Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
04/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 5 - Replication of "Pioglitazone use and risk of bladder cancer: population based cohort study"
15/05/2018 Paracetamol versus Ibuprofen and the risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding and Renal Impairment
15/05/2018 Are patients with high normal platelet counts at increased risk of cancer? The NORMA study
15/05/2018 Is seasonal influenza vaccine effectiveness reduced in people receiving repeat vaccinations? A retrospective cohort study using the Clinical Practice Research Database
15/05/2018 Developing indicators for failure or delays in recognising clinical deterioration and escalation of care across primary care
15/05/2018 The association between inflammatory markers measured in blood and incident seizures
17/05/2018 High-need patients with chronic conditions: primary and secondary care utilisation and costs, by social and demographic characteristics in high income countries.
21/05/2018 Blood eosinophilia, withdrawal of inhaled corticosteroids and risk of COPD exacerbations and mortality
21/05/2018 Treatment patterns and burden of agitation in patients with Alzheimer's disease in the UK
21/05/2018 Trends in acute exacerbation and related hospitalization among COPD patients in the UK (2005-2013)
22/05/2018 Evaluation of the Burden and Management of Musculoskeletal Diseases
22/05/2018 Long-term relative effectiveness of monotherapy antihypertensive drugs in patients newly diagnosed with hypertension. A cohort study in the UK Clinical Practice Research Datalink (CPRD)
22/05/2018 The Association of oral bisphosphonate use with mortality risk following a major osteoporotic fracture in the UK
23/05/2018 Use of non-steroidal anti-inflammatory drugs and risk of acute myocardial infarction in patients undergone total hip or knee replacement surgery: a population-based cohort study
23/05/2018 Acute exacerbation of idiopathic pulmonary fibrosis in the UK: incidence, mortality and disease severity
25/05/2018 Up-titration and distribution of dose of metformin monotherapy in the real-world
30/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 11 - Replication of "Co-administration of statins with cytochrome P450 3A4 inhibitors in a UK primary care population"
30/05/2018 Persistence and adherence to controlled release formulations of sodium valproate for the treatment of epilepsy and their clinical and resource use implications.
30/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 6 - Replication of "Glucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK CPRD"
01/06/2018 Determinants associated with treatment modification in the first year of treatment in patients with type 2 diabetes mellitus in the United Kingdom, before and after implementation of the new guideline: a retrospective cohort study