Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
10/02/2020 Time Trends in identification of Autism Spectrum Disorders
10/02/2020 Incidence, prevalence, treatment patterns and health care resource use of women with vasomotor symptoms in the UK: A descriptive study using electronic medical records
07/02/2020 Cardiovascular comorbidity prevalence in males with haemophilia A
31/01/2020 Epidemiology, outcomes, treatment patterns, and health resource utilization among English patients with peripheral artery disease (PAD) and with PAD related lower-extremity revascularization (PAD-LER)
31/01/2020 Real World Effectiveness and Adverse Events Caused by ACE inhibitors and ARBs for Reduction in Cardiovascular Events
27/01/2020 Prevalence, Treatment Pathway and Patient Outcomes of Primary Hypercholesterolaemia and Dyslipidaemia in England: The 4Ps Study
23/01/2020 Use of Hydrochlorothiazide and the Risk of Melanoma and Non-Melanoma Skin Cancer: A Population-Based Cohort Study
17/01/2020 Examining neurologic and thromboembolic risks when using skeletal muscle relaxants with warfarin
17/01/2020 Mapping the risk of post-diagnosis infections in patients with multiple sclerosis in the UK population
16/01/2020 An observational study of comorbidities and clinical events among patients with Progressive Supranuclear Palsy (PSP)
08/01/2020 Comparison of the prevalent new user and active comparator new user designs for assessing the real-world safety and effectiveness of medications
06/01/2020 Use of electronic primary care records to obtain control populations for assessing excess risk of long-term morbidity and mortality in chronic diseases
06/01/2020 Sodium-glucose transport protein 2 inhibitors and the risk of early breast cancer
20/12/2019 Developing risk prediction models to support individualised HbA1c target setting using routinely collected primary and secondary care data from the United Kingdom (UK)
20/12/2019 Comparative effectiveness and safety of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the risk of major cardiovascular events, cancer and renal outcomes
20/12/2019 Risk of skin cancer associated with use of thiazides and thiazide-like diuretics: a cohort study
18/12/2019 Cardiovascular Risk Profiles: Comparing the Glucagon-Like Peptide-1 Receptor Agonist Cardiovascular Outcomes Trials REWIND, LEADER and SUSTAIN-6 in a Real World Population with Type 2 Diabetes in UK Primary Care
17/12/2019 Improved characterization of the overlap syndrome of heart failure, diabetes mellitus and chronic kidney disease
13/12/2019 Assessment of production batch information of vaccines in the Clinical Practice Research Datalink
06/12/2019 The prevalence of liver enzyme and function testing in UK primary care