Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
03/07/2017 Comparison of Outcomes for Patients Hospitalised with Decompensated Heart Failure in the UK and Japan
30/06/2017 Post-authorization Safety Study: Evaluation of Cardiovascular Events in Users of Mirabegron and Other Treatments for Overactive Bladder in the CPRD
28/06/2017 What are the optimal cardiovascular risk assessment and treatment targets among patients diagnosed with specific inflammatory disorders?
28/06/2017 Determining the annual proportion of women who could receive an opportunistic assessment of familial breast cancer in primary care to inform an economic model
28/06/2017 Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints: Heart Failure Study Component
27/06/2017 Understanding the role of serum electrolytes in the presentation of specific fatal and non-fatal cardiovascular disease syndromes: a research proposal using linked CPRD-HES-ONS data
22/06/2017 Intra- and Post-operative Bleeding Events in Selected Operations in the English Inpatient Hospital Setting: Incidence, Risk Factors, and Impact on Length of Stay
22/06/2017 An examination of the clinical management of children and young people aged 12-24 diagnosed with depression for the first time
20/06/2017 Fluoroquinolone use and the risk of tendon rupture: a cohort and nested case-control study in the UK Clinical Practice Research Datalink
09/06/2017 Ethnic inequalities in trajectories of cardio-metabolic risk factor control and outcomes of type two diabetes
09/06/2017 Aromatase Inhibitors and Risk of Cardiovascular Disease in Post-Menopausal Women with Breast Cancer
09/06/2017 Use of aspirin and statins in patients with retinal vascular occlusion and its association with cardiovascular diseases
08/06/2017 X-linked Hypophosphataemia: UK prevalence and health care usage
07/06/2017 Down Syndrome; co-morbidities, life expectancy and causes of mortality
07/06/2017 Glucagon-like peptide-1 analogues and the risk of diabetic retinopathy
07/06/2017 A cohort study of cancers and all cause and cause specific mortality in eczema
06/06/2017 Development and validation of clinical prediction rules to help with decision making and early detection of multiple myeloma
06/06/2017 To assess whether landmarking and/or latent classes are better than traditional methods for assessing the relationship between changes in lung function (FEV1) over time and mortality in a primary care COPD cohort with multiple co-morbidities
02/06/2017 Safety and Effectiveness of Direct Oral Anticoagulants and Warfarin for Stroke Prevention in Non-Valvular Atrial Fibrillation; A Multi-Database Cohort Study with Meta-Analysis
31/05/2017 Comparison of real world outcomes of HF patients in the UK and the USA