Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
08/12/2016 Alternative methods to account for patients with a prior history of treatment in comparative effectiveness studies: an illustration with insulin glargine and breast cancer
08/12/2016 A comparison of the EMPA-REG OUTCOME clinical trial population with T2DM patients treated in the routine clinical practice: An exploratory study using the Clinical Practice Research Datalink (CPRD).
08/12/2016 Pericarditis diagnosis in the CPRD: a potential early indicator of undetected cancer and marker of subsequent increased cancer risk
08/12/2016 What is the incidence of Developmental Dysplasia of the Hip requiring intervention, and what proportion are diagnosed after six months of age?
08/12/2016 Diabetes, glycaemic control and risk of infectious disease: cohort and case-crossover studies in primary care
08/12/2016 Association of Polycystic Ovary Syndrome with patient and offspring mental health outcomes: a retrospective, observational study
01/12/2016 Identification of patients with post-stroke focal spasticity of the upper or lower limb who were treated with botulinum toxin A, and health-economic evaluation of treatment with botulinum toxin A: a cohort study in England
30/11/2016 Measuring the potential adverse impact of the adoption of prescribing guidelines in primary care
24/11/2016 Aromatase Inhibitors and Risk of Colorectal Cancer in Post-menopausal women with breast cancer
24/11/2016 A study estimating the occurrence of lower back pain annually in the UK
24/11/2016 Therapy decisions in newly diagnosed COPD patients in GOLD groups A and B- follow up of patients receiving different therapies. A non-interventional study using the Clinical Practice Research Datalink (CPRD) database.
14/11/2016 Investigating the cost effectiveness of alternative oral antiplatelet regimens in patients with type 2 diabetes in England.
09/11/2016 Diagnosis and treatment of dementia in primary care in the UK
08/11/2016 Gender differences in Chronic Obstructive Pulmonary Disease: baseline characteristics, progression, and exacerbations in the United Kingdom's Clinical Practice Research Datalink
07/11/2016 20 year trends for prevalence and incidence of Resistant Hypertension in the United Kingdom and prognosis in adults with hypertension
29/10/2016 Investigating safety of 'metabolically healthy obesity' and sustainability from community and tertiary based databases in the UK
28/10/2016 Annual Healthcare Resource Use and Costs for Eczema in Children: A Cost of Illness Study for the English NHS
24/10/2016 Trends in NHS prescribing of dual NRT (DNRT) and varenicline in pregnancy and effects on infants
18/10/2016 Primary Care and Access To Surgical Treatment For Women With Urinary Incontinence
18/10/2016 Incidence, prevalence, mortality and health-service use among people with systemic sclerosis (scleroderma) in the UK Clinical Practice Research Datalink