Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

 

ISAC Approval Date Title
30/10/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT):Study 15 - Replication of "Concurrent use of long-acting bronchodilators in COPD and the risk of adverse cardiovascular events."
25/10/2018 Burden of Hypereosinophilic syndrome (HES) in the UK
25/10/2018 Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study
12/10/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 13 - Replication of "Metformin and the incidence of viral associated cancers in patients with type 2 diabetes."
11/10/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT):Study 15 - Replication of "Concurrent use of long-acting bronchodilators in COPD and the risk of adverse cardiovascular events."
11/10/2018 Incretin-based drugs and the risk of lung cancer in patients with type 2 diabetes
24/09/2018 Identifying patients with familial hypercholesterolemia who could benefit from treatment with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors: Development and validation of a logistic regression predictive model
21/09/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 7 - Replication of "Antibiotic treatment failure in four common infections in UK primary care 1991-2012: longitudinal analysis"
19/09/2018 Impact of EU label changes for systemic diclofenac & hydroxyzine products: post-referral prescribing trends
11/09/2018 Uptake of pneumococcal and zoster vaccines by clinical risk groups in England
10/09/2018 Initiation of Combination Therapy in Type 2 Diabetes Patients with high HbA1c at diagnosis
10/09/2018 Sodium-glucose co-transporter 2 inhibitors and the risk of fractures in patients with type 2 diabetes
29/08/2018 Age at onset of multiple cardiovascular disease conditions: differences in ethnic subgroups by diabetes status
22/08/2018 Testosterone replacement therapy and the risk of prostate cancer in men with age-related hypogonadism
07/08/2018 Relationship between Body Mass Index (BMI) trajectory and the risk of cardiovascular disease and diabetes among overweight and obese people: A UK Primary Care-based cohort study
01/08/2018 A study on the epidemiology of tinnitus in the United Kingdom
01/08/2018 Impact of subsequent major adverse cardiovascular events on mortality in a post-myocardial infarction population: a retrospective UK database analysis
01/08/2018 Defining patient groups at short-term high risk of fracture and evaluating current practice of osteoporosis treatment and rate of different fractures and cardiovascular events in these patient groups
23/07/2018 Evaluating effect modification using propensity score matching and disease risk score methods: an empirical study
20/07/2018 Using electronic health records to assess effectiveness of national policy in dementia recognition in the UK