Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
22/09/2015 The risk of fragility fracture in inflammatory arthritis: evidence for the effective and equitable targeting of prevention
23/09/2015 Evidence for and implications of channeling in the use of nonprescription acetaminophen and ibuprofen in an electronic medical records database
02/10/2015 Evaluation of the clinical and economic outcomes associated with Bydureon versus basal insulin in people with type 2 diabetes
05/10/2015 An evaluation of the epidemiology and burden of illness of congenital adrenal hyperplasia in the United Kingdom
06/10/2015 The association between Huntington's disease and cancer before and after the Huntington's diagnosis - a two-phase study
06/10/2015 Effects of pulmonary rehabilitation on exacerbation number and severity in people with Chronic Obstructive Pulmonary Disease
08/10/2015 The risk of depression and suicidality in patients with psoriasis, psoriatic arthritis or ankylosing spondylitis: a retrospective United Kingdom database analysis
12/10/2015 The efficacy and safety of concomitant treatment with telmisartan, candesartan or bisoprolol in combination with amlodipine in patients with essential arterial hypertension: outcomes in real world practice
14/10/2015 A study of multifactorial intervention in type 2 diabetes and chronic kidney disease
14/10/2015 The association between lansoprazole and tuberculosis disease; a primary care based cohort study
19/10/2015 Usage Patterns of Selected Systemic NSAIDs (Including Diclofenac): A Retrospective Cohort Study
27/10/2015 Prediagnostic presentations and comorbidities of multiple sclerosis in primary care: a case-control study
27/10/2015 Morbidity among HIV-positive people in England: a cross-sectional, population-based CALIBER study
27/10/2015 Determinants of Zoster vaccination acceptance in people eligible for NHS shingles vaccination programme
04/11/2015 Stress Urinary Incontinence and Suicidality Seen in the Clinical Practice Research Datalink (CPRD)
04/11/2015 Descriptive Characteristics of the Clinical Practice Research Datalink (CPRD) EMIS database.
16/11/2015 Is gout a risk factor for erectile dysfunction?
17/11/2015 The role of systemic inflammatory diseases in long-term morbidity and mortality: a retrospective, matched-cohort study in the Clinical Practice Research Datalink
19/11/2015 Using pharmacoepidemiology to test medications associated with altered breast cancer risk identified from connectivity mapping
19/11/2015 Effects of selective serotonin reuptake inhibitors on the risk of mortality in patients with epilepsy: a CALIBER study using linked data