CPRD PROVE Plus: verification and provision of supplementary information of coded records for selected patients from observational studies. GPs complete a study-specific questionnaire to verify coded data and provide additional information from non coded data.

These studies require approval through CPRD’s Research Data Governance process. Researchers need to engage with CPRD by contacting prior to protocol submission. 

CPRD PROVE pricing information

Data enabled clinical trials support

CPRD offers data enabled clinical trials support for low-intervention, randomised, phase IV clinical effectiveness trials taking place in a primary care setting. This service incorporates:

  • Location and recruitment of trial participants using electronic health record (EHR) searches followed by clinical review
  • Point of care randomisation and enrolment
  • Centralised trial monitoring via the online study platform
  • Patient follow-up via EHR
  • Provision of a trial dataset

The DaRe2THINK study is an example of CPRD’s data enabled clinical trials service.  

Patient referrals

Patients are invited to participate in academic led studies following location via EHR searches and clinical review. Studies can be randomised or non-randomised and typically involve collection and analysis of primary care EHR and linked data.

An example of current research activity is The Long COVID (TLC) study

Cluster trials

CPRD can support cluster randomised trials carried out in a primary care setting. Trials involve the recruitment of GP practices which are randomised to either intervention or control arms. CPRD can support delivery of a GP practice level intervention and provide outcomes data. These studies typically will involve collection and analysis of primary care EHR and linked data. 

Find out more

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Find out about our observational research services

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