Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
30/06/2016 Assessment of Metformin Use Pattern in UK using CPRD
29/06/2016 Pharmacoepidemiology of pancreatin use in non-cystic fibrosis patients and comparison of all-cause mortality with that of their matched controls
29/06/2016 Long-term severe non-dermatological outcomes in eczema
29/06/2016 Comparative effectiveness of lansoprazole and omeprazole for the prevention of gastrointestinal bleeding and malignancy
29/06/2016 Characterisation and cardiovascular risk profile of type 2 diabetes mellitus patients according to initiation of antidiabetic medications
29/06/2016 Generalizability of Clinical Trial Results: Value of Individual Data versus Aggregate Data
22/06/2016 Immunosuppressive therapy and Parkinson's disease risk
21/06/2016 What is the occurrence of clinically diagnosed coeliac disease and dermatitis herpetiformis in the UK today? A population based cohort study utilising electronically linked health records.
21/06/2016 Diabetes, use of metformin and the risk of meningioma
21/06/2016 Three months versus 28 day prescriptions: a retrospective analysis of CPRD data to determine differences in the cost of drug wastage, dispensing fees and prescriber time
16/06/2016 Oral anticoagulants for atrial fibrillation and the risk of fractures
16/06/2016 The association between bariatric surgery and renal outcomes
14/06/2016 The characteristics and treatment patterns of Parkinson's disease patients in the UK
14/06/2016 GLP-1 agonists and the risk of breast cancer in patients with type 2 diabetes
14/06/2016 Use of parenteral corticosteroids and risk of type 2 diabetes mellitus.
09/06/2016 A retrospective database study of the prescribing of zonisamide in UK general practice: a drug utilisation study as part of post marketing safety surveillance.
06/06/2016 Using pharmacoepidemiology to test medications associated with altered risk of breast cancer progression identified from connectivity mapping
06/06/2016 Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin aldosterone system blockers in CPRD
06/06/2016 Cataract in patients with diabetes mellitus
03/06/2016 A Joint Drug Utilisation Study (DUS) of valproate and related substances, in Europe, using databases