Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
18/07/2017 Can CHA2DS2-VASc score be used to identify patients under 65 years old at high risk of atrial fibrillation?
18/07/2017 The association between glycated haemoglobin (HbA1c), glycaemia and chronic kidney disease with or without anaemia.
14/07/2017 Impact of methods for measuring the prevalence and incidence of chronic disease in the UK population based on electronic medical record (EMR) data
14/07/2017 Quantifying variation in UK primary care test use: A 15 year retrospective CPRD analysis of temporal and geographical variation in test use.
12/07/2017 Understanding clinical and healthcare predictors of diagnostic timeliness in patients with suspected cancer
12/07/2017 Renal function and prescribing patterns of DPP-4 inhibitors in the UK: The extent of regional variation, dose adjustment and therapy switching.
12/07/2017 The associations between inFLAmmatory and non-inflammatory oral Mucosal diseases and hEad and Neck squamous Cell carcinOma (FLAMENCO).
12/07/2017 Meningococcal B vaccine: incidence of convulsion following vaccination and compliance with timing of vaccine doses in the UK
07/07/2017 Incidence and prevalence of nontuberculous mycobacterial pulmonary disease (NTMPD) in the UK since 2004
06/07/2017 Persistence and compliance to anti-osteoporosis medications in the United Kingdom
05/07/2017 Effectiveness of proton pump inhibitors in idiopathic pulmonary fibrosis
03/07/2017 Comparison of Outcomes for Patients Hospitalised with Decompensated Heart Failure in the UK and Japan
30/06/2017 Post-authorization Safety Study: Evaluation of Cardiovascular Events in Users of Mirabegron and Other Treatments for Overactive Bladder in the CPRD
28/06/2017 Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints: Heart Failure Study Component
28/06/2017 Determining the annual proportion of women who could receive an opportunistic assessment of familial breast cancer in primary care to inform an economic model
28/06/2017 What are the optimal cardiovascular risk assessment and treatment targets among patients diagnosed with specific inflammatory disorders?
27/06/2017 Understanding the role of serum electrolytes in the presentation of specific fatal and non-fatal cardiovascular disease syndromes: a research proposal using linked CPRD-HES-ONS data
22/06/2017 An examination of the clinical management of children and young people aged 12-24 diagnosed with depression for the first time
22/06/2017 Intra- and Post-operative Bleeding Events in Selected Operations in the English Inpatient Hospital Setting: Incidence, Risk Factors, and Impact on Length of Stay
20/06/2017 Fluoroquinolone use and the risk of tendon rupture: a cohort and nested case-control study in the UK Clinical Practice Research Datalink