Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
09/06/2017 Ethnic inequalities in trajectories of cardio-metabolic risk factor control and outcomes of type two diabetes
09/06/2017 Use of aspirin and statins in patients with retinal vascular occlusion and its association with cardiovascular diseases
09/06/2017 Aromatase Inhibitors and Risk of Cardiovascular Disease in Post-Menopausal Women with Breast Cancer
08/06/2017 X-linked Hypophosphataemia: UK prevalence and health care usage
07/06/2017 A cohort study of cancers and all cause and cause specific mortality in eczema
07/06/2017 Glucagon-like peptide-1 analogues and the risk of diabetic retinopathy
07/06/2017 Down Syndrome; co-morbidities, life expectancy and causes of mortality
06/06/2017 To assess whether landmarking and/or latent classes are better than traditional methods for assessing the relationship between changes in lung function (FEV1) over time and mortality in a primary care COPD cohort with multiple co-morbidities
06/06/2017 Development and validation of clinical prediction rules to help with decision making and early detection of multiple myeloma
02/06/2017 Safety and Effectiveness of Direct Oral Anticoagulants and Warfarin for Stroke Prevention in Non-Valvular Atrial Fibrillation; A Multi-Database Cohort Study with Meta-Analysis
31/05/2017 Comparison of real world outcomes of HF patients in the UK and the USA
25/05/2017 Zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in elderly in England
24/05/2017 Association between diabetes control and risk of fractures: a follow-up and a nested case control
24/05/2017 Changes in cause of mortality over time in people with chronic respiratory disease in the UK
23/05/2017 Retrospective Comparative Effectiveness Study Assessing Treatment and Rates of Exacerbation among Chronic Obstructive Pulmonary Disease Subjects in England
23/05/2017 Pharmacological Heart Failure Treatment in a Population-Based Cohort using Linked Electronic Health Records
22/05/2017 Is morbidity in the UK expanding or contracting in later life? An exploratory study investigating temporal patterns in morbidity before death using primary care data
19/05/2017 The use and protective effect of antibiotics against complications of infection in patients in primary care: a cohort study using linked data from CPRD, HES, and ONS
18/05/2017 The role of hepatitis B in the progression of Non-Alcoholic Fatty Liver Disease (NAFLD) in type 2 diabetes melltius (T2DM) patients.
18/05/2017 Assessing the risk of infection among babies born to mothers with Systemic Lupus Erythematosus; a study of the first two years of life.