Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
25/07/2017 Investigating the impact of the introduction of a named GP assigned to patients 75 and over on their continuity of care and emergency hospital admission
25/07/2017 Seizure frequency and resource utilisation associated with initiation of perampanel, eslicarbazepine and rufinamide in patients with epilepsy
25/07/2017 Characterising the risk of major bleeding in patients with Non-Valvular Atrial Fibrillation: non-interventional study of patients taking Direct Oral Anticoagulants in the EU
25/07/2017 Effects of financially-induced inhaler switching on the risk of an acute exacerbation in patients with asthma or chronic obstructive pulmonary disease (COPD): a self-controlled case series
25/07/2017 Healthcare resource utilisation and costs of major bleeding events and ischemic stroke among non-valvular atrial fibrillations patients in the UK
24/07/2017 Eligibility for blood pressure lowering treatment and subsequent cardiovascular disease burden under four different treatment approaches: a cohort study
20/07/2017 Impact of the definition of osteoarthritis and the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink.
18/07/2017 Can CHA2DS2-VASc score be used to identify patients under 65 years old at high risk of atrial fibrillation?
18/07/2017 The association between glycated haemoglobin (HbA1c), glycaemia and chronic kidney disease with or without anaemia.
18/07/2017 Incidence of major bleeding events and ischaemic stroke among non-valvular atrial fibrillation patients in the UK
18/07/2017 Steroid Use and the risk of Venous Thromboembolism in Asthma Patients
14/07/2017 Quantifying variation in UK primary care test use: A 15 year retrospective CPRD analysis of temporal and geographical variation in test use.
14/07/2017 Impact of methods for measuring the prevalence and incidence of chronic disease in the UK population based on electronic medical record (EMR) data
12/07/2017 Understanding clinical and healthcare predictors of diagnostic timeliness in patients with suspected cancer
12/07/2017 The associations between inFLAmmatory and non-inflammatory oral Mucosal diseases and hEad and Neck squamous Cell carcinOma (FLAMENCO).
12/07/2017 Meningococcal B vaccine: incidence of convulsion following vaccination and compliance with timing of vaccine doses in the UK
12/07/2017 Renal function and prescribing patterns of DPP-4 inhibitors in the UK: The extent of regional variation, dose adjustment and therapy switching.
07/07/2017 Incidence and prevalence of nontuberculous mycobacterial pulmonary disease (NTMPD) in the UK since 2004
06/07/2017 Persistence and compliance to anti-osteoporosis medications in the United Kingdom
05/07/2017 Effectiveness of proton pump inhibitors in idiopathic pulmonary fibrosis