Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
11/10/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT):Study 15 - Replication of "Concurrent use of long-acting bronchodilators in COPD and the risk of adverse cardiovascular events."
11/10/2018 Incretin-based drugs and the risk of lung cancer in patients with type 2 diabetes
09/10/2018 Incidence of Cervical Intraepithelial Neoplasia (CIN) among women aged 18 years and above in the UK between 2000 and 2017
03/10/2018 A cross sectional description of prostate cancer subgroups.
28/09/2018 Towards an accessible methodology in precision medicine: methods for time-to-event data and non-regular inferences with an application to treatment of type 2 diabetes
24/09/2018 Identifying patients with familial hypercholesterolemia who could benefit from treatment with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors: Development and validation of a logistic regression predictive model
21/09/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 7 - Replication of "Antibiotic treatment failure in four common infections in UK primary care 1991-2012: longitudinal analysis"
20/09/2018 An investigation of the adverse outcomes and resource use associated with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and their relationship with glucocorticoid (GC) treatment
20/09/2018 The resource use, financial costs and related epidemiology of treating people with HIV and its associated comorbidities vs. matched controls in the UK general population
19/09/2018 Impact of EU label changes for systemic diclofenac & hydroxyzine products: post-referral prescribing trends
11/09/2018 Uptake of pneumococcal and zoster vaccines by clinical risk groups in England
11/09/2018 Difference in Response to Inhaled Corticosteroids between smoking and non-smoking asthma patients.
10/09/2018 Mortality trends in people with and without type 2 diabetes in UK: a CPRD observational study
10/09/2018 Initiation of Combination Therapy in Type 2 Diabetes Patients with high HbA1c at diagnosis
10/09/2018 Referral rates of severe asthma patients to asthma specialists in the UK and the impact on healthcare use
10/09/2018 Sodium-glucose co-transporter 2 inhibitors and the risk of fractures in patients with type 2 diabetes
29/08/2018 Age at onset of multiple cardiovascular disease conditions: differences in ethnic subgroups by diabetes status
29/08/2018 The burden of incontinence of urine associated with prostate cancer treatment: documenting the prevalence and highlighting the difference between prostate cancer treatment modalities
29/08/2018 The relationship between partner bereavement and being diagnosed with dementia
22/08/2018 Prediction of anticoagulation control and associated health economic outcomes in patients with atrial fibrillation (AF) managed on warfarin