Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
13/01/2017 How do we better understand the current management of patients with Chronic Rhinosinusitis within the National Health Service?
13/01/2017 A nested case-controlled study of the association between incident pneumonia, dysphagia and the formulation of commonly prescribed medication among people with dementia.
13/01/2017 The incidence and mortality of complicated diverticular disease and associated outcomes following intervention
11/01/2017 Proton pump inhibitor use and risk of iron deficiency: a case-control study.
10/01/2017 Eczema and Dry Skin - Observational Analysis of Patients Prescription Patterns and Healthcare Utilization
10/01/2017 The role of statins in the survival of total arthroplasty of the hip and knee.
10/01/2017 A population-based assessment of the cardiovascular effects of 5-alpha reductase inhibitors
22/12/2016 Neuroprotective Effects of Minocycline in Schizophrenia Patients: Retrospective Cohort Studies Using the Clinical Practice Research Datalink
21/12/2016 Prescribing of antidiabetic drug therapy and comparative incidence of outcomes associated with Type 2 Diabetes
21/12/2016 Cohort study assessing the association between hormone therapy use in female breast cancer survivors and subsequent risk of cardiovascular diseases in the UK
20/12/2016 A data-driven approach for identifying falls subgroups through semantic similarity analysis
20/12/2016 Assessing the association between incretin-based drugs and the incidence of colon cancer in patients with type 2 diabetes
16/12/2016 Post-authorization Safety Study: Evaluation of Neoplasm Events in Users of Mirabegron and Other Treatments for Overactive Bladder in the CPRD
12/12/2016 The risk of hypomagnesemia and electrolyte disturbances associated with the use of long-term proton pump Inhibitor: a population-based cohort study.
09/12/2016 Using Big data Research to tackle antIbiotic resisTance (BRIT)
08/12/2016 Equitable access to smoking cessation therapies for older smokers
08/12/2016 Burden of Hyperkalemia among individuals seeking health care services in England
08/12/2016 Patterns of LDL-C lowering by Statins and their association with Cardiovascular Outcomes in the General Population
08/12/2016 Understanding the diagnostic pathway for brain tumours in adults and its potential impact on clinical care and outcomes
08/12/2016 Assessment of the Risk of Hypertension and Cardiovascular Disease In Women with a History of Pregnancy Complications.