Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
07/03/2019 A personalized approach to depression care: Discovering adaptive treatment strategies
28/02/2019 Epidemiology and treatment pathways of ankylosing spondylitis: a retrospective UK database analysis
27/02/2019 Levothyroxine for the Treatment of Subclinical Hypothyroidism in Pregnancy: A Population-based Assessment
22/02/2019 The association between fracture risk and diabetes duration, complications and regulation in diabetes mellitus
21/02/2019 The impact of musculoskeletal conditions on outcome of hospital care for acute coronary syndrome and stroke: a linked electronic health record study
21/02/2019 Characterisation and natural history of non-exacerbating chronic obstructive pulmonary disease patients in a general practice-based population
14/02/2019 Comparative safety profile of antidiabetic drug regimens containing SGLT-2 inhibitors and/or GLP-1 receptor agonists among type 2 diabetes patients
12/02/2019 Use of Sodium-glucose co-transporter-2 inhibitors, changes in body mass index and risk of major osteoporotic fracture
12/02/2019 What are the optimal blood pressure targets for patients in atrial fibrillation treated with non-vitamin K antagonist oral anticoagulants?
11/02/2019 Utilization, Effectiveness, and Safety of SGLT2 Inhibitors Among Patients with Type 2 Diabetes Mellitus
11/02/2019 The weight loss effects of glucagon-like peptide-1 receptor agonists and the risk of breast cancer in women with type 2 diabetes
08/02/2019 Risks of antidepressants on cardiovascular mortality and morbidity, suicidality, falls and fractures in people with obesity and depression in primary care
08/02/2019 Treatment pathways to severe asthma and health care resource utilisation in the UK
08/02/2019 Investigating the extent to which exposure to varicella boosts Varicella zoster virus-immunity: a self-controlled case-series, 1997-2018
08/02/2019 Trends in incidence of first diabetic foot ulcer and mortality in patients with T1 AND T2 DM
05/02/2019 The association of cancer and autism spectrum condition in a UK population
01/02/2019 Characterising end of life health care expenditure
29/01/2019 Incidence of major adverse cardiovascular and cerebrovascular events (MACE) in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis: a retrospective analysis of a United Kingdom database
29/01/2019 Fractured wrist; predictors of poor long-term clinical and socioeconomic outcomes (The FILTER Study)
25/01/2019 Inflammatory Skin Diseases and the Risk of Chronic Kidney Disease - Cross-sectional and Cohort Studies