Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
01/03/2017 Domestic violence and abuse and prescription of emergency contraception: a nested case-control study in CPRD
01/03/2017 Burden of disease in patients with COPD and high blood eosinophil counts
22/02/2017 Changes over time in the monitoring of cardiovascular risk in primary care, and the use of statins for the primary and secondary prevention of cardiovascular disease.
20/02/2017 A study on the epidemiology of treated glaucoma in the United Kingdom
17/02/2017 An evaluation of the prevalence, epidemiology and burden of illness of hypophosphatasia (HPP) in the United Kingdom.
17/02/2017 Use of hormone replacement therapy and risk of venous thromboembolism
14/02/2017 Comparative effectiveness and safety of novel oral anticoagulants in atrial fibrillation
14/02/2017 Association of urinary tract infections with antipsychotic drug use in older patients
14/02/2017 Sulphonylurea treatment and risk of myocardial infarction and all-cause mortality: a population-based cohort study
14/02/2017 Developing a co-morbidity tool to predict mortality for linked primary and secondary care data.
14/02/2017 The effect of month of birth on the risk of being diagnosed with learning disability and depression.
14/02/2017 Potentially inappropriate prescribing in people with dementia in England: a prospective cohort study.
14/02/2017 Non-specific effects of vaccination in England
14/02/2017 Estimating the effect of statin and metformin on cancer incidence and mortality in national linked electronic health records: a CALIBER study
02/02/2017 A Drug Utilisation Study of domperidone in the United Kingdom using Clinical Practice Research Datalink (CPRD)
01/02/2017 Investigating the impact of BMI of patient with type 2 diabetes on length and cost of hospital stay for complications related to diabetes.
01/02/2017 Association between Rheumatoid Arthritis and comorbidities: a combined retrospective case-control and prospective cohort study.
01/02/2017 The risk of cardiovascular diseases among survivors of site-specific adult cancers: a matched cohort study
01/02/2017 Assessment of the rate of vaccine co-administrations with Bexsero
01/02/2017 Unintended effects of zaleplon, zolpidem, zopiclone (Z-drugs) use for sleep disturbance in people with dementia