Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
11/02/2019 Evaluation of clinical progression of chronic kidney disease and its predictors using statistical and machine learning techniques: a retrospective cohort study from United Kingdom
11/02/2019 Utilization, Effectiveness, and Safety of SGLT2 Inhibitors Among Patients with Type 2 Diabetes Mellitus
11/02/2019 The weight loss effects of glucagon-like peptide-1 receptor agonists and the risk of breast cancer in women with type 2 diabetes
08/02/2019 Risks of antidepressants on cardiovascular mortality and morbidity, suicidality, falls and fractures in people with obesity and depression in primary care
08/02/2019 Treatment pathways to severe asthma and health care resource utilisation in the UK
08/02/2019 Investigating the extent to which exposure to varicella boosts Varicella zoster virus-immunity: a self-controlled case-series, 1997-2018
08/02/2019 Trends in incidence of first diabetic foot ulcer and mortality in patients with T1 AND T2 DM
04/02/2019 Characterization of mild, moderate and severe asthma patients in the UK CPRD database
01/02/2019 Characterising end of life health care expenditure
29/01/2019 Incidence of major adverse cardiovascular and cerebrovascular events (MACE) in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis: a retrospective analysis of a United Kingdom database
29/01/2019 Fractured wrist; predictors of poor long-term clinical and socioeconomic outcomes (The FILTER Study)
25/01/2019 Inflammatory Skin Diseases and the Risk of Chronic Kidney Disease - Cross-sectional and Cohort Studies
24/01/2019 C-reactive protein as a biomarker of response to inhaled corticosteroids in COPD
17/01/2019 Dose adjustment or discontinuous use of direct oral anticoagulants related to the concurrent use of potential interacting drugs
17/01/2019 Identifying predictors of drug treatment response in bipolar disorder
17/01/2019 Effectiveness of long acting muscarinic-antagonist- (LAMA) as an add-on to inhaled corticosteroids / long acting beta-agonists (LABA) in smoking asthmatics
10/01/2019 Mapping the opportunities for earlier diagnosis and characterising the management costs of psoriasis and impact of key co-morbidities
21/12/2018 The pattern of incident fractures in patients with diabetes mellitus compared to matched controls
19/12/2018 Withdrawal of historical inhaled corticosteroids in primary care using electronic records
19/12/2018 Understanding the predictive values of symptoms, prescriptions, and investigation patterns for cancer and non-neoplastic disease in primary care consultees