Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
15/05/2019 Hypertension detection and cardiovascular outcomes: a retrospective cohort study using data from the Clinical Practice Research Datalink database
08/05/2019 Determinants of blood pressure lowering treatment prescribing for primary prevention: a cohort study in UK primary care
03/05/2019 An evaluation of patient outcomes for Type 2 Diabetes Mellitus (T2DM) patients prescribed dipeptidyl peptidase-4 (DPP4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors or Sulphonylureas (SUs) at first intensification
26/04/2019 Prediction of imminent fracture risk in new users of oral bisphosphonates or recently fractured subjects: a multinational European real-world cohort study
18/04/2019 Describing the characteristics of patients who die of COPD with no evidence of prior diagnosis
18/04/2019 Safety of five years of pertussis vaccination in pregnancy in England: a cohort study
15/04/2019 Maternal post-natal GP checks: exploring the equity of care provision in England
04/04/2019 Differences in risk of long-term cardiovascular and renal outcomes between men and women after a reduction in kidney function following initiation of a renin-angiotensin system inhibitor
01/04/2019 Cardiovascular risk prediction in daily practice: can machine-learning based risk prediction models improve the accuracy of risk prediction for individual patients?
29/03/2019 Risk of non-melanoma skin cancer among hypertensive adults in the United Kingdom treated with angiotensin converting enzyme inhibitors: a population based, active comparator, new user, retrospective cohort study
26/03/2019 All Cause and Cardiovascular Mortality in type 2 diabetes patients using Detemir or Glargine
19/03/2019 Validation of CPRD database transformed to Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM)
18/03/2019 Developing and validating a novel clinical severity index for cardiovascular disease in primary care
13/03/2019 Epidemiology of Endometriosis in the Adolescent Population
13/03/2019 Bereavement amongst those with chronic kidney disease - does it affect outcomes?
13/03/2019 Delayed treatment intensification and risk of micro- and macrovascular complications in insulin-treated patients with type 2 diabetes; a United Kingdom Clinical Practice Research Datalink Retrospective Cohort Study
12/03/2019 Database - Prescription Event Monitoring (D-PEM) study to identify, quantify and characterise identified adverse events associated with the use of a widely prescribed medication in primary care in the UK
12/03/2019 Determining the optimal timing of triple therapy initiation in patients with chronic obstructive pulmonary disease (COPD) in the United Kingdom (UK): A retrospective, longitudinal cohort study
07/03/2019 A personalized approach to depression care: Discovering adaptive treatment strategies
28/02/2019 Epidemiology and treatment pathways of ankylosing spondylitis: a retrospective UK database analysis