Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
14/06/2016 GLP-1 agonists and the risk of breast cancer in patients with type 2 diabetes
14/06/2016 Use of parenteral corticosteroids and risk of type 2 diabetes mellitus.
09/06/2016 A retrospective database study of the prescribing of zonisamide in UK general practice: a drug utilisation study as part of post marketing safety surveillance.
06/06/2016 Using pharmacoepidemiology to test medications associated with altered risk of breast cancer progression identified from connectivity mapping
06/06/2016 Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin aldosterone system blockers in CPRD
06/06/2016 Cataract in patients with diabetes mellitus
03/06/2016 A Joint Drug Utilisation Study (DUS) of valproate and related substances, in Europe, using databases
01/06/2016 Use of blood eosinophil count to predict inhaled steroid responsiveness in patients with COPD using primary care health records
01/06/2016 An investigation of the completeness and accuracy of the recording of stroke events (including by subtype) in primary (CPRD) and secondary care databases (HES and ONS)
26/05/2016 Discovering prognostic subtypes of cardiovascular diseases, using linked electronic healthcare records from 2 million people
26/05/2016 Long-term outcomes of NHS Health Checks in England.
23/05/2016 AED treatment sequencing and effectiveness in epilepsy patients, in real life clinical practice in England
23/05/2016 A Drug Utilisation Study of Rifaximin 550mg
23/05/2016 The utilization and toxicity profile of oral corticosteroids among asthma patients in the UK: an epidemiological study using Data from the Clinical Practice Research Datalink (CPRD).
18/05/2016 Development of an identification tool for patients over 65 years at risk of death or emergency hospital admission during cold weather.
17/05/2016 A longitudinal safety study of patients with psoriasis and psoriatic arthritis treated with either Otezla (apremilast) or a comparator drug
17/05/2016 Estimation of multi-treatment effects from observational data with application to diabetes mellitus
17/05/2016 Burden of medically attended acute gastroenteritis and aetiology: a cohort study in CPRD in England.
12/05/2016 Does the use of inhaled corticosteroids increase the incidence and disease burden of Type 2 Diabetes, osteoporosis or pneumonia compared to non-ICS therapies in patients with Chronic Obstructive Pulmonary Disease.
03/05/2016 Descriptive Epidemiology of Multimorbidity in Primary Care: A Cross-Sectional Study