Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

 

ISAC Approval Date Title
19/07/2016 Unsupervised clustering and topological analysis of Type-2 Diabetes and prediabetes patients in CALIBER using clinical data from electronic medical records
12/07/2016 Linaclotide Utilisation Study in the UK - Extended Feasibility Counts
11/07/2016 Age- and lifestyle-related chronic disease and causes of mortality among adults with cerebral palsy in the United Kingdom.
11/07/2016 Cancer and risk of herpes zoster - case-control study in the Clinical Practice Research Datalink
07/07/2016 Profiling the natural history of Crigler-Najjar syndrome using the Clinical Practice Research Datalink
06/07/2016 Sequelae of gastrointestinal infections: incidence, risk factors, and economic impact on primary and secondary care settings.
06/07/2016 Stability of blood eosinophils in COPD and controls and the impact of eosinophil count, age, gender and smoking status
05/07/2016 Statin use and incident hand osteoarthritis: A propensity-score matched sequential cohort study
05/07/2016 Androgen Deprivation Therapy and Risk of Dementia
05/07/2016 Patient Characteristics Associated With Initiation Of Insulin Glargine Among Patients With Type 1 Or Type 2 Diabetes Mellitus In The United Kingdom
04/07/2016 Safety study to quantify the risk of ulceration (including all sites of occurrence), and related events (including perforations, fistula, abscess and bleeding) and death among patients treated with nicorandil with and without diverticular disease
30/06/2016 Assessment of Metformin Use Pattern in UK using CPRD
29/06/2016 Long-term severe non-dermatological outcomes in eczema
29/06/2016 Pharmacoepidemiology of pancreatin use in non-cystic fibrosis patients and comparison of all-cause mortality with that of their matched controls
29/06/2016 Generalizability of Clinical Trial Results: Value of Individual Data versus Aggregate Data
29/06/2016 Characterisation and cardiovascular risk profile of type 2 diabetes mellitus patients according to initiation of antidiabetic medications
29/06/2016 Comparative effectiveness of lansoprazole and omeprazole for the prevention of gastrointestinal bleeding and malignancy
22/06/2016 Immunosuppressive therapy and Parkinson's disease risk
21/06/2016 What is the occurrence of clinically diagnosed coeliac disease and dermatitis herpetiformis in the UK today? A population based cohort study utilising electronically linked health records.
21/06/2016 Diabetes, use of metformin and the risk of meningioma