Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
29/03/2017 Evaluation of the impact of glucose-lowering treatment with pioglitazone on stroke outcomes
29/03/2017 The relationship between non-valvular atrial fibrillation and dementia
27/03/2017 Ovulation-Inducing Fertility Treatments and the Long-Term Risk of Breast Cancer
13/03/2017 The diagnostic utility of inflammatory markers in primary care: a prospective cohort study.
12/03/2017 Accounting for multimorbidity, competing risk and direct treatment disutility in risk prediction tools for the primary prevention of cardiovascular disease and fracture.
10/03/2017 The risk of fractures in new users of statins: A propensity-score matched sequential cohort study
08/03/2017 Exploration of long term cardiovascular outcomes following pregnancy complicated by hypertensive disorders or pregnancy
08/03/2017 Statin prescribing and depression after incident stroke
08/03/2017 Pattern of use of Direct Oral AntiCoagulant (DOAC) in Non-Valvular Atrial Fibrillation (NVAF) patients in UK general practices
06/03/2017 Canagliflozin in patients with type 2 diabetes: understanding the real world evidence: CAPTURE study 'Capture - treatment patterns in EMEA'
05/03/2017 Stratified 30 day excess risks of emergency hospital admissions and death following gastrointestinal endoscopy
01/03/2017 Domestic violence and abuse and prescription of emergency contraception: a nested case-control study in CPRD
01/03/2017 Burden of disease in patients with COPD and high blood eosinophil counts
22/02/2017 Changes over time in the monitoring of cardiovascular risk in primary care, and the use of statins for the primary and secondary prevention of cardiovascular disease.
20/02/2017 A study on the epidemiology of treated glaucoma in the United Kingdom
17/02/2017 Use of hormone replacement therapy and risk of venous thromboembolism
17/02/2017 An evaluation of the prevalence, epidemiology and burden of illness of hypophosphatasia (HPP) in the United Kingdom.
14/02/2017 The effect of month of birth on the risk of being diagnosed with learning disability and depression.
14/02/2017 Non-specific effects of vaccination in England
14/02/2017 Association of urinary tract infections with antipsychotic drug use in older patients