Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
15/07/2015 The impact of obesity on healthcare resource utilisation.
17/07/2015 To establish the causal roles of environmental factors on exacerbations of COPD
23/07/2015 The effect of metformin on patient outcome after acute myocardial infarction
12/08/2015 Mortality of people with learning disability
17/08/2015 Alcohol misuse and injury outcomes in adolescents aged 10-24 using linked UK health data
18/08/2015 Risk of fragility fracture across inflammatory conditions: a UK population study
28/08/2015 Cluster Headache Patient Prevalence and Prescribed Treatments in the UK Clinical Practice Research Datalink
28/08/2015 Demographic and clinical characteristics of T2DM patients treated with DPP-4 and SGLT2 inhibitors in the absence of a current clinical guideline - A CPRD Study
01/09/2015 Medical resource use and costs associated with diabetes complications in the population of diabetes patients receiving insulin therapy in the United Kingdom
04/09/2015 Time to treatment intensification and associated outcomes among patients with Type 2 diabetes mellitus in the UK
11/09/2015 Healthcare resource utilisation and economic impact among kidney transplant patients during the last year before graft failure in the UK: a retrospective observational study
11/09/2015 Healthcare resource utilisation and economic impact among liver transplant patients during the last year before graft failure in the UK: a retrospective observational study
14/09/2015 The incidence of Guillain-Barre Syndrome in the United Kingdom from April 2005 to March 2015.
15/09/2015 Can Continuity Of Primary Care Decrease Unscheduled Secondary Care Use?
22/09/2015 The risk of fragility fracture in inflammatory arthritis: evidence for the effective and equitable targeting of prevention
02/10/2015 Evaluation of the clinical and economic outcomes associated with Bydureon versus basal insulin in people with type 2 diabetes
05/10/2015 An evaluation of the epidemiology and burden of illness of congenital adrenal hyperplasia in the United Kingdom
06/10/2015 The association between Huntington's disease and cancer before and after the Huntington's diagnosis - a two-phase study
06/10/2015 Effects of pulmonary rehabilitation on exacerbation number and severity in people with Chronic Obstructive Pulmonary Disease
08/10/2015 The risk of depression and suicidality in patients with psoriasis, psoriatic arthritis or ankylosing spondylitis: a retrospective United Kingdom database analysis