Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

 

ISAC Approval Date Title
30/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 11 - Replication of "Co-administration of statins with cytochrome P450 3A4 inhibitors in a UK primary care population"
30/05/2018 Persistence and adherence to controlled release formulations of sodium valproate for the treatment of epilepsy and their clinical and resource use implications.
30/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 6 - Replication of "Glucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK CPRD"
01/06/2018 Determinants associated with treatment modification in the first year of treatment in patients with type 2 diabetes mellitus in the United Kingdom, before and after implementation of the new guideline: a retrospective cohort study
01/06/2018 Using CPRD to describe the current management of heart failure in England and model risk trajectories to improve shared decision-making
01/06/2018 Rate and risk of cardiovascular events and all-cause mortality in individuals with type 2 diabetes, with and without microalbuminuria - a cohort study in the CPRD database
08/06/2018 Prescribing of high dose oral ibuprofen (1800mg/day or more) in UK primary care
08/06/2018 The cumulative incidence of seizures during 21 days after new use of oral antibiotics - a cohort study
08/06/2018 The utilisation of linaclotide in patients with Irritable Bowel Syndrome predominantly with constipation (IBS-C) in the United Kingdom: a retrospective observational study using the Clinical Practice Research Datalink
08/06/2018 Replication of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) in a cohort study using electronic primary care data
11/06/2018 Investigating the potential side effects of the human papillomavirus vaccine: a novel regression discontinuity analysis using the UK Clinical Practice Research Datalink
11/06/2018 Deriving parameters of long-term cardiovascular outcomes and health care utilisation for a cost-effectiveness model in patients with familial hypercholesterolaemia diagnosed in primary care
11/06/2018 Use of primary care and hospital services in children aged less than 15 years in England; descriptive study
14/06/2018 Descriptive Analysis of Pro-Arrhythmic Risk of Drug Therapies
15/06/2018 What influence does obesity have on healthcare utilisation cost for patients with and without cardiovascular diseases?
15/06/2018 Comparing the effectiveness of COPD treatments in the UK
18/06/2018 Investigating healthcare utilisation for heart failure patients with or without cardiac implantable electronic devices in England: retrospective cohort study.
20/06/2018 Health Impact Assessment to predict the impact of an increase in tobacco pricing on the burden of COPD in Italy, Sweden and the United Kingdom
20/06/2018 The impact of not speaking English as a first language on diabetes control and outcomes in primary care
22/06/2018 Prevalence, incidence, and natural history of gastroparesis in the United Kingdom: real world evidence from the Clinical Practice Research Datalink