Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
10/02/2016 Evaluating the utility of the CPRD GOLD-HTI linkage: anticoagulant prescribing at the GP practice compared to hospital dispensed medication at discharge date
10/02/2016 Demography and pattern of causes of death in recognised alcohol misusers in the English General Practice (GP) population
10/02/2016 Depression, prescription of antidepressant drugs and changes in body weight: A cohort study using electronic health records
18/02/2016 Use of routinely collected national data to determine the delays that lead to poor outcome for cancer patients in the UK
19/02/2016 Investigating the effects of commonly prescribed drugs on the prevention and treatment of Alzheimer's and other neurodegenerative diseases: are there drugs already available that can be repurposed?
23/02/2016 Association between HbA1c and all-cause mortality in people with type 2 diabetes treated with glucose-lowering therapies with a higher and lower risk of inducing hypoglycaemia: a retrospective cohort study.
23/02/2016 Risk of hypoglycaemia in users of sulphonylureas with renal impairment: a population-based cohort study
23/02/2016 Comorbidity in the aging HIV population of the UK: a CPRD analysis.
25/02/2016 Predicting first admission and readmission in heart failure patients
25/02/2016 Validity of UK general practice prescribing safety indicators in predicting adverse events
08/03/2016 Natural history, characteristics, and treatment patterns in patients with primary biliary cirrhosis and cholestatic pruritis
09/03/2016 Predictors of complications of venous thromboembolism
10/03/2016 Investigating the utility of blood pressure variability in cardiovascular risk prediction
14/03/2016 Benign and Malignant Tumors in Patients with Myotonic Dystrophy Type I
14/03/2016 Low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride and diverse non-cardiovascular diseases: a large population-based cohort study using CALIBER dataset
17/03/2016 The risk of cardiovascular related death following cytomegalovirus (CMV) infection in England: an open cohort study using data from the Clinical Practice Research Datalink (CPRD)
24/03/2016 Evaluating the impact of NICE guidelines for suspected cancers in respect of diagnostic interval and other outcomes
24/03/2016 Hyperglycaemia and early detection of pancreatic cancer
31/03/2016 Post-marketing study of ropinirole prolonged release tablets in Parkinson's disease: Evaluation outcomes associated with long term use of Ropinirole-PR using the UK clinical practice research datalink (UK-CPRD)
31/03/2016 Risk of eczema in children: a population-based study