Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
09/11/2016 Diagnosis and treatment of dementia in primary care in the UK
08/11/2016 Gender differences in Chronic Obstructive Pulmonary Disease: baseline characteristics, progression, and exacerbations in the United Kingdom's Clinical Practice Research Datalink
07/11/2016 20 year trends for prevalence and incidence of Resistant Hypertension in the United Kingdom and prognosis in adults with hypertension
29/10/2016 Investigating safety of 'metabolically healthy obesity' and sustainability from community and tertiary based databases in the UK
28/10/2016 Annual Healthcare Resource Use and Costs for Eczema in Children: A Cost of Illness Study for the English NHS
24/10/2016 Drug utilization study of dexamfetamine in European countries
24/10/2016 Trends in NHS prescribing of dual NRT (DNRT) and varenicline in pregnancy and effects on infants
18/10/2016 Clinical effectiveness of combining two drugs versus monotherapy as initial treatment strategy in hypertension - a matched cohort study in CPRD
18/10/2016 Incidence, prevalence, mortality and health-service use among people with systemic sclerosis (scleroderma) in the UK Clinical Practice Research Datalink
18/10/2016 Impact of hospital admission upon patterns of primary care prescribing
18/10/2016 Primary Care and Access To Surgical Treatment For Women With Urinary Incontinence
18/10/2016 Use of novel regression discontinuity design to investigate safety of statins in the UK Clinical Practice Research Datalink
14/10/2016 What are the long-term health outcomes in low birth weight and premature babies born with chronic lung disease who are discharged home on oxygen?
13/10/2016 Oophorectomy and risk of primary liver cancer and fatty liver disease among women in the UK Clinical Practice Research Datalink
13/10/2016 Rates of cytomegalovirus among children with organ transplants
13/10/2016 Renal Outcomes with DPP-4 Inhibitors Compared with Sulfonylurea as Add-on to Metformin among Patients with Type 2 Diabetes Mellitus in the UK
13/10/2016 Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints: Mortality Study
11/10/2016 The relationship between prior antibiotic exposure and antibiotic "response failure" in children presenting with acute respiratory tract infections (RTI) in primary care: an observational cohort study
30/09/2016 Estimating the annual incidence of paediatric burns across the United Kingdom
22/09/2016 Metformin and the incidence of viral-induced cancers in patients with Type-2 diabetes