Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
11/05/2020 Risk of cardiovascular and related diseases in asthma patients and bronchodilator users in the UK
05/05/2020 The association between amoxicillin exposure in infancy and the development of asthma in later childhood in the UK: A retrospective cohort study using Clinical Practice Research Datalink
05/05/2020 Antimicrobial stewardship during the COVID-19 epidemic. Cohort study
05/05/2020 Consultations for non-specific symptoms commonly reported with COVID-19 and other acute respiratory infections in the Clinical Practice Research Datalink: long term trends and patient characteristics
28/04/2020 Utilisation and safety of Glycopyrronium Bromide (GPB) oral solution for the treatment of sialorrhoea in children <18 years in the UK
27/04/2020 Underlying conditions in coronavirus (COVID-19) infection: definition, prevalence, mortality and understanding risk
22/04/2020 Resource burden and treatment pathway for Type 2 Diabetic patients with Diabetic Kidney Disease in England: A study utilising primary and secondary care datasets
22/04/2020 Proton Pump Inhibitors and Gastric Cancer Incidence: A Population-based Cohort Study
20/04/2020 Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) Study
20/04/2020 Investigating early diagnoses of patients with ankylosing spondylitis using machine learning: a predictive modelling study
20/04/2020 Psychological distress associated with the current COVID-19 outbreak: evidence from electronic health records
20/04/2020 COVID-19 related risks in cancer survivors: a matched cohort study using linked UK electronic health records data
16/04/2020 COVID-19 and drugs acting on the renin angiotensin system
15/04/2020 Descriptive analysis of primary care consultations in England from 2000 to 2018
09/04/2020 Pharmacological risk factors for COVID-19 infection: a matched prospective cohort study of patients in primary care
31/03/2020 The use of primary care services among individuals with dementia approaching the end-of-life, and its association with multiple hospital admissions: a retrospective cohort study
27/03/2020 A primary care-based cohort study evaluating the utility of indefinite regular monitoring blood tests in detecting asymptomatic toxicity from long-term methotrexate and leflunomide prescription
27/03/2020 Cardiovascular disease in type 2 diabetes: characterisation of treatment variation in the UK CPRD
25/03/2020 Identifying risk factors for infection with the new coronavirus (COVID-19)
23/03/2020 Characterisation, prediction of complications, and safety of emergent therapies for viral outbreaks and pneumonia: a rapid network study to inform management of COVID-19