Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

 

ISAC Approval Date Title
16/12/2016 Post-authorization Safety Study: Evaluation of Neoplasm Events in Users of Mirabegron and Other Treatments for Overactive Bladder in the CPRD
12/12/2016 The risk of hypomagnesemia and electrolyte disturbances associated with the use of long-term proton pump Inhibitor: a population-based cohort study.
09/12/2016 Using Big data Research to tackle antIbiotic resisTance (BRIT)
08/12/2016 Pericarditis diagnosis in the CPRD: a potential early indicator of undetected cancer and marker of subsequent increased cancer risk
08/12/2016 A comparison of the EMPA-REG OUTCOME clinical trial population with T2DM patients treated in the routine clinical practice: An exploratory study using the Clinical Practice Research Datalink (CPRD).
08/12/2016 Equitable access to smoking cessation therapies for older smokers
08/12/2016 Burden of Hyperkalemia among individuals seeking health care services in England
08/12/2016 Patterns of LDL-C lowering by Statins and their association with Cardiovascular Outcomes in the General Population
08/12/2016 Understanding the diagnostic pathway for brain tumours in adults and its potential impact on clinical care and outcomes
08/12/2016 Assessment of the Risk of Hypertension and Cardiovascular Disease In Women with a History of Pregnancy Complications.
08/12/2016 Alternative methods to account for patients with a prior history of treatment in comparative effectiveness studies: an illustration with insulin glargine and breast cancer
08/12/2016 What is the incidence of Developmental Dysplasia of the Hip requiring intervention, and what proportion are diagnosed after six months of age?
08/12/2016 Diabetes, glycaemic control and risk of infectious disease: cohort and case-crossover studies in primary care
08/12/2016 Association of Polycystic Ovary Syndrome with patient and offspring mental health outcomes: a retrospective, observational study
01/12/2016 Identification of patients with post-stroke focal spasticity of the upper or lower limb who were treated with botulinum toxin A, and health-economic evaluation of treatment with botulinum toxin A: a cohort study in England
30/11/2016 Measuring the potential adverse impact of the adoption of prescribing guidelines in primary care
24/11/2016 Aromatase Inhibitors and Risk of Colorectal Cancer in Post-menopausal women with breast cancer
24/11/2016 A study estimating the occurrence of lower back pain annually in the UK
24/11/2016 Therapy decisions in newly diagnosed COPD patients in GOLD groups A and B- follow up of patients receiving different therapies. A non-interventional study using the Clinical Practice Research Datalink (CPRD) database.
14/11/2016 Investigating the cost effectiveness of alternative oral antiplatelet regimens in patients with type 2 diabetes in England.