Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
08/07/2020 The Incidence of Cancer Overall and Site-Specific Cancer Among Patients with Type 2 Diabetes Between 1988 and 2019
08/07/2020 Descriptive analysis of patterns of primary care demand in England during the COVID-19 pandemic
07/07/2020 Primary care service use towards end of life among patients who died before and during the COVID-19 epidemic: a nationwide cohort study using the Clinical Practice Research DataLink
01/07/2020 Evaluation of the drivers in heterogeneity in unplanned hospital admissions and mortality in frail and multimorbidity elderly patients before and during/after COVID-19
29/06/2020 Selective Serotonin Reuptake Inhibitors and the Risk of Type 2 Diabetes Mellitus in Children and Youths
23/06/2020 Examining methodology to identify patterns of consulting in primary care for different groups of patients before a diagnosis of cancer: a matched retrospective cohort study
23/06/2020 The prevalent new-user design for cohort studies with no active comparator: The example of statins and cancer
18/06/2020 Risk factors and outcomes of COVID-19 in individuals with Down syndrome
17/06/2020 Area, maternal and child determinants of MMR uptake
12/06/2020 Assessing factors associated with the COVID-19 risk in people with asthma
09/06/2020 Exploring the role of electronic Frailty Index (eFI) using routine primary care electronic health care records data to predict hospitalization and mortality in older patients with type 2 diabetes
09/06/2020 Risk factors for and long-term outcomes in people with covid-19 admitted to hospital in England
02/06/2020 Clinical contact with health services for mental illness and self-harm before, during and after the COVID-19 pandemic
28/05/2020 A qualitative questionnaire based study exploring attitudes, beliefs and experiences of patients and healthcare professionals, in relation to short-acting beta-2-agonist and inhaled corticosteroid prescription and adherence
28/05/2020 Surgical interventions to treat severe pressure sores - The SIPS study
28/05/2020 Glycaemic Control in Type 2 Diabetes Patients after Switching from Basal-Bolus Treatment to Biphasic Insulin Aspart 30/70: a Descriptive Study
28/05/2020 Trend and mechanism of socioeconomic disparity in infant mortality
19/05/2020 Early Life Antibiotic Exposure and Incident Chronic Diseases in Childhood
19/05/2020 Prevalence, patient characteristics and treatment patterns of adult Atopic Dermatitis in UK primary care
15/05/2020 Diagnosis and management of infectious disease in primary care during the COVID-19 lockdown: changes in antibacterial and antiviral use