Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
31/07/2019 Use of the STarT Back Screening Tool for Low Back Pain in Primary Care
26/07/2019 5-Alpha Reductase Inhibitors and the Risk of Anaemia
26/07/2019 Trends in Prescription of Antihypertensive Medications in UK Primary Care Practices, 1988-2018
26/07/2019 Suspected cancer symptoms and blood test results in primary care before a diagnosis of lung cancer: a case-control study
23/07/2019 Real world data on utilisation and safety of Movicol paediatric plain among children <2 years
18/07/2019 Prevalence of established cardiovascular disease in patients with type 2 diabetes mellitus in the UK
11/07/2019 Investigating capacity for NICE guidance on recognition and referral for suspected cancer
10/07/2019 Association of serum bilirubin level with renal outcomes in patients with type 2 diabetes and patients with essential hypertension
04/07/2019 Variation in healthcare utilisation across primary and secondary care for patients with type 1 and type 2 diabetes
28/06/2019 Trends in Acid Suppressant Drug Prescriptions in Primary Care in the United Kingdom
12/06/2019 Potentially unintended discontinuation of medication following hospitalisation: a retrospective cohort study
12/06/2019 Treatment patterns among new users of maintenance asthma medications in the United Kingdom
31/05/2019 An observational study to establish the cardiovascular-renal-metabolism comorbidity epidemiology and healthcare utilisation in England
31/05/2019 Trends in cancer incidence and mortality in people with pre-diabetes and diabetes among different ethnicities
29/05/2019 An exploratory study of antibiotic prescribing in the CPRD Aurum database
23/05/2019 Herpes zoster vaccine and the risk of Bell's palsy and Guillain-Barre Syndrome in the UK
21/05/2019 Classification and prediction of missing ethnicity in diabetic patients from electronic health record data
20/05/2019 Distribution of risk of cardiovascular diseases and fractures among elderly women with a recent fracture in CPRD: a cross-sectional study
15/05/2019 Hypertension detection and cardiovascular outcomes: a retrospective cohort study using data from the Clinical Practice Research Datalink database
08/05/2019 Determinants of blood pressure lowering treatment prescribing for primary prevention: a cohort study in UK primary care