Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
21/06/2016 Three months versus 28 day prescriptions: a retrospective analysis of CPRD data to determine differences in the cost of drug wastage, dispensing fees and prescriber time
16/06/2016 Oral anticoagulants for atrial fibrillation and the risk of fractures
16/06/2016 The association between bariatric surgery and renal outcomes
14/06/2016 The characteristics and treatment patterns of Parkinson's disease patients in the UK
14/06/2016 GLP-1 agonists and the risk of breast cancer in patients with type 2 diabetes
14/06/2016 Use of parenteral corticosteroids and risk of type 2 diabetes mellitus.
09/06/2016 A retrospective database study of the prescribing of zonisamide in UK general practice: a drug utilisation study as part of post marketing safety surveillance.
06/06/2016 Using pharmacoepidemiology to test medications associated with altered risk of breast cancer progression identified from connectivity mapping
06/06/2016 Cataract in patients with diabetes mellitus
06/06/2016 Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin aldosterone system blockers in CPRD
03/06/2016 A Joint Drug Utilisation Study (DUS) of valproate and related substances, in Europe, using databases
01/06/2016 Use of blood eosinophil count to predict inhaled steroid responsiveness in patients with COPD using primary care health records
01/06/2016 An investigation of the completeness and accuracy of the recording of stroke events (including by subtype) in primary (CPRD) and secondary care databases (HES and ONS)
26/05/2016 Discovering prognostic subtypes of cardiovascular diseases, using linked electronic healthcare records from 2 million people
26/05/2016 Long-term outcomes of NHS Health Checks in England.
23/05/2016 The utilization and toxicity profile of oral corticosteroids among asthma patients in the UK: an epidemiological study using Data from the Clinical Practice Research Datalink (CPRD).
23/05/2016 AED treatment sequencing and effectiveness in epilepsy patients, in real life clinical practice in England
23/05/2016 A Drug Utilisation Study of Rifaximin 550mg
18/05/2016 Development of an identification tool for patients over 65 years at risk of death or emergency hospital admission during cold weather.
17/05/2016 Estimation of multi-treatment effects from observational data with application to diabetes mellitus