Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
16/05/2017 Ocular morbidity associated with Giant Cell Arteritis and Polymyalgia Rheumatica: a controlled cohort study using the UK Clinical Practice Research Datalink
16/05/2017 Comorbidity as a predictor of referral to, and outcome from, joint replacement surgery in primary care patients with newly diagnosed arthritis: a population-based cohort study
16/05/2017 Association between glycated hemoglobin (HbA1c), weight and hypoglycemia to treatment choice and medication adherence in Type 2 Diabetes Mellitus (T2DM)
12/05/2017 Uptake and effectiveness of the seasonal trivalent influenza vaccine in autoimmune inflammatory rheumatic disease patients receiving corticosteroids and disease modifying anti-rheumatic drugs
12/05/2017 Life-Limiting Conditions in Children and Young People: Prevalence and GP involvement
11/05/2017 Development and validation of multimorbidity scores for health services outcomes
10/05/2017 Characterization of Chronic Obstructive Pulmonary Disease (COPD) patients initiating inhaled triple therapy in the United Kingdom
09/05/2017 The risk of depression and anxiety in adults diagnosed with vitiligo compared to the general population, in the UK
09/05/2017 Parkinson's disease and the risk of epileptic seizures - cohort study with nested case-control analysis
02/05/2017 Predicting prostate cancer progression: Associations between routine primary care data and prostate cancer outcomes.
27/04/2017 Risk of developing chronic obstructive pulmonary disease or lung cancer in smokers taking enzyme-inducing antiepileptic drugs
27/04/2017 Exploring the effects of non-alcoholic fatty liver disease (NAFLD) on non-communicable disease and healthcare utilisation
27/04/2017 Blood eosinophilia as a biomarker for response to inhaled corticosteroids in COPD.
27/04/2017 Social determinants of uptake of maternal influenza and pertussis vaccine
27/04/2017 Interruption of Renin-Angiotensin-Aldosterone System Inhibition Treatment and Associations with Adverse Outcomes
27/04/2017 Estimating the prevalence of hyperkalemia in the UK, in patients with chronic kidney disease and/or heart failure
21/04/2017 Assessing the internal and external validity of confidence interval calibration in observation studies
21/04/2017 The Burden of Skin Cancer in UK Primary Care 2004-2014: a Time-Trend Analysis from the Clinical Practice Research Datalink.
21/04/2017 Sub-optimal Asthma Control in patients treated with medium or high fixed dose combination of Inhaled Corticosteroid and Long Acting Beta-Agonists in the United Kingdom's Clinical Practice Research Datalink
10/04/2017 Autoimmune diseases and risk of glioma