Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
13/02/2018 Determining profiles of musculoskeletal health using electronic health records
13/02/2018 Risk of Serious Infections in Patients with Psoriasis: a Cohort Study using the Clinical Practice Research Datalink
08/02/2018 Evaluating the impact of changes in hypertension guidelines on the management of hypertension and outcomes.
08/02/2018 Chronic kidney disease stage G3-G5 and the risk of subsequent fractures after hip fracture
06/02/2018 Incretin-based drugs and the incidence of cholangiocarcinoma among patients with type 2 diabetes.
06/02/2018 Completion of Recommended Hepatitis Vaccination Schedules Among Adults in the United Kingdom
05/02/2018 Prevalence of gas trapping in COPD - estimation from spirometry
05/02/2018 Aripiprazole and risk of psychiatric treatment failure
01/02/2018 Incidence of Type II Diabetes in Chronic Obstructive Pulmonary Disease
24/01/2018 Comparison of methodologies for establishing NHS Health Check pre-screening strategies using existing electronic health records
24/01/2018 Epidemiology study of Invasive Extra-Intestinal pathogenic Escherichia coli (ExPEC) Disease in adults and elderly using real world healthcare databases
24/01/2018 Feasibility study to establish the value of linked CPRD and HES data to support medical device vigilance
22/01/2018 Partner bereavement and subsequent diagnosis of specific skin diseases
18/01/2018 A study of pneumonia following self-limiting respiratory tract infections managed in primary care
18/01/2018 Bendroflumethiazide versus Indapamide for Primary Hypertension: Observational (BISON) study within CPRD
17/01/2018 Cardiovascular and cerebrovascular safety of testosterone replacement therapy in hypogonadal men
17/01/2018 Lifestyle and socio-economic risk factors for non-valvular atrial fibrillation
15/01/2018 Excess risk and predictors of fracture/s following bariatric surgery for obese patients in the NHS: a real-world self-controlled case series and cohort study
18/12/2017 Methodological guidelines for the use of regression discontinuity designs in clinical settings.
18/12/2017 Risk factors for venous thromboembolism and serious bleeding events in patients with active breast, prostate, ovary, colorectal and lung cancer