Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
05/08/2020 Excess mortality during the COVID-19 pandemic
31/07/2020 Indirect acute effects of the COVID-19 pandemic on physical and psychological morbidity in the UK
30/07/2020 An investigation of excess mortality and end-of-life morbidity patterns before and during the COVID-19 pandemic. A retrospective analysis using primary care data
30/07/2020 Using linked primary care and viral surveillance data to develop risk stratification models to inform management of severe COVID-19
08/07/2020 Descriptive analysis of patterns of primary care demand in England during the COVID-19 pandemic
07/07/2020 Primary care service use towards end of life among patients who died before and during the COVID-19 epidemic: a nationwide cohort study using the Clinical Practice Research DataLink
01/07/2020 Evaluation of the drivers in heterogeneity in unplanned hospital admissions and mortality in frail and multimorbidity elderly patients before and during/after COVID-19
18/06/2020 Risk factors and outcomes of COVID-19 in individuals with Down syndrome
12/06/2020 Assessing factors associated with the COVID-19 risk in people with asthma
09/06/2020 Risk factors for and long-term outcomes in people with covid-19 admitted to hospital in England
02/06/2020 Clinical contact with health services for mental illness and self-harm before, during and after the COVID-19 pandemic
28/05/2020 A qualitative questionnaire based study exploring attitudes, beliefs and experiences of patients and healthcare professionals, in relation to short-acting beta-2-agonist and inhaled corticosteroid prescription and adherence
28/05/2020 Glycaemic Control in Type 2 Diabetes Patients after Switching from Basal-Bolus Treatment to Biphasic Insulin Aspart 30/70: a Descriptive Study
19/05/2020 Prevalence, patient characteristics and treatment patterns of adult Atopic Dermatitis in UK primary care
15/05/2020 Diagnosis and management of infectious disease in primary care during the COVID-19 lockdown: changes in antibacterial and antiviral use
05/05/2020 The association between amoxicillin exposure in infancy and the development of asthma in later childhood in the UK: A retrospective cohort study using Clinical Practice Research Datalink
05/05/2020 Antimicrobial stewardship during the COVID-19 epidemic. Cohort study
05/05/2020 Consultations for non-specific symptoms commonly reported with COVID-19 and other acute respiratory infections in the Clinical Practice Research Datalink: long term trends and patient characteristics
28/04/2020 Utilisation and safety of Glycopyrronium Bromide (GPB) oral solution for the treatment of sialorrhoea in children <18 years in the UK
27/04/2020 Underlying conditions in coronavirus (COVID-19) infection: definition, prevalence, mortality and understanding risk