Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
14/02/2017 Developing a co-morbidity tool to predict mortality for linked primary and secondary care data.
14/02/2017 Sulphonylurea treatment and risk of myocardial infarction and all-cause mortality: a population-based cohort study
14/02/2017 Estimating the effect of statin and metformin on cancer incidence and mortality in national linked electronic health records: a CALIBER study
14/02/2017 Comparative effectiveness and safety of novel oral anticoagulants in atrial fibrillation
14/02/2017 Trajectories of metabolic and clinical parameters prior to the onset of dementia in people with Type 2 diabetes
14/02/2017 Potentially inappropriate prescribing in people with dementia in England: a prospective cohort study.
02/02/2017 A Drug Utilisation Study of domperidone in the United Kingdom using Clinical Practice Research Datalink (CPRD)
01/02/2017 Association between Rheumatoid Arthritis and comorbidities: a combined retrospective case-control and prospective cohort study.
01/02/2017 Investigating the impact of BMI of patient with type 2 diabetes on length and cost of hospital stay for complications related to diabetes.
01/02/2017 Unintended effects of zaleplon, zolpidem, zopiclone (Z-drugs) use for sleep disturbance in people with dementia
01/02/2017 Assessment of the rate of vaccine co-administrations with Bexsero
01/02/2017 The risk of cardiovascular diseases among survivors of site-specific adult cancers: a matched cohort study
26/01/2017 Investigation of the comparative safety of opioid drugs within CPRD- part of the International Pharmacosurveillance Study
26/01/2017 Clinical burden of illness and healthcare resource utilisation among COPD patients stratified by their moderate-severe exacerbation frequency, inhaled triple maintenance treatment status and blood eosinophil levels
23/01/2017 Derivation and validation of statistical models to forecast acute death and longer term survival in people with cirrhosis
23/01/2017 The Use of Angiotensin Converting Enzyme Inhibitors and the Risk of Lung Cancer
23/01/2017 Effects of changing pre-eclampsia management on acute renal failure and other maternal and perinatal outcomes in the United Kingdom: An interrupted time-series analysis
23/01/2017 Associations between absolute value, and change in value, of albumin-creatinine ratio and major adverse health outcomes
18/01/2017 Potential benefits of antithrombotic treatment in reducing risk of subsequent cardiovascular events among patients with a prior myocardial infarction in England
13/01/2017 Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN): A case control study using the Clinical Practice Research Datalink (CPRD).