Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
14/03/2016 Low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride and diverse non-cardiovascular diseases: a large population-based cohort study using CALIBER dataset
10/03/2016 Investigating the utility of blood pressure variability in cardiovascular risk prediction
09/03/2016 Predictors of complications of venous thromboembolism
08/03/2016 Natural history, characteristics, and treatment patterns in patients with primary biliary cirrhosis and cholestatic pruritis
25/02/2016 Validity of UK general practice prescribing safety indicators in predicting adverse events
25/02/2016 Predicting first admission and readmission in heart failure patients
23/02/2016 Association between HbA1c and all-cause mortality in people with type 2 diabetes treated with glucose-lowering therapies with a higher and lower risk of inducing hypoglycaemia: a retrospective cohort study.
23/02/2016 Comorbidity in the aging HIV population of the UK: a CPRD analysis.
23/02/2016 Risk of hypoglycaemia in users of sulphonylureas with renal impairment: a population-based cohort study
19/02/2016 Investigating the effects of commonly prescribed drugs on the prevention and treatment of Alzheimer's and other neurodegenerative diseases: are there drugs already available that can be repurposed?
18/02/2016 Use of routinely collected national data to determine the delays that lead to poor outcome for cancer patients in the UK
10/02/2016 Evaluating the utility of the CPRD GOLD-HTI linkage: anticoagulant prescribing at the GP practice compared to hospital dispensed medication at discharge date
10/02/2016 Depression, prescription of antidepressant drugs and changes in body weight: A cohort study using electronic health records
10/02/2016 Demography and pattern of causes of death in recognised alcohol misusers in the English General Practice (GP) population
09/02/2016 Does better quality of primary care influence admissions and health outcomes for people with serious mental illness (SMI)? A linked patient-level analysis of the full patient care pathway
22/01/2016 Treatment of first-time traumatic anterior shoulder dislocation (UK.TASH-D Study)
14/01/2016 Risk factors for influenza-related complications in children
05/01/2016 Mapping patient cohort data from a clinical coding space into a distance space: novel tools for hypothesis generation, stratification and cohort identification.
04/01/2016 Domperidone and risk of primary liver cancer in the UK Clinical Practice Research Datalink
31/12/2015 Association between Diabetes Mellitus and Incident Meniere's Disease