Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
02/06/2020 Clinical contact with health services for mental illness and self-harm before, during and after the COVID-19 pandemic
02/06/2020 Reducing the burden of recurrent wheeze in preschool children in England: A birth cohort study
28/05/2020 Surgical interventions to treat severe pressure sores – The SIPS study
28/05/2020 Effect of metformin on incident dementia risk among adults with type 2 diabetes
28/05/2020 A qualitative questionnaire based study exploring attitudes, beliefs and experiences of patients and healthcare professionals, in relation to short-acting beta-2-agonist and inhaled corticosteroid prescription and adherence
28/05/2020 Using the Clinical Practice Research Datalink to test medications associated with increased risk of upper gastrointestinal cancer identified from a Scottish screening study
28/05/2020 Antithrombotic treatment and outcome of patients with acute ischemic stroke and no atrial fibrillation: A real-world study in Clinical Practice Research Datalink
28/05/2020 Intra-articular Corticosteroid injections in Osteoarthritis; the RUbICOn study
28/05/2020 Investigating inflammatory conditions in relation to colorectal cancer incidence and mortality by subsite and clinical features at presentation
28/05/2020 Glycaemic Control in Type 2 Diabetes Patients after Switching from Basal-Bolus Treatment to Biphasic Insulin Aspart 30/70: a Descriptive Study
28/05/2020 Trend and mechanism of socioeconomic disparity in infant mortality
19/05/2020 Understanding the diagnosis and prognosis of the presentation of breathlessness in adults from primary care
19/05/2020 Prevalence, patient characteristics and treatment patterns of adult Atopic Dermatitis in UK primary care
19/05/2020 Early Life Antibiotic Exposure and Incident Chronic Diseases in Childhood
15/05/2020 Diagnosis and management of infectious disease in primary care during the COVID-19 lockdown: changes in antibacterial and antiviral use
15/05/2020 Investigating population-wide differences in cancer disease trajectories: Identification of pre-cancer diagnostic routes and post-cancer disease trajectories in patients with multimorbidity using statistical and machine learning approaches
13/05/2020 Evaluating the clinical outcomes of antithrombotic therapy in patients with cirrhosis and atrial fibrillation or ischaemic heart disease
11/05/2020 Assessment of burden of illness of heart failure with reduced ejection fraction in the United Kingdom
11/05/2020 Risk of cardiovascular and related diseases in asthma patients and bronchodilator users in the UK
11/05/2020 Incidence, Prevalence and Burden of Narcolepsy in Europe: A Multi-database Study