Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
15/05/2018 The association between inflammatory markers measured in blood and incident seizures
04/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 5 - Replication of "Pioglitazone use and risk of bladder cancer: population based cohort study"
02/05/2018 Impact of removing Quality and Outcomes Framework financial incentives from English Primary Care
30/04/2018 Health care use and cost trajectories of people in the last year of life : improving planning and resource allocation in end of life care
30/04/2018 The epidemiology and healthcare burden of opioid therapy in the United Kingdom
26/04/2018 Blood Eosinophil Levels and Severe Asthma Exacerbations Among Paediatric Patients with Asthma in the English Primary Care Setting
26/04/2018 5-ASA in Crohn's Disease: The CROHN'S Investigation (Clinical and treatment Resource use, patient Outcomes and Health impact using National prescribing Systems)
25/04/2018 Mapping opportunities for earlier detection of Bipolar Disorder - Linking big data to improve patient outcomes (MOBILISE)
25/04/2018 Unmet Needs, Symptom Burden, and Health Care Utilisation of Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Respiratory Maintenance Therapy in the United Kingdom (UK)
20/04/2018 Management of hyperthyroidism in pregnancy; data from a large UK primary care cohort
18/04/2018 Cessation of renin-angiotensin system inhibitors after acute kidney injury and outcome
18/04/2018 Antibiotic Choice in UK General Practice - rates and drivers of potentially inappropriate antibiotic type in UK general practices
05/04/2018 Epidemiology, outcomes, treatment patterns, and health resource utilization among English patients with coronary artery disease (CAD), peripheral artery disease (PAD), and CAD or PAD
05/04/2018 Comparison of Outcomes for Patients Hospitalised for Heart Failure (HHF) in the UK, Japan, USA and Taiwan
03/04/2018 Individual-level cost-of-illness Analysis for FoResight and Modelling for European HEalth Policy and Regulation (FRESHER) Project using linked English Data
28/03/2018 Utilisation pattern of hormonal replacement therapy in UK general practice between 2000 and 2016
28/03/2018 A Comparison of the Effectiveness and Safety of Direct Oral Anticoagulants (DOACs) versus. Warfarin in Older People with Atrial Fibrillation
26/03/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 2 - Replication of "Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study"
26/03/2018 Beta 2 agonists and the incidence of Parkinson's disease
21/03/2018 Survival of patients with heart failure in community (SurviveHF)