Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
26/01/2017 Clinical burden of illness and healthcare resource utilisation among COPD patients stratified by their moderate-severe exacerbation frequency, inhaled triple maintenance treatment status and blood eosinophil levels
26/01/2017 Investigation of the comparative safety of opioid drugs within CPRD- part of the International Pharmacosurveillance Study
23/01/2017 Derivation and validation of statistical models to forecast acute death and longer term survival in people with cirrhosis
23/01/2017 The Use of Angiotensin Converting Enzyme Inhibitors and the Risk of Lung Cancer
23/01/2017 Effects of changing pre-eclampsia management on acute renal failure and other maternal and perinatal outcomes in the United Kingdom: An interrupted time-series analysis
23/01/2017 Associations between absolute value, and change in value, of albumin-creatinine ratio and major adverse health outcomes
18/01/2017 Potential benefits of antithrombotic treatment in reducing risk of subsequent cardiovascular events among patients with a prior myocardial infarction in England
13/01/2017 The incidence and mortality of complicated diverticular disease and associated outcomes following intervention
13/01/2017 A nested case-controlled study of the association between incident pneumonia, dysphagia and the formulation of commonly prescribed medication among people with dementia.
13/01/2017 How do we better understand the current management of patients with Chronic Rhinosinusitis within the National Health Service?
13/01/2017 Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN): A case control study using the Clinical Practice Research Datalink (CPRD).
11/01/2017 Proton pump inhibitor use and risk of iron deficiency: a case-control study.
10/01/2017 The role of statins in the survival of total arthroplasty of the hip and knee.
10/01/2017 Eczema and Dry Skin - Observational Analysis of Patients Prescription Patterns and Healthcare Utilization
10/01/2017 A population-based assessment of the cardiovascular effects of 5-alpha reductase inhibitors
22/12/2016 Neuroprotective Effects of Minocycline in Schizophrenia Patients: Retrospective Cohort Studies Using the Clinical Practice Research Datalink
21/12/2016 Prescribing of antidiabetic drug therapy and comparative incidence of outcomes associated with Type 2 Diabetes
21/12/2016 Cohort study assessing the association between hormone therapy use in female breast cancer survivors and subsequent risk of cardiovascular diseases in the UK
20/12/2016 Assessing the association between incretin-based drugs and the incidence of colon cancer in patients with type 2 diabetes
20/12/2016 A data-driven approach for identifying falls subgroups through semantic similarity analysis