Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of ISAC Approval Title
07/05/2021 Natural history of coagulopathy and use of anti-thrombotic agents in COVID-19 patients: a cohort study
27/04/2021 Long COVID in non-hospitalised individuals: symptoms, risk factors and syndromes
09/04/2021 Impact of the COVID-19 Crisis on Treatments, Natural History, Health Care Resource Utilisation, and Medical Cost in Hypertrophic Cardiomyopathy in England
23/03/2021 The Impact of COVID-19 lockdown on the lives of People with Obesity (PwO): A UK primary care based study
16/03/2021 Healthcare utilisation, symptoms, prescriptions and new disease in people with COVID-19 managed in the community or hospital
09/03/2021 CORYLUS UK: A retrospective observational cohort study of the impact of COVID-19 on systemic lupus erythematosus patients in England using data from linked primary and secondary care databases
22/02/2021 The direct and indirect effects of Covid-19 on long-term conditions: A retrospective cohort study using primary and secondary care electronic health records
11/02/2021 COVID-19 recording in Clinical Practice Research Datalink primary care data and linked Second Generation Surveillance System SARS-CoV-2 virology test data
02/02/2021 Real world evidence in asthma and chronic obstructive pulmonary disease to understand the burden of COVID-19 infection in United Kingdom
21/01/2021 Cohort study of risk factors of acute and chronic cardiovascular events in COVID-19 patients
19/01/2021 The descriptive epidemiology of Adverse Events of Special Interest for COVID-19 and other vaccines in the general population and after seasonal influenza and COVID-19 disease
13/01/2021 Impact of COVID-19 pandemic on routine clinical management of patients with neurological diseases: a descriptive retrospective cohort study
15/12/2020 Investigating the effect of cardiovascular risk level on severe outcomes of COVID-19
01/12/2020 Understanding the association between diabetes and severe COVID-19 infection
24/11/2020 Feasibility analysis of a European infrastructure for COVID-19 vaccine monitoring: Background rates of Adverse Events of Special Interest
10/11/2020 Acute and long-term health outcomes for people who survived COVID-19: matched cohort analyses using UK primary and secondary care data
20/10/2020 MuSculoskeletal paiN durIng the COVID-19 PandEmic: an observational study of UK national primary care electronic health records (the SNIPE Study)
19/10/2020 Near real time vaccine safety monitoring for COVID-19 vaccines
20/08/2020 Defining clinical research phenotypes using SNOMED CT
05/08/2020 Excess mortality during the COVID-19 pandemic