Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
10/04/2017 Topical corticosteroids and risk of type 2 diabetes: a nested case-control study
10/04/2017 Unmet Need and Time Waiting for Intervention with Specialist Therapy in Asthma
10/04/2017 The Prevalence and Clinical Burden of Primary Chylomicronaemia in the UK
06/04/2017 Unintended effects of novel oral anticoagulants (NOAC) vs warfarin in real world settings
03/04/2017 Prophylactic (Risk-reducing) Mastectomy Rates in the UK: Analysis of the Clinical Practice Research Datalink
03/04/2017 Prescribing Pathways to Triple Therapy in Chronic Obstructive Pulmonary Disease
03/04/2017 Rotavirus vaccine effectiveness against all cause medically attended acute gastroenteritis and hospitalizations in children in England
03/04/2017 An observational retrospective cohort study to evaluate chronic disease onset associated with long-term oral corticosteroid use and the related cost impact on patients in the OPCRD / CPRD databases
31/03/2017 Drug utilization study of mirabegron (Betmiga) using real-world healthcare databases from the Netherlands, Spain, United Kingdom and Finland
29/03/2017 The relationship between non-valvular atrial fibrillation and dementia
29/03/2017 Acute exacerbations of chronic obstructive pulmonary disease: Clinical history and effects on rate of recurrent events and risk of death
29/03/2017 Evaluation of the impact of glucose-lowering treatment with pioglitazone on stroke outcomes
27/03/2017 Ovulation-Inducing Fertility Treatments and the Long-Term Risk of Breast Cancer
13/03/2017 The diagnostic utility of inflammatory markers in primary care: a prospective cohort study.
10/03/2017 The risk of fractures in new users of statins: A propensity-score matched sequential cohort study
08/03/2017 Exploration of long term cardiovascular outcomes following pregnancy complicated by hypertensive disorders or pregnancy
08/03/2017 Statin prescribing and depression after incident stroke
08/03/2017 Pattern of use of Direct Oral AntiCoagulant (DOAC) in Non-Valvular Atrial Fibrillation (NVAF) patients in UK general practices
06/03/2017 Canagliflozin in patients with type 2 diabetes: understanding the real world evidence: CAPTURE study 'Capture - treatment patterns in EMEA'
05/03/2017 Stratified 30 day excess risks of emergency hospital admissions and death following gastrointestinal endoscopy