Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
28/08/2020 An assessment of patient characteristics and treatment patterns among ASCVD patients with hypercholesterolemia, ASCVD-risk equivalent patients with hypercholesterolemia and FH patients
26/08/2020 Understanding the health of transgender people: A population-based cross-sectional and linked cohort study
24/08/2020 The value of additional risk factors in addition to current prediction rules to better predict 10-year cardiovascular risk
21/08/2020 Helicobacter pylori infection, its treatment and colorectal cancer risk: A two-phase study using treatment data from the UK Clinical Practice Database and serology information from the UK biobank
21/08/2020 Multimorbidity and pregnancy: epidemiology, clusters, prescriptions, and preterm birth
21/08/2020 Is chronic obstructive pulmonary disease, diabetes, and life-style variables reco(r)ded similarly in CPRD GOLD and Aurum?
20/08/2020 Defining clinical research phenotypes using SNOMED CT
18/08/2020 To investigate trends in the occurrence of severe, food-induced allergic reactions
14/08/2020 Antibiotic treatment and major bleeding in anticoagulant medication users: analysis of health record data to support safer monitoring and prescribing
13/08/2020 Healthcare Resource Use, Baseline Characteristics, Clinical Outcomes and Survival Among Patients Undergoing SAVR vs TAVR in England
06/08/2020 Epidemiology, treatment patterns and healthcare resource use associated with prurigo nodularis in the UK: a retrospective analysis using the Clinical Practice Research Datalink
05/08/2020 Excess mortality during the COVID-19 pandemic
31/07/2020 Indirect acute effects of the COVID-19 pandemic on physical and psychological morbidity in the UK
30/07/2020 The economic burden of dementia and associated research funding in the United Kingdom in 2018: a comparative study of four chronic conditions
30/07/2020 Using linked primary care and viral surveillance data to develop risk stratification models to inform management of severe COVID-19
30/07/2020 An investigation of excess mortality and end-of-life morbidity patterns before and during the COVID-19 pandemic. A retrospective analysis using primary care data
30/07/2020 Using Real-World Data to Examine the Impact of Different Target Populations on the Representativeness of Cardiovascular Outcome Trials of Antidiabetic Drugs
29/07/2020 Real-world utilization of and comparative outcomes arising from novel oral anticoagulants for atrial fibrillation and stroke prevention in the United Kingdom
29/07/2020 Adverse pregnancy outcomes and maternal cardiometabolic health: an observational cohort study using electronic medical records
29/07/2020 Re-evaluating the cost effectiveness of implantable cardioverter defibrillator (ICD) or cardiac resynchronisation therapy with defibrillation (CRT-D) for heart failure using real world data from the Clinical Practice Research Datalink