Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
20/03/2018 Dosage regimens and interrupted treatment in heart failure: a national retrospective cohort study in primary care.
19/03/2018 Risk factor trends and aetiological mechanisms leading to Heart Failure (HF) and outcomes; a study of ethnicity, gender and deprivation in the UK general population
14/03/2018 Evaluating and Discovering Indicators of Care from Observational Data: A Case Study on Atrial Fibrillation
13/03/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Replication of "Identification of impaired fasting glucose, healthcare utilization and progression to diabetes in the UK using the Clinical Practice Research Datalink (CPRD)".
13/03/2018 Cholesterol lowering medications and risk of fatty liver disease and liver cancer
13/03/2018 Utilization and Adverse Outcomes of Ondansetron and Fluconazole Therapy during Pregnancy
13/03/2018 Distal Renal Tubular Acidosis and Cystinuria in Adult and Paediatric populations: epidemiology, patient pathways and costs in the U.K
09/03/2018 Evaluating and enhancing the primary care medicines review in patients with complex health needs
08/03/2018 Statin use in chronic obstructive pulmonary disease (COPD) patients and risk of exacerbations: a propensity score matched cohort study
08/03/2018 Blood eosinophil and creatine reactive protein as biomarkers of response to inhaled corticosteroids in COPD
08/03/2018 An observational retrospective cohort analysis in adults with systemic lupus erythematosus/lupus nephritis to describe the characteristics of disease severity, disease activity (flare frequency), treatment, costs, and outcomes
08/03/2018 Rates of Staphylococcus Aureus infection among users of Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers: a cohort study
06/03/2018 Evaluation of the patterns of presentation and treatment of cough in order to understand the prevalence and epidemiology of chronic cough: a preliminary investigation
06/03/2018 Is smoking a risk factor for autoimmune hepatitis? An English registry-based case-control study using data from the Clinical Practice Research Datalink and linked Hospital Episode Statistics
05/03/2018 Prescribing trends of gabapentinoids in UK primary care
28/02/2018 Causes of mortality in patients with comorbid COPD and heart failure in the United Kingdom, 2005-2017
19/02/2018 Characteristics of patients initiating and switching oral anticoagulants (OACs) for non-valvular atrial fibrillation (NVAF) in the UK general practices
19/02/2018 Distribution of COPD patients by COPD GOLD Classification and their primary health-care and respiratory medication utilization in the Clinical Practice Research Datalink (CPRD)
15/02/2018 Risk and clinical impact of nontuberculous mycobacterial disease (NTM) within the general and chronic respiratory disease UK primary care patient populations, 2006-2016.
14/02/2018 Is patient-level achievement of primary care diabetes targets associated with emergency hospital admissions or mortality among the population with type 2 diabetes? A national observational study.