Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
21/04/2017 Sub-optimal Asthma Control in patients treated with medium or high fixed dose combination of Inhaled Corticosteroid and Long Acting Beta-Agonists in the United Kingdom's Clinical Practice Research Datalink
21/04/2017 The Burden of Skin Cancer in UK Primary Care 2004-2014: a Time-Trend Analysis from the Clinical Practice Research Datalink.
21/04/2017 Assessing the internal and external validity of confidence interval calibration in observation studies
10/04/2017 The Prevalence and Clinical Burden of Primary Chylomicronaemia in the UK
10/04/2017 Unmet Need and Time Waiting for Intervention with Specialist Therapy in Asthma
10/04/2017 Topical corticosteroids and risk of type 2 diabetes: a nested case-control study
10/04/2017 Autoimmune diseases and risk of glioma
06/04/2017 Unintended effects of novel oral anticoagulants (NOAC) vs warfarin in real world settings
03/04/2017 Rotavirus vaccine effectiveness against all cause medically attended acute gastroenteritis and hospitalizations in children in England
03/04/2017 Prophylactic (Risk-reducing) Mastectomy Rates in the UK: Analysis of the Clinical Practice Research Datalink
03/04/2017 An observational retrospective cohort study to evaluate chronic disease onset associated with long-term oral corticosteroid use and the related cost impact on patients in the OPCRD / CPRD databases
03/04/2017 Prescribing Pathways to Triple Therapy in Chronic Obstructive Pulmonary Disease
31/03/2017 Drug utilization study of mirabegron (Betmiga) using real-world healthcare databases from the Netherlands, Spain, United Kingdom and Finland
29/03/2017 Acute exacerbations of chronic obstructive pulmonary disease: Clinical history and effects on rate of recurrent events and risk of death
29/03/2017 Evaluation of the impact of glucose-lowering treatment with pioglitazone on stroke outcomes
29/03/2017 The relationship between non-valvular atrial fibrillation and dementia
27/03/2017 Ovulation-Inducing Fertility Treatments and the Long-Term Risk of Breast Cancer
13/03/2017 The diagnostic utility of inflammatory markers in primary care: a prospective cohort study.
12/03/2017 Accounting for multimorbidity, competing risk and direct treatment disutility in risk prediction tools for the primary prevention of cardiovascular disease.
10/03/2017 The risk of fractures in new users of statins: A propensity-score matched sequential cohort study