Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
22/08/2016 Weight loss as a predictor of cancer and serious disease in primary care.
22/08/2016 A feasibility study to develop within primary care IT systems a computer program for flagging patients with risk factors for HIV who would benefit from having an HIV test
17/08/2016 Residual Risk and Burden of Cardiovascular Diseases in the United Kingdom
16/08/2016 External validation of risk scores for dementia in the CPRD population
15/08/2016 Comprehensive ascertainment of bleeding in patients prescribed different combinations of dual antiplatelet therapy (DAPT) and triple therapy (TT, DAPT plus an anticoagulant) after coronary interventions in the UK (The ADAPTT Study).
02/08/2016 Obstructive airway disease phenotype discovery using cluster analysis techniques in CPRD
02/08/2016 Metabolic syndrome and risk of meningioma - population-based case-control analysis
02/08/2016 Comparison of information on diagnosis of musculoskeletal outcomes in the Million Women Study cohort and CPRD-GOLD: a record linkage study
01/08/2016 Use and costs of primary care consultations and prescription medications in relation to body mass index in middle-aged UK women
01/08/2016 Comparison of Health Economic Outcomes for Patients with Asthma who switch from Seretide to flutiform or Fostair using the CPRD-HES Linked Database
29/07/2016 Trimethoprim and sudden death in patients over 65 years with urinary tract infection
28/07/2016 Safety and associated costs of glucocorticoid therapy for the treatment of chronic inflammatory diseases
28/07/2016 Association between cardiovascular disease and zoster risk - case-control study in the Clinical Practice Research Datalink
28/07/2016 An analytical framework for increasing the efficiency and validity of research using primary care databases
25/07/2016 Proton pump inhibitor use and risk of developing Alzheimer's disease or vascular dementia
20/07/2016 Estimation of undiagnosed lysosomal acid lipase deficiency in a paediatric population: a UK database study
20/07/2016 Longitudinal Analyses of Body Mass Index and Risk of Parkinson's Disease in CPRD
20/07/2016 Risk of major bleeds associated with the use of direct oral anticoagulants in venous thromboembolism
20/07/2016 Characteristics of patients initiating empagliflozin or other non-insulin glucose lowering drugs in the United Kingdom
20/07/2016 Use of Nalmefene (Selincro) in the UK: Cohort design using longitudinal electronic medical records (EMR)