Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
25/05/2017 Zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in elderly in England
25/05/2017 Sex differences in risk factors and health service delivery for cardiometabolic diseases
24/05/2017 Changes in cause of mortality over time in people with chronic respiratory disease in the UK
24/05/2017 Association between diabetes control and risk of fractures: a follow-up and a nested case control
23/05/2017 Retrospective Comparative Effectiveness Study Assessing Treatment and Rates of Exacerbation among Chronic Obstructive Pulmonary Disease Subjects in England
23/05/2017 Pharmacological Heart Failure Treatment in a Population-Based Cohort using Linked Electronic Health Records
22/05/2017 Is morbidity in the UK expanding or contracting in later life? An exploratory study investigating temporal patterns in morbidity before death using primary care data
19/05/2017 The use and protective effect of antibiotics against complications of infection in patients in primary care: a cohort study using linked data from CPRD, HES, and ONS
18/05/2017 The role of hepatitis B in the progression of Non-Alcoholic Fatty Liver Disease (NAFLD) in type 2 diabetes melltius (T2DM) patients.
18/05/2017 Assessing the risk of infection among babies born to mothers with Systemic Lupus Erythematosus; a study of the first two years of life.
16/05/2017 Association between glycated hemoglobin (HbA1c), weight and hypoglycemia to treatment choice and medication adherence in Type 2 Diabetes Mellitus (T2DM)
16/05/2017 Comorbidity as a predictor of referral to, and outcome from, joint replacement surgery in primary care patients with newly diagnosed arthritis: a population-based cohort study
16/05/2017 Ocular morbidity associated with Giant Cell Arteritis and Polymyalgia Rheumatica: a controlled cohort study using the UK Clinical Practice Research Datalink
12/05/2017 Life-Limiting Conditions in Children and Young People: Prevalence and GP involvement
12/05/2017 Uptake and effectiveness of the seasonal trivalent influenza vaccine in autoimmune inflammatory rheumatic disease patients receiving corticosteroids and disease modifying anti-rheumatic drugs
11/05/2017 Development and validation of multimorbidity scores for health services outcomes
10/05/2017 Characterization of Chronic Obstructive Pulmonary Disease (COPD) patients initiating inhaled triple therapy in the United Kingdom
09/05/2017 Parkinson's disease and the risk of epileptic seizures - cohort study with nested case-control analysis
09/05/2017 The risk of depression and anxiety in adults diagnosed with vitiligo compared to the general population, in the UK
02/05/2017 Predicting prostate cancer progression: Associations between routine primary care data and prostate cancer outcomes.