Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
22/05/2019 Assessment of Functional Outcomes after Restorative Proctectomy for Rectal Cancer - A Population-Based Cohort Study
21/05/2019 Classification and prediction of missing ethnicity in diabetic patients from electronic health record data
20/05/2019 Distribution of risk of cardiovascular diseases and fractures among elderly women with a recent fracture in CPRD: a cross-sectional study
15/05/2019 Psoriasis and the risk of cancer incidence and mortality: a cohort study
15/05/2019 Hypertension detection and cardiovascular outcomes: a retrospective cohort study using data from the Clinical Practice Research Datalink database
08/05/2019 Determinants of blood pressure lowering treatment prescribing for primary prevention: a cohort study in UK primary care
03/05/2019 An evaluation of patient outcomes for Type 2 Diabetes Mellitus (T2DM) patients prescribed dipeptidyl peptidase-4 (DPP4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors or Sulphonylureas (SUs) at first intensification
26/04/2019 Prediction of imminent fracture risk in new users of oral bisphosphonates or recently fractured subjects: a multinational European real-world cohort study
18/04/2019 Describing the characteristics of patients who die of COPD with no evidence of prior diagnosis
15/04/2019 Maternal post-natal GP checks: exploring the equity of care provision in England
04/04/2019 Differences in risk of long-term cardiovascular and renal outcomes between men and women after a reduction in kidney function following initiation of a renin-angiotensin system inhibitor
02/04/2019 An investigation into the association of asthma and fractures
01/04/2019 Cardiovascular risk prediction in daily practice: can machine-learning based risk prediction models improve the accuracy of risk prediction for individual patients?
29/03/2019 Risk of non-melanoma skin cancer among hypertensive adults in the United Kingdom treated with angiotensin converting enzyme inhibitors: a population based, active comparator, new user, retrospective cohort study
26/03/2019 All Cause and Cardiovascular Mortality in type 2 diabetes patients using Detemir or Glargine
22/03/2019 Sodium channel-inhibiting drugs and cancer survival: a cohort study
19/03/2019 Validation of CPRD database transformed to Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM)
18/03/2019 Developing and validating a novel clinical severity index for cardiovascular disease in primary care
13/03/2019 Epidemiology of Endometriosis in the Adolescent Population
13/03/2019 Bereavement amongst those with chronic kidney disease - does it affect outcomes?