Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

 

ISAC Approval Date Title
20/07/2018 Dipeptidyl peptidase-4 inhibitors and the risk of bullous pemphigoid among patients with type 2 diabetes
16/07/2018 Correlation of forced expiratory volume in one second with mortality and resource use in patients with asthma
12/07/2018 Describing monotherapy and combination use in male and female patients with treatment for Lower Urinary Tract Symptoms. A retrospective, observational study using the UK CPRD
10/07/2018 The extent of medication complexity in general practice
10/07/2018 The combine effect of renin angiotensin aldosterone system blockage and Sodium-glucose co-transporter-2 receptor inhibition on renal outcomes in type 2 diabetes
09/07/2018 Risk Stratification and multimorbidity in Chronic Obstructive Pulmonary Disease (COPD)
09/07/2018 Impact of ethnicity on the development of kidney disease in the UK, a retrospective database study
04/07/2018 Prognostic relevance of severe hypoglycaemia and factors associated with poor outcomes in subjects experiencing severe hypoglycaemia
04/07/2018 A cohort study investigating the association of flucloxacillin and liver injury within people previously exposed to the drug
28/06/2018 Risk factors for overtreatment and undertreatment of glucose-control in patients with diabetes mellitus and association of overtreatment with mortality
22/06/2018 Prevalence, incidence, and natural history of gastroparesis in the United Kingdom: real world evidence from the Clinical Practice Research Datalink
20/06/2018 The impact of not speaking English as a first language on diabetes control and outcomes in primary care
18/06/2018 Investigating healthcare utilisation for heart failure patients with or without cardiac implantable electronic devices in England: retrospective cohort study.
15/06/2018 Comparing the effectiveness of COPD treatments in the UK
15/06/2018 Health benefits of sustained weight loss in people with overweight or obesity
11/06/2018 Investigating the potential side effects of the human papillomavirus vaccine: a novel regression discontinuity analysis using the UK Clinical Practice Research Datalink
08/06/2018 The cumulative incidence of seizures during 21 days after new use of oral antibiotics - a cohort study
08/06/2018 Replication of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) in a cohort study using electronic primary care data
08/06/2018 Prescribing of high dose oral ibuprofen (1800mg/day or more) in UK primary care
01/06/2018 Determinants associated with treatment modification in the first year of treatment in patients with type 2 diabetes mellitus in the United Kingdom, before and after implementation of the new guideline: a retrospective cohort study