Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
22/02/2021 The direct and indirect effects of Covid-19 on long-term conditions: A retrospective cohort study using primary and secondary care electronic health records
11/02/2021 COVID-19 recording in Clinical Practice Research Datalink primary care data and linked Second Generation Surveillance System SARS-CoV-2 virology test data
02/02/2021 Real world evidence in asthma and chronic obstructive pulmonary disease to understand the burden of COVID-19 infection in United Kingdom
21/01/2021 Cohort study of risk factors of acute and chronic cardiovascular events in COVID-19 patients
19/01/2021 The descriptive epidemiology of Adverse Events of Special Interest for COVID-19 and other vaccines in the general population and after seasonal influenza and COVID-19 disease
13/01/2021 Impact of COVID-19 pandemic on routine clinical management of patients with neurological diseases: a descriptive retrospective cohort study
15/12/2020 Investigating the effect of cardiovascular risk level on severe outcomes of COVID-19
01/12/2020 Understanding the association between diabetes and severe COVID-19 infection
24/11/2020 Feasibility analysis of a European infrastructure for COVID-19 vaccine monitoring: Background rates of Adverse Events of Special Interest
10/11/2020 Acute and long-term health outcomes for people who survived COVID-19: matched cohort analyses using UK primary and secondary care data
20/10/2020 MuSculoskeletal paiN durIng the COVID-19 PandEmic: an observational study of UK national primary care electronic health records (the SNIPE Study)
19/10/2020 Near real time vaccine safety monitoring for COVID-19 vaccines
20/08/2020 Defining clinical research phenotypes using SNOMED CT
05/08/2020 Excess mortality during the COVID-19 pandemic
31/07/2020 Indirect acute effects of the COVID-19 pandemic on physical and psychological morbidity in the UK
30/07/2020 Using Real-World Data to Examine the Impact of Different Target Populations on the Representativeness of Cardiovascular Outcome Trials of Antidiabetic Drugs
30/07/2020 An investigation of excess mortality and end-of-life morbidity patterns before and during the COVID-19 pandemic. A retrospective analysis using primary care data
30/07/2020 Using linked primary care and viral surveillance data to develop risk stratification models to inform management of severe COVID-19
29/07/2020 Real-world utilization of and comparative outcomes arising from novel oral anticoagulants for atrial fibrillation and stroke prevention in the United Kingdom
23/07/2020 Exploring patterns of healthcare resource utilisation and COPD exacerbations in patients with chronic obstructive pulmonary disease for health technology assessment